Kanser Hastalarında ABO ve Rhesus Kan Gruplarının Dağılımı

Yıl 2020, Cilt: 46 Sayı: 3, 379 - 384, 01.12.2020

Fatih İnci , Fatih Karataş

https://doi.org/10.32708/uutfd.812217

Cited By: 1

Öz

Literatürde ABO ve Rhesus (Rh) kan gruplarının kanser hastalığı ile ilişkisine dair yapılan çalışmalar incelendiğinde mutlak bir sonuç çıkarmak mümkün olmamakta, sonuçlar ülkelere ve çalışmanın yapıldığı merkezlere göre değişkenlik gösterebilmektedir. Bu çalışmanın amacı kliniğimizde ABO-Rh kan gruplarının kanser alt tiplerine göre dağılımını değerlendirmektir. Ocak 2015- Ocak 2020 tarihleri arasında Tıbbi Onkoloji kliniğinde kanser tanısıyla takip ve tedavi edilen hastaların kan gruplarının kanser tiplerine göre dağılımı incelendi ve veriler kanser olmayan kontrol grubu ile karşılaştırıldı. Katılımcıların yaş, cinsiyet gibi sosyodemografik verileri, kanser alt tipi ve kan grupları (ABO-Rh) retrospektif olarak hasta dosyası ve hastane otomasyon sisteminden tarandı. Çalışmaya 1894’ü (%22.1) kanser hastası, 6681’i (%77.9) kontrol grubu olmak üzere 8575 birey dahil edildi. Kontrol grubu ve kanser hastalarında kan gruplarının dağılımında istatistiksel olarak anlamlı farklılık saptandı (p<0.001). Malign melanom, böbrek, kolorektal, meme, over kanserlerinde ARh(+) kan grubu; pankreas kanserinde ise ORh(+) kan grubu anlamlı derecede yüksek oranda saptandı. Diğer kanser tiplerinde kan grupları açısından bir farklılık tespit edilmedi. Çok değişkenli lojistik regresyon analizine göre; A ve O kan grupları ve ileri yaşın kanser hastalığı için bağımsız prediktif faktörler olduğu belirlendi. Kanser hastaları ve kontrol grubunda ABO-Rh kan gruplarının dağılımının farklı olduğu görüldü. Kanser alt tipleri incelendiğinde pankreas kanserinde O kan grubunun, malign melanom ve böbrek tümörlerde ise A kan grubunun daha yüksek oranda olduğu görüldü. Sağlıklı kişilere göre ileri yaş, A ve O kan gruplarının kanser hastalığı için bağımsız prediktif faktörler olduğu görüldü.

Anahtar Kelimeler

ABO, Rh, kan grubu, kanser, risk

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Distribution of ABO and Rhesus Blood Groups in Cancer Patients

Öz

When studies on the relation of ABO and Rhesus (Rh) blood groups with cancer are examined in the literature, it is not possible to draw an absolute conclusion, the results may vary according to the countries and centers where the study was conducted. The aim of this study is to evaluate the distribution of ABO-Rh blood groups according to cancer subtypes in our clinic. The distribution of blood groups of patients who were followed up for cancer between January 2015 and 2020 according to their cancer types was examined and the data were compared with the non-cancer control group. Participants' sociodemographic data such as age and gender, cancer type and blood groups (ABO-Rh) were retrospectively scanned from the hospital automation system. The study included 1894 (22.1%) cancer patients and 6681 (77.9%) control group. There was a statistically significant difference in blood groups of control group and cancer patients (p<0.001). ARh(+) blood group in melanoma, renal, colorectal, breast and ovarian cancers; ORh (+) blood group was found with a significantly higher rate in pancreatic cancer. In multivariate regression analysis, being group A and group O and increasing age were found to be independent predictive factors for cancer. It was observed that the distribution of ABO-Rh blood groups was different in the control group and cancer patients. In cancer subtypes, the rate of O blood group in pancreatic cancer and A blood group in melanoma and renal cell tumors were found to be higher. According to healthy people, advanced age, A and O blood groups were found to be independent risk factors for cancer diagnosis.

Anahtar Kelimeler

ABO, Rh, blood group, cancer, risk

Proje Numarası

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Kaynakça

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