Vezikula Seminalis ve Duktus Deferens Yerleşimli Lokalize Amiloidozis Olgularının Retrospektif Analizi

Year 2019, Volume: 45 Issue: 1, 87 - 91, 01.04.2019

Mine Özşen Berna Aytaç Vuruşkan Hakan Vuruşkan

https://doi.org/10.32708/uutfd.460836

Abstract

Amiloidoz, sistemik veya lokalize tutulum
gösterebilen, amiloid proteinin ekstraselüler matrikste birikimi  ile karakterize heterojen bir hastalık
grubudur. Lokalize amiloidoz, amiloid birikiminin tek bir dokuya sınırlı
kalması sonucu gelişen ve lokalize bir kitle oluşturması nedeniyle de klinik
olarak maligniteleri taklit edebilen non-neoplastik bir hastalıktır.  Bu çalışmada vezikula seminalis ve duktus
deferens yerleşimli lokalize amiloidoz serimizin sunulması ve bu tümörlerin
klinikopatolojik özelliklerinin literatür bilgileri eşliğinde sunulması
amaçlanmıştır. Çalışmamızda Uludağ Üniversitesi Tıp Fakültesi Tıbbi Patoloji
Anabilim Dalı arşivi taranarak 2013–2018 yılları arasında tanı almış vezikula
seminalis ve duktus deferens yerleşimli lokalize amiloidoz olguları incelendi. Sistoprostatektomi
prosedürü uygulanan 4 olguda sadece vezikula seminalislerde, prostatektomi
prosedürü uygulanan 6 olgunun 5'inde hem vezikula seminalis hem de duktus
deferenslerde ve 1 olguda ise sadece duktus deferenslerde lokalize amiloidoz
saptandı. Olguların tamamında subepitelyal yerleşimli, eozinofilik, amorf,
homojen madde şeklinde gözlenen birikimlere Kongo red boyaması uygulandı. Kongo
red histokimyasal boyaması ile bu alanlarda kiremit kırmızısı boyanma saptandı
ve polarize ışık mikroskobi bakısında elma yeşili refle verdiği tespit edildi. Sonuç
olarak, lokalize amiloidoz çok farklı lokalizasyonlarda saptanabilmekle
birlikte vezikula seminalis ve duktus deferens lokalizasyonunda nispeten
nadirdir. İnsidental saptanmaları nedeniyle biyopsi örnekleri
değerlendirilirken amiloid birikimi açısından da olguların değerlendirilmesi ve
gerekli görülen olgularda Kongo red boyamasının yapılması önem arz etmektedir.

Keywords

Duktus deferens, Genitoüriner sistem, Lokalize amiloidoz, Vezikula seminalis

A Retrospective Analysis of Cases with Localized Amyloidosis of the Vesicula Seminalis and the Ductus Deferens

Abstract

Amyloidosis is a
heterogeneous group of diseases characterized by accumulation of amyloid
protein in the extracellular matrix, which may be systemic or localized.
Localized amyloidosis is a non-neoplastic disease that results from limited
amyloid accumulation to a single tissue, and clinically mimics malignancies
forming a localized mass. In this descriptive study, we aim to report our
series of localized amyloidosis in the vesicula seminalis and the ductus
deferens as well as clinicopathologic characteristics of these tumors in literature
data. In this study, we examined the localized amyloidosis cases of the
vesicula seminalis and the ductus deferens, diagnosed between 2013 and 2018 by searching
the archives of Uludag University, Faculty of Medicine, Department of  Pathology. The sites where localized
amyloidosis was detected include only the vesicula seminalis in four cases who
underwent a cystoprostatectomy procedure, both the vesicula seminalis and the
ductus deferens in five out of six cases with a prostatectomy procedure, and
only the ductus deferens in one case. The deposits in the form of
subepithelial, eosinophilic, amorphous and homogeneous substance were treated
with Congo Red staining in all cases. The histochemical treatment with Congo Red
yielded tile reddish staining in these areas, making them appear apple-green on
the polarized light microscopy. In conclusion, localized amyloidoses are
relatively rare in the vesicula seminalis and the ductus deferens, although
they can be detected at very different locations. Since they are incidentally
detected, it is important to evaluate a case in terms of amyloid deposits while
examining biopsy specimens, as well as staining with Congo Red when necessary. 

Keywords

Ductus deferens, genitourinary system, localized amyloidosis, vesicula seminalis

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