Köpek ve kedilerde primer kemik tümörleri: 98 vaka

Year 2024, , 10 - 20, 15.01.2024

Arda Selin Tunç , Kürşat Filikci , Mehmet Sağlam , Osman Kutsal

https://doi.org/10.33188/vetheder.1363187

Abstract

Bu çalışmanın amacı kedi ve köpeklerde kemik tümörlerinin ırk, yaş, cinsiyet ve lokasyona göre dağılımını belirleyerek güncel literatüre katkı sağlamaktır. Kemik tümörleri köpeklerde kedilere göre daha yaygındır ve her iki türde de en sık görülen primer kemik tümörü osteosarkomdur. Ankara Üniversitesi Veteriner Fakültesi Patoloji Anabilim Dalı biyopsi ve nekropsi raporları, köpek ve kedilerde primer kemik tümörü olguları retrospektif olarak incelendi. Bu çalışmanın dönemi 2001'den 2020'ye kadar (20 yıl) kapsamaktadır. Köpeklerde 70, kedilerde 28 olmak üzere toplam 98 kemik tümörü tespit edildi. Köpeklerde görülen vakaların 13'ü (%18,57) nekropsi, 57'si (%81,43) ise biyopsi idi. Kemik tümörlerinin cinsiyet dağılımı dişi köpeklerde (n:28, %40) ve erkek köpeklerde (n:38, %54,29) görülmektedir. Ayrıca kedilerde dişilerde (n:17, %60,7) ve erkeklerde (n:11, %39,3) gözlendi. Köpeklerin %57,14'ü (n=40) safkan, %31,43'ü (n=22) melez ırk olmasına rağmen, kedilerde %75'i (n=21) melez ve %7,1'i (n=2) safkandı. Köpeklerde tümörlerin yerleşim yerleri apendiküler (%65,71, n=46), aksiyal (%30, n=21) iken, kedilerde tümörlerin yerleşim yerleri apendiküler (%50, n=14), aksiyel (%39,29, n=11) ve hem apendiküler hem de aksiyaldi (%10,71, n:3). Köpeklerde 13 benign (%18,57) ve 57 malign (%81,43) tümör görülürken, kedilerde 4 benign (%14,29) ve 24 malign (%85,71) tümör görüldü. Veriler SPSS programında analiz edilmiş ve veriler arasında anlamlı bir ilişki tespit edilememiştir (P>0.05). Bu çalışma kedi ve köpeklerin karşılaştırmalı onkolojisine katkı sağlayacak ve yol gösterecektir.

Keywords

kedi, kemik, köpek, primer, tümör

Ethical Statement

An ethical statement was received from the authors that the data, information and documents presented in this article were obtained within the framework of academic and ethical rules and that all information, documents, evaluations and results were presented in accordance with scientific ethics and moral rules.

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Thanks

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Primary bone tumors in dogs and cats: 98 cases

Abstract

The aim of this study is to contribute to the current literature by determining the distribution of bone tumors in dogs and cats by breed, age, gender and location. Bone tumors are more common in dogs than cats, and the most common primary bone tumor in both species is osteosarcoma. The biopsy and necropsy reports of the Ankara University, Faculty of Veterinary Medicine, Department of Pathology , were retrospectively studied examining for cases of primary bone tumors in dogs and cats. This study's period encompassed from 2001 through 2020 (20 years). A total of 98 bone tumors were detected 70 in dogs and 28 in cats. Of the cases in dogs, 13 (18.57%) were necropsy, while 57 (81.43%) were biopsy. Sex distribution of bone tumors is in female dogs (n:28, 40%) and in male dogs (n:38, 54.29%). Also, females (n:17, 60.7%) and males (n:11, 39.3%) were observed in cats. in dogs, although 57.14% (n=40) were purebreds and 31.43% (n=22) were mongrel breeds, in cats, 75% of them were mongrel (n=21) and 7.1% (n=2) were purebred. While locations of tumors in dogs were appendicular (65.71%, n=46), axial (30%, n=21), locations of tumors in cats were appendicular (50%, n=14), axial (39.29%, n=11) and both appendicular and axial (10.71%, n:3). While 13 benign (18.57%) and 57 malignant (81.43%) tumors were observed in dogs, 4 benign (14.29%) and 24 malignant (85.71%) tumors were observed in cats. The data were analyzed in the SPSS program and no significant relationship was detected between the data (P>0.05). This study would contribute and conduce the comparative oncology for dogs and cats.

Keywords

bone, cat, dog, primary, tumor

Project Number

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References

• Thompson KG, Dittmer KE. Tumors of bone. In: Meuten DJ, editor. Tumors in domestic animals. 5th ed. Iowa State Press: Ames, Wiley Black; 2017. p.356-424.
• Leonardi L. Tumor of the musculoskeletal system. In: Leonardi L, editor. Bone tumors in domestic animals: comparative clinical pathology. Springer; 2022. p.31-145.
• Quigley PJ, Leedale AH. Tumors involving bone in the domestic cat: a review of fifty-eight cases. Vet Pathol 1983;20(6):670-686.
• Shida T, Yamada T, Maruo T, Ishida T, Kawamura H, Takeda H, et al. A retrospective study in 1,070 feline tumor cases of Japan. Journal of the Japanese Veterinary Cancer Society 2010;1:1-7.
• Sabattini S, Renzi A, Buracco P, Defourny S, Garnier‐Moiroux M, Capitani O, Bettini G. Comparative assessment of the accuracy of cytological and histologic biopsies in the diagnosis of canine bone lesions. J Vet Intern Med 2017;31(3):864-871.
• Mangham DC, Athanasou NA. Guidelines for histopathological specimen examination and diagnostic reporting of primary bone tumours. Clin Sarcoma Res 2011;1(1):1-13.
• Trost ME, Kommers GD, Brown CC, Barros CS, Irigoyen LF, Fighera RA, et al. Primary bone neoplasms in dogs: 90 cases. Pesqui Vet Bras 2012;32:1329-1335.
• Kutsal O, Kaya Ü, Vural SA, Sağlam M. A survey of bone tumors in dogs and cats from 1986 to 2000 in Ankara. Turk J Vet Anim Sci 2003;27(1):109-115.
• Luna GL. Manual of histologic staining methods of the armed forces institute of pathology. McGraw Hill Book Co, New York; 1968.
• Harvey ND. How old is my dog? Identification of rational age groupings in pet dogs based upon normative age-linked processes. Front Vet Sci 2021;8: 643085.
• Quimby J, Gowland S, Carney HC, DePorter T, Plummer P, Westropp J. 2021 AAHA/AAFP feline life stage guidelines. J Feline Med Surg 2021;23(3):211-233.
• Al-Khan AA, Gunn HJ, Day MJ, Tayebi M, Ryan SD, Kuntz CA, et al. Immunohistochemical validation of spontaneously arising canine osteosarcoma as a model for human osteosarcoma. J Comp Pathol 2017;157(4):256-265.
• Beck J, Ren L, Huang S, Berger E, Bardales K, Mannheimer J, et al. Canine and murine models of osteosarcoma. Vet Pathol 2022;59(3):399-414.
• Selvarajah GT, Kirpensteijn J. Prognostic and predictive biomarkers of canine osteosarcoma. Vet J 2010;185(1):28-35.
• Fiani N, Arzi B, Johnson EG, Murphy B, Verstraete FJ. Osteoma of the oral and maxillofacial regions in cats: 7 cases (1999-2009). J Am Vet Med Assoc 2011;238(11):1470-1475.
• Ehrhart N. Longitudinal bone transport for treatment of primary bone tumors in dogs: technique description and outcome in 9 dogs. Vet Surg 2005;34(1):24-34.
• Volker MK, Luskin IR. Oral osteoma in 6 dogs. J Vet Dent 2014;31(2):88-91.
• Dernell WS, Straw RC, Withrow SJ. Tumors of the skeletal system. In: MacEwen E, editor. Small animal clinical oncology. 3rd ed. W.B. Saunders, Philadelphia; 2001. p.378-417.
• Thompson RR, Pool KG. Tumors of bones. In: Meuten DJ, editor. Tumors in domestic animals. 4th ed. Iowa State Press: Ames; 2002. p.245-318.
• Dittmer KE, Pemberton S. A holistic approach to bone tumors in dogs and cats: radiographic and histologic correlation. Vet Pathol 2021;58(5):841-857.