Radiological and Biochemical Diagnosis of Skeletal Developmental Disorders Due to Growth in Van Cats

Abstract

In this study, fourty Van Cats, twenty cats from each gender, were used. Extremities and other parts of the animals' body were examined radiologically at three months intervals, starting from three months old. Besides, in every examination animals' blood test were done. In the conclusion of the clinical examination metabolic bone diseases in eight animals and hip dysplasia in another eight were diagnosed. The distribution of the diseases in animals were as following, rachitism in three cats, hyperthyrophic osteopathy in two and nutritional secondary hyperparathyroidism in three. In biological tests, average concentrations of Calcium (Ca), Phosphorus (P), Magnesium (Mg) and Alkaline Phosphatase (ALP) were 9.1 mg/dl, 3.6 mg/dl and 2.3 mg/dl, 200 U/L in rachitic animals, 10.9 mg/dl, 8.4 mg/dl and 2.3 mg/dl, 260 U/L in animals with hyperthyrophic osteopathy, 8.6 mg/dl, 8.2 mg/dl and 2.3 mg/dl, 206 U/L in animals with nutritional secondary hyperparathyroidism. The ratio of Ca and P was 2.6 mg/dl in rachitic animals, 1.3 mg/dl in animals with hyperthyrophic osteopathy and 1.1 mg/dl in animals with nutritional secondary hyperparathyroidism. As a result, metabolic bone diseases occur depending on nutrition in Van Cats. Radiological and biochemical results are essential in the accurate diagnosis of these diseases. Therefore, for the cats which are diagnosed with metabolic bone disease, clinical findings should be supported with radiological and biochemical examinations.

Keywords

• Alkalinephosphatase,Phosphour,Developing defaults,Calcium,Magnesium,Van Cat

Van Kedilerinde Büyümeye Bağlı İskelet Gelişim Bozukluklarının Radyolojik ve Biyokimyasal Tanısı

Abstract

Bu çalışmada her iki cinsiyetten 20 adet erkek ve 20 adet dişi olmak üzere toplam 40 adet Van kedisi kullanılmıştır. Çalışmaya alınan hayvanların 3 aylıktan itibaren 3’er ay aralıklar ile ekstremite ve vücudun diğer kısımlarının radyolojik muayeneleri gerçekleştirilmiştir. Ayrıca her muayenede kanları alınmıştır. Klinik muayene sonucunda; 3 kedide raşitizma, 2 kedide hipertrofik osteopati, 3 kedide nutrisyonel sekonder hiperparatroidizm olmak üzere toplam 8 Van Kedisinde metabolik kemik hastalıkları ve 8 adetinde de kalça eklemi displazisi tespit edilmiştir. Yapılan biyokimyasal testlerde ortalama Kalsiyum (Ca), Fosfor (P), Magnezyum (Mg) ve Alkelen fosfataz (ALP) konsantrasyonları raşitizmalı hayvanlarda 9.1 mg/dl, 3.6 mg/dl ve 2.3 mg/dl, 200 U/L, hipertrofik osteopatili hayvanlarda 10.9 mg/dl, 8.4 mg/dl ve 2.3 mg/dl, 260 U/L, Nutrisyonel sekonder hiperparatiroidizm (NSH)’lihayvanlarda 8.6 mg/dl, 8.2 mg/dl ve 2.3 mg/dl, 206 U/L olarak tespit edildi. Ca, P oranı raşitizmalı hayvanlarda 2.6 mg/dl, hipertrofik osteopatili hayvanlarda 1.3 mg/dl, nutrisyonel sekonder hiperparatroidizmli hayvanlarda 1.1 mg/dl olarak belirlendi. Sonuç olarak Van Kedilerinde beslenmeye bağlı olarak metabolik kemik hastalıklarının oluştuğu, bu hastalıkların kesin teşhislerinin konulmasında radyolojik ve biyokimyasal sonuçların önem arzettiği, bu yüzden metabolik kemik hastalığı saptanan kedilerde klinik bulguların radyolojik ve biyokimyasal muayenelerle desteklenmesi gerektiği kanısına varılmıştır.

Keywords

• Alkalenfosfataz,Fosfor,Gelişim bozukluğu,Kalsiyum,Magnezyum,Van Kedisi

References

1. Alkan Z (1999). Veteriner Radyoloji. Mina Ltd. Ştd. Ankara Arnbjerg J (1997). Bone problems of growing dogs. Dept. Of. Radiology. Royal Vet. University. Copenhagen. Denmark Bakır B, Yiğit MF, Belge A, Atasoy N, Alkan İ (1997). Van kedilerinde kalça eklemi displazisi. YYÜ Vet Fak Derg, 8(1-2): 102-106 Büyükpamukçu M, Berkin Ş (1985). Kemik hastalıkları In: Veteriner Patoloji, IV. Cilt 3. Bölüm. A.Ü. Basımevi, Ankara. Capen CC, Rosol TJ (1989). Calcium regulating hormones and diseases of abnormal mineral (Calcium, Phosphorus, Magnesium) metabolism. In: Clinical Biochemistry of Domestic Animals, Ed. J. J. Kaneko, 4th Ed, Academic Press, Inc, San Diego. Coles EH (1986). Mineral balance and parathyroid function In: Veterinary Clinical Pathology, Chap. 13, 231-240, W.B. Saunders Comp, Philadelphia. Jones TC, Hunt RD (2001). The musculoskeletal system In: Veterinary Pathology, Fifth Edition, Lea & Febiger, Philadelphia. Kealy JK, McAllister H (2000). Bones and joınts In: Diagnostik Radiology and Ultrasonography of the Dog and Cat, Third Edition Chapt. 4 W.B. Saunders Company, Philadelphia Keller GG, Reed AL, Lattımer JC, Corley EA (1999). Hip dysplasia: A Feline Population Study. Veterinary Radiology & Ultrasound, 40, 4, 460 – 464. Kul M (1996). Konya yöresindeki buzağılarda şekillenen metabolik kemik hastalıklarının teşhisindebBiyokimyasal ve radyolojik kriterlerin önemi, S.Ü. Sağlık Bilimler Enstitüsü Doktora Tezi, Konya. Küçüker N (1969). Kedilerde raşitizmanın klinik-radyolojik teşhisi ve tedavisi üzerinde araştırmalar. Ankara Üniversitesi Veteriner Fakültesi Yayınları. 245, Ankara. Lenehan TM, Fetter AW (1985). Hypertrophic osteopathy In: Textbook of Small Animal Orthopedics, Ed, C.H. Newton, D.M. Nunamaker, Part VI, Chapt. 51, J.B. Lippincott Comp, Philadelphia. McGavin MD, Carlton WW, Zachary JF (2001). Thomson’s Special Veterinary Pathology 3 th Ed, Mosby İnc, London. Samsar E, Akın F (2000). Genel Cerrahi. Özkan Matbaacılık Ltd. Şti. Ankara. Schreiner CA, Nagode LA (2003). Vitamin D dependent rickets type 2 in a four –month-old cat. JAVMA, Vol 222, No. 3, 337-339. Thrall DE (1998). Textbook of Veterinary Diagnostik Radiology. Third Edition. Chap. 13,16. W.B. Saunder Company, Philadelphia. Tomsa K, Glaus T, Hauser B, Flücklger M, Arnold P, Wess G, Reusch C (1999). Nutrisyonel sekonder hiperparatroidism in six cats. Journal of Small Animal Practice, vol 40, (11), 533-539. Toyoda T, Ochiai K, Komatsu M, Kimura T and Umemura T (2004). Nutritional secondary hyperparathyroidism and Osteodystrophia fibrosa in a Hodgon’s hawk-eagle (Spizaetus nipalensis), Avian Pathology, 33 (1), 93/12. Watson ADJ (1990). Diseases of Muscle and Bone In: Canine Orthopedics, Ed. Whittick, W.G. Second Edition. Section V, Chapter 22, Lea & Febiger, Philadelphia. Whittick WG (1990). Canine Orthopedics. 42-47 Lea  Febiger, Philadelphia. Wills JM, Simpson KW (1994). Skelatal disease In: The Waltham Book of Clinical Nutrition of the Dog and Cat, 405-420, Pergamon. Won DS, Park C, In YJ and Park HM (2004). A case of nutritional secondary hyperparathyroidism in a siberian tiger cub, J Vet Med Sci, 66 (5), 551-553.