Effects of Repeated Low-Dose N-Acetylcysteine Administration on Oxidative Stress and Growth Performance in Saanen Goat Kids During Weaning

Abstract

Oxidative stress related to the weaning period in ruminants may increase susceptibility to diseases. However, information regarding the physiological changes associated with oxidative stress in goats during the weaning period is limited. In this study, twenty healthy male Saanen goat kids were randomly assigned to treatment and control groups, at approximately seventy-five days of age. N-acetylcysteine (NAC) was administered intramuscularly at a dose of 15 mg/kg to the treatment group two days before and for seven days following weaning. Blood samples were collected from both groups two days before, seven days after, and fourteen days after weaning. Total antioxidant capacity (TAC) and total oxidant status (TOS) were measured in the serum samples. Additionally, the body weights of all kids were recorded on the blood sampling days. No significant differences were found between groups in terms of body weight, TAC, TOS, and oxidative stress index (OSI). However, there were significant differences within groups in TOS, OSI, and live weight analysis. In conclusion, although low doses of NAC were not significantly effective in improving growth rates, they did temporarily reduce TOS levels.

Keywords

• Growth rate
• Goat kid
• N-Acetylcysteine
• Oxidative stress
• Weaning

Saanen Oğlaklarında Sütten Kesim Döneminde Tekrarlayan Düşük Doz N-Asetilsistein Uygulamasının Oksidatif Stres ve Büyüme Performansı Üzerine Etkileri

Abstract

Sütten kesim dönemine bağlı oksidatif stres, geviş getiren hayvanlarda hastalıklara yatkınlığı artırabilir. Ancak, sütten kesim döneminde keçilerde oksidatif stres ile ilişkili fizyolojik değişimlere dair bilgiler sınırlıdır. Bu çalışmada, yaklaşık yetmiş beş günlük yaşta olan yirmi sağlıklı erkek Saanen oğlağı rastgele olarak tedavi ve kontrol gruplarına ayrılmıştır. Tedavi grubuna, sütten kesimden iki gün önce ve sütten kesimi takip eden yedi gün boyunca 15 mg/kg dozunda N-Asetilsistein (NAC) intramüsküler yolla uygulanmıştır. Her iki gruptan da sütten kesimden iki gün önce, sütten kesimi takiben yedi ve on dört gün sonra kan örnekleri alınmıştır. Serum örneklerinde toplam antioksidan kapasite (TAC) ve toplam oksidan kapasite (TOS) düzeyleri ölçülmüştür. Ayrıca, tüm oğlakların canlı ağırlıkları da kan örnekleme günlerinde kaydedilmiştir. Gruplar arasında canlı ağırlık, TAC, TOS ve oksidatif stres indeksi (OSI) bakımından anlamlı bir fark bulunmamıştır. Ancak, grupların kendi iç analizlerinde TOS, OSI ve canlı ağırlık verilerinde anlamlı farklılıklar gözlemlenmiştir. Sonuç olarak, düşük dozda NAC uygulamasının büyüme oranlarını anlamlı düzeyde artırmadığı, ancak TOS düzeylerini geçici olarak düşürdüğü belirlenmiştir.

Keywords

• Büyüme Oranı
• Oğlak
• N-Asetilsistein
• Oksidatif Stres
• Sütten Kesme

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