Year 2020, Volume 11 , Issue 2, Pages 80 - 114 2020-08-28

PHARMACOTHERAPY of COVID-19
COVID-19 FARMAKOTERAPİSİ

Begüm YURDAKÖK DİKMEN [1] , Yağız PAT [2] , Ergin DİLEKOZ [3] , Gökçe Yağmur SUMMAK [4] , Oguz KUL [5] , Ayhan FİLAZİ [6]


The novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been described as a global pandemic. Regardless the efforts all over the world, there is still no effective treatment or vaccine. Therefore, prevention, early virus detection and identification methods are crutially important for disease control. Treatment protocols are constantly updated with the results of controlled randomized clinical trials; however, the majority of research with a large number of patients are still not concluded. Individualized medicine is forefront since there is no uniform drug application in treatment as the drug efficacy and safety changes with respect to individual differences (such as changing phenotype, other chronic diseases). Treatment protocols are constantly being updated and drug research using artificial intelligence/in silico methods for new compounds and drug repurposing gained prominence. This review provides updated information on some of the agents used in the treatment of COVID-19.
SARS-CoV-2'nin neden olduğu yeni koronavirüs hastalığı (COVID-19) global bir pandemi olarak tanımlanmıştır. Tüm dünyada yoğun araştırmalara karşın halen etkili bir tedavisi veya aşısı bulunmamaktadır. Bu nedenle korunma, erken virüs tespiti ve tanımlanma yöntemleri hastalığın kontrolü için önem taşımaktadır. Kontrollü randomize klinik araştırmaların sonuçları ile sürekli olarak tedavi protokolleri güncellenmektedir; ancak çok sayıda hasta ile yapılan araştırmaların çoğunluğu halen devam etmektedir. Bireysel farklılıklara (değişen fenotip, diğer kronik hastalıklar gibi) bağlı ilaç etkinliği ve güvenirliğine ilişkin değişiklikler nedeniyle tedavide tek tip ilaç uygulaması bulunmamaktadır. Tedavi protokolleri sürekli güncellenmektedir ve yapay zeka/in siliko araştırmalarla yeni ilaçların geliştirilmesi ve ilaç yeniden konumlandırma araştırmaları hızla devam etmektedir. Bu derleme, COVID-19 tedavisinde kullanılan bazı ajanlar hakkında güncel bilgi sunmaktadır.
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Primary Language tr
Subjects Veterinary Sciences
Journal Section Review
Authors

Orcid: 0000-0002-0385-3602
Author: Begüm YURDAKÖK DİKMEN (Primary Author)
Institution: ANKARA UNIVERSITY, ANKARA FACULTY OF VETERINARY MEDICINE
Country: Turkey


Orcid: 0000-0003-4268-4933
Author: Yağız PAT
Institution: ADNAN MENDERES ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0001-5868-364X
Author: Ergin DİLEKOZ
Institution: Gazı University
Country: Turkey


Orcid: 0000-0001-6274-3385
Author: Gökçe Yağmur SUMMAK
Institution: ANKARA ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-1282-650X
Author: Oguz KUL
Institution: KIRIKKALE ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-2800-6215
Author: Ayhan FİLAZİ
Institution: ANKARA ÜNİVERSİTESİ
Country: Turkey


Thanks Değerli bilimsel katkı ve yönlendirici önerilerinden dolayı Prof.Dr. Ş.Şefik Alkan'a teşekkürlerimizi sunarız.
Dates

Publication Date : August 28, 2020

APA Yurdakök Di̇kmen, B , Pat, Y , Di̇lekoz, E , Summak, G , Kul, O , Fi̇lazi̇, A . (2020). COVID-19 FARMAKOTERAPİSİ . Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni , 11 (2) , 80-114 . DOI: 10.38137/vetfarmatoksbulten.769889