Case Report
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Year 2019, , 197 - 200, 22.11.2019
https://doi.org/10.36483/vanvetj.551217

Abstract

References

  • Reference 1-Cristo TG, Vargas CB, Biezus G, Costa LS, Dal Pont TP, Kanamura CT, Salbego FZ, Traverso SD, Casagrande RA (2017). Braz J Vet Pathol, 10 (3), 105-110.
  • Reference 2-Fan TM, Barger AM, Sprandel IT, Fredrickson RL (2008). Investigating TrkA expression in canine appendicular osteosarcoma. J Vet Intern Med, 22 (5), 1181-1188.
  • Reference 3-Farese JP, Ashton J, Milner R, Ambrose LL, Van Gilder J (2004). The effect of the bisphosphonate alendronate on viability of canine osteosarcoma cells in vitro. In Vitro Cell Dev Biol Anim, 40 (3-4), 113-117.
  • Reference 4-Fieten H, Spee B, Ijzer J, Kik MJ, Penning LC, Kirpensteijn J (2009). Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Vet Pathol, 46 (5), 869-877.
  • Reference 5-Gebhard C, Fuchs-Baumgartinger A, Razzazi-Fazeli E, Miller I, Walter I (2016). Distribution and activity levels of matrix metalloproteinase 2 and 9 in canine and feline osteosarcoma. Can J Vet Res, 80 (1), 66-73.
  • Reference 6-Hoenerhoff MJ, Kiupel M, Rosenstein D, Pool RR (2004). Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog. Vet Pathol, 41 (3), 264-268.
  • Reference 7-Kirpensteijn J, Timmermans-Sprang EP, van Garderen E, Rutteman GR, Lantinga-van Leeuwen IS, Mol JA (2002). Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. Mol Cell Endocrinol, 197 (1-2), 179-185.
  • Reference 8-Kutsal O, Kaya Ü, Vural S, Sağlam M (2003). Köpek ve Kedilerde 1986-2000 Yılları Arasında Ankara'da İncelenen Kemik Tümörleri. Turk J Vet Anim Sci, 27: 109-115.
  • Reference 9-Leonardo L, Laura P, Serena BM (2018). miR-1 and miR-133b expression in canine osteosarcoma. Res Vet Sci, 117:133-137.
  • Reference 10-McNeill CJ, Overley B, Shofer FS, Kent MS, Clifford CA, Samluk M, Haney S, Van Winkle TJ, Sorenmo KU (2007). Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs. Vet Comp Oncol, 5 (2), 90-98.
  • Reference 11-Millanta F, Asproni P, Cancedda S, Vignoli M, Bacci B, Poli A (2012). Immunohistochemical expression of COX-2, mPGES and EP2 receptor in normal and reactive canine bone and in canine osteosarcoma. J Comp Pathol, 147 (2-3), 153-160.
  • Reference 12-Moore GE, Mathey WS, Eggers JS, Estep JS (2000). Osteosarcoma in adjacent lumbar vertebrae in a dog. J Am Vet Med Assoc, 217 (7), 1038-1040.
  • Reference 13-Mullins MN, Lana SE, Dernell WS, Ogilvie GK, Withrow SJ, Ehrhart EJ (2004). Cyclooxygenase-2 expression in canine appendicular osteosarcomas. J Vet Intern Med, 18 (6), 859-865.
  • Reference 14-Murphy BG, Mok MY, York D, Rebhun R, Woolard KD, Hillman C, Dickinson P, Skorupski K (2017). Evaluation of P16 expression in canine appendicular osteosarcoma. BMC Veterinary Research, 13 (1), 189.
  • Reference 15-Nagamine E, Hirayama K, Matsuda K, Okamoto M, Ohmachi T, Kadosawa T, Taniyama H (2015). Diversity of Histologic Patterns and Expression of Cytoskeletal Proteins in Canine Skeletal Osteosarcoma. Vet Pathol, 52 (5), 977-984.
  • Reference 16-Ohta G, Sakai H, Kachi S, Hirata A, Yonemaru K, Kitajima A, Yanai T, Masegi T (2004). Assessment of proliferative potentials of canine osteosarcomas and chondrosarcomas by MIB-1 immunohistochemistry and bromodeoxyuridine incorporation. J Comp Pathol, 131 (1), 18-27.
  • Reference 17-Pagano C, Boudreaux B, Shiomitsu K (2016). Safety And Toxicity Of An Accelerated Coarsely Fractionated Radiation Protocol For Treatment Of Appendicular Osteosarcoma In 14 Dogs: 10 Gy × 2 Fractions. Vet Radiol Ultrasound, 57 (5), 551-556.
  • Reference 18-Pazzi P, Tompkins S, Kirberger RM (2013). Canine spirocercosis-associated extraskeletal osteosarcoma with central nervous system metastasis. J S Afr Vet Assoc, 84(1), E1-4.
  • Reference 19-Peterson MR, Frommelt RA, Dunn DG (2000). A study of the lifetime occurrence of neoplasia and breed differences in a cohort of German Shepherd Dogs and Belgian Malinois military working dogs that died in 1992. J Vet Intern Med, 14 (2), 140-145.
  • Reference 20-Petty JC, Lana SE, Thamm DH, Charles JB, Bachand AM, Bush JM, Ehrhart EJ (2008). Vet Comp Oncol, 6 (2), 133-140.
  • Reference 21-Piskun CM, Muthuswamy A, Huelsmeyer MK, Thompson V, Stein TJ (2011). Wnt/β-catenin expression does not correlate with serum alkaline phosphatase concentration in canine osteosarcoma patients. PLoS One, 6 (10), e26106.
  • Reference 22-Sagartz JE, Bodley WL, Gamblin RM, Couto CG, Tierney LA, Capen CC (1996). p53 tumor suppressor protein overexpression in osteogenic tumors of dogs. Vet Pathol, 33 (2), 213-221.
  • Reference 23-Sanches DS, Pires CG, Fukumasu H, Cogliati B, Matsuzaki P, Chaible LM, Torres LN, Ferrigno CR, Dagli ML (2009). Expression of connexins in normal and neoplastic canine bone tissue. Vet Pathol, 46 (5), 846-859.
  • Reference 24-Selvarajah GT, Verheije MH, Kik M, Slob A, Rottier PJ, Mol JA, Kirpensteijn J (2012). Expression of epidermal growth factor receptor in canine osteosarcoma: association with clinicopathological parameters and prognosis. Vet J, 193 (2), 412-419.
  • Reference 25-Shoeneman JK, Ehrhart EJ, Eickhoff JC, Charles JB, Powers BE, Thamm DH (2012). Expression and function of survivin in canine osteosarcoma. Cancer Res, 72 (1), 249-259.
  • Reference 26-Sivacolundhu RK, Runge JJ, Donovan TA, Barber LG, Saba CF, Clifford CA, de Lorimier LP, Atwater SW, DiBernardi L, Freeman KP, Bergman PJ (2013). Ulnar osteosarcoma in dogs: 30 cases (1992-2008). J Am Vet Med Assoc, 243 (1), 96-101.
  • Reference 27-Thompson KG, Dittmer KE (2017). Tumors of Bone. In: Tumors of Domestic Animals, Moulton JE (Ed), 356-424, Wiley Blackwell, Iowa.
  • Reference 28-Wehrle-Martinez AS, Dittmer KE, Aberdein D, Thompson KG (2016). Osteocalcin and Osteonectin Expression in Canine Osteosarcoma. Vet Pathol, 53 (4), 781-787.
  • Reference 29-Wilson H, Huelsmeyer M, Chun R, Young KM, Friedrichs K, Argyle DJ (2008). Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet J, 175 (1), 69-75.
  • Reference 30-Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB (2019). Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol, 17 (1), 49-60.
  • Reference 31-Wolfesberger B, Walter I, Hoelzl C, Thalhammer JG, Egerbacher M (2006). Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells. Res Vet Sci, 80 (3), 308-316.

Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog

Year 2019, , 197 - 200, 22.11.2019
https://doi.org/10.36483/vanvetj.551217

Abstract

In
this study, we aimed to evaluate histopathologically the case of osteosarcoma
detected in an Belgian Malinois race dog. The material of the study consisted
of a 8.5-year-old Belgian Malinois race female dog weighing 30 kg. With the complaints
of abdominal distention, difficulty in breathing, loss of appetite, fatigue,
the dog brought to the Veterinary Faculty of Kafkas University Animal Hospital
died on the way and was sent to the Department of Pathology for necropsy. In
the follow-up, some of the tissue samples taken from the systemic necropsy
animal were determined in the decalcified solution and another part in the
buffered formaldehyde solution. Following routine procedures, 5 μm thick
sections were taken from the prepared paraffin blocks for Hematoxylin Eosin
staining. To determine the histopathological changes, the sections were
examined by light microscope. In the light of the histopathological findings,
osteosarcoma was diagnosed in the brain and lung metastatic foci.

References

  • Reference 1-Cristo TG, Vargas CB, Biezus G, Costa LS, Dal Pont TP, Kanamura CT, Salbego FZ, Traverso SD, Casagrande RA (2017). Braz J Vet Pathol, 10 (3), 105-110.
  • Reference 2-Fan TM, Barger AM, Sprandel IT, Fredrickson RL (2008). Investigating TrkA expression in canine appendicular osteosarcoma. J Vet Intern Med, 22 (5), 1181-1188.
  • Reference 3-Farese JP, Ashton J, Milner R, Ambrose LL, Van Gilder J (2004). The effect of the bisphosphonate alendronate on viability of canine osteosarcoma cells in vitro. In Vitro Cell Dev Biol Anim, 40 (3-4), 113-117.
  • Reference 4-Fieten H, Spee B, Ijzer J, Kik MJ, Penning LC, Kirpensteijn J (2009). Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Vet Pathol, 46 (5), 869-877.
  • Reference 5-Gebhard C, Fuchs-Baumgartinger A, Razzazi-Fazeli E, Miller I, Walter I (2016). Distribution and activity levels of matrix metalloproteinase 2 and 9 in canine and feline osteosarcoma. Can J Vet Res, 80 (1), 66-73.
  • Reference 6-Hoenerhoff MJ, Kiupel M, Rosenstein D, Pool RR (2004). Multipotential Osteosarcoma with Various Mesenchymal Differentiations in a Young Dog. Vet Pathol, 41 (3), 264-268.
  • Reference 7-Kirpensteijn J, Timmermans-Sprang EP, van Garderen E, Rutteman GR, Lantinga-van Leeuwen IS, Mol JA (2002). Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. Mol Cell Endocrinol, 197 (1-2), 179-185.
  • Reference 8-Kutsal O, Kaya Ü, Vural S, Sağlam M (2003). Köpek ve Kedilerde 1986-2000 Yılları Arasında Ankara'da İncelenen Kemik Tümörleri. Turk J Vet Anim Sci, 27: 109-115.
  • Reference 9-Leonardo L, Laura P, Serena BM (2018). miR-1 and miR-133b expression in canine osteosarcoma. Res Vet Sci, 117:133-137.
  • Reference 10-McNeill CJ, Overley B, Shofer FS, Kent MS, Clifford CA, Samluk M, Haney S, Van Winkle TJ, Sorenmo KU (2007). Characterization of the biological behaviour of appendicular osteosarcoma in Rottweilers and a comparison with other breeds: a review of 258 dogs. Vet Comp Oncol, 5 (2), 90-98.
  • Reference 11-Millanta F, Asproni P, Cancedda S, Vignoli M, Bacci B, Poli A (2012). Immunohistochemical expression of COX-2, mPGES and EP2 receptor in normal and reactive canine bone and in canine osteosarcoma. J Comp Pathol, 147 (2-3), 153-160.
  • Reference 12-Moore GE, Mathey WS, Eggers JS, Estep JS (2000). Osteosarcoma in adjacent lumbar vertebrae in a dog. J Am Vet Med Assoc, 217 (7), 1038-1040.
  • Reference 13-Mullins MN, Lana SE, Dernell WS, Ogilvie GK, Withrow SJ, Ehrhart EJ (2004). Cyclooxygenase-2 expression in canine appendicular osteosarcomas. J Vet Intern Med, 18 (6), 859-865.
  • Reference 14-Murphy BG, Mok MY, York D, Rebhun R, Woolard KD, Hillman C, Dickinson P, Skorupski K (2017). Evaluation of P16 expression in canine appendicular osteosarcoma. BMC Veterinary Research, 13 (1), 189.
  • Reference 15-Nagamine E, Hirayama K, Matsuda K, Okamoto M, Ohmachi T, Kadosawa T, Taniyama H (2015). Diversity of Histologic Patterns and Expression of Cytoskeletal Proteins in Canine Skeletal Osteosarcoma. Vet Pathol, 52 (5), 977-984.
  • Reference 16-Ohta G, Sakai H, Kachi S, Hirata A, Yonemaru K, Kitajima A, Yanai T, Masegi T (2004). Assessment of proliferative potentials of canine osteosarcomas and chondrosarcomas by MIB-1 immunohistochemistry and bromodeoxyuridine incorporation. J Comp Pathol, 131 (1), 18-27.
  • Reference 17-Pagano C, Boudreaux B, Shiomitsu K (2016). Safety And Toxicity Of An Accelerated Coarsely Fractionated Radiation Protocol For Treatment Of Appendicular Osteosarcoma In 14 Dogs: 10 Gy × 2 Fractions. Vet Radiol Ultrasound, 57 (5), 551-556.
  • Reference 18-Pazzi P, Tompkins S, Kirberger RM (2013). Canine spirocercosis-associated extraskeletal osteosarcoma with central nervous system metastasis. J S Afr Vet Assoc, 84(1), E1-4.
  • Reference 19-Peterson MR, Frommelt RA, Dunn DG (2000). A study of the lifetime occurrence of neoplasia and breed differences in a cohort of German Shepherd Dogs and Belgian Malinois military working dogs that died in 1992. J Vet Intern Med, 14 (2), 140-145.
  • Reference 20-Petty JC, Lana SE, Thamm DH, Charles JB, Bachand AM, Bush JM, Ehrhart EJ (2008). Vet Comp Oncol, 6 (2), 133-140.
  • Reference 21-Piskun CM, Muthuswamy A, Huelsmeyer MK, Thompson V, Stein TJ (2011). Wnt/β-catenin expression does not correlate with serum alkaline phosphatase concentration in canine osteosarcoma patients. PLoS One, 6 (10), e26106.
  • Reference 22-Sagartz JE, Bodley WL, Gamblin RM, Couto CG, Tierney LA, Capen CC (1996). p53 tumor suppressor protein overexpression in osteogenic tumors of dogs. Vet Pathol, 33 (2), 213-221.
  • Reference 23-Sanches DS, Pires CG, Fukumasu H, Cogliati B, Matsuzaki P, Chaible LM, Torres LN, Ferrigno CR, Dagli ML (2009). Expression of connexins in normal and neoplastic canine bone tissue. Vet Pathol, 46 (5), 846-859.
  • Reference 24-Selvarajah GT, Verheije MH, Kik M, Slob A, Rottier PJ, Mol JA, Kirpensteijn J (2012). Expression of epidermal growth factor receptor in canine osteosarcoma: association with clinicopathological parameters and prognosis. Vet J, 193 (2), 412-419.
  • Reference 25-Shoeneman JK, Ehrhart EJ, Eickhoff JC, Charles JB, Powers BE, Thamm DH (2012). Expression and function of survivin in canine osteosarcoma. Cancer Res, 72 (1), 249-259.
  • Reference 26-Sivacolundhu RK, Runge JJ, Donovan TA, Barber LG, Saba CF, Clifford CA, de Lorimier LP, Atwater SW, DiBernardi L, Freeman KP, Bergman PJ (2013). Ulnar osteosarcoma in dogs: 30 cases (1992-2008). J Am Vet Med Assoc, 243 (1), 96-101.
  • Reference 27-Thompson KG, Dittmer KE (2017). Tumors of Bone. In: Tumors of Domestic Animals, Moulton JE (Ed), 356-424, Wiley Blackwell, Iowa.
  • Reference 28-Wehrle-Martinez AS, Dittmer KE, Aberdein D, Thompson KG (2016). Osteocalcin and Osteonectin Expression in Canine Osteosarcoma. Vet Pathol, 53 (4), 781-787.
  • Reference 29-Wilson H, Huelsmeyer M, Chun R, Young KM, Friedrichs K, Argyle DJ (2008). Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet J, 175 (1), 69-75.
  • Reference 30-Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB (2019). Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma. Vet Comp Oncol, 17 (1), 49-60.
  • Reference 31-Wolfesberger B, Walter I, Hoelzl C, Thalhammer JG, Egerbacher M (2006). Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells. Res Vet Sci, 80 (3), 308-316.
There are 31 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Articles
Authors

Emin Karakurt

Hilmi Nuhoğlu

Enver Beytut

Serpil Dağ

Publication Date November 22, 2019
Submission Date April 9, 2019
Acceptance Date October 17, 2019
Published in Issue Year 2019

Cite

APA Karakurt, E., Nuhoğlu, H., Beytut, E., Dağ, S. (2019). Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog. Van Veterinary Journal, 30(3), 197-200. https://doi.org/10.36483/vanvetj.551217
AMA Karakurt E, Nuhoğlu H, Beytut E, Dağ S. Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog. Van Vet J. November 2019;30(3):197-200. doi:10.36483/vanvetj.551217
Chicago Karakurt, Emin, Hilmi Nuhoğlu, Enver Beytut, and Serpil Dağ. “Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog”. Van Veterinary Journal 30, no. 3 (November 2019): 197-200. https://doi.org/10.36483/vanvetj.551217.
EndNote Karakurt E, Nuhoğlu H, Beytut E, Dağ S (November 1, 2019) Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog. Van Veterinary Journal 30 3 197–200.
IEEE E. Karakurt, H. Nuhoğlu, E. Beytut, and S. Dağ, “Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog”, Van Vet J, vol. 30, no. 3, pp. 197–200, 2019, doi: 10.36483/vanvetj.551217.
ISNAD Karakurt, Emin et al. “Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog”. Van Veterinary Journal 30/3 (November 2019), 197-200. https://doi.org/10.36483/vanvetj.551217.
JAMA Karakurt E, Nuhoğlu H, Beytut E, Dağ S. Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog. Van Vet J. 2019;30:197–200.
MLA Karakurt, Emin et al. “Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog”. Van Veterinary Journal, vol. 30, no. 3, 2019, pp. 197-00, doi:10.36483/vanvetj.551217.
Vancouver Karakurt E, Nuhoğlu H, Beytut E, Dağ S. Multiple Metastases of Observed Osteosarcoma Case in A Belgian Malinois Race Female Dog. Van Vet J. 2019;30(3):197-200.

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