No Association Between IRS2 Gly1057Asp Polymorphism and Esophageal Cancer

Yıl 2021, Cilt: 14 Sayı: 3, 298 - 303, 30.12.2021

İsmail Gülaçar Zehra Kaya , Necat Almalı Can Ateş , Gözde Yeşil Sayın , Gökhan Görgişen

https://doi.org/10.52976/vansaglik.933072

Öz

Introduction: The aim of this study was to figure out the relationship between IRS2 Gly1057Asp variant and susceptibility to esophageal cancer.
Material and Methods: A case-control study was conducted to select 70 esophageal cancer patients and 100 healthy control samples. Genomic DNA was extracted from peripheral whole blood samples and real time polymerase chain reaction (RT-PCR) based SNP genotyping was performed using predesigned Taqman assay.
Results: There was no significant difference in the frequency distribution of genotypes between patients and control group.
Conclusion: There is no significant correlation between the IRS2 Gly1057Asp variant and the risk of esophageal cancer.

Anahtar Kelimeler

IRS2 Gly1057Asp, rs1805097, esophageal cancer

IRS2 Gly1057Asp Polimorfizmi ile Özofagus Kanseri Arasında İlişki Yoktur

Öz

Amaç: Bu çalışmanın amacı IRS2 Gly1057Asp varyantı ile özofagus kanseri yatkınlığı arasındaki ilişkiyi ortaya çıkarmaktır.
Materyal ve Metod: Çalışma 70 özofagus kanseri ve 100 sağlıklı kontrol örneğini içeren vaka-kontrol çalışmasıdır. Genomik DNA, periferal kandan izole edilmiş olup, gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR) temelli SNP genotipleme için ticari olarak dizayn edilmiş Taqman assay kullanılmıştır.
Bulgular: Genotip dağılımında hasta ve kontrol örnekler arasında anlamlı bir farklılık saptanmamıştır.
Sonuç: IRS2 Gly1057Asp varyantı ile özofagus kanser gelişim riski arasında anlamlı bir ilişki belirlenememiştir.

Anahtar Kelimeler

IRS2 Gly1057Asp, rs1805097, Özofagus Kanseri

Kaynakça

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