Research Article
BibTex RIS Cite

Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi

Year 2020, Volume: 46 Issue: 1, 53 - 57, 01.04.2020
https://doi.org/10.32708/uutfd.632167

Abstract

Bu çalışmada sinonazal bölgenin en sık opere edilen benign tümörü olan invertedpapillom(İP) tanısı ile endonazal endoskopik cerrahi uygulanan hastalarda klinik sonuçların ve rekürrens ile tümör evresi arasında ilişki olup olmadığının belirlenmesi amaçlanmıştır. Bu retrospektif çalışmada üçüncü basamak hizmet veren bir üniversite hastanesinin KBB anabilim dalında 2005 ile 2019 yılları arasında İP tanısı ile endoskopik cerrahi uygulanmış ve çalışma kriterlerine uyan 75 hastanın tıbbi verileri değerlendirilmiştir. Hastaların demografik verileri, primer semptomları, ameliyat öncesi görüntülemeleri, ameliyat notları, tümör evreleri ile takipte gelişen rekürrens ve malign transformasyon oranları tespit edildi. Tümör evresi ile nüks arasında ilişki olup olmadığı istatistiksel olarak hesaplandı. 50 hastaya primer cerrahi ve 25 hastaya ise rekürren cerrahi uygulandığı görüldü. Hastaların tümör evreleri; T1 (n:11, %14), T2 (n:39, %52), T3 (n:16, %21) ve T4 (n:9, %12) olarak bulundu. Tümörün en sık yerleştiği bölgeler, 52 hastada lateral nazal duvar-maksillersinüs medial duvarı ve 28 hastada etmoid hücrelerdi. Takip süresinde 4 hastada (%5) skuamöz hücreli kansere dönüşüm izlendi. Nüks gelişmesi oranları ile tümör evresi arasında anlamlı (p<0.001) ilişki saptandı; T1: 1/11 (%0,9), T2: 7/39 (%18), T3: 9/16 (%56) ve T4:8/9 (%88). Endoskopik endonazal cerrahi ile İP tedavisinde son yıllarda çok başarılı sonuçlar elde edilmektedir. Ancak effektif cerrahilere rağmen bu tümörlerde rekürrens veya malign transformas-yon riski halen yüksektir. Bu nedenle cerrahi sonrası endoskopik ve görüntüleme yöntemleri ile düzenli takipler yapılması mutlak gerekliliktir.

References

  • Barnes L, Eveson J, Reichart P, Sidransky D. World Health Organization Classi-fication of Tumours. Pathology and genetics of head and neck tumours. Lyon:IARC Press; 2005. ISBN 92 832 2417 5.
  • Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD. Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis. Am J Rhinol Allergy. 2018;32:167-174.
  • Busquets JM, Hwang PH. Endoscopic resection of sinonasal inverted papilloma: a meta-analysis. Otolaryngol Head Neck Surg. 2006;134(3):476-82. Review.
  • Lee JJ, Roland LT, Licata JJ, Orlowski HLP, Jiramongkolchai P, Piccirillo JF, et al. Morphologic, intraoperative, and histologic risk factors for sinonasal inverted papilloma recurrence. Laryngoscope. 2019 May 21. doi: 10.1002/lary.28078.
  • Molina JP, Llorente Pendas JL, Rodrigo Tapia JP, Alvarez Marcos C, Obeso Agüera S, Suárez Nieto C. [Inverted sinonasal papillomas. Review of 61 cases]. Acta Otorrinolaringol Esp. 2009;60:402-8.
  • Kim WS, Hyun DW, Kim CH, Yoon JH. Treatment outcomes of sinonasal inverted papillomas according to surgical approaches. Acta Otolaryngol. 2010;130:493-7.
  • MR, Brandwein MS, Lawson W. Sinonasal papillomas: clinicopathologic review of 40 patients with inverted and oncocytic schneiderian papillomas. Laryngoscope. 2002;112:1372-7.
  • Sbrana MF, Borges RFR, Pinna FR, Neto DB, Voegels RL. Sinonasal inverted papilloma: rate of recurrence and malignant transformation in 44 operated patients. Braz J Otorhinolaryngol. 2019 Aug 12. pii: S1808-8694(19)30088-6. doi: 10.1016/j.bjorl.2019.07.003.
  • Lisan Q, Laccourreye O, Bonfils P.Sinonasal inverted papilloma: From diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133:337-341.
  • Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, et al. Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review. Eur Arch Otorhinolaryngol. 2017;274:2991-3000.
  • Krouse JH. Development of a staging system for inverted papillomas. Laryngoscope. 2000;110:965-8.
  • Lisan Q, Moya-Plana A, Bonfils P. Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. 2017;143:1104-10.

Uludag Experience in Endonasal Endoscopic Inverted Papilloma Surgery

Year 2020, Volume: 46 Issue: 1, 53 - 57, 01.04.2020
https://doi.org/10.32708/uutfd.632167

Abstract

In this study, we aimed to evaluate the clinical outcomes and the relation between tumour stage and recurrence rates in patients who underwent endonasal endoscopic surgery with the diagnosis of inverted papilloma (IP)-the most common operated benign tumour of sinonasal region. The medical records of 75 patients who complied the inclusion criteria and underwent endoscopic surgery with diagnosis of IP between the years 2005 and 2019 at the ENT department of a tertiary university hospital were enrolled in this study. The demographic data of the patients, primary symptoms, preoperative imagings, operation notes, tumour stages and recurrence or malign transformation rates during follow-up were all documented. The relation between tumour stages and recurrence rates were calculated. We performed primary surgery in 50 patients and recurrent surgery for relapses in 25 patients. The tumor stages of patients were found as; T1 (n:11, 14%), T2 (n:39, 52%), T3 (n:16, 21%) and T4 (n:9, 12%). The most common locations of tumour were found as; lateral nasal wall-medial wall of maxillary sinus in 52 patients and ethmoid cells in 28 patients. In four patients (5%) malignant transformation was observed during follow-up. There was significant relation (p<0.001) between recurrence rates and tumour stages as; T1: 1/11 (9%), T2: 7/39 (18%), T3: 9/16 (56%) ve T4:8/9 (88%) relatively.

References

  • Barnes L, Eveson J, Reichart P, Sidransky D. World Health Organization Classi-fication of Tumours. Pathology and genetics of head and neck tumours. Lyon:IARC Press; 2005. ISBN 92 832 2417 5.
  • Goudakos JK, Blioskas S, Nikolaou A, Vlachtsis K, Karkos P, Markou KD. Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis. Am J Rhinol Allergy. 2018;32:167-174.
  • Busquets JM, Hwang PH. Endoscopic resection of sinonasal inverted papilloma: a meta-analysis. Otolaryngol Head Neck Surg. 2006;134(3):476-82. Review.
  • Lee JJ, Roland LT, Licata JJ, Orlowski HLP, Jiramongkolchai P, Piccirillo JF, et al. Morphologic, intraoperative, and histologic risk factors for sinonasal inverted papilloma recurrence. Laryngoscope. 2019 May 21. doi: 10.1002/lary.28078.
  • Molina JP, Llorente Pendas JL, Rodrigo Tapia JP, Alvarez Marcos C, Obeso Agüera S, Suárez Nieto C. [Inverted sinonasal papillomas. Review of 61 cases]. Acta Otorrinolaringol Esp. 2009;60:402-8.
  • Kim WS, Hyun DW, Kim CH, Yoon JH. Treatment outcomes of sinonasal inverted papillomas according to surgical approaches. Acta Otolaryngol. 2010;130:493-7.
  • MR, Brandwein MS, Lawson W. Sinonasal papillomas: clinicopathologic review of 40 patients with inverted and oncocytic schneiderian papillomas. Laryngoscope. 2002;112:1372-7.
  • Sbrana MF, Borges RFR, Pinna FR, Neto DB, Voegels RL. Sinonasal inverted papilloma: rate of recurrence and malignant transformation in 44 operated patients. Braz J Otorhinolaryngol. 2019 Aug 12. pii: S1808-8694(19)30088-6. doi: 10.1016/j.bjorl.2019.07.003.
  • Lisan Q, Laccourreye O, Bonfils P.Sinonasal inverted papilloma: From diagnosis to treatment. Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133:337-341.
  • Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, et al. Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review. Eur Arch Otorhinolaryngol. 2017;274:2991-3000.
  • Krouse JH. Development of a staging system for inverted papillomas. Laryngoscope. 2000;110:965-8.
  • Lisan Q, Moya-Plana A, Bonfils P. Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. 2017;143:1104-10.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects Otorhinolaryngology
Journal Section Research Article
Authors

Uygar Demir 0000-0002-9590-1420

Publication Date April 1, 2020
Acceptance Date April 1, 2020
Published in Issue Year 2020 Volume: 46 Issue: 1

Cite

APA Demir, U. (2020). Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(1), 53-57. https://doi.org/10.32708/uutfd.632167
AMA Demir U. Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi. Uludağ Tıp Derg. April 2020;46(1):53-57. doi:10.32708/uutfd.632167
Chicago Demir, Uygar. “Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, no. 1 (April 2020): 53-57. https://doi.org/10.32708/uutfd.632167.
EndNote Demir U (April 1, 2020) Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46 1 53–57.
IEEE U. Demir, “Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi”, Uludağ Tıp Derg, vol. 46, no. 1, pp. 53–57, 2020, doi: 10.32708/uutfd.632167.
ISNAD Demir, Uygar. “Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/1 (April 2020), 53-57. https://doi.org/10.32708/uutfd.632167.
JAMA Demir U. Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi. Uludağ Tıp Derg. 2020;46:53–57.
MLA Demir, Uygar. “Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 46, no. 1, 2020, pp. 53-57, doi:10.32708/uutfd.632167.
Vancouver Demir U. Endonazal Endoskopik İnverted Papillom Cerrahisinde Uludağ Deneyimi. Uludağ Tıp Derg. 2020;46(1):53-7.

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


Creative Commons License
Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

2023