Immunological and Antimicrobial Effects of Autologous Platelet Concentrates

Abstract

Antibiotic resistance has remarkable potential in human beings and veterinary medicine. However, to prevent the clinical reflection of this resistance from reaching the feared dimensions, there is a requirement for antimicrobial treatment options supported and improved with new molecular biocursors at the preclinical point. Platelet-rich plasma (PRP) and fibrin (PRF) are biomaterial products that recently used to increase the anti-infective defense system by platelet growth factors to support postoperative wound healing, bone regeneration, graft stabilization, biofilm inhibition, catheter hygiene, and hemostasis. Recently, research has been carried out on antibacterial, antifungal, and prevention of clinical biofilm formation. Autologous platelet concentrates are autogenous and do not cause any immunological reaction or infection. Therefore, the choice and application of regenerative therapies are being favored due to their nominal invasive procedures. In particular, PRP and PRF are of interest because of their influence to stimulate and speed up the injury area healing process. Cytokines and growth factors involved in the formation of PRP are played an important role in the recovery process. This article aims to evaluate the antibacterial, antifungal and antibiofilm properties of PRP and PRF in the field of microbiology. In addition, the act of growth factors in the process of healing and their use in regenerative treatments were also evaluated.

Keywords

• Anti-Infective Agents
• Immunologic factors
• Platelet-Rich Fibrin
• Platelet-Rich Plasma

Otolog Trombosit Konsantrelerinin İmmunolojik ve Antimikrobiyal Etkileri

Abstract

Antibiyotik direnci, insan ve veteriner tıbbında dikkate değer bir potansiyele sahiptir. Ancak bu direncin klinik yansımasının korkulan boyutlara ulaşmasını önlemek için preklinik noktada yeni moleküler biyokürsörlerle desteklenen ve geliştirilen antimikrobiyal tedavi seçeneklerine ihtiyaç vardır. Platelet zengin plazma (PRP) ve platelet zengin fibrin (PRF), postoperatif yara iyileşmesini, kemik rejenerasyonunu, greft stabilizasyonunu, biyofilm inhibisyonunu, kateter hijyenini ve hemostazı desteklemek için trombosit büyüme faktörleri ile anti-enfektif savunma sistemini artırmak için son zamanlarda kullanılan biyomateryal ürünlerdir. Son zamanlarda antibakteriyel, antifungal ve klinik biyofilm oluşumunun önlenmesi üzerine araştırmalar yapılmaktadır. Otolog trombosit konsantreleri otojendir ve herhangi bir immünolojik reaksiyona veya enfeksiyona neden olmaz. Bu nedenle, nominal invaziv prosedürleri nedeniyle rejeneratif tedavilerin seçimi ve uygulanması tercih edilmektedir. Özellikle PRP ve PRF, yara iyileşme sürecini uyarma ve hızlandırma etkileri nedeniyle ilgi görmektedir. PRP oluşumunda rol oynayan sitokinler ve büyüme faktörleri iyileşme sürecinde önemli rol oynamaktadır. Bu makale, mikrobiyoloji alanında PRP ve PRF'nin antibakteriyel, antifungal ve antibiyofilm özelliklerini değerlendirmeyi amaçlamaktadır. Ayrıca büyüme faktörlerinin iyileşme sürecindeki etkisi ve rejeneratif tedavilerde kullanımları da değerlendirilmiştir.

Keywords

• Anti-enfektif ajanlar
• İmmünolojik faktörler
• Trombosit Zengin Fibrin
• Trombositten Zengin Plazma

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