Evaluation of Stem Cell Applications in Periodontal Regenerative Therapy: A Current Perspective Between 2003-2022

Abstract

The periodontium comprises the fundamental tissues of the tooth, namely the gingiva, periodontal ligament, cementum, and alveolar bone. Prolonged accumulation of microbial dental plaque on the tooth and gingival margin leads to pathological changes in the periodontal tissues. However, the mechanical and regenerative techniques employed to address the breakdown of periodontal tissue have been unsuccessful in fully restoring the periodontium to its original, disease-free condition. The growing understanding and recognition of the potential uses of stem cell therapy have led to the emergence of new perspectives on periodontal regeneration approaches. This review investigates mesenchymal stem cells and their use in periodontal regeneration treatment.

Keywords

• Cell transplantation
• mesenchymal stem cells
• periodontal treatment
• tissue engineering

Periodontal Rejeneratif Tedavide Kök Hücre Uygulamalarının Değerlendirilmesi: 2003-2022 Yılları Arasında Güncel Bir Perspektif

Abstract

Periodonsiyum dişin başlıca temel dokularını, diş eti, periodontal ligament, sement ve alveol kemiğini içerir. Diş ve diş eti kenarlarında mikrobiyal diş plağının uzun süreli birikmesi periodontal dokularda patolojik değişikliklere yol açar. Ancak periodontal dokunun uğradığı bu hasarı gidermek için kullanılan mekanik ve rejeneratif teknikler periodonsiyumu orijinal, hastalıksız durumuna tamamen döndürmede başarısız olmuştur. Kök hücre tedavisinin potansiyel kullanımlarının giderek daha iyi anlaşılması ve tanınması, periodontal rejenerasyon yaklaşımlarına ilişkin yeni bakış açılarının ortaya çıkmasına yol açmıştır. Bu derlemede mezenkimal kök hücreler ve bunların periodontal rejenerasyon tedavisindeki kullanımı araştırılmaktadır.

Keywords

• Doku mühendisliği
• hücre transplantasyonu
• mezenkimal kök hücreler
• periodontal tedavi

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