İlaç Erupsiyonları

Yıl 2019, Cilt: 45 Sayı: 2, 231 - 241, 01.08.2019

Sinan Özçelik

https://doi.org/10.32708/uutfd.521346

Öz

İlaç erupsiyonu önemli bir sağlık
sorunudur. Çoğu ilaç erupsiyonu hafif seyrederken, bazıları hayatı tehdit edici
özellikte, çok az bir kısmı da ölümcül olabilmektedir. İlaç erupsiyonları her
türlü dermatozu taklit edebilir. Tüm güçlüklere rağmen ilaç erüpsiyonu tanısı
esas olarak klinik bulgulara dayanır. Klinik yaklaşımda esas olan ilaç
ilişkisinin ortaya konmasıdır. Bu açıdan yapılacak bir nedensellik
değerlendirmesi için Naronjo İlaç Yan Etki Olasılık Ölçeği ve Dünya Sağlık
Örgütü - Uppsala İzlem Merkezi’ne ait Nedensellik Değerlendirme Sistemi gibi
geliştirilmiş birtakım ölçekler vardır. Reaksiyon şüphesi olan olgularda
kullanılmalıdır. İlaç reaksiyonlarında öncelikli yaklaşım önlenmesine yönelik
çalışmalara ağırlık verilmesidir. Bunun için mutlak ihtiyaç olmadıkça ilaçlar
kullanılmamalı, toplum bu konuda tekrar tekrar bilgilendirilmeli ve akılcı ilaç
kullanımına önem verilmelidir.

Anahtar Kelimeler

ilaç erupsiyonu, nedensellik değerlendirmesi

Drug Eruptions

Öz

Drug eruption is a major
health problem. While most drug eruptions are mild, self-limited, some has
life-threatening potentional and a very small number of it may be fatal. Drug
eruptions can mimic any kind of dermatoses. Despite all the difficulties the
diagnosis of drug eruption is mainly based on clinical findings. What’s
essential in clinical approach is to show the association between the drug and
the eruption. There’s a few causality assessment scales such as “Naranjo
Adverse Drug Reaction Probability Scale” and “Causality Assessment provided by
World Health Organization-Uppsala Monitoring Centre” should be used if there’s
any suspicion. Prevention should be a priority while dealing with drug
reactions. Drugs should not be used unless absolutely necessary, society should
be informed repeatedly and the importance of rational drug use should always be
kept on the agenda. 

Anahtar Kelimeler

drug eruptions, causality assessment

Kaynakça

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