Evaluation of intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukins (IL-6, IL-8) and C-reactive protein (CRP) levels in neonatal calves with presumed septicemia

Abstract

In this study; intercellular molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and C-reactive protein (CRP) levels were evaluated in neonatal calves with presumed septicemia. The material of this study consisted of a total of 30 calves. Study group consisted of 20 septicemic calves and 10 clinically healthy calves and with same breed and weight and their ages were between 1 and 10 days. The statistical analysis indicated that leukocyte (WBC), red blood cell (RBC), hematocrit (Hct) hemoglobin (Hb) and mean corpuscular haemoglobin concentration (MCHC) values in neonatal calves with presumed septicemia were higher than those of the control group (P<0.05), whereas PLT values of neonatal calves with septicemia were lower than those of the control group (P<0.05). The levels of ICAM-1, TNF-α, IL-6, IL-8 and CRP values in septicemic calves were higher than those of the control group (P<0.05). As a result, it was concluded that analyzes of TNF-α, IL-6, IL-8 and particularly ICAM-1 concentrations may be considered in evaluating the severity and prognosis of patients with septicemia, as well as monitoring the efficacy of the treatment of the disease.

Keywords

• Calf
• Septicemia
• Acute Phase Proteins
• Cytokines
• ICAM

Septisemi Şüpheli Yenidoğan Buzağılarda Hücrelerarası Adhezyon Molekül-1 (ICAM-1), Tümör nekroz faktörü α (TNF-α), İnterlökinler (IL-6, IL-8) ve C-reaktif protein (CRP) Seviyelerinin Değerlendirilmesi

Abstract

Bu çalışmada; septisemi şüpheli yenidoğan buzağılarda hücreler arası molekül-1 (ICAM-1), Tümör nekroz faktörü α (TNF-α), İnterlökin-6 (IL-6), İnterlökin-8 (IL-8) ve C-reaktif protein (CRP) düzeyleri değerlendirildi. Bu çalışmanın materyalini aynı cins ve kiloya sahip ve yaşları 1-10 gün arasında değişen 20 septisemik buzağı ile 10 sağlıklı buzağı olmak üzere toplam 30 buzağı oluşturdu. İstatistiksel analizde, septisemili buzağıların lökosit (WBC), Eritrosit (RBC), hematokrit (Hct) hemoglobin (Hb) ve ortalama korpüsküler hemoglobin konsantrasyonu (MCHC) değerleri kontrol grubunun aynı parametrelerine göre yüksek tespit edilirken (P <0.05), septisemili yenidoğan buzağıların PLT değerleri kontrol grubunun PLT değerlerine göre düşük (P <0.05) saptandı. Septisemik buzağılarda ICAM-1, TNF-α, IL-6, IL-8 ve CRP değerleri kontrol grubunun aynı değerlerine göre anlamlı düzeyde  tespit edildi (P<0.05).

Sonuç olarak, TNF-α, IL-6, IL-8 ve özellikle ICAM-1 konsantrasyonlarının analizlerinin septisemili vakalarda hastalığın şiddetini ve prognozunu değerlendirmede yararlı parametreler olabileceği, bununla birlikte bu parametrelerin  tedavi etkinliğinin takibinde göz önünde bulundurulması gereken parametreler olacağı kanısına varıldı.

Keywords

• Buzağı
• Septisemi
• Akut Faz Proteini
• Sitokin
• ICAM

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