Investigation of the Antidiabetic Effects of Mistletoe (Viscum album L.) Extract in Experimental Diabetes in Rats

Year 2019, Volume: 30 Issue: 2, 121 - 125, 26.07.2019

Avin Kawa Ahmed Nihat Mert Handan Mert

Abstract

Diyabet çoklu etiyolojisi, karbonhidrat, yağ ve protein metabolizması
bozuklukları ve kronik hiperglisemi ile seyreden metabolik bir hastalıktır. V. Album (ökse otu) yaprak ekstreleri,
diyabet semptomlarını hafifletmek, diyabete yararlı bir etki sağlamak için
kullanılan yöresel bir bitkidir. Bu çalışmanın amacı, V. album ekstraktlarının streptozotosin (STZ) kaynaklı diyabetik
sıçanlar üzerindeki antidiyabetik ve antioksidan aktivitelerini araştırmaktır. Araştırmada
32 adet, dişi 6-7 haftalık Wistar sıçanları kullanıldı. Sıçanlar rastgele 4
gruba, ayrıldı. Grup I  (Kontrol), Grup II (V.
album), Grup III (Diyabetik), Grup IV (Diyabetik + V. album). Deneme sonunda tüm gruplardaki sıçanların kan örnekleri
alınıp hemen serumları ayrıldı. Total
kolesterol, HDL, trigliserit, folik asit, vitamin D, vitamin B₁₂  ve glukoz düzeyleri otoanalizörde saptandı.
TAC ve TOS analizleri ELISA’da ölçüldü. Diyabetik+V. album grubunda diyabet
grubuna göre glukoz (p≤0.05), vitamin B₁₂ (p≤0.05)  ve TOS (p≤0.05)  düzeyleri önemle azalırken, TAC düzeyi önemle
yükseldi (p≤0.05). Sonuç olarak; V.
album ekstreleri  antidiyabetik
etkilere sahiptir. Sadece 20 günlük deneme süresince V. album ile tedavi edildiğinde glukoz seviyesini önemli ölçüde
azaltmıştır. V. album, diyabetik
komplikasyonların oluşumunu önlemeye yardımcı olabilecek güçlü bir antioksidan
aktiviteye sahiptir.

Keywords

Diyabet, Lipoproteinler, Ökse otu, Toplam antioksidan kapasite, Toplam oksidatif durum

Supporting Institution

Van YYU Directory of Scientific Research

Project Number

2016- TYL-5198

References

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