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The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients
Abstract
We aimed to compare the short-term efficacies of losartan treatment alone and in combination with cilazapril or carvedilol on blood pressure, glycemic control, insülin resistance (IR) and lipid profile in hypertensive type 2 diabetic patients. The study included 21 type 2 diabetic and hypertensive patients. After 2 weeks follow-up (Period 1), patients received losartan 50 mg/day for 6 weeks (Period 2). Then, patients were divided into 3 groups for 6 weeks: losartan 100 mg/day (Group 1), losartan 50 mg/day and carvedilol 25 mg/day (Group 2) or cilazapril 5 mg/day (Group 3) (Period 3). After losartan treatment, mean body mass index, blood pressure, waist and hip circumferences decreased significantly. Systolic blood pressures decreased in all groups in period 3. Only the decrease in diastolic blood pressure in Group 3 was significant. Body mass index in Group 1, waist circumference in Group 1 and Group 3, and hip circumference in Group 1 significantly decreased. In period 1, 2 and 3, glucose, insulin, HOMA IR, fructosamine, HbA1c and lipid values of the patients did not change significantly. High-dose losartan, losartan+cilazapril and losartan+carvedilol treatments decreased blood pressure in type 2 diabetic patients. However, these regimens did not affect glycemic control, IR and lipid profile.
Keywords
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
September 1, 2017
Submission Date
September 1, 2017
Acceptance Date
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Published in Issue
Year 2017 Volume: 43 Number: 3
APA
Erek, M., Ersoy, A., & Ersoy, C. (2017). The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients. Journal of Uludağ University Medical Faculty, 43(3), 123-128. https://izlik.org/JA79EL28NR
AMA
1.Erek M, Ersoy A, Ersoy C. The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients. Journal of Uludağ University Medical Faculty. 2017;43(3):123-128. https://izlik.org/JA79EL28NR
Chicago
Erek, Müge, Alparslan Ersoy, and Canan Ersoy. 2017. “The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients”. Journal of Uludağ University Medical Faculty 43 (3): 123-28. https://izlik.org/JA79EL28NR.
EndNote
Erek M, Ersoy A, Ersoy C (September 1, 2017) The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients. Journal of Uludağ University Medical Faculty 43 3 123–128.
IEEE
[1]M. Erek, A. Ersoy, and C. Ersoy, “The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients”, Journal of Uludağ University Medical Faculty, vol. 43, no. 3, pp. 123–128, Sept. 2017, [Online]. Available: https://izlik.org/JA79EL28NR
ISNAD
Erek, Müge - Ersoy, Alparslan - Ersoy, Canan. “The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients”. Journal of Uludağ University Medical Faculty 43/3 (September 1, 2017): 123-128. https://izlik.org/JA79EL28NR.
JAMA
1.Erek M, Ersoy A, Ersoy C. The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients. Journal of Uludağ University Medical Faculty. 2017;43:123–128.
MLA
Erek, Müge, et al. “The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients”. Journal of Uludağ University Medical Faculty, vol. 43, no. 3, Sept. 2017, pp. 123-8, https://izlik.org/JA79EL28NR.
Vancouver
1.Müge Erek, Alparslan Ersoy, Canan Ersoy. The Effect of Different Antihypertensive Drug Regimens on Insulin Resistance in Hypertensive Type 2 Diabetic Patients. Journal of Uludağ University Medical Faculty [Internet]. 2017 Sep. 1;43(3):123-8. Available from: https://izlik.org/JA79EL28NR