Androgenetic Alopecia

Abstract

Androgenetic alopecia is a form of hair loss that can occur with different pathological mechanisms in people with genetic predisposition, and the clinic may vary in men and women. Although androgenetic alopecia is common and its diagnosis is usually easy, there is no standard treatment guideline for patient management. The purpose of the management of androgenetic alopecia is to stop follicular miniaturization and to increase hair density. Therapies used in the management of androgenetic alopecia are potassium ion channel modifiers (topical minoxidil and oral minoxidil), 5α reductase inhibitors (oral finasteride, topical finasteride and oral dutasteride), androgen receptor antagonists (spironolactone, cyproterone acetate, flutamide, cortexolone 17 alpha propionate solution and topical minoxidil) , other medical treatments (topical prostaglandin analogues, topical ketoconazole, topical melatonin, Wnt / β catenin signaling pathway activators and JAK-STAT pathway inhibitors), physical treatments (low-grade laser light therapy, laser treatments, microneedling, mesotherapy, PRP and stem cell treatments), complementary therapies (hair transplantation, nutritional supplements and camouflage methods) and combination therapies. In this review, it is aimed to provide information about current treatment methods in the management of androgenetic alopecia in men and women.

Keywords

• Androgenetic alopecia
• pathogenesis
• patient management
• minoxidil
• finasteride

Androgenetik Alopesi

Abstract

Androgenetik alopesi genetik yatkınlığı olan kişilerde farklı patolojik mekanizmalarla ortaya çıkabilen, erkek ve kadınlarda kliniği değişiklik gösterebilen bir saç dökülme şeklidir. Androgenetik alopesi her ne kadar sık görülüyor ve tanısı genellikle kolay koyuluyor olsa da hasta yönetimi için standart bir tedavi rehberi yoktur. Androgenetik alopesi yönetiminde amaç foliküler minyatürizasyonu durdurmak ve saç dansitesini arttırmaktır. Androgenetik alopesi yönetiminde kullanılan tedaviler potasyum iyon kanalı düzenleyicileri (topikal minoksidil ve oral minoksidil), 5α redüktaz inhibitörleri (oral finasterid, topikal finasterid ve oral dutasterid), androjen reseptör antagonistleri (spironolak-ton, siproteron asetat, flutamid, korteksolon 17 alfa propionat ve topikal fluridil), diğer medikal tedaviler (topikal prostoglandin analogları, topikal ketokonazol, topikal melatonin, Wnt/β katenin sinyal yolağı aktivatörleri ve JAK-STAT yolağı inhibitörleri), fiziksel tedaviler (düşük dereceli lazer ışık tedavisi, lazer tedavileri, mikroiğneleme, mezoterapi, PRP ve kök hücre tedavileri), tamamlayıcı tedaviler (saç transplantasyonu, besin takviyeleri ve kamuflaj yöntemleri) ve kombinasyon tedavileridir. Bu derlemede erkek ve kadında androgenetik alopesi yönetiminde güncel tedavi yöntemleri hakkında bilgi verilmesi amaçlanmıştır.

Keywords

• Androgenetik alopesi
• patogenez
• hasta yönetimi
• minoksidil
• finasterid

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