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Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi

Year 2021, Volume: 47 Issue: 2, 211 - 218, 01.08.2021
https://doi.org/10.32708/uutfd.911525

Abstract

Merkezi sinir sistemi içerisinde nörotransmitter ve nöromodülatör etkiye sahip histamin, davranış durumunun, biyolojik ritmin, vücut ağırlığının, enerji metabolizmasının, termoregülasyonun, sıvı dengesinin, stresin ve üremenin düzenlenmesinde anahtar role sahiptir. Histaminin merkezi akut enjeksiyonlarının hipotalamo-hipofizer-gonadal (HPG) aks içerisinde etkili olduğunu ve histaminin merkezi H1 ve H2 reseptör-lerinin bu etkiye aracılık ettiğini gösterdik. Fakat çalışmalarda, histaminin ve histamin reseptör antagonistlerinin uzun süreli merkezi tedavilerinin HPG aks içerisindeki etkilerine dair açıklayıcı bir bilgi bulunmamaktadır. Çalışmada, kronik olarak intraserebroventriküler (i.s.v.) enjekte edilen histamin ve antagonistlerinin hipotalamo-hipofizer-gonadal (HPG) aksta rol oynayan, gonadotropin salgılatıcı hormonun (GnRH), folikül stimüle edici hormonun (FSH), lüteinleştirici hormonun (LH) ve testosteron hormonunun plazma seviyelerine etkileri araştırılmıştır. Çalışma Sprague-Dawley ırkı sıçanlarda gerçekleştirilmiştir. Histamin (100 nmol), histaminerjik H1 reseptör antagonisti klorfeni-ramin (100 nmol), histaminerjik H2 reseptör antagonisti ranitidin (100 nmol) veya histaminerjik H3/H4 reseptör antagonisti tiyoperamid (100 nmol) i.s.v. olarak 7 gün boyunca enjekte edilmiştir. Histamin ve antagonistlerinin kronik enjeksiyonu GnRH’nın plazma seviyelerinde anlamlı bir fark oluşturmamıştır. Kronik histamin veya klorfeniramin tedavisi sonucu plazma FSH seviyelerinde artış (p<0,05) ve LH ve testosteron (p<0,05) seviyelerinde ise bir düşüş gözlenmiştir. Kronik ranitidin veya tiyoperamid tedavisi ise plazma FSH düzeylerinde bir etki oluşturmamış fakat LH ve testosteron seviyelerinde artışlara neden olmuştur (p<0,05). Sonuç olarak elde edilen veriler, histamin ve merkezi H1 reseptör antagonistinin uzun süreli tedavisinin, LH ve testosteron seviyeleri üzerinde inhibe edici etkilere sahip olduğunu göstermektedir. Bunun yanında, merkezi H2 ve H3/H4 reseptör antagonistleri ile yapılan kronik tedavinin üremenin düzenlenmesine katkı sağlayabileceği görülmektedir.

References

  • Fink G. 60 YEARS OF NEUROENDOCRINOLOGY: MEMOIR: Harris' neuroendocrine revolution: of portal vessels and self-priming. J Endocrinol 2015;226(2).
  • Amory JK, Bremner WJ. Regulation of testicular function in men: implications for male hormonal contraceptive development. J Steroid Biochem Mol Biol 2003;85,357-361.
  • Clarke I, Cummins J. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 1982;111,1737–9.
  • Huhtaniemi I. A short evolutionary history of FSH-stimulated spermatogenesis. Hormones (Athens) 2015;14,468-78.
  • Sharpe RM, McKinnell C, Kivlin C, Fisher JS. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 2003;125,769-784.
  • Matsumoto AM, Bremner WJ. Modulation of pulsatile gonadotropin secretion by testosterone in men. J Clin Endocrinol Metab 1984;58,609–14.
  • Sheckter CB, Matsumoto AM, Bremner WJ. Testosterone administration inhibits gonadotropin secretion by an effect on the human pituitary. J Clin Endocrinol Metab 1989;68,397–401.
  • Haas HL, Sergeeva OA, Selbach O. Histamine in the Nervous System. Physiol Rev 2008;88, 1183–241.
  • Badr FM. Effect of sexual maturation and androgens on prostaglandin levels in tissues of the male reproductive system in mice. Endocrinology 1976;98,1523-7.
  • Mayerhofer A, Bartke A, Amador AG, Began T. Histamine affects testicular steroid production in the golden hamster. Endocrinology 1989;125,2212-4.
  • Khan UW, Rai U. Differential effects of histamine on Leydig cell and testicular macrophage activities in wall lizards: precise role of H1/H2 receptor subtypes. J Endocrinol 2007;194,441-8.
  • Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol 2001;63,637-72.
  • Fogel WA, Stasiak A, Lewinski A, Maksymowicz M, Jochem J. Satiety signalling histaminergic system system and brain-gut peptides in regulation of food intake in rats with portocaval anastomosis. J Physiol Pharmacol 2008;59,135-44.
  • Yalcin M, Savci V, Jochem J. Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2009;60,133-7.
  • Altinbas B, Yilmaz MS, Savci V, Jochem J, Yalcin M. Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. Auton Neurosci 2015;187,63-9.
  • Altinbas B, Guvenc G, Erkan LG, Ilhan T, Niaz N, Yalcin M. Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius. Brain Res 2016;1649,132–40.
  • Schwartz JC, Arrang JM, Garbarg M, Pollard H, Ruat M. Histaminergic transmission in the mammalian brain. Physiol Rev 1991;71,1-51.
  • Knigge U, Warberg J. Neuroendocrine functions of histamine. Agents Actions Suppl 1991a;33,29-53.
  • Knigge U, Warberg J. The role of histamine in the neuroendocrine regulation of pituitary hormone secretion. Acta Endocrinol 1991b;124,609-19.
  • Kjaer A, Knigge U, Bach FW, Warberg J. Histamine- and stress-induced secretion of ACTH and beta-endorphin: involvement of corticotropin-releasing hormone and vasopressin. Neuroendocrinology 1992;56,419-28.
  • Mitsuma T, De-Heng S, Nogimori T, Chaya M, Hirooka Y, Ohtake K. Effect of histamine and its blockers on plasma beta-endorphin-like immunoreactivity in rats. Endocrinol Exp 1987;21,95-102.
  • Knigge UP. Histaminergic regulation of prolactin secretion. Dan Med Bull 1990;37,109-24.
  • Bugajski J, Janusz Z. Central histaminergic stimulation of pituitary-adrenocortical response in the rat. Life Sci 1983;33,1179-89.
  • Kjaer A, Larsen PJ, Knigge U, Warberg J. Histaminergic activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 1994;135,1171-7.
  • Radacs M, Galfi M, Juhasz A, Varga C, Molnar A, Laszlo F, Laszlo FA. Histamine-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue cultures. Regul Pept 2006;134,82-8.
  • Lee AW, Devidze N, Pfaff DW, Zhou J. Functional genomics of sex hormonedependent neuroendocrine systems: specific and generalized actions in the CNS. Prog Brain Res 2006;158,243–72.
  • Noris G, Hol D, Clapp C, Martinez- dela-Escalera G. Histamine directly stimulates gonadotropin-releasing hormone secretion from GT1-1 cells via H1 receptors coupled to phosphoinositide hydrolysis. Endocrinology 1995;136,2967–74.
  • Jochem J, Savci V, Filiz N, Rybus-Kalinowska B, Fogel WA, Yalcin M. Involvement of the histaminergic system in cytidine 5’-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2010;61,37–43.
  • King JA, Millar RP. Evolutionary aspects of gonadotropin-releasing hormone and its receptor. Cell Mol Neurobiol 1995;15:5-23.
  • dAnglemont-de-Tassigny X, Fagg LA, Carlton MBL, Colledge WH. Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals. Endocrinology 2008;149,3926–32.
  • Matsumoto AM, Karpas AE, Bremner WJ. Chronic human chorionic gonadotropin administration in normal men: evidence that follicle stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man. J Clin Endocrinol Metab 1986;62,1184–92.
  • Orr EL, Quay WB. The effects of castration on histamine levels and 24 hour rhythm in the male rat hypothalamus. Endocrinology 1975;97,481–4.
  • Par G, Szekeres-Bartho J, Buzas E, Pap E, Falus A. Impaired reproduction of histamine deficient (histidine-decarboxylase knockout) mice is caused predominantly by a decreased male mating behavior. Am J Reprod Immunol 2003;50,152–8.
  • Niaz N, Guvenc G, Altinbas B, Toker MB, Aydin B, Udum-Kucuksen D, et al. Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats. Brain Res 2018;1699,150-7.
  • Miyake A, Ohtsuka S, Nishizaki T, Tasaka K, Aono T, Tanizawa O, et al. Involvement of H1 histamine receptor in basal and estrogen-stimulated luteinizing hormone-releasing hormone secretion in rats in vitro. Neuroendocrinology 1987;45,191–6.
  • Ojeda SR, McCann SM. Control of LH and FSH release by LHRH: influence of putative neurotransmitters. Clin Obstet Gynaecol 1978;5,283-303.
  • Horvath JE, Bajo AM, Schally AV, Kovacs M, Herbert F, Kate G. Effects of long-term treatment with the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl and the LHRH antagonist Cetrorelix on the levels of pituitary LHRH receptors and their mRNA expression in rats. Proc Natl Acad Sci USA 2002;99,15048-53.
  • Swerdloff RS, Heber D, Bhasin S, Rajfer J. Effect of GnRH superactive analogs (alone and combined with androgen) on testicular function in man and experimental animals. J Steroid Biochem 1983;19,491-7.
  • Culler MD, Negro-Vilar A. Pulsatile follicle-stimulating hormone secretion is independent of luteinizing hormone-releasing hormone (LHRH): pulsatile replacement of LHRH bioactivity in LHRH immunoneutralized rats. Endocrinology 1987;20,2011–21.
  • Kovacs M, Koppan M, Mezo I, Teplan I, Flerko B. Antiovulatory doses of antagonists of LH- RH inhibit LH and progesterone but not FSH and estradiol release. J Neuroendocrinol 1993;5,603–8.
  • Lumpkin MD, DePaolo LV, Negro-Vilar A. Pulsatile release of follicle-stimulating hormone in ovariectomized rats is inhibited by porcine follicular fluid (Inhibin). Endocrinology 1986;114,201–6.
  • Mizunuma H, Samson WK, Lumpkin MD, Moltz JH, Fawcett CP, McCann SM. Purification of a bioactive FSH-releasing factor (FSHRF). Brain Res Bull 1983;10,623–9.
  • Culler MD, Negro-Vilar A. Evidence that pulsatile follicle stimulating hormone secretion is independent of endogenous luteinizing hormone-releasing hormone. Endocrinology 1986;118,609–12.
  • Church MK, Casale TB. Principles of pharmacotherapy. Allergy 2012;147–69.
  • Lokaj-Berisha V, Gacaferri-Lumezi B, Berisha N, Gashi-Hoxha S. A Pilot Study on BMI, Serum Testosterone and Estradiol Levels in Allergic Male Patients. Open Access Maced J Med Sci 2015;3,595-600.
  • Habibi A, Riley ET. Antihistamines: H1- and H2- Blockers. Complications in Anesthesia 2007;92–3.
  • Knigge U, Dejgaard A, Wollesen F, Ingerslev O, Bennett P, Christiansen PM. The acute and long term effect of the H2-receptor antagonists cimetidine and ranitidine on the pituitary-gonadal axis in men. Clin Endocrinol (Oxf) 1983;18,307-13.
  • Corinaldesi R, Pasquali R, Paternico A, Stanghellini V, Paparo GF, Ricci Maccarini M, et al. Effects of short- and long-term administrations of famotidine and ranitidine on some pituitary, sexual and thyroid hormones. Drugs Exp Clin Res 1987;13,647-54.
  • Prast H, Fischer HP, Prast M, Philippu A. In vivo modulation of histamine release by autoreceptors and muscarinic acetylcholine receptors in the rat anterior hypothalamus. Naunyn-Schmiedeberg's Arch Pharmacol 1994;350,599-604.
  • Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, et al. Highly potent and selective ligands for histamine H3 receptors. Nature 1987;327,117-25.
  • Jansen FP, Mochizuki T, Yamamoto Y, Timmerman H, Yamatodani A. In vivo modulation of rat hypothalamic histamine release by the histamine H3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application. Eur J Pharmacol 1998;362,149-55.

The Effect of Chronically Intracerebroventricular Injected Histamine and Its Antagonists on the Hypothalamic-Pituitary-Axis

Year 2021, Volume: 47 Issue: 2, 211 - 218, 01.08.2021
https://doi.org/10.32708/uutfd.911525

Abstract

Histamine, which has neurotransmitter and neuromodulatory effects in the CNS, has a key role in regulating behavioral state, biological rhythm, body weight, energy metabolism, thermoregulation, fluid balance, stress, and reproduction. We have shown that acute central injections of histamine are effective in the hypothalamic-pituitary-gonadal (HPG) axis and that histamine central H1/H2 receptors mediate this effect. However, there is no explanatory information about the effects of long-term central treatments of histamine and histamine receptor antagonists in the HPG axis in studies. In the study, the effects of chronically intracerebroventricular (i.c.v.) injected histamine and its antagonists on plasma levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone hormone, which play a role in the HPG axis, were investigated. Studies were performed in male Sprague–Dawley rats. Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100 nmol), H2 receptor antagonist ranitidine (100 nmol), or H3/H4 receptor antagonist thioperamide (100 nmol) was injected i.c.v. for 7 days. Chronic injection of histamine and its antagonists did not make a significant difference in plasma levels of GnRH. Chronic histamine or chlorpheniramine treatment increased plasma FSH levels (p<0,05) and decreased LH/testosterone levels (p<0,05). Chronic ranitidine or thioperamide treatment did not have an effect on plasma FSH levels but caused increases in LH and testosterone levels (p<0,05). The resulting data suggest that long-term treatment of histamine and central H1 receptor antagonist has inhibitory effects on LH and testosterone levels. Besides, it appears that chronic treatment with central H2, H3/H4 receptor antagonists can contribute to the regulation of reproduction.

References

  • Fink G. 60 YEARS OF NEUROENDOCRINOLOGY: MEMOIR: Harris' neuroendocrine revolution: of portal vessels and self-priming. J Endocrinol 2015;226(2).
  • Amory JK, Bremner WJ. Regulation of testicular function in men: implications for male hormonal contraceptive development. J Steroid Biochem Mol Biol 2003;85,357-361.
  • Clarke I, Cummins J. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 1982;111,1737–9.
  • Huhtaniemi I. A short evolutionary history of FSH-stimulated spermatogenesis. Hormones (Athens) 2015;14,468-78.
  • Sharpe RM, McKinnell C, Kivlin C, Fisher JS. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 2003;125,769-784.
  • Matsumoto AM, Bremner WJ. Modulation of pulsatile gonadotropin secretion by testosterone in men. J Clin Endocrinol Metab 1984;58,609–14.
  • Sheckter CB, Matsumoto AM, Bremner WJ. Testosterone administration inhibits gonadotropin secretion by an effect on the human pituitary. J Clin Endocrinol Metab 1989;68,397–401.
  • Haas HL, Sergeeva OA, Selbach O. Histamine in the Nervous System. Physiol Rev 2008;88, 1183–241.
  • Badr FM. Effect of sexual maturation and androgens on prostaglandin levels in tissues of the male reproductive system in mice. Endocrinology 1976;98,1523-7.
  • Mayerhofer A, Bartke A, Amador AG, Began T. Histamine affects testicular steroid production in the golden hamster. Endocrinology 1989;125,2212-4.
  • Khan UW, Rai U. Differential effects of histamine on Leydig cell and testicular macrophage activities in wall lizards: precise role of H1/H2 receptor subtypes. J Endocrinol 2007;194,441-8.
  • Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol 2001;63,637-72.
  • Fogel WA, Stasiak A, Lewinski A, Maksymowicz M, Jochem J. Satiety signalling histaminergic system system and brain-gut peptides in regulation of food intake in rats with portocaval anastomosis. J Physiol Pharmacol 2008;59,135-44.
  • Yalcin M, Savci V, Jochem J. Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2009;60,133-7.
  • Altinbas B, Yilmaz MS, Savci V, Jochem J, Yalcin M. Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. Auton Neurosci 2015;187,63-9.
  • Altinbas B, Guvenc G, Erkan LG, Ilhan T, Niaz N, Yalcin M. Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius. Brain Res 2016;1649,132–40.
  • Schwartz JC, Arrang JM, Garbarg M, Pollard H, Ruat M. Histaminergic transmission in the mammalian brain. Physiol Rev 1991;71,1-51.
  • Knigge U, Warberg J. Neuroendocrine functions of histamine. Agents Actions Suppl 1991a;33,29-53.
  • Knigge U, Warberg J. The role of histamine in the neuroendocrine regulation of pituitary hormone secretion. Acta Endocrinol 1991b;124,609-19.
  • Kjaer A, Knigge U, Bach FW, Warberg J. Histamine- and stress-induced secretion of ACTH and beta-endorphin: involvement of corticotropin-releasing hormone and vasopressin. Neuroendocrinology 1992;56,419-28.
  • Mitsuma T, De-Heng S, Nogimori T, Chaya M, Hirooka Y, Ohtake K. Effect of histamine and its blockers on plasma beta-endorphin-like immunoreactivity in rats. Endocrinol Exp 1987;21,95-102.
  • Knigge UP. Histaminergic regulation of prolactin secretion. Dan Med Bull 1990;37,109-24.
  • Bugajski J, Janusz Z. Central histaminergic stimulation of pituitary-adrenocortical response in the rat. Life Sci 1983;33,1179-89.
  • Kjaer A, Larsen PJ, Knigge U, Warberg J. Histaminergic activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 1994;135,1171-7.
  • Radacs M, Galfi M, Juhasz A, Varga C, Molnar A, Laszlo F, Laszlo FA. Histamine-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue cultures. Regul Pept 2006;134,82-8.
  • Lee AW, Devidze N, Pfaff DW, Zhou J. Functional genomics of sex hormonedependent neuroendocrine systems: specific and generalized actions in the CNS. Prog Brain Res 2006;158,243–72.
  • Noris G, Hol D, Clapp C, Martinez- dela-Escalera G. Histamine directly stimulates gonadotropin-releasing hormone secretion from GT1-1 cells via H1 receptors coupled to phosphoinositide hydrolysis. Endocrinology 1995;136,2967–74.
  • Jochem J, Savci V, Filiz N, Rybus-Kalinowska B, Fogel WA, Yalcin M. Involvement of the histaminergic system in cytidine 5’-diphosphocholine-induced reversal of critical haemorrhagic hypotension in rats. J Physiol Pharmacol 2010;61,37–43.
  • King JA, Millar RP. Evolutionary aspects of gonadotropin-releasing hormone and its receptor. Cell Mol Neurobiol 1995;15:5-23.
  • dAnglemont-de-Tassigny X, Fagg LA, Carlton MBL, Colledge WH. Kisspeptin Can Stimulate Gonadotropin-Releasing Hormone (GnRH) Release by a Direct Action at GnRH Nerve Terminals. Endocrinology 2008;149,3926–32.
  • Matsumoto AM, Karpas AE, Bremner WJ. Chronic human chorionic gonadotropin administration in normal men: evidence that follicle stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man. J Clin Endocrinol Metab 1986;62,1184–92.
  • Orr EL, Quay WB. The effects of castration on histamine levels and 24 hour rhythm in the male rat hypothalamus. Endocrinology 1975;97,481–4.
  • Par G, Szekeres-Bartho J, Buzas E, Pap E, Falus A. Impaired reproduction of histamine deficient (histidine-decarboxylase knockout) mice is caused predominantly by a decreased male mating behavior. Am J Reprod Immunol 2003;50,152–8.
  • Niaz N, Guvenc G, Altinbas B, Toker MB, Aydin B, Udum-Kucuksen D, et al. Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats. Brain Res 2018;1699,150-7.
  • Miyake A, Ohtsuka S, Nishizaki T, Tasaka K, Aono T, Tanizawa O, et al. Involvement of H1 histamine receptor in basal and estrogen-stimulated luteinizing hormone-releasing hormone secretion in rats in vitro. Neuroendocrinology 1987;45,191–6.
  • Ojeda SR, McCann SM. Control of LH and FSH release by LHRH: influence of putative neurotransmitters. Clin Obstet Gynaecol 1978;5,283-303.
  • Horvath JE, Bajo AM, Schally AV, Kovacs M, Herbert F, Kate G. Effects of long-term treatment with the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl and the LHRH antagonist Cetrorelix on the levels of pituitary LHRH receptors and their mRNA expression in rats. Proc Natl Acad Sci USA 2002;99,15048-53.
  • Swerdloff RS, Heber D, Bhasin S, Rajfer J. Effect of GnRH superactive analogs (alone and combined with androgen) on testicular function in man and experimental animals. J Steroid Biochem 1983;19,491-7.
  • Culler MD, Negro-Vilar A. Pulsatile follicle-stimulating hormone secretion is independent of luteinizing hormone-releasing hormone (LHRH): pulsatile replacement of LHRH bioactivity in LHRH immunoneutralized rats. Endocrinology 1987;20,2011–21.
  • Kovacs M, Koppan M, Mezo I, Teplan I, Flerko B. Antiovulatory doses of antagonists of LH- RH inhibit LH and progesterone but not FSH and estradiol release. J Neuroendocrinol 1993;5,603–8.
  • Lumpkin MD, DePaolo LV, Negro-Vilar A. Pulsatile release of follicle-stimulating hormone in ovariectomized rats is inhibited by porcine follicular fluid (Inhibin). Endocrinology 1986;114,201–6.
  • Mizunuma H, Samson WK, Lumpkin MD, Moltz JH, Fawcett CP, McCann SM. Purification of a bioactive FSH-releasing factor (FSHRF). Brain Res Bull 1983;10,623–9.
  • Culler MD, Negro-Vilar A. Evidence that pulsatile follicle stimulating hormone secretion is independent of endogenous luteinizing hormone-releasing hormone. Endocrinology 1986;118,609–12.
  • Church MK, Casale TB. Principles of pharmacotherapy. Allergy 2012;147–69.
  • Lokaj-Berisha V, Gacaferri-Lumezi B, Berisha N, Gashi-Hoxha S. A Pilot Study on BMI, Serum Testosterone and Estradiol Levels in Allergic Male Patients. Open Access Maced J Med Sci 2015;3,595-600.
  • Habibi A, Riley ET. Antihistamines: H1- and H2- Blockers. Complications in Anesthesia 2007;92–3.
  • Knigge U, Dejgaard A, Wollesen F, Ingerslev O, Bennett P, Christiansen PM. The acute and long term effect of the H2-receptor antagonists cimetidine and ranitidine on the pituitary-gonadal axis in men. Clin Endocrinol (Oxf) 1983;18,307-13.
  • Corinaldesi R, Pasquali R, Paternico A, Stanghellini V, Paparo GF, Ricci Maccarini M, et al. Effects of short- and long-term administrations of famotidine and ranitidine on some pituitary, sexual and thyroid hormones. Drugs Exp Clin Res 1987;13,647-54.
  • Prast H, Fischer HP, Prast M, Philippu A. In vivo modulation of histamine release by autoreceptors and muscarinic acetylcholine receptors in the rat anterior hypothalamus. Naunyn-Schmiedeberg's Arch Pharmacol 1994;350,599-604.
  • Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, et al. Highly potent and selective ligands for histamine H3 receptors. Nature 1987;327,117-25.
  • Jansen FP, Mochizuki T, Yamamoto Y, Timmerman H, Yamatodani A. In vivo modulation of rat hypothalamic histamine release by the histamine H3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application. Eur J Pharmacol 1998;362,149-55.
There are 51 citations in total.

Details

Primary Language Turkish
Subjects Endocrinology, Urology, Medical Physiology
Journal Section Research Article
Authors

Burçin Altınbaş 0000-0002-9534-736X

Gökçen Güvenç Bayram 0000-0002-1413-3651

Murat Yalçın 0000-0002-5600-8162

Publication Date August 1, 2021
Acceptance Date June 22, 2021
Published in Issue Year 2021 Volume: 47 Issue: 2

Cite

APA Altınbaş, B., Güvenç Bayram, G., & Yalçın, M. (2021). Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 47(2), 211-218. https://doi.org/10.32708/uutfd.911525
AMA Altınbaş B, Güvenç Bayram G, Yalçın M. Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi. Uludağ Tıp Derg. August 2021;47(2):211-218. doi:10.32708/uutfd.911525
Chicago Altınbaş, Burçin, Gökçen Güvenç Bayram, and Murat Yalçın. “Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin Ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47, no. 2 (August 2021): 211-18. https://doi.org/10.32708/uutfd.911525.
EndNote Altınbaş B, Güvenç Bayram G, Yalçın M (August 1, 2021) Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47 2 211–218.
IEEE B. Altınbaş, G. Güvenç Bayram, and M. Yalçın, “Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi”, Uludağ Tıp Derg, vol. 47, no. 2, pp. 211–218, 2021, doi: 10.32708/uutfd.911525.
ISNAD Altınbaş, Burçin et al. “Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin Ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 47/2 (August 2021), 211-218. https://doi.org/10.32708/uutfd.911525.
JAMA Altınbaş B, Güvenç Bayram G, Yalçın M. Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi. Uludağ Tıp Derg. 2021;47:211–218.
MLA Altınbaş, Burçin et al. “Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin Ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 47, no. 2, 2021, pp. 211-8, doi:10.32708/uutfd.911525.
Vancouver Altınbaş B, Güvenç Bayram G, Yalçın M. Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi. Uludağ Tıp Derg. 2021;47(2):211-8.

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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