Distribution of ABO and Rhesus Blood Groups in Cancer Patients

Abstract

When studies on the relation of ABO and Rhesus (Rh) blood groups with cancer are examined in the literature, it is not possible to draw an absolute conclusion, the results may vary according to the countries and centers where the study was conducted. The aim of this study is to evaluate the distribution of ABO-Rh blood groups according to cancer subtypes in our clinic. The distribution of blood groups of patients who were followed up for cancer between January 2015 and 2020 according to their cancer types was examined and the data were compared with the non-cancer control group. Participants' sociodemographic data such as age and gender, cancer type and blood groups (ABO-Rh) were retrospectively scanned from the hospital automation system. The study included 1894 (22.1%) cancer patients and 6681 (77.9%) control group. There was a statistically significant difference in blood groups of control group and cancer patients (p<0.001). ARh(+) blood group in melanoma, renal, colorectal, breast and ovarian cancers; ORh (+) blood group was found with a significantly higher rate in pancreatic cancer. In multivariate regression analysis, being group A and group O and increasing age were found to be independent predictive factors for cancer. It was observed that the distribution of ABO-Rh blood groups was different in the control group and cancer patients. In cancer subtypes, the rate of O blood group in pancreatic cancer and A blood group in melanoma and renal cell tumors were found to be higher. According to healthy people, advanced age, A and O blood groups were found to be independent risk factors for cancer diagnosis.

Keywords

• ABO
• Rh
• blood group
• cancer
• risk

Kanser Hastalarında ABO ve Rhesus Kan Gruplarının Dağılımı

Abstract

Literatürde ABO ve Rhesus (Rh) kan gruplarının kanser hastalığı ile ilişkisine dair yapılan çalışmalar incelendiğinde mutlak bir sonuç çıkarmak mümkün olmamakta, sonuçlar ülkelere ve çalışmanın yapıldığı merkezlere göre değişkenlik gösterebilmektedir. Bu çalışmanın amacı kliniğimizde ABO-Rh kan gruplarının kanser alt tiplerine göre dağılımını değerlendirmektir. Ocak 2015- Ocak 2020 tarihleri arasında Tıbbi Onkoloji kliniğinde kanser tanısıyla takip ve tedavi edilen hastaların kan gruplarının kanser tiplerine göre dağılımı incelendi ve veriler kanser olmayan kontrol grubu ile karşılaştırıldı. Katılımcıların yaş, cinsiyet gibi sosyodemografik verileri, kanser alt tipi ve kan grupları (ABO-Rh) retrospektif olarak hasta dosyası ve hastane otomasyon sisteminden tarandı. Çalışmaya 1894’ü (%22.1) kanser hastası, 6681’i (%77.9) kontrol grubu olmak üzere 8575 birey dahil edildi. Kontrol grubu ve kanser hastalarında kan gruplarının dağılımında istatistiksel olarak anlamlı farklılık saptandı (p<0.001). Malign melanom, böbrek, kolorektal, meme, over kanserlerinde ARh(+) kan grubu; pankreas kanserinde ise ORh(+) kan grubu anlamlı derecede yüksek oranda saptandı. Diğer kanser tiplerinde kan grupları açısından bir farklılık tespit edilmedi. Çok değişkenli lojistik regresyon analizine göre; A ve O kan grupları ve ileri yaşın kanser hastalığı için bağımsız prediktif faktörler olduğu belirlendi. Kanser hastaları ve kontrol grubunda ABO-Rh kan gruplarının dağılımının farklı olduğu görüldü. Kanser alt tipleri incelendiğinde pankreas kanserinde O kan grubunun, malign melanom ve böbrek tümörlerde ise A kan grubunun daha yüksek oranda olduğu görüldü. Sağlıklı kişilere göre ileri yaş, A ve O kan gruplarının kanser hastalığı için bağımsız prediktif faktörler olduğu görüldü.

Keywords

• ABO
• Rh
• kan grubu
• kanser
• risk

References

1. 1. Jemal, A., et al., Global cancer statistics. CA: a cancer journal for clinicians, 2011. 61(2): p. 69-90.
2. 2. Franchini, M., G.M. Liumbruno, and G. Lippi, The prognostic value of ABO blood group in cancer patients. Blood Transfusion, 2016. 14(5): p. 434.
3. 3. Huang, J.Y., et al., ABO blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one, 2017. 12(9): p. e0184295.
4. 4. Aird, I., H.H. Bentall, and J.F. Roberts, Relationship between cancer of stomach and the ABO blood groups. British medical journal, 1953. 1(4814): p. 799.
5. 5. Amundadottir, L., et al., Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nature genetics, 2009. 41(9): p. 986-990.
6. 6. Li, B., et al., Association between the ABO blood group and risk of common cancers. Journal of evidence-based medicine, 2014. 7(2): p. 79-83.
7. 7. Eren, C., İstanbul İlinde ABO ve Rh Kan Grupları Dağılımının Analizi. Dicle Medical Journal/Dicle Tip Dergisi, 2019. 46(2).
8. 8. Salduz, Z.I.Y., et al., ABO and Rh blood group distribution in Istanbul Province (Turkey). İstanbul Med J, 2015. 16: p. 98-100.

9. 9. Aird, I., et al., The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus. British Medical Journal, 1954. 2(4883): p. 315.
10. 10. Saxena, S., et al., Association of ABO blood group and breast cancer in Jodhpur. Indian J Physiol Pharmacol, 2015. 59(1): p. 63-68.
11. 11. Özkasap, S., et al., Analysis of ABO and Rh blood groups distribution in East Karadeniz region of Turkey. Dicle Med J, 2013. 40(1): p. 100-104.
12. 12. Ronco, A.L., et al., Rh factor, family history and risk of breast cancer: A case–control study in Uruguay. Cancer Detection and Prevention, 2009. 32(4): p. 277-285.
13. 13. Oral, A. and T. Sahin, Prognostic role of ABO blood group and Rhesus factor in cirrhotic patients with hepatocellular carcinoma. Scientific Reports, 2019. 9(1): p. 1-6.
14. 14. Roots, I., et al., Debrisoquine hydroxylation phenotype, acetylation phenotype, and ABO blood groups as genetic host factors of lung cancer risk. Klin Wochenschr, 1988. 66(Suppl 11): p. 87-97.
15. 15. Oguz, A., et al., Lack of any association between blood groups and lung cancer, independent of histology. Asian Pac J Cancer Prev, 2013. 14(1): p. 453-6.
16. 16. Ko, K., et al., Prognostic significance of blood type A in patients with renal cell carcinoma. Urology journal, 2016. 13(4): p. 2765-2772.
17. 17. Stakišaitis, D., et al., ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity. Oncology letters, 2018. 16(1): p. 1321-1331.
18. 18. Klatte, T., et al., Impact of ABO blood type on outcomes in patients with primary nonmuscle invasive bladder cancer. The Journal of urology, 2014. 191(5): p. 1238-1243.
19. 19. Markt, S.C., et al., ABO blood group alleles and prostate cancer risk: results from the breast and prostate cancer cohort consortium (BPC3). The Prostate, 2015. 75(15): p. 1677-1681.
20. 20. Chang, L., et al., Incidence and metastasis of cutaneous malignant melanoma with respect to ABO blood groups: a case-controlled study in northeast of China. PloS one, 2014. 9(2): p. e88096.
21. 21. Marinaccio, M., et al., Blood groups of the ABO system and survival rate in gynecologic tumors. Minerva ginecologica, 1995. 47(3): p. 69-76.
22. 22. Henderson, J., V. Seagroatt, and M. Goldacre, Ovarian cancer and ABO blood groups. Journal of Epidemiology & Community Health, 1993. 47(4): p. 287-289.
23. 23. Gates, M.A., et al., ABO blood group and incidence of epithelial ovarian cancer. International journal of cancer, 2011. 128(2): p. 482-486.
24. 24. Kahramanca, Ş., et al., Kolorektal Kanserlerde Kan Grubu Özellikleri. Turkish Journal of Colorectal Disease, 2018. 28(2): p. 76.
25. 25. Khalili, H., et al., ABO blood group and risk of colorectal cancer. Cancer Epidemiology and Prevention Biomarkers, 2011. 20(5): p. 1017-1020.
26. 26. Stamatakos, M., et al. Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor. in International seminars in surgical oncology. 2009. Springer.
27. 27. Flavarjani, A.H.M., et al., Study of the association between blood types and breast cancer among Isfahanian women with breast cancer. Advanced Biomedical Research, 2014. 3.
28. 28. Miao, S.Y., et al., Influence of ABO blood group and R hesus factor on breast cancer risk: A meta‐analysis of 9665 breast cancer patients and 244 768 controls. Asia‐Pacific Journal of Clinical Oncology, 2014. 10(2): p. 101-108.
29. 29. DIXIT, R., et al., Epıdemıologıcal Study Of Breast Cancer Patıents And Theır Assocıatıon Wıth Abo Blood Group.
30. 30. Su, M., et al., Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China. World journal of gastroenterology, 2001. 7(5): p. 657.
31. 31. Singh, K., et al., Relative risk of various head and neck cancers among different blood groups: an analytical study. Journal of clinical and diagnostic research: JCDR, 2014. 8(4): p. ZC25.
32. 32. Yu, H., et al., Association of ABO Blood Groups and Risk of Gastric Cancer. Scandinavian Journal of Surgery, 2019: p. 1457496919863886.
33. 33. Edgren, G., et al., Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. American journal of epidemiology, 2010. 172(11): p. 1280-1285.
34. 34. Pandey, M., A. Gautam, and V. Shukla, ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. BMJ, 1995. 310(6995): p. 1639.
35. 35. Engin, H., et al., ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region. Asian pacific journal of cancer prevention, 2012. 13(1): p. 131-133.
36. 36. Wolpin, B.M., et al., ABO blood group and the risk of pancreatic cancer. Journal of the National Cancer Institute, 2009. 101(6): p. 424-431.
37. 37. Yapar, A. and F.C. Sökmen, The Relationship between AB0 Blood Group and Malignant Soft-Tissue Sarcomas AB0 Kan Grubu ve Malign Yumuşak Doku Sarkomları Arasındaki İlişki.
38. 38. Güner, Ş.İ. and E. Güner, ABO Blood Types and Risk of Testicular Cancer in Turkish Population: Preliminary Results. Bull Urooncol, 2019. 18: p. 135-137.
39. 39. Allouh, M.Z., et al., Glioblastoma and ABO blood groups: further evidence of an association between the distribution of blood group antigens and brain tumours. Blood Transfusion, 2017. 15(6): p. 543.
40. 40. Tavasolian, F., et al., Relationship between ABO blood group and Acute Lymphoblastic Leukemia. Iranian journal of pediatric hematology and oncology, 2014. 4(1): p. 1.
41. 41. Janardhana, V., D.N. Propert, and R.E. Green, ABO blood groups in hematologic malignancies. Cancer genetics and cytogenetics, 1991. 51(1): p. 113-120.
42. 42. Ershler, W.B. and D.L. Longo, Aging and Cancer: Issues of Basic and Clinical Science. JNCI: Journal of the National Cancer Institute, 1997. 89(20): p. 1489-1497.
43. 43. SMETANA, K., et al., Ageing as an important risk factor for cancer. Anticancer research, 2016. 36(10): p. 5009-5017.