Year 2021, Volume 47 , Issue 1, Pages 63 - 66 2021-04-01

Evaluation of Subclinical Atherosclerosis with Serum Endothelin-1 Levels
Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi

Şeyda GÜNAY [1] , Emre SARANDÖL [2] , Ali AYDINLAR [3]


Atherosclerosis and related diseases are the leading causes of death worldwide. Endothelial dysfunction occurs before the onset of atherosclerotic involvement in coronary arteries. It is important to diagnose atherosclerosis before organ involvement occurs. In this study, it was aimed to evaluate subclinical atherosclerosis by serum endothelin-1 (ET-1) levels in the subclinical period. Patients who presented with a complaint of chest pain and were scheduled for an exercise stress test (EST) or myocardial perfusion scintigraphy (MPS) in terms of coronary ischemia were included in the study. Patients with known angiographically proven coronary artery disease (CAD) were excluded from the study. Before the ischemia test, blood samples were taken from the patients for serum ET-1 measurement. Those with ischemia were evaluated by coronary angiography (CAG). According to the CAG results, those with clinically significant CAD (group-1) and those without clinically significant CAD (group-2) were grouped. Those without ischemia were defined as group-3. A total of 48 patients (mean age: 57.4 ± 10.9 years, and 23 (48%) females) without a known history of CAD were included in the study. 13 (27%) of the patients were diabetic, 26 (54%) of the patients were hypertensive hypertensive and 10 (20%) of the patients were hyperlipidemic. While ischemia was not detected in 17 patients (35.4%) with EST or MPS (group-3), 31 patients had ischemia and underwent CAG. Among those, clinically significant CAD was detected in 21 (67.7%) patients (group-1), and clinically significant CAD was not detected in 10 (32.3%) patients (group-2). Median [min-max] serum endothelin-1 level in group-1 was 15.9 [8.8-93.4] ng / L, in group- 2 it was 26.9 [8.5 -55.5] ng / L , and in group-3 it was 21.8[8.6-97.4] ng / L. There was no statistically significant difference between the groups in terms of serum ET-1 levels (p = 0.127). Serum ET-1 levels are not predictive of subclinical atherosclerosis in patients with suspected coronary artery disease.
Ateroskleroz ve ilişkili hastalıklar tüm dünyada en önde gelen ölüm nedenidir. Koroner arterlerde aterosklerotik tutulumun başlamasından daha önce endotel işlev bozukluğu ortaya çıkar. Aterosklerozu organ tutulumu ortaya çıkmadan teşhis etmek önemlidir. Bu çalışmada, subklinik aterosklerozun serum endotelin-1 (ET-1) düzeyi ile değerlendirilmesi amaçlandı. Göğüs ağrısı şikayeti ile başvuran ve koroner iskemi açısından egzersiz stres testi (EST) veya miyokard perfüyon sintigrafisi (MPS) planlanan hastalar çalışmaya alındı. Öyküsünde anjiyografik olarak kanıtlanmış koroner arter hastalığı (KAH) olan hastalar çalışmaya dahil edilmedi. İskemi testi öncesinde hastalardan serum ET-1 ölçümü için kan örneği alındı. İskemi saptananlar koroner anjiyografi (KAG) ile değerlendirilidi. KAG sonuçlarına göre hastalar, klinik olarak anlamlı KAH olanlar (grup-1) ve olmayanlar (grup-2) olarak gruplandı. İskemi saptanmayanlar ise grup-3 olarak tanımlandı. Bilinen KAH öyküsü olmayan 48 hasta (ortalama yaş:57,4±10,9 ve 23’ü (%48) kadın) çalışmaya alındı. Hastaların 13’ü (%27) diyabetik, 26’sı (%54) hipertansif ve 10’u (%20) hiperlipidemikti. 17 hastada (%35,4) EST veya MPS ile iskemi saptanmazken (grup-3), 31 hastada iskemi mevcuttu. İskemi saptanarak KAG yapılan hastaların 21’inde (%67,7) klinik olarak anlamlı KAH saptandı (grup-1), 10’unda (%32,3) klinik olarak anlamlı KAH saptanmadı (grup-2). Medyan [min-maks] serum endotelin-1 seviyesi grup-1’de 15,9 [8,8-93,4] ng/L, grup-2’de 26,9 [8,5-55,5]ng/L, grup-3’te 21,8 [8,6-97,4] ng/L saptandı. Serum ET-1 düzeyleri açısndan gruplar arasında istatiksel açıdan anlamlı farklılık saptanmadı (p=0,127). Koroner arter hastalığı şüphesi olan hastalarda serum ET-1 düzeyleri subklinik ateroskleroz için öngördürücü değildir.
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Primary Language tr
Subjects Cardiac and Cardiovascular Systems
Journal Section Research Article
Authors

Orcid: 0000-0003-0012-345X
Author: Şeyda GÜNAY (Primary Author)
Institution: Bursa Uludağ Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bursa.
Country: Turkey


Orcid: 0000-0002-2593-7196
Author: Emre SARANDÖL
Institution: Bursa Uludağ Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Bursa.
Country: Turkey


Orcid: 0000-0002-8974-8837
Author: Ali AYDINLAR
Institution: Bursa Uludağ Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bursa.
Country: Turkey


Dates

Publication Date : April 1, 2021

Bibtex @research article { uutfd857404, journal = {Uludağ Üniversitesi Tıp Fakültesi Dergisi}, issn = {1300-414X}, eissn = {2645-9027}, address = {Uludağ Üniversitesi Tıp Fakültesi Dekanlığı, Görükle Kampüsü 16059, Nilüfer, BURSA}, publisher = {Bursa Uludağ University}, year = {2021}, volume = {47}, pages = {63 - 66}, doi = {10.32708/uutfd.857404}, title = {Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi}, key = {cite}, author = {Günay, Şeyda and Sarandöl, Emre and Aydınlar, Ali} }
APA Günay, Ş , Sarandöl, E , Aydınlar, A . (2021). Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi . Uludağ Üniversitesi Tıp Fakültesi Dergisi , 47 (1) , 63-66 . DOI: 10.32708/uutfd.857404
MLA Günay, Ş , Sarandöl, E , Aydınlar, A . "Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi" . Uludağ Üniversitesi Tıp Fakültesi Dergisi 47 (2021 ): 63-66 <https://dergipark.org.tr/en/pub/uutfd/issue/61997/857404>
Chicago Günay, Ş , Sarandöl, E , Aydınlar, A . "Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi". Uludağ Üniversitesi Tıp Fakültesi Dergisi 47 (2021 ): 63-66
RIS TY - JOUR T1 - Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi AU - Şeyda Günay , Emre Sarandöl , Ali Aydınlar Y1 - 2021 PY - 2021 N1 - doi: 10.32708/uutfd.857404 DO - 10.32708/uutfd.857404 T2 - Uludağ Üniversitesi Tıp Fakültesi Dergisi JF - Journal JO - JOR SP - 63 EP - 66 VL - 47 IS - 1 SN - 1300-414X-2645-9027 M3 - doi: 10.32708/uutfd.857404 UR - https://doi.org/10.32708/uutfd.857404 Y2 - 2021 ER -
EndNote %0 Uludağ Üniversitesi Tıp Fakültesi Dergisi Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi %A Şeyda Günay , Emre Sarandöl , Ali Aydınlar %T Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi %D 2021 %J Uludağ Üniversitesi Tıp Fakültesi Dergisi %P 1300-414X-2645-9027 %V 47 %N 1 %R doi: 10.32708/uutfd.857404 %U 10.32708/uutfd.857404
ISNAD Günay, Şeyda , Sarandöl, Emre , Aydınlar, Ali . "Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi". Uludağ Üniversitesi Tıp Fakültesi Dergisi 47 / 1 (April 2021): 63-66 . https://doi.org/10.32708/uutfd.857404
AMA Günay Ş , Sarandöl E , Aydınlar A . Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi. Uludağ Tıp Derg. 2021; 47(1): 63-66.
Vancouver Günay Ş , Sarandöl E , Aydınlar A . Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2021; 47(1): 63-66.
IEEE Ş. Günay , E. Sarandöl and A. Aydınlar , "Subklinik Aterosklerozun Serum Endotelin-1 Düzeyi ile Değerlendirilmesi", Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 47, no. 1, pp. 63-66, Apr. 2021, doi:10.32708/uutfd.857404