Year 2020, Volume 31 , Issue 2, Pages 60 - 66 2020-07-03

Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi
Effect of Postpartum Routine Intrauterine Treatment on Fertility in Dairy Cows

Egemen ERÇETİN [1] , Yunus ÇETİN [2]


Bu çalışmada, ineklerde postpartum rutin intrauterin Dimetil Sülfo Oksid (DMSO), DMSO + oksitetrasiklin ve intramuskular PGF2α uygulamalarının fertiliteye etkisini belirlemek amaçlandı. Bu amaçla 150 baş inek rastgele 3 gruba ayrıldı. Vaginal akıntıları ve uterus boyutları 1’den 3’e değişen ölçüde skorlandı. DMSO gurubuna (n=47) postpartum 25-35 gün aralığında ilki, postpartum 40-55 gün aralığında ikincisi olmak üzere iki defa serum fizyolojikle seyreltilen %25’lik DMSO 120 ml intrauterin olarak verildi. Ayrıca PGF2α luteolitik dozda uygulandı. DO grubuna (n=46), postpartum 25-35 gün aralığında ilki, postpartum 40-55 gün aralığında ikincisi olmak üzere iki defa serum fizyolojik ile seyreltilen %25’lik DMSO ve 4 gr oksitetrasiklin 120 ml intrauterin olarak verildi, PGF2α luteolitik dozda uygulandı. PG grubuna (n=42) 25-35 gün aralığında ilki, postpartum 40-55 gün aralığında ikincisi olmak üzere iki defa kas içi PGF2α luteolitik dozda uygulandı. Vaginal akıntı skoru 1 olan ineklerde gebelik başı tohumlama sayısı akıntı skoru 2-3 olanlara göre anlamlı derecede düşük bulundu (p<0.05). Antibiyotik kullanılan grupta gebelik oranları PGF2α ve DMSO kullanımına göre farklılık göstermedi. Erken postpartum dönemde intrauterin antibiyotik kullanımın fertilite parametrelerine etkisinin PGF2α ve DMSO’dan farklı olmadığı sonucuna varıldı. DMSO’nun intrauterin rutin kullanımının oransal olarak fertiliteyi iyileştirdiği ancak daha fazla sayıda inekte çalışılması gerektiği sonucuna varıldı.

In this study, it was aimed to determine effect of postpartum routine intrauterin dimethyl sulfoxide (DMSO), DMSO + oxytetracycline and intramuscular PGF2α administration on fertility in cows. For this purpose, 150 cows were randomly divided into 3 groups for this study. Vaginal discharge and uterine size were scored with varying degrees from 1 to 3. DMSO group (n = 47) first in the postpartum interval of 25 to 35 days, secondly in the postpartum interval of 40 to 55 days, were twice administered 120 ml from 25% DMSO as intrauterine. In addition, PGF2α was administered at a luteolytic dose. For the DO group (n=46), first in the postpartum interval of 25 to 35 days in postpartum, secondly in the postpartum interval of 40 to 55 days, were twice 25% DMSO and 4 g oxytetracycline, all diluted with serum physiologic were administered 120 ml as intrauterine. Furthermore, PGF2α was also given at the luteolytic dose. To the prostaglandin group (n=42) PGF2α was given twice intramuscular luteolytic dose, firstly in 25-35 days and secondly in postpartum 40-55 days. Number of artificial insemination for one pregnancy, in cows with a vaginal discharge score of 1, was accepted significantly lower than a vaginal discharge score of 2-3 (p<0.05). In antibiotic group, pregnancy rates did not differ according to PGF2α and DMSO usage. In early postpartum period, the use of intrauterine antibiotics was concluded that the effect on fertility parameters was not different from PGF2α and DMSO. It was concluded that intrauterine routine use of DMSO improves fertility proportionally but more cows should be studied.

  • 1. Ahmadi MR, Derakhshandeh A, Shirian S, Daneshbod Y, Ansari- Lari M, Nazifi S (2017): Detection of bacterial biofilm in uterine of repeat breeder dairy cows. Asian pacific Journal of Reproduction., 6(3), 136-139.
  • 2. Armengol R, Fraile L (2015): Comparison of two treatment strategies for cows with metritis in high-risklactating dairy cows. Theriogenology.,83(8),1344-51.
  • 3. Aslan S, Arbaıter K, Dickie MB (1995): İneklerde puerperal dönemde düzenli kontrollerin fertilite üzerinde ki etkileri. Ankara Üniv Vet Fak Derg., 42,307-315.
  • 4. Azawi OI (2008): Postpartum uterine infection in cattle. An Reprod Sci., 105, 187-208.
  • 5. Baez GM, Barletta RV, Guenther JN, Gaska JM, Wiltbank MC (2015): Effect of Uterine Size on Fertility of Lactating Dairy Cows. Theriogenology, 85(8),1357-66.
  • 6. BonDurant RH (1999): Inflammation in the bovine female reproductive tract. J Anim Sci., 77,101–110.
  • 7. Brick TA, Schuenemann GM, Bas S, Daniels JB, Pinto CR, Rings DM, Raiala- Schltz PJ (2012): Effect of intrauterine dextrose or antibiotic therapy on reproductive preformance of lactating dairy cows diagnosed with clinical endometritis. J Dairy Sci., 95, 1894-1905.
  • 8. Bromfield JJ, Santos JEP, Block J, Williams RS ve Sheldon IM (2015): Uterine infection: linking infection and innate immunity with infertility in the high- producing dairy cow. J Anim Sci., 93, 2021-2033.
  • 9. Chastant MS (2015): Impact of bovine Herpesvirus 4 (BoHV-4) on reproduction. Transbound Emerg Dis., 62(3), 245-51.
  • 10. Cohen RO, Bernstein M, Ziv G (1995): Isolation and antimicrobial susceptibility of Actinomyces pyogenes recovered from the uterus of dairy cows with retained fetal membranes and post parturient endometritis. Theriogenology. 43, 1389-1397.
  • 11. Dubuc J, Duffield TF, Leslie KE, Walton JS, Leblanc SJ (2011): Randomized clinical trial of antibiotic and prostaglandin treatments for uterine health and reproductive performance in dairy cows. J Dairy Sci., 94(3) 1325–38.
  • 12. Frazer GS, Rosol TJ, Threlfall WR (1988): Effect of serial intrauterine dimethyl sulfoxide infusions on the incidence of periglandular fibrosis in category II horse endometria. Theriogenology., 29(5), 1091-8.
  • 13. Giuliodori MJ, Magnasco M, Magnasco RP, Lacau-Mengido IM,i de la Sota RL ( 2017): Purulent vaginal discharge in grazing dairy cows: Risk factors, reproductive performance, and prostaglandin F2α treatment. J Dairy Sci., 100(5), 3805-3815.
  • 14. Gorden PJ, Ydstie JA, Kleinhenz MD, Wulf LW, Gehring R, Lee CJ, Wang C, Coetz JF (2016): A study to examine the relationship between metritis severity and depletion of oxytetracycline in plasma and milk after intrauterine infusion. J Dairy Sci.,99(10) 8314-8322.
  • 15. Haimerl P, Arlt S, Borchardt S, Heuwieser W (2017): Antibiotic treatment of metritis in dairy cows—A meta-analysis. J Dairy Sci., 100(5), 3783-3795.
  • 16. Jacob SW, Wood DC (1967): Dimethyle Sulfoxide (DMSO). Toxicology, Pharmacology and Clinical experience. Am J Surg., 114(3), 414-26.
  • 17. Kasimanickam R, Duffield TF, Foster RA, Gartley CJ, Leslie KE, Walton JS, Johnson WH (2004): Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows. Theriogenology.,62,9-23.
  • 18. Kaya D (2008): İneklerde kronik endometritis olgularında lotogen®, eucacomp® ve PGF2α uygulamalarının fertilite parametreleri üzerindeki etkilerinin araştırılması. Doktora Tezi, Ankara Üniversitesi Sağlık Bilimleri Enstitüsü.
  • 19. Kaya S, Kuru M, Kaçar C (2015): İneklerde Uterus Enfeksiyonları Tedavi Seçenekleri. Türkiye Klinikleri J Vet Sci., 6(1), 30-8.
  • 20. Knutti B, Busato A, Kuüpfer U. (2000): Reproductive efficiency of cows with endometritis after treatment with intrauterine infusions or prostaglandin injections or no treament. J Vet Med A Physiol Pathol Clin Med.,47(10), 609–15.
  • 21. Kristen DL, Ryan AF, Patrick MM, Grace IB, Margo LH, Bradley RB (2017):In vitro biofilm disruption and bacterial killing using non-antibiotic compounds against gram-negative equine uterine pathogens. Equine Veterinary Science., 53, 94-99.
  • 22. Küplülü Ş, Vural R, Polat MI (2011): İneklerde Uterus Enfeksiyonlarının Etiyopatogenezisi, Klinik semptomları ve sağaltım girişimleri. Türkiye Klinikleri, J Vet Sci., 2(1), 58-65.
  • 23. LeBlanc SJ, Duffıeld TF, LEslie KE, Bateman KG, Keefe GP, Walton JS, Johnson WH (2002): The Effect of Treatment of Clinical Endometritis on Reproductive Performance in Dairy Cows. J Dairy Sci., 85(9), 2237-49.
  • 24. LeBlanc SJ, Duffield TF,Leslie KE, Bateman KG, Keefe GP,Walton JS, Johnson WH (2002): The effect of treatment of clinical endometritis on reproductive performance in dairy cows. J. Dairy Sci. 85(9) 2237–2249.
  • 25. LeBlanc SJ, Osawa T, Dubuc J (2011) Reproductive tract defense and disease in postpartum dairy cow. Theriogenology.,76(9), 1610-8.
  • 26. Leslie KE (1983): The events of normal and abnormal postpartum reproductive endocrinology and uterine involution in dairy cows: a review. Can Vet J., 24, 67-71.
  • 27. Ley WB, Bowen JM, Sponenberg DP, Lessard PN (1989): Dımethyl sulfoxıde ıntrauterine therapy in the mare: effects upon endometrial histological features and biopsy classification. Theriogenology., 32(2),263-76.
  • 28. Machado VS, Oikonomou G, Ganda EK, Stephens L, Milhomem M, Freitas GL, Zinicola M, Pearson J, Wieland M, Guard C, Gilbert RO, Bicalho RC (2015): The effect of intrauterine infusion of dextrose on clinical andometritis cure rate and reproductive performance of dairy cows. J Dairy sci., 98, 1-10.
  • 29. Makkı M, Gheısarı HR, Ahmadı MR (2016): Effect of different intrauterine oxytetracycline Treatment on reproductive performance of dairy cows with clinical endometritis and determination of oxytetracycline residues in milk. İstanbul Üniversitesi Veteriner Fakültesi Dergisi.,42(1).
  • 30. Malinowski E, Lessa H, Markiewicz H, Kaptur M, Nadolny M, Niewitecki W (2011): Sensitivity to antibiotics of Arcanobacterium pyogenes and Escherichia coli from the uteri of cows with metritis/endometritis. Vet J., 187, 234-38.
  • 31. Mari G, Lacono E, Toni F, Predieri PG, Merlo B (2012): Evaluation of the effectiveness of intrauterine treatment with formosulphathiazole of clinical endometritis in postpartum dairy cows. Theriogenology., 78, 189-200.
  • 32. Mateus L, da Costa, F, Bernardo F, Silva JR (2002) Influence of puerperal uterine infection on uterine involution and postpartum ovarian activity in dairy cows. Reprod Domest Anim., 37, 31–35.
  • 33. Nakao T, Moriyoshi M, Kawata K (1988): Efekt of postpartum intrauterine treatment with 2% polyvinylpyrrolidon- iodine solution on reproductive efficiency in cows. Theriogenology., 30,1033–43.
  • 34. Noakes DE, Parkinson TJ, England GCV (2001): Arthur’ s V eterinary Reproduction and Obstetrics. 8th Edition. London, WB Sounders.
  • 35. Okawa H, Fujikura A, Wijayagunawardane MMP, Taniguchi M, Takagi M (2017): Effect of diagnosis and treatment of clinical endometritis based on vaginal discharge score grading system in postpartum Holstein cows. J Vet Med Sci.,79(9),1545-1551.
  • 36. Öcal H, Kalkan C (2012): Puerperal dönem fizyolojisi. Editörler: Semacan A, Kaymaz M, Fındık M, Rişvanlı A, Köker A, Çiftlik Hayvanlarında Doğum ve Jinekoloji, Medipres, s: 313-343.
  • 37. Öcal H, Kalkan C, Timurkan H, Deveci H (1992): Süt İneklerinde İntrauterin İlaç Uygulamasının Ovaryum Faaliyetleri ve Uterus Üzerine Etkisi, Y Y Ü Vet Fak Derg, 3(1-2), 91-105.
  • 38. Pascotini OB, Hostens M, Dini P, Vandepitte J, Ducatelle R, Opsomer G (2016): Comparison between cytology and histopathology to evaluate subclinical endometritis in dairy cows. Theriogenology., 86, 1550-1556.
  • 39. Pyörälä S, Taponen J, Katila T (2014): Use of antimicrobials in the treatment of reproductive diseases in cattle and horses. Reproduction in Domestic Animals, 49, 16- 26.
  • 40. Scalia D, Lacetera N, Bernabucci U, Demeyere K, Ducateau L, Burvenich C (2006): In vitro effects of nonesterified fatty acids on bovine neutrophils oxidative burst and viability. J Dairy Sci, 89:147–54
  • 41. SeldonIM,LewisGS,LeblacnkS,GılbertRO(2006):Definingpostpartumuterine disease in cattle. Theriogenology., 65, 1516-1530.
  • 42. Semacan A (1993): Postpartum Sorunlu ve Normal İneklerde PGF2α Kontrollü Tohumlamaların Fertilite Üzerine Etkisi, Doktora Tezi, Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü.
  • 43. Sheldon IM, Cronin J, Goetze L, Donofrio G, Schuberth HJ (2009): Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle. Biol Reprod, 81, 1025–32.
  • 44. SheldonIM,LewisGS,LeBlancS,GilbertRO(2006):Definingpostpartumuterine disease in cattle. Theriogenology, 65(8), 1516-30.
  • 45. Sheldon IM, Noakes DE (1988): Comparison of three treatments for bovine endometritis. Vet Rec., 142(21), 575-9.
  • 46. StevensonJS,CallEP(1998):Reproductivedisordersintheperiparturientdairycow. J Dairy Sci,71(9),2572-83.
  • 47. Studer E, Morrow DE (1978): Postpartum evaluation of bovine reproductive potential: comparison of findings from genital tract examination per rectum, uterine culture and endometrial biopsy. J Am Vet Med Assoc., 172, 489-494.
  • 48. WagenerK,GablerC,DrillichM(2017):Areviewoftheongoingdiscussionabout definition, diagnosis and pathomechanism of subclinical endometritis in dairy cows. Theriogenology., 94,21-30.
  • 49. Westermann S, Drillich M, Kaufmann TB, Madoz LV, Heuwieser W (2010): Clinical approach to determine false positive findings of clinical endometritis by vaginoscopy by the use of uterine bacteriology and cytology in dairy cows. Theriogenology., 74(7), 1248-55.
  • 50. Wexler P (2005): Dimethyl Suşfoxide (DMSO). Ed(s): Gad SE, Sullivan DW. Encyclopedia of Toxicology 2nd Edition, volume 2, Elsevier, USA, p:166-168.
  • 51. Williams EJ, Fischer DP, Noakes DE, Englan WCG, Rycroft A, Dobson H, Sheldon IM (2007): The Relationship between uterine pathogen growth density and ovarian function in the postpartum diary cow. Theriogenology.,68 549-559.
  • 52. Williams EJ, Fischer DP, Pfeiffer DU, England GC, Noakes DE, Dobson H, Sheldon IM (2005): Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle. Theriogenology.,63 (1),102-17.
  • 53. ÇetinY,ÖGüngör,İTaşal,CSipahi,SSendag,AWehrendEffectsofpostpartum intrauterine treatments on reproductive performance of dairy cows. Reproduction in Domestic Animals. (İn press). Tarih yok
  • 54. Zhang D, Zhao J, Wang Q, Liu Y, Tian C, Zhao Y, Yu L, Liu M (2017): Trueperella pyogenes isolated from dairy cows with endometritis in Inner Mongolia, China: Tetracycline susceptibility and tetracycline-resistance gene distribution. Microb Pathog., 105, 51 56.
Primary Language tr
Subjects Veterinary
Journal Section Araştırma Makaleleri
Authors

Author: Egemen ERÇETİN (Primary Author)
Institution: MEHMET AKİF ERSOY ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
Country: Turkey


Author: Yunus ÇETİN
Institution: MEHMET AKİF ERSOY ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
Country: Turkey


Dates

Application Date : April 22, 2019
Acceptance Date : March 6, 2020
Publication Date : July 3, 2020

Bibtex @research article { vanvetj552072, journal = {Van Veterinary Journal}, issn = {2149-3359}, eissn = {2149-8644}, address = {YYÜ Veteriner Fakültesi Dergi Editörlüğü Kampüs Van Turkey}, publisher = {Yuzuncu Yil University}, year = {2020}, volume = {31}, pages = {60 - 66}, doi = {10.36483/vanvetj.552072}, title = {Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi}, key = {cite}, author = {Erçeti̇n, Egemen and Çeti̇n, Yunus} }
APA Erçeti̇n, E , Çeti̇n, Y . (2020). Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi . Van Veterinary Journal , 31 (2) , 60-66 . DOI: 10.36483/vanvetj.552072
MLA Erçeti̇n, E , Çeti̇n, Y . "Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi" . Van Veterinary Journal 31 (2020 ): 60-66 <https://dergipark.org.tr/en/pub/vanvetj/issue/55797/552072>
Chicago Erçeti̇n, E , Çeti̇n, Y . "Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi". Van Veterinary Journal 31 (2020 ): 60-66
RIS TY - JOUR T1 - Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi AU - Egemen Erçeti̇n , Yunus Çeti̇n Y1 - 2020 PY - 2020 N1 - doi: 10.36483/vanvetj.552072 DO - 10.36483/vanvetj.552072 T2 - Van Veterinary Journal JF - Journal JO - JOR SP - 60 EP - 66 VL - 31 IS - 2 SN - 2149-3359-2149-8644 M3 - doi: 10.36483/vanvetj.552072 UR - https://doi.org/10.36483/vanvetj.552072 Y2 - 2020 ER -
EndNote %0 Van Veterinary Journal Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi %A Egemen Erçeti̇n , Yunus Çeti̇n %T Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi %D 2020 %J Van Veterinary Journal %P 2149-3359-2149-8644 %V 31 %N 2 %R doi: 10.36483/vanvetj.552072 %U 10.36483/vanvetj.552072
ISNAD Erçeti̇n, Egemen , Çeti̇n, Yunus . "Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi". Van Veterinary Journal 31 / 2 (July 2020): 60-66 . https://doi.org/10.36483/vanvetj.552072
AMA Erçeti̇n E , Çeti̇n Y . Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi. Van Vet J. 2020; 31(2): 60-66.
Vancouver Erçeti̇n E , Çeti̇n Y . Sütçü İneklerde Postpartum Rutin İntrauterin Tedavilerin Fertiliteye Etkisi. Van Veterinary Journal. 2020; 31(2): 60-66.