Bakteriyel Translokasyon

Yıl 1995, Cilt: 1 Sayı: 2, 143 - 151, 06.11.1995

Banur Boynukara Mustafa Berktaş

Öz

Bakteriyel translokasyon, yaklaşık yüz yıldır,
canlı mikroorganizmaların intestinal epiteliyal bariyeri geçmesi olarak
tanımlanmıştır. Bununla birlikte, mikrobiyal translokasyonun kesin mekanizması
bilinmemektedir. Aktif epiteliyal hücrelerin bakterileri içine almaları ve
fagositler aracılığı ile olan transport, mezenterik lenf yumruları ve uzak
organlara bakterilerin ekstraintestinal hareketi için muhtemel etkenler olarak
ileri sürülmüştür. Translokasyon, immunosupresif ve şiddetli hastalarda
intestinal orijinli portal sepsisle birlikte asıl proses olarak ileri
sürülmüştür. Oysa birçok etiyolojik faktör bakteriyel translokasyonun
patojenitesinde etkili olabilir. Mevcut klinik gözlemler, yalnız köpek, fare ve
rat çalışmalarına dayandırılmıştır. Halihazırda araştırmalar, gastrointestinal
bakteriyel enfeksiyon ile intestinal mukozanın bütünlüğü arasındaki İlişkiyi
ortaya koymak için devam etmektedir.

Anahtar Kelimeler

Bakteriyel translokasyon

Bacterial Translocation

Öz

The phenomenon of bacterial translocation, the movement of viable indigenous microorganisms across the intestinal epithelial barrier, has been recognized for almost 100 years. At the present time, the precise mechanism of microbial transport is unknoum. Active ephitelial uptake and phagocyte-mediated transport have been proposed as likely eıvplanations for the extraintestinal movement of bacteria to mesenteric lymph nodes and distant organ sites. Translocation has been proposed as the pivotal process assosiated ıvith intestinal origin portal sepsis in seriously ili and immunocompromised patients. While several etiologic factors can be implicated in the pathogenesis of bacterial translocation, the present clinical implications are based almost solely on studies of dogs, rats and mice. Present investigations continue to suggest a causel relationship betıveen intestinal mucosal integrity and infection by indigenous gastrointestinal bacteria.

Anahtar Kelimeler

Bacterial translocation

Kaynakça

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