Research Article
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Kardiyopulmoner Resüsitasyon Başarısını Etkileyen Faktörlerin Retrospektif Olarak İncelenmesi

Year 2025, Volume: 51 Issue: 1, 29 - 35, 27.05.2025
https://doi.org/10.32708/uutfd.1562460

Abstract

Kardiyopulmoner resüsitasyon (KPR) uygulanan hastalarda sağkalımı etkileyen faktörleri belirlemek amacıyla yapılan çalışmamızda, bir yıl içinde hastanemizde KPR uygulanan 1576 hastaya ait 1995 KPR kayıt formu incelendi. Çalışmaya 18 yaş altı hastalar ve birden fazla KPR uygulananların ilk resüsitasyonları dışındaki veriler alınmadı. Geriye kalan 1228 hastanın dosya ve KPR formlarındaki hasta özellikleri, KPR ile ilgili bilgiler ve laboratuvar parametreleri kaydedildi. Spontan dolaşımın geri dönüşü (SDGD), ilk 24 ve 48 saatlik sağkalım üzerine etkileri araştırıldı. İstatistiksel analizde tek ve çok değişkenli lojistik regresyon analizi kullanıldı. Hastaların %37,9’u kadın, %62,1’i erkek olup, yaş ortalaması 64,0±14,1 yıl idi. SDGD oranı %32,41, ilk 24 ve 48. saat sağkalım oranları sırasıyla %8,15 ve %7,46 olarak bulundu. SDGD’yi etkileyen bağımsız risk faktörleri arasında yatış süresi, yoğun bakım ve acil serviste arrest, sepsis, metastaz, karaciğer yetmezliği, solunum depresyonu ve ventriküler fibrilasyon/nabızsız ventriküler taşikardi ilk ritmi yer aldı. İlk 24 ve 48 saatte mortalite oranları yoğun bakımda arrest (OR=3,01 ve 4,57), yüksek SAPS II (Simplified Acute Physiology Score II) skoru, yüksek GOFAR (Good Outcome Following Attempted Resuscitation) ve PAR (Prognosis After Resuscitation) skorlarıyla ilişkilendirildi. Sonuç olarak, hastane içi KPR’de sağkalım tahmininde SAPS II, GOFAR ve PAR skorlarının kullanılabileceği, yoğun bakımda arrestin sağkalımı olumsuz etkilediği saptandı.

References

  • 1. Özköse Z. Erişkinler için kardiyopulmoner resüsitasyon: I - Temel yaşam desteği. Gazi Tıp Dergisi 2005;16:1-13.
  • 2. Link MS, Berkow LC, Kudenchuk PJ, et al. Part 7: Adult advanced cardiovascular life support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2015;132:444-64.
  • 3. Olasveengen TM, Mancini ME, Perkins GD, et al. Adult basic life support: International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 2020 Nov:156:A35-A79.
  • 4. Xue J, Leng Q, Gao Y. Factors influencing outcomes after cardiopulmonary resuscitation in emergency department. World J Emerg Med 2013;4:183–9.
  • 5. Nolan JP, Soar J, Smith GB et al. Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit. Resuscitation 2014;85:987-92.
  • 6. Sandroni C, Nolan J, Cavallaro F, Antonelli M. In-hospital cardiac arrest: Incidence, prognosis and possible measures to improve survival. Intensive Care Med 2007;33(2):237-45.
  • 7. Ebell MH, Preston PS. The effect of the APACHE II Score and selected clinical variables on survival following cardiopulmonary resuscitation. Fam Med 1993;25:191-6.
  • 8. Cooper S, Janghorbani M, Cooper G. A decade of in-hospital resuscitation: Outcomes and prediction of survival? Resuscitation 2006;68:231-7.
  • 9. Danciu SC, Klein L, Hosseini MM, et al. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation 2004;62:35-42.
  • 10. Sandroni C, Ferro G, Santangelo S, et al. In-hospital cardiac arrest: Survival depends mainly on the effectiveness of the emergency response. Resuscitation 2004;62:291-7.
  • 11. Goldberger ZD, Chan PS, Berg RA, et al. Duration of resuscitation efforts and survival after in-hospital cardiac arrest: An observational study. Lancet 2012;380:1473-81.
  • 12. Radeschi G, Mina A, Berta G, et al. Incidence and outcome of in-hospital cardiac arrest in Italy: A multicentre observational study in the Piedmont region. Resuscitation 2017;119:48-55.
  • 13. Yilmaz S, Omurlu IK. Survival after cardiopulmonary arrest in a tertiary care hospital in Turkey. Ann Saudi Med 2019;39(2):92-99.
  • 14. Wallace SK, Abella BS, Shofer FS, et al. Effect of time of day on prehospital care and outcomes after out of hospital cardiac arrest. Circulation 2013;127:1591-6.
  • 15. Khan NU, Razzak JA, Ahmed H, et al. Cardiopulmonary resuscitation: Outcome and its predictors among hospitalized adult patients in Pakistan. Int J Emerg Med 2008;1:27–34.
  • 16. Peters R, Boyde M. Improving survival after in-hospital cardiac arrest: the Australian experience. Am J Crit Care 2007;16:240-7.
  • 17. Reisfield GM, Wallace SK, Munsell MF, et al. Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation:A meta-analysis. Resuscitation 2006;71:152-60.
  • 18. Nadkarni VM, Larkin GL, Peberdy MA, et al. First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults. JAMA 2006;295(1):50–57.
  • 19.Roedl K, Wallmüller C, Drolz A, et al. Outcome of in-and out-of-hospital cardiac arrest survivors with liver cirrhosis. Ann Intensive Care 2017;6:103.
  • 20.Khalafi K, Ravakhah K, West BC. Avoiding the futility ofresuscitation. Resuscitation 2001;50:161-6.
  • 21.Ebell MH, Afonso AM. Pre-arrest predictors of failure to survive after in hospital cardiopulmonary resuscitation: A meta-analysis. Fam Pract 2011;28:505-15.
  • 22.Vos R, Koster RW, De Haan RJ, et al. In-hospital cardiopulmonary resuscitation: Prearrest morbidity and outcome. Arch Intern Med 1999;159:845-50.
  • 23.Isenschmid C, Kalt J, Gamp M et al. Routine blood markersfrom different biological pathways improve early risk stratification in cardiac arrest patients: Results from the prospective, observational COMMUNICATE study. Resuscitation 2018;130:138-145.
  • 24.Fontana V, Spadaro S, Villois P, et al. Can red blood cell distribution width predict outcome after cardiac arrest? MinervaAnestesiol 2018;84:693-702.
  • 25.Kim J, Kim K, Lee JH et al. Red blood cell distribution width as an independent predictor of all-cause mortality in out of hospital cardiac arrest. Resuscitation 2012;83:1248-52.
  • 26.Karabıyık L. Yoğun bakımda skorlama sistemleri. YoğunBakım Dergisi 2010;9:129-43.
  • 27.Liu W,Lai C, Hii C, et al. Outcomes and cost analysis ofpatients with successful in-hospital cardiopulmonaryresuscitation. Int J Gerontol2011;5:196-9.
  • 28.Ohlsson MA, Kennedy LM, Ebell MH, Juhlin T, Melander O. Validation of the Good Outcome Following Attempted Resuscitation Score on in-hospital cardiac arrest in Southern Sweden. Int J Cardiol 2016;221:294-7.
  • 29.Bowker L, Stewart K. Predicting unsuccessful cardiopulmonary resuscitation (CPR): A comparison of three morbidity scores. Resuscitation1999;40:89-95.
  • 30.Parlakgümüş A, Nursalı TZ, Yorgancı K. Bir cerrahi yoğun bakım ünitesinde kardiyopulmoner resusitasyon sonuçları. Yoğun Bakım Derg 2010;2:40-4.
  • 31.Amer MS, Abdel Rahman TT, Aly WW, Ahmad NG.Cardiopulmonary resuscitation: Outcome and its predictors among hospitalized elderly patients in Egypt. Geriatr Gerontol Int 2014;14:309-14.
  • 32.Hagiwara S, Oshima K, Furukawa K, et al. The significance ofalbumin corrected anion gap in patients with cardiopulmonaryarrest. Ann Thorac Cardiovasc Surg 2013;19:283-8.
  • 33.Kim IB, Chung SW, Moon DS, Byun KH. Factors ofcardiopulmonary resuscitation outcome for in-hospital adult patients. Korean J Crit CareMed 2007;22:83-90.
  • 34.Salciccioli JD, Cristia C, Chase M, et al. Performance of SAPSII and SAPS III scores in post-cardiac arrest. MinervaAnestesiol 2012;78:1341–7.
  • 35.Enohumah K, Hinz J, Mörer O, et al. Outcome ofcardiopulmonary resuscitation in the ICU in a university hospital. Crit Care 2006;10:381.

A Retrospective Analysis of Factors Affecting the Success of Cardiopulmonary Resuscitation

Year 2025, Volume: 51 Issue: 1, 29 - 35, 27.05.2025
https://doi.org/10.32708/uutfd.1562460

Abstract

In our study conducted to determine the factors affecting survival in patients undergoing cardiopulmonary resuscitation (CPR), 1995 CPR record forms belonging to 1576 patients who underwent CPR in our hospital within one year were examined. Patients under the age of 18 were excluded from the study, as were resuscitation data of patients who underwent more than one CPR, except for their first resuscitation. Patient characteristics, characteristics related to CPR implementation, and laboratory parameters were recorded from the files and CPR registration forms of the remaining 1,228 patients. The effects of all these data on return of spontaneous circulation (ROSC) and survival in the first 24 and 48 hours after CPR were investigated. Univariate and multivariate logistic regression analyses were used for statistical evaluation. It was determined that 37.9% of the patients were female and 62.1% were male, with a mean age of 64.0±14.1 years. The ROSC rate was found to be 32.41%, while survival rates at the first 24 and 48 hours were 8.15% and 7.46%, respectively. In determining the ROSC rate, length of stay, arrest in the intensive care unit (ICU) and emergency room, sepsis, metastasis, liver failure, presence of respiratory depression, ventricular fibrillation/pulseless ventricular tachycardia in the first rhythm were determined as independent risk factors. Mortality rates in the first 24 and 48 hours were associated with arrest in the ICU (OR=3.01 and 4.57), high Simplified Acute Physiology Score II (SAPS II) score, high Good Outcome Following Attempted Resuscitation (GOFAR) and Prognosis After Resuscitation (PAR) scores. In conclusion, it was determined that SAPS II, GOFAR and PAR scores could be used to predict survival in in-hospital CPR, and that, the occurrence of arrest in the intensive care unit has an adverse effect on survival.

References

  • 1. Özköse Z. Erişkinler için kardiyopulmoner resüsitasyon: I - Temel yaşam desteği. Gazi Tıp Dergisi 2005;16:1-13.
  • 2. Link MS, Berkow LC, Kudenchuk PJ, et al. Part 7: Adult advanced cardiovascular life support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2015;132:444-64.
  • 3. Olasveengen TM, Mancini ME, Perkins GD, et al. Adult basic life support: International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 2020 Nov:156:A35-A79.
  • 4. Xue J, Leng Q, Gao Y. Factors influencing outcomes after cardiopulmonary resuscitation in emergency department. World J Emerg Med 2013;4:183–9.
  • 5. Nolan JP, Soar J, Smith GB et al. Incidence and outcome of in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit. Resuscitation 2014;85:987-92.
  • 6. Sandroni C, Nolan J, Cavallaro F, Antonelli M. In-hospital cardiac arrest: Incidence, prognosis and possible measures to improve survival. Intensive Care Med 2007;33(2):237-45.
  • 7. Ebell MH, Preston PS. The effect of the APACHE II Score and selected clinical variables on survival following cardiopulmonary resuscitation. Fam Med 1993;25:191-6.
  • 8. Cooper S, Janghorbani M, Cooper G. A decade of in-hospital resuscitation: Outcomes and prediction of survival? Resuscitation 2006;68:231-7.
  • 9. Danciu SC, Klein L, Hosseini MM, et al. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation 2004;62:35-42.
  • 10. Sandroni C, Ferro G, Santangelo S, et al. In-hospital cardiac arrest: Survival depends mainly on the effectiveness of the emergency response. Resuscitation 2004;62:291-7.
  • 11. Goldberger ZD, Chan PS, Berg RA, et al. Duration of resuscitation efforts and survival after in-hospital cardiac arrest: An observational study. Lancet 2012;380:1473-81.
  • 12. Radeschi G, Mina A, Berta G, et al. Incidence and outcome of in-hospital cardiac arrest in Italy: A multicentre observational study in the Piedmont region. Resuscitation 2017;119:48-55.
  • 13. Yilmaz S, Omurlu IK. Survival after cardiopulmonary arrest in a tertiary care hospital in Turkey. Ann Saudi Med 2019;39(2):92-99.
  • 14. Wallace SK, Abella BS, Shofer FS, et al. Effect of time of day on prehospital care and outcomes after out of hospital cardiac arrest. Circulation 2013;127:1591-6.
  • 15. Khan NU, Razzak JA, Ahmed H, et al. Cardiopulmonary resuscitation: Outcome and its predictors among hospitalized adult patients in Pakistan. Int J Emerg Med 2008;1:27–34.
  • 16. Peters R, Boyde M. Improving survival after in-hospital cardiac arrest: the Australian experience. Am J Crit Care 2007;16:240-7.
  • 17. Reisfield GM, Wallace SK, Munsell MF, et al. Survival in cancer patients undergoing in-hospital cardiopulmonary resuscitation:A meta-analysis. Resuscitation 2006;71:152-60.
  • 18. Nadkarni VM, Larkin GL, Peberdy MA, et al. First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults. JAMA 2006;295(1):50–57.
  • 19.Roedl K, Wallmüller C, Drolz A, et al. Outcome of in-and out-of-hospital cardiac arrest survivors with liver cirrhosis. Ann Intensive Care 2017;6:103.
  • 20.Khalafi K, Ravakhah K, West BC. Avoiding the futility ofresuscitation. Resuscitation 2001;50:161-6.
  • 21.Ebell MH, Afonso AM. Pre-arrest predictors of failure to survive after in hospital cardiopulmonary resuscitation: A meta-analysis. Fam Pract 2011;28:505-15.
  • 22.Vos R, Koster RW, De Haan RJ, et al. In-hospital cardiopulmonary resuscitation: Prearrest morbidity and outcome. Arch Intern Med 1999;159:845-50.
  • 23.Isenschmid C, Kalt J, Gamp M et al. Routine blood markersfrom different biological pathways improve early risk stratification in cardiac arrest patients: Results from the prospective, observational COMMUNICATE study. Resuscitation 2018;130:138-145.
  • 24.Fontana V, Spadaro S, Villois P, et al. Can red blood cell distribution width predict outcome after cardiac arrest? MinervaAnestesiol 2018;84:693-702.
  • 25.Kim J, Kim K, Lee JH et al. Red blood cell distribution width as an independent predictor of all-cause mortality in out of hospital cardiac arrest. Resuscitation 2012;83:1248-52.
  • 26.Karabıyık L. Yoğun bakımda skorlama sistemleri. YoğunBakım Dergisi 2010;9:129-43.
  • 27.Liu W,Lai C, Hii C, et al. Outcomes and cost analysis ofpatients with successful in-hospital cardiopulmonaryresuscitation. Int J Gerontol2011;5:196-9.
  • 28.Ohlsson MA, Kennedy LM, Ebell MH, Juhlin T, Melander O. Validation of the Good Outcome Following Attempted Resuscitation Score on in-hospital cardiac arrest in Southern Sweden. Int J Cardiol 2016;221:294-7.
  • 29.Bowker L, Stewart K. Predicting unsuccessful cardiopulmonary resuscitation (CPR): A comparison of three morbidity scores. Resuscitation1999;40:89-95.
  • 30.Parlakgümüş A, Nursalı TZ, Yorgancı K. Bir cerrahi yoğun bakım ünitesinde kardiyopulmoner resusitasyon sonuçları. Yoğun Bakım Derg 2010;2:40-4.
  • 31.Amer MS, Abdel Rahman TT, Aly WW, Ahmad NG.Cardiopulmonary resuscitation: Outcome and its predictors among hospitalized elderly patients in Egypt. Geriatr Gerontol Int 2014;14:309-14.
  • 32.Hagiwara S, Oshima K, Furukawa K, et al. The significance ofalbumin corrected anion gap in patients with cardiopulmonaryarrest. Ann Thorac Cardiovasc Surg 2013;19:283-8.
  • 33.Kim IB, Chung SW, Moon DS, Byun KH. Factors ofcardiopulmonary resuscitation outcome for in-hospital adult patients. Korean J Crit CareMed 2007;22:83-90.
  • 34.Salciccioli JD, Cristia C, Chase M, et al. Performance of SAPSII and SAPS III scores in post-cardiac arrest. MinervaAnestesiol 2012;78:1341–7.
  • 35.Enohumah K, Hinz J, Mörer O, et al. Outcome ofcardiopulmonary resuscitation in the ICU in a university hospital. Crit Care 2006;10:381.
There are 35 citations in total.

Details

Primary Language Turkish
Subjects Anaesthesiology
Journal Section Research Article
Authors

Nuh Kumru 0000-0001-6571-5224

Selcan Yerebakan Akesen 0000-0002-9518-541X

Suna Gören 0000-0002-1190-6831

Publication Date May 27, 2025
Submission Date October 7, 2024
Acceptance Date February 13, 2025
Published in Issue Year 2025 Volume: 51 Issue: 1

Cite

AMA Kumru N, Yerebakan Akesen S, Gören S. Kardiyopulmoner Resüsitasyon Başarısını Etkileyen Faktörlerin Retrospektif Olarak İncelenmesi. Journal of Uludağ University Medical Faculty. May 2025;51(1):29-35. doi:10.32708/uutfd.1562460

ISSN: 1300-414X, e-ISSN: 2645-9027

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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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