Influence of Antropometric Parameter, Sleep Position and Gender on Severity of Obstructive Sleep Apnea Syndrome

Abstract

Obstructive Sleep Apnea syndrome (OSAS) frequently seen in the adult population is an important public health problem. Obesity is an important risk factor of OSAS. Severity of sleep apnea syndrome may differ according to sleep position, sleep stage, gender and body mass ındex (BMI). Therefore, we aimed to evaluate the relationship between the severity of Obstructive Sleep Apnea Syndrome and sleep stage, sleep position with gender. One hundred fifty-one subjects (93 (61,58 %) men, 58 (38,41%) women) were analyzed. Recorded demographic features, over-night polysomnographic data and risk factors of the subjects were reviewed retrospectively. Diagnosis of OSAS was made according to the 3. edition of International of Sleep Disorders Classification. Famele subjects had signicantly higher age, BMI, diabetes and hypertension (p=0.001, p= 0.001, p= 0.034, p= 0.001). The severity of OSAS was higher in male subjects. It was significantly in supin position (AHI: 44.34±28.07/hour in males, AHI: 35.09±26.76/hour in females, p=0.048). The severity of OSAS in REM stage was higher in female subjects (p=0.016). Although age, BMI, hypertension and diabetes was signicantly higher in females than males in this study, OSAS severity in male patients was higher. The difference was significantly in supin position in sleep. The severity of OSAS in REM sleep stage was higher in females than males. This condition suggests that regional fat accumulation is a more important predictor for OSAS than general obesity due to differences in fat distrubution by gender.

Keywords

• Obstructive
• Sleep Apnea Syndrome
• gender
• body mass ındex

Obtrüktif Uyku Apne Sendromu Şiddetine Antropometrik Parametre Cinsiyet ve Uyku Pozisyonunun Etkisi

Abstract

Obstrüktif Uyku apne sendromu (OUAS), yetişkin popülasyonda oldukça sık görülen önemli bir halk sağlığı problemidir. Obezite bu send-romun gelişimi için en önemli risk faktörüdür. OUAS şiddeti beden kitle indeksi (BKİ), uyku evresi, pozisyonu ve cinsiyete göre değişiklik göstermektedir. Bu çalışmada OUAS şiddetine BKİ, uyku evresi, uyku pozisyonu yanında cinsiyetin etkisinin değerlendirilmesi amaçlanmıştır. Çalışmaya polisomnografi incelemesi sonrasında OUAS tanısı alan 93 (%61,58) erkek, 58 (%38,41) kadın olmak üzere toplam 151 hasta alınmıştır. Hastaların demografik özellikleri, polisomnografi parametreleri ve risk faktörleri retrospektif olarak kaydedilmiştir. OUAS tanısı üçüncü Uluslararası Uyku Bozuklukları Sınıflama Klavuzuna göre koyulmuştur. Kadın cinsiyette yaş, BKİ, diabet ve hipertansiyon gibi kardiyovasküler risk faktörleri erkek cinsiyete göre anlamlı yüksek bulunmuştur (p=0,001, p=0,001, p=0,034, p=0,001). Buna rağmen OUAS şiddeti erkek cinsiyette anlamlı bulunmasa da daha yüksek bulunmuştur (p>0,05). Bu yükseklik sırtüstü pozisyonda istatistiksel olarak anlamlı bulunmuştur (erkeklerde AHİSIRT: 44,34±28,07/saat, kadınlarda AHİSIRT: 35,09±26,76/saat, p=0,048). REM uyku evresinde ise OUAS şiddeti kadınlarda fazla bulunmuştur (p=0,016). Bu çalışmada OUAS risk faktörlerinden olan yaş, BKİ, hipertansiyon ve diabet mevcudiyeti, kadın cinsiyette erkek cinsiyete göre istatistiksel olarak anlamlı yüksek bulunmuştur. Buna rağmen OUAS şiddeti erkek cinsiyette daha yüksek bulunmuştur. Bu yükseklik sırtüstü pozisyonda istatistiksel olarak anlamlı bulunmuştur. REM uyku evresinde ise OUAS şiddeti kadın cinsiyette daha fazla bulunmuştur. Bu durum cinsiyetler arasında yağ dağılımındaki farklılıkları düşündürmekte ve genel bir obeziteden ziyade bölgesel yağ birikiminin OUAS için daha önemli bir prediktör olduğunu düşündürmektedir.

Keywords

• Obstrüktif
• Uyku Apne Sendromu
• cinsiyet
• beden kitle indeksi

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