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DOSIMETRIC COMPARISON OF SCALP AND ORGANS AT RISK WITH DIFFERENT RADIOTHERAPY TECHNIQUES IN MALIGN GLIAL TUMORS

Year 2018, Volume: 44 Issue: 2, 95 - 101, 01.08.2018
https://doi.org/10.32708/uutfd.431230

Abstract

In
malign glial tumors treated with radiotherapy (RT); despite the current
treatment plan with volumetric arc (t-VMAT) technique, 1 arc VMAT and static 5
field intensity modulated RT technique wre compered dosimetrically. Sixteen malign
glial tumors treated with at least 50 Gy RT were included. Sixteen, 30 and 24
Gray thresholds doses were used for mean, 1 and 9 cc scalp volumes. There was
no statistically significant difference between methods in terms of planning
treatment volume and risky organ doses. Significant reductions in scalp doses
were observed (p < 0.05) with the inclusion of scalp regardless of the planning
methods. Despite the hair loss in acute period, there was no permanent hair
loss in any case in 12-month follow-up. It has been shown by this study, the
inclusion of scalp into the treatment plan does not have a negative effect on
the target volume doses, and our patients may be protected from cosmetic and
psychosocial side effects caused by permanent hair loss.

References

  • 1. Gondi V, Vogelbaum MA, Grimm S, Mehta MP (eds). Primary intracranial neoplasms. In: Halperin EC, Wazer DE, Perez CA, Brady LW, eds. Principles and Practice of Radiation Oncology, 6th ed. Philadelphia, LWW, 2013; 938-973.
  • 2. Stupp R, Brada M, Van Den Bent, Tonn JC, Penthheroudakis G, ESMO Guidelines Working Group. High-grade Glioma: Esmo Clinical Practice Guidelines For Diagnosis, Treatment And Follow-Up. Ann Oncol, 2014, 25, Suppl 3.
  • 3. Gzell C, Back M, Wheeler H, Bailey D, Foote M. Radiotherapy in Glioblastoma: The Past, The Present And The Future. Clin Oncol, 2017, 29 (1): 15-25.
  • 4. Gondi V, Pugh SL, Tome WA, et al. Preservation of memory with conformal compartmnt during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol, 32 (34): 3810-6.
  • 5. Lawenda BD, Gagne HM, Gierga DP, et al. Permanent alopecia after cranial irradiation: dose-response relationship. Int J Radiat Oncol Biol Phys. 2004, 60 (3): 879-87.
  • 6. Severs GA, Griffin T, Werner-Wasik M. Cicatricial alopecia secondary to radiation therapy: case report and review of the literatüre. Cutis 2008, 81 (2): 147-53.
  • 7. Roberge D, Parker W, Niazi TM, Olivares M. Treating the contents and not the container: dosimetric study of hair-sparing whole brain intensity modulated radiation therapy. Technol Cancer Res Treat, 2005, 4 (5): 567-70.
  • 8. Mancini BR, Kim LH, Shaitelman SF, et al. Intensity modulated or volumetric modulated radiation therapy (IMRT or VMAT) to reduce alopecia, xerostomia, and otitis after whole brain radiation therapy for brain metastases: a planning analysis. Int J Radiat Oncol Biol Phys. 2010, 78 (3), suppl, abstract no 3422, page S840.
  • 9. Mahadevan A, Sampson C, LaRosa S, et al. Dosimetric Analysis Of The Alopecia Preventing Effect Of Hippocampus Sparing Whole Brain Radiation Therapy. Radiat Oncol, 2015, 10: 245.
  • 10. Kao J, Darakchiev B, Conboy L, et al. Tumor Directed, Scalp Sparing Intensity Modulated Whole Brain Radiotherapy For Brain Metastases. Technol Cancer Res Treat, 2015, 14 (5): 547-555.
  • 11. Schiopu SR, Habl G, Hafner M, et al. Craniospinal irradiation using helical tomotherapy for central nervous system tumors. J Radiat Res, 2017, 58 (2): 238-246.
  • 12. Sood S, Pokhrel D, McClinton C, et al. Volumetric-modulated arc therapy (VMAT) for whole brain radiotherapy: not only for hippocampal sparing, but also for reduction of dose to organs at risk. Med Dosim, 2017, 42 (4): 375-383.
  • 13. https://ctep.cancer.gov
  • 14. https://www.rtog.org
  • 15. https://icru.org
  • 16. Wagner D, Christiansen H, Wolff H, Vorwerk H. Radiotherapy Of Malignant Gliomas: Comparison Of Volumetric Single Arc Technique (Rapidarc), Dynamic İntensity-Modulated Technique And 3d Conformal Technique. Radiother Oncol, 2009, 93 (3): 593-596.
  • 17. Panet‐Raymond V, Ansbacher W, Zavgorodni S, et.al. Coplanar Versus Noncoplanar İntensity‐Modulated Radiation Therapy (IMRT) And Volumetric‐Modulated Arc Therapy (VMAT) Treatment Planning For Fronto‐Temporal High‐Grade Glioma. J Appl Clin Med Phys. 2012, 13(4):3826.
  • 18. Yuan J, Lei M, Yang Z, et al. Dosimetric Comparison Between İntensity-Modulated Radiotherapy And Rapidarc With Single Arc And Dual Arc For Malignant Glioma İnvolving The Parietal Lobe. Mol Clin Oncol, 2016, 5 (1): 181-188.
  • 19. Briere TM, McAleer MF, Lawrence LB, Yang JN. Sparing of normal tissues with volumetric arc radiation therapy for glioblastoma: single institution clinical experience. Radiat Oncol, 2017, 12 (1): 79.
  • 20. Canyılmaz E, Hanedan Uslu GD, Colak F, et al. Comparison Of Dose Distributions Hippocampus in High Grade Gliomas Irradiation With Linac-Based IMRT And Volumetric Arc Therapy: A Dosimetric Study. Springerplus, 2015, 4: 114.
  • 21. Uto M, Mizowaki T, Ogura K, Hiraoka M. Non-coplanar volumetric-modulated arc therapy (VMAT) for craniopharyngiomas reduces radiation doses to the bilateral hippocampus: a planning study comparing dynamic conformal arc therapy, coplanar VMAT, and non-coplanar VMAT. Radiat Oncol, 2016, 11: 86.
  • 22. Malkinson FD, Keane JT, Radiobiology of the skin: review of some effects on epidermis and hair. The Journal of Investigative Dermatology, 1981, 77: 133-138.
  • 23. Shakespeare TP, Dwyer M, Mukherjee R, Yeghiaian-Alvandi R, Gebski V. Estimating risks of radiotherapy complications as part of infromed consent: the high degree of variability between radiation oncologists may be related to experience. Int J Radiat Oncol Biol Phys., 2002, 54 (3): 647-53.
  • 24. Haider M, Hamadah I, Almutawa A. Radiation- and chemotherapy-induced permanent alopecia: case series. J Cutan Med Surg, 2013, 17 (1): 55-61.
  • 25. De Puysseleyr A, De Velde JV, Speleers B, et al. Hair-Sparing Whole Brain Radiotherapy With Volumetric Arc Therapy İn Patients Treated For Brain Metastases: Dosimetric And Clinical Results Of A Phase II Trial. Radiat Oncol, 2014, 9: 170.
  • 26. Pokhrel D, Sood S, Lominska C, et al. Potential For Reduced Radiation‐induced Toxicity Using Intensity‐Modulated Arc Therapy For Whole‐Brain Radiotherapy With Hippocampal Sparing. J Appl Clin Med Phys, 2015, 16 (5): 131-141.

Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması

Year 2018, Volume: 44 Issue: 2, 95 - 101, 01.08.2018
https://doi.org/10.32708/uutfd.431230

Abstract

Volumetrik ark (t-VMAT) tekniği ile radyoterapi (RT)
uygulanan malign glial tümörlü hastalarda mevcut tedavi planına karşın 1 ark
VMAT ve statik 5 alan yoğunluk ayarlı RT tekniği dozimetrik olarak
karşılaştırıldı. Çalışmaya en az 50 Gy RT alan 18 malign glial tümörlü olgu
dahil edildi. Saçlı deri ortalama, 1 ve 9 cc dozları için 16, 30 ve 24 Gray
eşik değerleri kullanıldı. Yöntemler arasında planlama tedavi volümü ve riskli
organ dozları açısından
anlamlı fark bulunamadı.
Planlamanın hangi yöntem ile yapıldığı önemli olmaksızın saçlı derinin
planlamaya dahil edilmesiyle birlikte saçlı deri dozlarının anlamlı azaldığı
görüldü (p < 0.05). Oniki aylık izlem süresi içinde akut dönemde saç kaybı
yaşamalarına rağmen hiçbir olguda kalıcı saç kaybı görülmedi. Bu çalışma ile
saçlı derinin tedavi planına dahil edilmesinin hedef volüm dozları açısından
olumsuz etkisi olmadığı gibi hastalarımızın kalıcı saç dökülmesinin yaratacağı
kozmetik ve psikososyal yan etkilerden korunabileceği ortaya konulmuştur. 

References

  • 1. Gondi V, Vogelbaum MA, Grimm S, Mehta MP (eds). Primary intracranial neoplasms. In: Halperin EC, Wazer DE, Perez CA, Brady LW, eds. Principles and Practice of Radiation Oncology, 6th ed. Philadelphia, LWW, 2013; 938-973.
  • 2. Stupp R, Brada M, Van Den Bent, Tonn JC, Penthheroudakis G, ESMO Guidelines Working Group. High-grade Glioma: Esmo Clinical Practice Guidelines For Diagnosis, Treatment And Follow-Up. Ann Oncol, 2014, 25, Suppl 3.
  • 3. Gzell C, Back M, Wheeler H, Bailey D, Foote M. Radiotherapy in Glioblastoma: The Past, The Present And The Future. Clin Oncol, 2017, 29 (1): 15-25.
  • 4. Gondi V, Pugh SL, Tome WA, et al. Preservation of memory with conformal compartmnt during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol, 32 (34): 3810-6.
  • 5. Lawenda BD, Gagne HM, Gierga DP, et al. Permanent alopecia after cranial irradiation: dose-response relationship. Int J Radiat Oncol Biol Phys. 2004, 60 (3): 879-87.
  • 6. Severs GA, Griffin T, Werner-Wasik M. Cicatricial alopecia secondary to radiation therapy: case report and review of the literatüre. Cutis 2008, 81 (2): 147-53.
  • 7. Roberge D, Parker W, Niazi TM, Olivares M. Treating the contents and not the container: dosimetric study of hair-sparing whole brain intensity modulated radiation therapy. Technol Cancer Res Treat, 2005, 4 (5): 567-70.
  • 8. Mancini BR, Kim LH, Shaitelman SF, et al. Intensity modulated or volumetric modulated radiation therapy (IMRT or VMAT) to reduce alopecia, xerostomia, and otitis after whole brain radiation therapy for brain metastases: a planning analysis. Int J Radiat Oncol Biol Phys. 2010, 78 (3), suppl, abstract no 3422, page S840.
  • 9. Mahadevan A, Sampson C, LaRosa S, et al. Dosimetric Analysis Of The Alopecia Preventing Effect Of Hippocampus Sparing Whole Brain Radiation Therapy. Radiat Oncol, 2015, 10: 245.
  • 10. Kao J, Darakchiev B, Conboy L, et al. Tumor Directed, Scalp Sparing Intensity Modulated Whole Brain Radiotherapy For Brain Metastases. Technol Cancer Res Treat, 2015, 14 (5): 547-555.
  • 11. Schiopu SR, Habl G, Hafner M, et al. Craniospinal irradiation using helical tomotherapy for central nervous system tumors. J Radiat Res, 2017, 58 (2): 238-246.
  • 12. Sood S, Pokhrel D, McClinton C, et al. Volumetric-modulated arc therapy (VMAT) for whole brain radiotherapy: not only for hippocampal sparing, but also for reduction of dose to organs at risk. Med Dosim, 2017, 42 (4): 375-383.
  • 13. https://ctep.cancer.gov
  • 14. https://www.rtog.org
  • 15. https://icru.org
  • 16. Wagner D, Christiansen H, Wolff H, Vorwerk H. Radiotherapy Of Malignant Gliomas: Comparison Of Volumetric Single Arc Technique (Rapidarc), Dynamic İntensity-Modulated Technique And 3d Conformal Technique. Radiother Oncol, 2009, 93 (3): 593-596.
  • 17. Panet‐Raymond V, Ansbacher W, Zavgorodni S, et.al. Coplanar Versus Noncoplanar İntensity‐Modulated Radiation Therapy (IMRT) And Volumetric‐Modulated Arc Therapy (VMAT) Treatment Planning For Fronto‐Temporal High‐Grade Glioma. J Appl Clin Med Phys. 2012, 13(4):3826.
  • 18. Yuan J, Lei M, Yang Z, et al. Dosimetric Comparison Between İntensity-Modulated Radiotherapy And Rapidarc With Single Arc And Dual Arc For Malignant Glioma İnvolving The Parietal Lobe. Mol Clin Oncol, 2016, 5 (1): 181-188.
  • 19. Briere TM, McAleer MF, Lawrence LB, Yang JN. Sparing of normal tissues with volumetric arc radiation therapy for glioblastoma: single institution clinical experience. Radiat Oncol, 2017, 12 (1): 79.
  • 20. Canyılmaz E, Hanedan Uslu GD, Colak F, et al. Comparison Of Dose Distributions Hippocampus in High Grade Gliomas Irradiation With Linac-Based IMRT And Volumetric Arc Therapy: A Dosimetric Study. Springerplus, 2015, 4: 114.
  • 21. Uto M, Mizowaki T, Ogura K, Hiraoka M. Non-coplanar volumetric-modulated arc therapy (VMAT) for craniopharyngiomas reduces radiation doses to the bilateral hippocampus: a planning study comparing dynamic conformal arc therapy, coplanar VMAT, and non-coplanar VMAT. Radiat Oncol, 2016, 11: 86.
  • 22. Malkinson FD, Keane JT, Radiobiology of the skin: review of some effects on epidermis and hair. The Journal of Investigative Dermatology, 1981, 77: 133-138.
  • 23. Shakespeare TP, Dwyer M, Mukherjee R, Yeghiaian-Alvandi R, Gebski V. Estimating risks of radiotherapy complications as part of infromed consent: the high degree of variability between radiation oncologists may be related to experience. Int J Radiat Oncol Biol Phys., 2002, 54 (3): 647-53.
  • 24. Haider M, Hamadah I, Almutawa A. Radiation- and chemotherapy-induced permanent alopecia: case series. J Cutan Med Surg, 2013, 17 (1): 55-61.
  • 25. De Puysseleyr A, De Velde JV, Speleers B, et al. Hair-Sparing Whole Brain Radiotherapy With Volumetric Arc Therapy İn Patients Treated For Brain Metastases: Dosimetric And Clinical Results Of A Phase II Trial. Radiat Oncol, 2014, 9: 170.
  • 26. Pokhrel D, Sood S, Lominska C, et al. Potential For Reduced Radiation‐induced Toxicity Using Intensity‐Modulated Arc Therapy For Whole‐Brain Radiotherapy With Hippocampal Sparing. J Appl Clin Med Phys, 2015, 16 (5): 131-141.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Oğuz Aydın

Süreyya Sarıhan

Duygu Bolat This is me

Habibe Altaş

Sema Gözcü Tunç

Zenciye Kıray This is me

Publication Date August 1, 2018
Acceptance Date July 9, 2018
Published in Issue Year 2018 Volume: 44 Issue: 2

Cite

APA Aydın, O., Sarıhan, S., Bolat, D., Altaş, H., et al. (2018). Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 44(2), 95-101. https://doi.org/10.32708/uutfd.431230
AMA Aydın O, Sarıhan S, Bolat D, Altaş H, Gözcü Tunç S, Kıray Z. Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması. Uludağ Tıp Derg. August 2018;44(2):95-101. doi:10.32708/uutfd.431230
Chicago Aydın, Oğuz, Süreyya Sarıhan, Duygu Bolat, Habibe Altaş, Sema Gözcü Tunç, and Zenciye Kıray. “Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri Ile Saçlı Deri Ve Riskli Organların Dozimetrik Karşılaştırılması”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 44, no. 2 (August 2018): 95-101. https://doi.org/10.32708/uutfd.431230.
EndNote Aydın O, Sarıhan S, Bolat D, Altaş H, Gözcü Tunç S, Kıray Z (August 1, 2018) Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması. Uludağ Üniversitesi Tıp Fakültesi Dergisi 44 2 95–101.
IEEE O. Aydın, S. Sarıhan, D. Bolat, H. Altaş, S. Gözcü Tunç, and Z. Kıray, “Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması”, Uludağ Tıp Derg, vol. 44, no. 2, pp. 95–101, 2018, doi: 10.32708/uutfd.431230.
ISNAD Aydın, Oğuz et al. “Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri Ile Saçlı Deri Ve Riskli Organların Dozimetrik Karşılaştırılması”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 44/2 (August 2018), 95-101. https://doi.org/10.32708/uutfd.431230.
JAMA Aydın O, Sarıhan S, Bolat D, Altaş H, Gözcü Tunç S, Kıray Z. Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması. Uludağ Tıp Derg. 2018;44:95–101.
MLA Aydın, Oğuz et al. “Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri Ile Saçlı Deri Ve Riskli Organların Dozimetrik Karşılaştırılması”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 44, no. 2, 2018, pp. 95-101, doi:10.32708/uutfd.431230.
Vancouver Aydın O, Sarıhan S, Bolat D, Altaş H, Gözcü Tunç S, Kıray Z. Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması. Uludağ Tıp Derg. 2018;44(2):95-101.

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