Year 2020, Volume 31 , Issue 2, Pages 87 - 92 2020-07-03

Sıçanlarda Silimarinin Beyin Hasarı Üzerine Koruyucu Etkisi
The Treatment Effect of Silymarin on Brain Damage in Rats

İ̇brahim AKTAŞ [1] , Murat SEVİMLİ [2]


Bu çalışmada silimarin’in sıçanlarda histolojik ve biyokimyasal parametrelerle valproik asite bağlı beyin hasarı üzerindeki olası koruyucu etkilerini değerlendirdik. Deney 21 Sprague Dawley erkek sıçan ile yapıldı. Sıçanlar üç gruba ayrıldı: grup 1 kontrol, grup 2 valproik asit ve grup 3 valproik asit + silimarin. Gruplara kontrol grubu dışında 14 gün boyunca 500 mg/kg/gün valproik asit ve 14 gün boyunca 100 mg/kg silimarin verildi. Valproik asit ile artmış serum glikoz, kolesterol, trigliserit ve kreatin kinaz BB seviyeleri, silimarin uygulaması ile tersine çevrildi. Ayrıca, valproik asitle beyin dokusunda artmış malondialdehit ve azalmış glutatyon düzeyleri, silimarin ile anlamlı önemli ölçüde baskılanmıştır. Valproik asit + silimarin grubunda oksidatif stres azaldı, antioksidan aktivite arttı ve valproik asit grubuna göre histopatolojik değişiklikler azaldı. Valproik asidin neden olduğu beyin hasarı, silimarin’in antioksidatif ve anti-apoptotik etkileri nedeniyle silimarin tedavisi ile azaltıldı. Silimarin, valproik asite bağlı beyin hasarının şiddetini azaltmak için yararlı olabilir.

Bu çalışmada, silymarinin sıçanlarda histolojik ve biyokimyasal parametreler kullanarak valproik aside bağlı beyin hasarı üzerindeki olası koruyucu etkilerini araştırmayı amaçladık. Deney 21 Sprague Dawley erkek sıçan ile yapıldı. Sıçanlar üç gruba ayrıldı: grup 1; kontrol, grup 2; valproik asit, grup 3; valproik asit + silimarin. Gruplara kontrol grubu hariç 14 gün boyunca 500 mg / kg / gün valproik asit ve 14 gün boyunca 100 mg / kg sililmarin verildi. Valproik asit ile artan glukoz, kolesterol, trigliserit ve kreatin kinaz BB seviyeleri silimarin tedavisi ile tersine çevrilmiştir (p <0.05). Ayrıca, beyin dokusunda valproik asit ile artan malondialdehit ve azalan glutatyon seviyesi, silimarin tarafından önemli ölçüde baskılanmıştır (p <0.05). Histolojik olarak, valproik asit + silimarin grubunda beyin hasarı anlamlı derecede düşük olarak tespit edildi. Valproik asit + silimarin grubunda histopatolojik bulgular valproik asit grubuna göre anlamlı olarak azaldı (p < 0.05). Bu çalışmada silimarinin valproik aside bağlı beyin hasarı üzerinde iyileştirici etkisi olduğu görülmüştür. Bu anlamda çalışmamızın silimarin ve valproik asit ile çalışılacak diğer çalışmalar için faydalı olacağına inanıyoruz.
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Primary Language en
Subjects Veterinary
Journal Section Araştırma Makaleleri
Authors

Orcid: 0000-0002-0956-8204
Author: İ̇brahim AKTAŞ (Primary Author)
Institution: Adiyaman University, Vocational School of Health Services
Country: Turkey


Orcid: 0000-0001-8463-6943
Author: Murat SEVİMLİ
Institution: FACULTY OF MEDICINE
Country: Turkey


Supporting Institution There are no financial supports.
Project Number Ethics committee report; it was obtained from the Laboratory Animals Ethics Committee (Protocol 2019/08) of Fırat University Faculty of Medicine and the study was conducted according to this protocol.
Dates

Application Date : December 11, 2019
Acceptance Date : April 17, 2020
Publication Date : July 3, 2020

Bibtex @research article { vanvetj658220, journal = {Van Veterinary Journal}, issn = {2149-3359}, eissn = {2149-8644}, address = {YYÜ Veteriner Fakültesi Dergi Editörlüğü Kampüs Van Turkey}, publisher = {Yuzuncu Yil University}, year = {2020}, volume = {31}, pages = {87 - 92}, doi = {10.36483/vanvetj.658220}, title = {The Treatment Effect of Silymarin on Brain Damage in Rats}, key = {cite}, author = {Aktaş, İ̇brahim and Sevi̇mli̇, Murat} }
APA Aktaş, İ , Sevi̇mli̇, M . (2020). The Treatment Effect of Silymarin on Brain Damage in Rats . Van Veterinary Journal , 31 (2) , 87-92 . DOI: 10.36483/vanvetj.658220
MLA Aktaş, İ , Sevi̇mli̇, M . "The Treatment Effect of Silymarin on Brain Damage in Rats" . Van Veterinary Journal 31 (2020 ): 87-92 <https://dergipark.org.tr/en/pub/vanvetj/issue/55797/658220>
Chicago Aktaş, İ , Sevi̇mli̇, M . "The Treatment Effect of Silymarin on Brain Damage in Rats". Van Veterinary Journal 31 (2020 ): 87-92
RIS TY - JOUR T1 - The Treatment Effect of Silymarin on Brain Damage in Rats AU - İ̇brahim Aktaş , Murat Sevi̇mli̇ Y1 - 2020 PY - 2020 N1 - doi: 10.36483/vanvetj.658220 DO - 10.36483/vanvetj.658220 T2 - Van Veterinary Journal JF - Journal JO - JOR SP - 87 EP - 92 VL - 31 IS - 2 SN - 2149-3359-2149-8644 M3 - doi: 10.36483/vanvetj.658220 UR - https://doi.org/10.36483/vanvetj.658220 Y2 - 2020 ER -
EndNote %0 Van Veterinary Journal The Treatment Effect of Silymarin on Brain Damage in Rats %A İ̇brahim Aktaş , Murat Sevi̇mli̇ %T The Treatment Effect of Silymarin on Brain Damage in Rats %D 2020 %J Van Veterinary Journal %P 2149-3359-2149-8644 %V 31 %N 2 %R doi: 10.36483/vanvetj.658220 %U 10.36483/vanvetj.658220
ISNAD Aktaş, İ̇brahim , Sevi̇mli̇, Murat . "The Treatment Effect of Silymarin on Brain Damage in Rats". Van Veterinary Journal 31 / 2 (July 2020): 87-92 . https://doi.org/10.36483/vanvetj.658220
AMA Aktaş İ , Sevi̇mli̇ M . The Treatment Effect of Silymarin on Brain Damage in Rats. Van Vet J. 2020; 31(2): 87-92.
Vancouver Aktaş İ , Sevi̇mli̇ M . The Treatment Effect of Silymarin on Brain Damage in Rats. Van Veterinary Journal. 2020; 31(2): 87-92.