Risperidone Therapy in a Dog with Dissociative Syndrome

Abstract

Recently describeddissociative syndrome is a progressive behavioral disorder with poor prognosis and almost 28% of animals do not seem to respond to the treatment. Inthe absence or lack of proper treatment, dissociation worsens and leads to severe cachexia. 4 years old Cocker spaniel-terrier mix male dog referred with complaints including receptivity loss to the environment, inattentiveness, dumb-looking periods, activity avoidance, withdrawal, and snapping the air as fly chasing without a reason. After elimination of somatic reasons, dissociative syndrome was diagnosed based on the history and behavioral examination. 0.5 ml Risperdal oral solution 1g/1m², 100 ml (Eczacıbaşı) was used sid based on 1 mg/m²dose for 11 kg dog (0.49 m²). Before and 1 month after therapy, serum serotonin and because of reported prolactin elevation, prolactin levels were measured. Before and after therapy, there was not a beyond reference value serotonin (370.5-441.9 ng/ml) and prolactin (1.8-2.1 ng/ml) difference. Significant clinical improvement, interactive and relatively increased receptivity and contact, not completely lost, but faded and decreased hallucitative symptoms were observed.

Keywords

• Dissociative syndrome,Dog,Risperidone,Prolactin,Serotonin,Hallucination

Disosiyatif Sendromlu Bir Köpeğe Risperidon Tedavisi

Abstract

Son zamanlarda tanımlanan disosiyatif sendrom, prognozu kötü olan ilerleyici bir davranış bozukluğudur ve hayvanların neredeyse %28'inde tedaviye yanıt vermemektedir. Tedavi edilmez veya tedaviye cevap vermezse, durum kötüleşir ve ciddi kaşeksi oluşturur. Materyali, çevreye duyarsızlık kaybı, dikkatsizlik, aptal görünümlü dönemler, hareketsizlik, içine kapanma ve havada olmayan sineğin peşinden koşmak gibi şikayetleri olan 4 yaşında Cocker spaniel-terrier erkek köpek oluşturdu. Somatik nedenlerin ortadan kaldırılmasından sonra, öykü ve davranışsal inceleme temel alınarak dissosiyatif sendrom teşhis edildi. 11 kg köpek (0.49 m²) için 0.5 ml Risperdal oral solüsyon 1 g/1 m², 100 ml (Eczacıbaşı) kullanıldı. Tedaviden önce ve tedaviden 1 ay sonra serum serotonin ve prolaktin düzeyleri ölçüldü. Tedaviden önce ve sonra, referans değerden yüksek bir serotonin (370.5-441.9 ng / ml) ve prolaktin (1.8-2.1 ng/ml) görülmedi. Klinik olarak çevreye karşı ilginin artması, sosyalleşme ve dikkat toplamada düzelme tamamen kaybolmasa bile oldukça azalmış halüsitatif semptomları görülmüştür.

Keywords

• Disosiyatif sendrom,Köpek,Risperidon,Prolaktin,Serotonin,Halüsinasyon

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