DNA Vaccines and Their Using in Veterinary Medicine

Year 2015, Volume 26, Issue 3, 177 - 182, 01.12.2015

İlke KARAYEL Feray ALKAN

Abstract

Veterinary area protects health of pet animals, farm animals and wild animals. Besides, it has many responsibilities about economical livestock management because of the infections in management, region, country or even large geographical area and human health because of the zoonotic infection. The formation of immune populations against several etiological agents correspondingly, the development of conventional vaccines or a portion of the etiological agent (nucleic acid or protein) containing vaccines (subunit vaccines, vector vaccines, DNA vaccines, etc.) are important issues in science. The purpose of this review is to provide general information about the DNA vaccines that are formed by expression plasmid vectors, which contain encoding genes of antigenic proteins of microorganism and draw attention to the use of veterinary facilities

Keywords

Vaccine, DNA Plasmid, Immunity

DNA Aşıları ve Veteriner Hekimlik Alanında Kullanımı

Abstract

Veteriner hekimlik alanı pet hayvanları, çiftlik hayvanları, vahşi yaşamdaki hayvanların sağlığının korunmasının yanı sıra, işletme, bölge ya da ülkedeki ve hatta pandemik enfeksiyonlar nedeniyle geniş coğrafyalardaki çiftlik hayvanlarının ekonomik yetiştiriciliği, zoonoz enfeksiyonlar nedeniyle de, insan sağlığına ilgili sorumlulukları içermektedir. Bu bağlamda, birçok etken için bağışık popülasyonların oluşturulması; dolayısıyla geleneksel aşılar ya da etiyolojik ajanın bir kısmını (nükleik asit ya da protein) içeren aşıların (subunit aşı, vektör aşı, DNA aşısı, vb.) geliştirilmesi bilimin önemli konularındandır. Bu derlemenin amacı, mikroorganizmaların çeşitli antijenik karakterdeki proteinlerini kodlayan genlerin yerleştirildiği ekspresyon plazmid vektörleri olan DNA aşılarına ilgili genel bilgileri sunmak ve veteriner hekimlikte kullanım olanaklarına dikkat çekmektir

Keywords

Aşı, DNA Plazmid, Bağışıklık

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