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Periodontal Rejeneratif Tedavide Kök Hücre Uygulamalarının Değerlendirilmesi: 2003-2022 Yılları Arasında Güncel Bir Perspektif

Year 2024, Volume: 5 Issue: 1, 12 - 23, 05.07.2024

Abstract

Periodonsiyum dişin başlıca temel dokularını, diş eti, periodontal ligament, sement ve alveol kemiğini içerir. Diş ve diş eti kenarlarında mikrobiyal diş plağının uzun süreli birikmesi periodontal dokularda patolojik değişikliklere yol açar. Ancak periodontal dokunun uğradığı bu hasarı gidermek için kullanılan mekanik ve rejeneratif teknikler periodonsiyumu orijinal, hastalıksız durumuna tamamen döndürmede başarısız olmuştur. Kök hücre tedavisinin potansiyel kullanımlarının giderek daha iyi anlaşılması ve tanınması, periodontal rejenerasyon yaklaşımlarına ilişkin yeni bakış açılarının ortaya çıkmasına yol açmıştır. Bu derlemede mezenkimal kök hücreler ve bunların periodontal rejenerasyon tedavisindeki kullanımı araştırılmaktadır.

References

  • 1. Menne MC, Seitidis G, Faggion CM Jr, Mavridis D, Pandis N. Early Optimistic Effect in Periodontology and Implant Dentistry Trials. J Dent Res. 2022;101(1):30-36.
  • 2. Bartold PM, McCulloch CA, Narayanan AS, Pitaru S. Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology. Periodontol 2000. 2000;24:253-269.
  • 3. Sedghi LM, Bacino M, Kapila YL. Periodontal Disease: The Good, The Bad, and The Unknown. Front Cell Infect Microbiol. 2021;11:766-944.
  • 4. Annunziata M, Oliva A, Buonaiuto C. In vitro cell-type specific biological response of human periodontally related cells to platelet-rich plasma. J Periodontal Res. 2005;40(6):489-495.
  • 5. Garrett S. Periodontal regeneration around natural teeth. Ann Periodontol. 1996;1(1):621-666.
  • 6. Han J, Menicanin D, Gronthos S, Bartold PM. Stem cells, tissue engineering and periodontal regeneration. Aust Dent J. 2014;59 Suppl 1:117-130.
  • 7. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. I. Clinical measures. J Periodontol. 1993;64(4):254-260.
  • 8. Smith MacDonald E, Nowzari H, Contreras A, Flynn J, Morrison J, Slots J. Clinical and microbiological evaluation of a bioabsorbable and a nonresorbable barrier membrane in the treatment of periodontal intraosseous lesions. J Periodontol. 1998;69(4):445-53. 9. Ivanovski S, Gronthos S, Shi S, Bartold PM. Stem cells in the periodontal ligament. Oral Dis. 2006;12(4):358-363.
  • 10. Sun E, Karaoz E. Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? Answers as transcriptomic aspect. Am J Stem Cells. 2020;9(4):57-67.
  • 11.Peterson B, Zhang J, Iglesias R. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng. 2005;11(1-2):120-129.
  • 12. Son YB, Kang YH, Lee HJ. Evaluation of odonto/osteogenic differentiation potential from different regions derived dental tissue stem cells and effect of 17β-estradiol on efficiency. BMC Oral Health. 2021;21(1):15.
  • 13. Kalra KTTP and Pushpa C. Tomar. Stem cell: basics, classification and applications. AJPCT. 2014;2(7):919-930.
  • 14. Langenbach F, Handschel J. Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Res Ther. 2013;4(5):117.
  • 15. Han J, Menicanin D, Gronthos S, Bartold PM. Stem cells, tissue engineering and periodontal regeneration. Aust Dent J. 2014;59:Suppl 1:117-130.
  • 16. Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol.1976;4(5):267-274.
  • 17. Longoni A, Utomo L, van Hooijdonk IE, Bittermann GK, Vetter VC, Kruijt Spanjer EC, Ross J, et al. The chondrogenic differentiation potential of dental pulp stem cells. Eur Cell Mater. 2020;39:121–135.
  • 18. Pei M. Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential. Biomaterials. 2017;117:10-23.
  • 19. Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019;8(8):886. 20. Volarevic V. Mesenchymal stem cell-derived factors: Immuno-modulatory effects and therapeutic potential. Bio-Factors. 2017;43:633–644.
  • 21. Marshak DR., Gardner RL. and Gottlieb D. Eds. Stem Cell Biology, Cold Spring Harbor, New York, 400-458.
  • 22. Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep. 2015;35(2):e00191.
  • 23. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood. 2003;101(8):2999-3001.
  • 24. Liu, L. Bone Marrow Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Periodontal Regeneration. Tissue Eng Part A.2021;27:962–976.
  • 25. Yoo SY, Lee JS, Cha JK, Kim SK, Kim CS. Periodontal healing using a collagen matrix with periodontal ligament progenitor cells in a dehiscence defect model in beagle dogs. J Periodontal Implant Sci. 2019;49;15–227.
  • 26. Oryan A, Kamali A, Moshiri A, Baghaban Eslaminejad M. Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence. Cells Tissues Organs. 2017;204(2):59-83.
  • 27. Kang HK. Osteogenic potential of embryonic stem cells in tooth sockets. Int J Mol Med. 2008;21:539–544.
  • 28. Inanç B, Elçin AE, Elçin YM. In Vitro Differentiation and Attachment of Human Embryonic Stem Cells on Periodontal Tooth Root Surfaces. Tissue Eng Part A. 2009;15(11):3427-3435.
  • 29. Ohazama A, Modino SAC, Miletich I, Sharpe PT. Stem-cell-based tissue engineering of murine teeth. J Dent Res. 2004;83:518–522.
  • 30. Wu HH, Guo Y, Pu YF, Tang ZH. Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs. Biosci Rep. 2021;41(3):192-207.
  • 31. Hynes K. Mesenchymal stem cells from iPS cells facilitate periodontal regeneration. J Dent Res. 2013;92:833–839.
  • 32. Yang H. Therapeutic effect of TSG-6 engineered iPSC-derived MSCs on experimental periodontitis in rats: A pilot study. PLoS One 2014;9(6):e100285.
  • 33. Houshmand B. Osteoblastic Differentiation of Human Stem Cells Derived from Bone Marrow and Periodontal Ligament Under the Effect of Enamel Matrix Derivative and Transforming Growth Factor-Beta. Int J Oral Maxillofac Implants. 2013;28:440–450.
  • 34. Mesimäki K. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg. 2009;38:201–209.
  • 35. Tobita M, Uysal CA, Guo X, Hyakusoku H, Mizuno H. Periodontal tissue regeneration by combined implantation of adipose tissue-derived stem cells and platelet-rich plasma in a canine model. Cytotherapy. 2013;15:1517–1526.
  • 36. Akita D, Kano K, Saito-Tamura Y. Use of Rat Mature Adipocyte-Derived Dedifferentiated Fat Cells as a Cell Source for Periodontal Tissue Regeneration. Front Physiol. 2016;7:50.
  • 37. Sharpe PT. Dental mesenchymal stem cells. Development. 2016;143:2273–2280.
  • 38. Asutay F, Polat S, Gül M, Subaşı C, Kahraman SA, Karaöz E. The effects of dental pulp stem cells on bone regeneration in rat calvarial defect model: micro-computed tomography and histomorphometric analysis. Arch Oral Biol. 2015;1729–1735.
  • 39. Mrozik KM, Wada N, Marino V, Richter W, Shi S, Wheeler DL, Gronthos S, et al. Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model. Regenerative Med. 2013;8:711–723.
  • 40. Shi H, Zong W, Xu X, Chen J. Improved biphasic calcium phosphate combined with periodontal ligament stem cells may serve as a promising method for periodontal regeneration. Am J Transl Res. 2018;10:4030.
  • 41. Duan X. İndüklenmiş pluripotent kök (iPS) hücrelerinin periodontal doku rejenerasyonunda uygulanması. Journal of cell. 2011;226,150–157.
  • 42. Tang HN, Xia Y, Yu Y, Wu RX, Gao LN, Chen FM. Stem cells derived from "inflamed" and healthy periodontal ligament tissues and their sheet functionalities: a patient-matched comparison. J Clin Periodontol. 2016;43(1):72-84.
  • 43. Zhai Q, Dong Z, Wang W, Li B, Jin Y. Dental stem cell and dental tissue regeneration. Front Med. 2019;13(2):152-159.
  • 44. Giuliani A, Manescu A, Langer M. Three years after transplants in human mandibles, histological and in-line holotomography revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications. Stem Cells Transl Med. 2013;2(4):316-324.
  • 45. Monti M, Graziano A, Rizzo S, Perotti C, Del Fante C, d'Aquino R, Redi CA, et al. In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental Pulp. J Cell Physiol. 2017;232:548–555.
  • 46. Ferrarotti F, Romano F, Gamba MN, Quirico A, Giraudi M, Audagna M, Aimetti M. Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. J Clin Periodontol. 2018;45(7):841-850.
  • 47. Cheng H, Chabok R, Guan X, Chawla A, Li Y, Khademhosseini A, Jang HL. Synergistic interplay between the two major bone minerals, hydroxyapatite and whitlockite nanoparticles, for osteogenic differentiation of mesenchymal stem cells. Acta Biomater. 2018; 69,342–351.
  • 48. Altıkat KM, Okte AE, Darıcı H. Evaluation of bone differential capacity of periodonsium origined mesenchimal stem cells in 2 and 3 dimensional culture environment. Doctoral thesis, Ankara: Gazi University, 2022: page: 110-120.

Evaluation of Stem Cell Applications in Periodontal Regenerative Therapy: A Current Perspective Between 2003-2022

Year 2024, Volume: 5 Issue: 1, 12 - 23, 05.07.2024

Abstract

The periodontium comprises the fundamental tissues of the tooth, namely the gingiva, periodontal ligament, cementum, and alveolar bone. Prolonged accumulation of microbial dental plaque on the tooth and gingival margin leads to pathological changes in the periodontal tissues. However, the mechanical and regenerative techniques employed to address the breakdown of periodontal tissue have been unsuccessful in fully restoring the periodontium to its original, disease-free condition. The growing understanding and recognition of the potential uses of stem cell therapy have led to the emergence of new perspectives on periodontal regeneration approaches. This review investigates mesenchymal stem cells and their use in periodontal regeneration treatment.

References

  • 1. Menne MC, Seitidis G, Faggion CM Jr, Mavridis D, Pandis N. Early Optimistic Effect in Periodontology and Implant Dentistry Trials. J Dent Res. 2022;101(1):30-36.
  • 2. Bartold PM, McCulloch CA, Narayanan AS, Pitaru S. Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology. Periodontol 2000. 2000;24:253-269.
  • 3. Sedghi LM, Bacino M, Kapila YL. Periodontal Disease: The Good, The Bad, and The Unknown. Front Cell Infect Microbiol. 2021;11:766-944.
  • 4. Annunziata M, Oliva A, Buonaiuto C. In vitro cell-type specific biological response of human periodontally related cells to platelet-rich plasma. J Periodontal Res. 2005;40(6):489-495.
  • 5. Garrett S. Periodontal regeneration around natural teeth. Ann Periodontol. 1996;1(1):621-666.
  • 6. Han J, Menicanin D, Gronthos S, Bartold PM. Stem cells, tissue engineering and periodontal regeneration. Aust Dent J. 2014;59 Suppl 1:117-130.
  • 7. Cortellini P, Pini Prato G, Tonetti MS. Periodontal regeneration of human infrabony defects. I. Clinical measures. J Periodontol. 1993;64(4):254-260.
  • 8. Smith MacDonald E, Nowzari H, Contreras A, Flynn J, Morrison J, Slots J. Clinical and microbiological evaluation of a bioabsorbable and a nonresorbable barrier membrane in the treatment of periodontal intraosseous lesions. J Periodontol. 1998;69(4):445-53. 9. Ivanovski S, Gronthos S, Shi S, Bartold PM. Stem cells in the periodontal ligament. Oral Dis. 2006;12(4):358-363.
  • 10. Sun E, Karaoz E. Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? Answers as transcriptomic aspect. Am J Stem Cells. 2020;9(4):57-67.
  • 11.Peterson B, Zhang J, Iglesias R. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng. 2005;11(1-2):120-129.
  • 12. Son YB, Kang YH, Lee HJ. Evaluation of odonto/osteogenic differentiation potential from different regions derived dental tissue stem cells and effect of 17β-estradiol on efficiency. BMC Oral Health. 2021;21(1):15.
  • 13. Kalra KTTP and Pushpa C. Tomar. Stem cell: basics, classification and applications. AJPCT. 2014;2(7):919-930.
  • 14. Langenbach F, Handschel J. Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Res Ther. 2013;4(5):117.
  • 15. Han J, Menicanin D, Gronthos S, Bartold PM. Stem cells, tissue engineering and periodontal regeneration. Aust Dent J. 2014;59:Suppl 1:117-130.
  • 16. Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol.1976;4(5):267-274.
  • 17. Longoni A, Utomo L, van Hooijdonk IE, Bittermann GK, Vetter VC, Kruijt Spanjer EC, Ross J, et al. The chondrogenic differentiation potential of dental pulp stem cells. Eur Cell Mater. 2020;39:121–135.
  • 18. Pei M. Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential. Biomaterials. 2017;117:10-23.
  • 19. Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019;8(8):886. 20. Volarevic V. Mesenchymal stem cell-derived factors: Immuno-modulatory effects and therapeutic potential. Bio-Factors. 2017;43:633–644.
  • 21. Marshak DR., Gardner RL. and Gottlieb D. Eds. Stem Cell Biology, Cold Spring Harbor, New York, 400-458.
  • 22. Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep. 2015;35(2):e00191.
  • 23. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood. 2003;101(8):2999-3001.
  • 24. Liu, L. Bone Marrow Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Periodontal Regeneration. Tissue Eng Part A.2021;27:962–976.
  • 25. Yoo SY, Lee JS, Cha JK, Kim SK, Kim CS. Periodontal healing using a collagen matrix with periodontal ligament progenitor cells in a dehiscence defect model in beagle dogs. J Periodontal Implant Sci. 2019;49;15–227.
  • 26. Oryan A, Kamali A, Moshiri A, Baghaban Eslaminejad M. Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence. Cells Tissues Organs. 2017;204(2):59-83.
  • 27. Kang HK. Osteogenic potential of embryonic stem cells in tooth sockets. Int J Mol Med. 2008;21:539–544.
  • 28. Inanç B, Elçin AE, Elçin YM. In Vitro Differentiation and Attachment of Human Embryonic Stem Cells on Periodontal Tooth Root Surfaces. Tissue Eng Part A. 2009;15(11):3427-3435.
  • 29. Ohazama A, Modino SAC, Miletich I, Sharpe PT. Stem-cell-based tissue engineering of murine teeth. J Dent Res. 2004;83:518–522.
  • 30. Wu HH, Guo Y, Pu YF, Tang ZH. Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs. Biosci Rep. 2021;41(3):192-207.
  • 31. Hynes K. Mesenchymal stem cells from iPS cells facilitate periodontal regeneration. J Dent Res. 2013;92:833–839.
  • 32. Yang H. Therapeutic effect of TSG-6 engineered iPSC-derived MSCs on experimental periodontitis in rats: A pilot study. PLoS One 2014;9(6):e100285.
  • 33. Houshmand B. Osteoblastic Differentiation of Human Stem Cells Derived from Bone Marrow and Periodontal Ligament Under the Effect of Enamel Matrix Derivative and Transforming Growth Factor-Beta. Int J Oral Maxillofac Implants. 2013;28:440–450.
  • 34. Mesimäki K. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg. 2009;38:201–209.
  • 35. Tobita M, Uysal CA, Guo X, Hyakusoku H, Mizuno H. Periodontal tissue regeneration by combined implantation of adipose tissue-derived stem cells and platelet-rich plasma in a canine model. Cytotherapy. 2013;15:1517–1526.
  • 36. Akita D, Kano K, Saito-Tamura Y. Use of Rat Mature Adipocyte-Derived Dedifferentiated Fat Cells as a Cell Source for Periodontal Tissue Regeneration. Front Physiol. 2016;7:50.
  • 37. Sharpe PT. Dental mesenchymal stem cells. Development. 2016;143:2273–2280.
  • 38. Asutay F, Polat S, Gül M, Subaşı C, Kahraman SA, Karaöz E. The effects of dental pulp stem cells on bone regeneration in rat calvarial defect model: micro-computed tomography and histomorphometric analysis. Arch Oral Biol. 2015;1729–1735.
  • 39. Mrozik KM, Wada N, Marino V, Richter W, Shi S, Wheeler DL, Gronthos S, et al. Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model. Regenerative Med. 2013;8:711–723.
  • 40. Shi H, Zong W, Xu X, Chen J. Improved biphasic calcium phosphate combined with periodontal ligament stem cells may serve as a promising method for periodontal regeneration. Am J Transl Res. 2018;10:4030.
  • 41. Duan X. İndüklenmiş pluripotent kök (iPS) hücrelerinin periodontal doku rejenerasyonunda uygulanması. Journal of cell. 2011;226,150–157.
  • 42. Tang HN, Xia Y, Yu Y, Wu RX, Gao LN, Chen FM. Stem cells derived from "inflamed" and healthy periodontal ligament tissues and their sheet functionalities: a patient-matched comparison. J Clin Periodontol. 2016;43(1):72-84.
  • 43. Zhai Q, Dong Z, Wang W, Li B, Jin Y. Dental stem cell and dental tissue regeneration. Front Med. 2019;13(2):152-159.
  • 44. Giuliani A, Manescu A, Langer M. Three years after transplants in human mandibles, histological and in-line holotomography revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications. Stem Cells Transl Med. 2013;2(4):316-324.
  • 45. Monti M, Graziano A, Rizzo S, Perotti C, Del Fante C, d'Aquino R, Redi CA, et al. In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental Pulp. J Cell Physiol. 2017;232:548–555.
  • 46. Ferrarotti F, Romano F, Gamba MN, Quirico A, Giraudi M, Audagna M, Aimetti M. Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. J Clin Periodontol. 2018;45(7):841-850.
  • 47. Cheng H, Chabok R, Guan X, Chawla A, Li Y, Khademhosseini A, Jang HL. Synergistic interplay between the two major bone minerals, hydroxyapatite and whitlockite nanoparticles, for osteogenic differentiation of mesenchymal stem cells. Acta Biomater. 2018; 69,342–351.
  • 48. Altıkat KM, Okte AE, Darıcı H. Evaluation of bone differential capacity of periodonsium origined mesenchimal stem cells in 2 and 3 dimensional culture environment. Doctoral thesis, Ankara: Gazi University, 2022: page: 110-120.
There are 46 citations in total.

Details

Primary Language English
Subjects Periodontics
Journal Section Review
Authors

Kadriye Merve Altıkat 0000-0001-8448-9365

Efe Töre

Publication Date July 5, 2024
Submission Date March 12, 2024
Acceptance Date June 27, 2024
Published in Issue Year 2024 Volume: 5 Issue: 1

Cite

APA Altıkat, K. M., & Töre, E. (2024). Evaluation of Stem Cell Applications in Periodontal Regenerative Therapy: A Current Perspective Between 2003-2022. Van Diş Hekimliği Dergisi, 5(1), 12-23.