Korpus Luteum Varlığının Rutin Ovariohisterektomi Uygulanan Klinik Olarak Sağlıklı Dişi Kedilerde Endometriyal Hiperplazi İçin Bir Risk Faktörü Olarak Değerlendirilmesi

Year 2026, Volume: 37 Issue: 1, 81 - 86, 29.03.2026

Damla Tuğçe Okur , İsmail Bolat , Alper Yasin Çiplak , Vefa Tohumcu , Şifanur Aydin

https://doi.org/10.36483/vanvetj.1833710

https://izlik.org/JA54DL29BU

Abstract

Bu prospektif kesitsel çalışmada, rutin ovariohisterektomi geçiren klinik olarak sağlıklı dişi kedilerde korpus luteum (CL) varlığının subklinik endometriyal hiperplazi ile ilişkili olup olmadığı araştırılmıştır. Rutin cerrahi amacıyla getirilen, 13–27 aylık, ASA I sınıfında yer alan elli dişi kedi çalışmaya dahil edilmiştir. Ovariohisterektomi sonrasında uterus ve ovaryumlar histopatolojik incelemeye tabi tutulmuş; CL ve kistler dahil tüm ovaryum yapıları ile uterin lezyonlar sistematik şekilde kaydedilmiştir. Uterus ve ovaryum bulgularının prevalansı tanımlayıcı istatistiklerle belirlenmiş; CL varlığı (luteal faz progesteron maruziyetinin dolaylı göstergesi olarak) ile endometriyal hiperplazi (EH) arasındaki ilişki Fisher’ın kesin testi kullanılarak, olasılık oranı (OR) ve %95 güven aralığı (GA) hesaplanarak değerlendirilmiştir. Üreme ile ilgili herhangi bir klinik şikayet bulunmamasına rağmen kedilerin %36’sında (18/50) EH, %20’sinde (10/50) kistik endometriyal hiperplazi (CEH) tespit edilmiş; ayrıca %12’sinde hafif endometritis ve %8’inde diğer hiperplastik lezyonlar belirlenmiştir. Ovaryum kistleri, çoğunlukla foliküler tipte olup, kedilerin %34’ünde saptanmış; CL ise %48’inde (24/50) gözlenmiştir. CL bulunan kedilerde EH prevalansı CL bulunmayanlara göre anlamlı derecede daha yüksek olup (%54.2’ye karşı %19.2; p=0.014), bu fark OR 4.96 (GA %95, 1.4–17.6) ile luteal fazdaki hayvanların EH geliştirme olasılığının yaklaşık beş kat arttığını göstermektedir. Bu bulgular, progesteron ilişkili endometriyal değişikliklerin genç ve klinik olarak sağlıklı dişi kedilerde yaygın ve büyük ölçüde subklinik olduğunu ortaya koymakta; CL varlığını erken uterin yeniden şekillenme açısından klinik olarak önemli bir risk faktörü olarak desteklemektedir. Bu lezyonların uzun dönem klinik öneminin daha kapsamlı araştırılmasına ihtiyaç vardır.

Keywords

Endometriyal hiperplazi , Kedi , Kistik endometriyal hiperplazi , Korpus luteum , Ovariohisterektomi , Progesteron

Ethical Statement

Atatürk Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu’ndan 26.03.2024 tarihinde E-75296309-050.01.04-2400111300 sayılı izin alınarak yapılmıştır.

Thanks

İstatistiksel analiz için Doç. Dr. Sıtkıcan Okur'a teşekkür ederler.

Corpus Luteum Presence as a Risk Factor for Endometrial Hyperplasia in Clinically Healthy Female Cats Undergoing Routine Ovariohysterectomy

https://izlik.org/JA54DL29BU

Abstract

In this prospective cross-sectional study, we investigated whether corpus luteum (CL) presence is associated with subclinical endometrial hyperplasia in clinically healthy female cats undergoing elective ovariohysterectomy. Fifty intact female cats (13-27 months, ASA I) presented for routine surgery were enrolled. Following ovariohysterectomy, uteri and ovaries were subjected to full-thickness histopathological examination, and uterine lesions and ovarian structures, including CL and cysts, were systematically recorded. Descriptive statistics were used to determine the prevalence of uterine and ovarian findings, and the association between CL presence (as a proxy for luteal-phase progesterone exposure) and endometrial hyperplasia (EH) was evaluated using Fisher’s exact test with calculation of odds ratio (OR) and 95% confidence interval (CI). Despite the absence of reproductive complaints, EH and cystic endometrial hyperplasia (CEH) were identified in 36% (18/50) and 20% (10/50) of female cats, respectively, while mild endometritis and other hyperplastic lesions were detected in 12% and 8%. Ovarian cysts, predominantly follicular, were present in 34% of cats, and CLs were observed in 48% (24/50). Female cats with CL had a significantly higher prevalence of EH than those without CL (54.2% vs 19.2%; p=0.014), corresponding to an OR of 4.96 (95% CI 1.4-17.6), indicating that luteal-phase animals were nearly five times more likely to exhibit EH. These findings demonstrate that progesterone-associated endometrial changes are common and largely subclinical in young, clinically healthy female cats and support CL presence as a clinically relevant risk factor for early uterine remodeling, warranting further investigation into the long-term significance of these lesions.

Keywords

Corpus luteum , Cystic endometrial hyperplasia , Endometrial hyperplasia , Feline , Ovariohysterectomy , Progesterone

Ethical Statement

This study was conducted with permission from the Atatürk University Local Animal Experiment Ethics Committee, dated March 26, 2024, under permit number E-75296309-050.01.04-2400111300.

Thanks

They would like to thank Associate Professor Sıtkıcan Okur for the statistical analysis.

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