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Reproduktif Sistemde ADAMTS Genleri

Year 2019, Volume: 45 Issue: 1, 111 - 118, 01.04.2019
https://doi.org/10.32708/uutfd.504161

Abstract

Güncel genetik
çalışmalarından ele edilen bilgilere göre pek çok gen çeşitli üreme organ ve
dokularında hayati rol oynamaktadır. Fertilitenin tüm makro- ve
mikro-süreçlerinde yoğun araştırmalar devam etmesine ve system çözülmeye
çalışılmasına rağmen, üreme sistemi patofizyolojisi halen tüm bilinmezliğiyle
karşımızda durmaktadır.  Ekstrasellüler matriks
(ECM) hücreler için yapısal bir destek olmasının yanısıra hücrenin şekli,
davranışı, diferansiasyonu, proliferasyonu, gen expresyonu ve hayatiyetleri
üzerinde  belirleyici rolü olan  fonksiyonel bir dokudur. “
A Disintegrin-like And Metalloproteinase
with Thrombospondin type-1 motif” (ADAMTS)
proteinleri, ECM yapılarının yıkımından sorumlu, vücutta birçok fizyolojik ve
patolojik  süreçte önemli rolleri olan
çinko bağımlı proteinazlardır. Bu
derlemenin amacı üremenin patofizyolojisinde ADAMTS‘lerin rolleri üzerine
yapılmış çalışmaları biraraya getirerek konuyla ilgili geniş bir perspektif
sunmaktır.

References

  • 1. Namlı Kalem M, Demircan K, Kalem Z, Demirin H, Eser A, Demirel M, İltemir Duvan ZC. Versatile Matricellular Proteins and Related Adamts Proteinases in Infertility. Turkiye Klinikleri J Gynecol Obst. 2016 DOİ:10.5336/gynobstet.2015-45243
  • 2. Unuane D, Tournaye H, Velkeniers B, Poppe K. Endocrine disorders and female infertility. Best Practice & Research Clinical Endocrinology & Metabolism 2011; 25(6): 861-73.
  • 3. Anderson RA, Sciorio R, Kinnel H, Bayne RAL . Cumulus gene expression as a predictor of human oocyte fertilization, embryo development and competence to establish a pregnancy.Reproduction 2009;138(4):629-37
  • 4. Stamou M I, Cox K H, Crowley Jr, W. F. . Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the “-Omics” Era. Endocrine reviews 2015; 36(6): 603-621.
  • 5. Demircan K, Cömertoğlu İ, Akyol S, Yiğitoğlu BN, Sarıkaya, E. A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS). Journal of the Turkish-German Gynecological Association2014; 15(4).
  • 6. Porter S, Clark I, Kevorkian L, Edwards D. The ADAMTS metalloproteinases. Biochem J 2005;386(1):15-27
  • 7. Kuno K, Kanada N, Nakashima E, Fujiki F. Molecular cloning of a gene encoding a new type of metalloproteinase – disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem 1997;272(1):556-62
  • 8. Stanton H, Melrose J, Little CB, Fosang AJ. Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta 2011;1812(12):1611-29
  • 9. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Moriyama N. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. The Journal of clinical investigation 2000; 105(10): 1345-1352.
  • 10. Mittaz L, Russell DL, Wilson T, Brasted M, Tkalcevic J, Salamonsen LA, Pritchard MA. (Adamts-1 is essential for the development and function of the urogenital system. Biology of reproduction 2004; 70(4): 1096-1105.
  • 11. Cal S, Arguelles JM, Fernandez PL, Lopez-Otin C: Identification, characterization, and intracellular processing of ADAM- TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem 2001; 276 (21) : 17932–17940.
  • 12. Cal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, López-Otı́n C. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene 2002; 283(1), 49-62.
  • 13. Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ, Beier DR: A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development 2003;19 (130) : 4665–4672.
  • 14. Hosper NA, Bank RA, van den Berg PP. Human amniotic fluid-derived mesenchymal cells from fetuses with a neural tube defect do not deposit collagen type i protein after TGF-beta1 stimulation in vitro. Stem Cells Dev 2014; 23: 555-62.
  • 15. Menke DB, Koubova J, Page DC. Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to posterior wave. Dev Biol 2003;262:303–12.
  • 16. Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM, et al. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development 2005;132:3045–54.
  • 17. Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, et al. Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet 2012;8:e1002569
  • 18. McClelland KS, Wainwright EN, Bowles J, Koopman P. Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos. PLoS One 2015;10:e0114932.
  • 19. Doyle KM, Russell DL, Sriraman V, Richards JS. Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptor. Mol Endocrinol 2004;18:2463–78.
  • 20. Freimann S, Ben-Ami I,DantesA, Armon L, BenYa'cov-KleinA, Ron-El R, et al. Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells. Biochem Biophys Res Commun 2005;333:935–43
  • 21. Gao S, De Geyter C, Kossowska K, Zhang H. FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles. Mol Hum Reprod 2007;13:465–71.
  • 22. Robker RL, Russell DL, Espey LL, Lydon JP, O’Malley BW, Richards JS. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci U S A. 2000;97:4689–94.
  • 23. Russell DL, Ochsner SA, Hsieh M, Mulders S, Richards JS. Hormone-regulated expression and localization of versican in the rodent ovary. Endocrinology 2003; 144:1020–31.
  • 24. Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, et al. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod 2005;72:1241–55.
  • 25. Brown HM, Dunning KR, Robker RL, Boerboom D, Pritchard M, Lane M, et al. ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice. Biol Reprod. 2010;83:549–57.
  • 26. Shozu M, Minami N, Yokoyama H, Inoue M, Kurihara H, Matsushima K, et al. ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. J Mol Endocrinol 2005;35:343–55.
  • 27. Brown HM, Dunning KR, Robker RL, Pritchard M, Russell DL. Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. Dev Biol 2006;300:699–709.
  • 28. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, et al. Human antral follicles b6 mm: a comparison between in vivo maturation and in vitro maturation in non-hCG primed cycles using cumulus cell gene expression. Mol Hum Reprod 2013;19:7–16.
  • 29. Yung Y, Maman E, Konopnicki S, Cohen B, Brengauz M, Lojkin I, et al. ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity. Mol Cell Endocrinol 2010;328:104–8.
  • 30. Rosewell KL, Al-Alem L, Zakerkish F, McCord L, Akin JW, Chaffin CL, et al. Induction of proteinases in the human preovulatory follicle of the menstrual cycle by human chorionic gonadotropin. Fertil Steril 2015;103:826–33.
  • 31. Huang X, Hao C, Shen X, Zhang Y, Liu X. RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients. Reprod Biol Endocrinol 2013;11:109.
  • 32. Wathlet S, Adriaenssens T, Segers I, Verheyen G, Van de Velde H, Coucke W, et al. Cumulus cell gene expression predicts better cleavage-stage embryo or blastocyst development and pregnancy for ICSI patients. Hum Reprod 2011;26:1035–51.
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ADAMTS Genes in Reproductive System

Year 2019, Volume: 45 Issue: 1, 111 - 118, 01.04.2019
https://doi.org/10.32708/uutfd.504161

Abstract

Data of recent
genetic studies suggest a critical role of multiple genes in various
reproductive organs and tissues. Even though scrutinizing studies about all
macro- and microprocesses in fertility are yet being held, and the system is
trying to be untangled, the pathophysiology of repruduction remains an
appealing subject to research, which encircles the known sieged by unknown. The
extracellular matrix (ECM) is not only a structural support for the cells, but
also is a functional mesh which has determining role in cellular shapes,
behaviors, differentiation, proliferation, gene expressions, and their life
cycles.
A disintegrin-like and metalloproteinase
with thrombospondin type-1 motif
(ADAMTS) proteins are a group of zinc-dependent metalloproteinases responsible
for degradation of ECM structures, which significantly act in many physiologic
and pathologic processes.  We aimed, in
this review, to pose a broad view about the pathophysiology of infertility
gathering the studies pertaining to matricellular proteins and ADAMTS enzymes
which participate in the riddle of matrix breakdown and renewal.

References

  • 1. Namlı Kalem M, Demircan K, Kalem Z, Demirin H, Eser A, Demirel M, İltemir Duvan ZC. Versatile Matricellular Proteins and Related Adamts Proteinases in Infertility. Turkiye Klinikleri J Gynecol Obst. 2016 DOİ:10.5336/gynobstet.2015-45243
  • 2. Unuane D, Tournaye H, Velkeniers B, Poppe K. Endocrine disorders and female infertility. Best Practice & Research Clinical Endocrinology & Metabolism 2011; 25(6): 861-73.
  • 3. Anderson RA, Sciorio R, Kinnel H, Bayne RAL . Cumulus gene expression as a predictor of human oocyte fertilization, embryo development and competence to establish a pregnancy.Reproduction 2009;138(4):629-37
  • 4. Stamou M I, Cox K H, Crowley Jr, W. F. . Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the “-Omics” Era. Endocrine reviews 2015; 36(6): 603-621.
  • 5. Demircan K, Cömertoğlu İ, Akyol S, Yiğitoğlu BN, Sarıkaya, E. A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS). Journal of the Turkish-German Gynecological Association2014; 15(4).
  • 6. Porter S, Clark I, Kevorkian L, Edwards D. The ADAMTS metalloproteinases. Biochem J 2005;386(1):15-27
  • 7. Kuno K, Kanada N, Nakashima E, Fujiki F. Molecular cloning of a gene encoding a new type of metalloproteinase – disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem 1997;272(1):556-62
  • 8. Stanton H, Melrose J, Little CB, Fosang AJ. Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta 2011;1812(12):1611-29
  • 9. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Moriyama N. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. The Journal of clinical investigation 2000; 105(10): 1345-1352.
  • 10. Mittaz L, Russell DL, Wilson T, Brasted M, Tkalcevic J, Salamonsen LA, Pritchard MA. (Adamts-1 is essential for the development and function of the urogenital system. Biology of reproduction 2004; 70(4): 1096-1105.
  • 11. Cal S, Arguelles JM, Fernandez PL, Lopez-Otin C: Identification, characterization, and intracellular processing of ADAM- TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem 2001; 276 (21) : 17932–17940.
  • 12. Cal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, López-Otı́n C. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. Gene 2002; 283(1), 49-62.
  • 13. Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ, Beier DR: A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development 2003;19 (130) : 4665–4672.
  • 14. Hosper NA, Bank RA, van den Berg PP. Human amniotic fluid-derived mesenchymal cells from fetuses with a neural tube defect do not deposit collagen type i protein after TGF-beta1 stimulation in vitro. Stem Cells Dev 2014; 23: 555-62.
  • 15. Menke DB, Koubova J, Page DC. Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to posterior wave. Dev Biol 2003;262:303–12.
  • 16. Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM, et al. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development 2005;132:3045–54.
  • 17. Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, et al. Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet 2012;8:e1002569
  • 18. McClelland KS, Wainwright EN, Bowles J, Koopman P. Rapid screening of gene function by systemic delivery of morpholino oligonucleotides to live mouse embryos. PLoS One 2015;10:e0114932.
  • 19. Doyle KM, Russell DL, Sriraman V, Richards JS. Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptor. Mol Endocrinol 2004;18:2463–78.
  • 20. Freimann S, Ben-Ami I,DantesA, Armon L, BenYa'cov-KleinA, Ron-El R, et al. Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells. Biochem Biophys Res Commun 2005;333:935–43
  • 21. Gao S, De Geyter C, Kossowska K, Zhang H. FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles. Mol Hum Reprod 2007;13:465–71.
  • 22. Robker RL, Russell DL, Espey LL, Lydon JP, O’Malley BW, Richards JS. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci U S A. 2000;97:4689–94.
  • 23. Russell DL, Ochsner SA, Hsieh M, Mulders S, Richards JS. Hormone-regulated expression and localization of versican in the rodent ovary. Endocrinology 2003; 144:1020–31.
  • 24. Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, et al. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod 2005;72:1241–55.
  • 25. Brown HM, Dunning KR, Robker RL, Boerboom D, Pritchard M, Lane M, et al. ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice. Biol Reprod. 2010;83:549–57.
  • 26. Shozu M, Minami N, Yokoyama H, Inoue M, Kurihara H, Matsushima K, et al. ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. J Mol Endocrinol 2005;35:343–55.
  • 27. Brown HM, Dunning KR, Robker RL, Pritchard M, Russell DL. Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. Dev Biol 2006;300:699–709.
  • 28. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, et al. Human antral follicles b6 mm: a comparison between in vivo maturation and in vitro maturation in non-hCG primed cycles using cumulus cell gene expression. Mol Hum Reprod 2013;19:7–16.
  • 29. Yung Y, Maman E, Konopnicki S, Cohen B, Brengauz M, Lojkin I, et al. ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity. Mol Cell Endocrinol 2010;328:104–8.
  • 30. Rosewell KL, Al-Alem L, Zakerkish F, McCord L, Akin JW, Chaffin CL, et al. Induction of proteinases in the human preovulatory follicle of the menstrual cycle by human chorionic gonadotropin. Fertil Steril 2015;103:826–33.
  • 31. Huang X, Hao C, Shen X, Zhang Y, Liu X. RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients. Reprod Biol Endocrinol 2013;11:109.
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There are 75 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review Articles
Authors

Ziya Kalem 0000-0002-5435-2074

Müberra Namlı Kalem 0000-0002-2316-5495

Coşkun Şimşir This is me 0000-0003-1825-6584

Publication Date April 1, 2019
Acceptance Date February 5, 2019
Published in Issue Year 2019 Volume: 45 Issue: 1

Cite

APA Kalem, Z., Namlı Kalem, M., & Şimşir, C. (2019). Reproduktif Sistemde ADAMTS Genleri. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 45(1), 111-118. https://doi.org/10.32708/uutfd.504161
AMA Kalem Z, Namlı Kalem M, Şimşir C. Reproduktif Sistemde ADAMTS Genleri. Uludağ Tıp Derg. April 2019;45(1):111-118. doi:10.32708/uutfd.504161
Chicago Kalem, Ziya, Müberra Namlı Kalem, and Coşkun Şimşir. “Reproduktif Sistemde ADAMTS Genleri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 45, no. 1 (April 2019): 111-18. https://doi.org/10.32708/uutfd.504161.
EndNote Kalem Z, Namlı Kalem M, Şimşir C (April 1, 2019) Reproduktif Sistemde ADAMTS Genleri. Uludağ Üniversitesi Tıp Fakültesi Dergisi 45 1 111–118.
IEEE Z. Kalem, M. Namlı Kalem, and C. Şimşir, “Reproduktif Sistemde ADAMTS Genleri”, Uludağ Tıp Derg, vol. 45, no. 1, pp. 111–118, 2019, doi: 10.32708/uutfd.504161.
ISNAD Kalem, Ziya et al. “Reproduktif Sistemde ADAMTS Genleri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 45/1 (April 2019), 111-118. https://doi.org/10.32708/uutfd.504161.
JAMA Kalem Z, Namlı Kalem M, Şimşir C. Reproduktif Sistemde ADAMTS Genleri. Uludağ Tıp Derg. 2019;45:111–118.
MLA Kalem, Ziya et al. “Reproduktif Sistemde ADAMTS Genleri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 45, no. 1, 2019, pp. 111-8, doi:10.32708/uutfd.504161.
Vancouver Kalem Z, Namlı Kalem M, Şimşir C. Reproduktif Sistemde ADAMTS Genleri. Uludağ Tıp Derg. 2019;45(1):111-8.

ISSN: 1300-414X, e-ISSN: 2645-9027

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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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