Cabergoline Administration after Ovariohysterectomy in a Queen with Fibroepithelial Hyperplasia

Year 2024, , 17 - 21, 30.06.2024

Tuğra Akkuş , Ömer Yaprakcı

https://doi.org/10.61262/vetjku.1471376

Abstract

In this case report, the diagnosis and treatment process of fibroepithelial hyperplasia developing in the mammary glands of an 11-month-old Tabby queen is presented. Anamnesis that the queen had been in estrus once before, it mammaries were gradually swollen in the last 15 days, her appetite and general condition were normal, and there was no previous progesterone administration. On physical examination, all mammary lobes were excessively tight bilaterally, swollen mammaries were gel-like and painless on palpation, hyperemia and milk secretion around the nipples were noted. Laboratory tests showed that serum progesterone level was 3.02 ng/mL and estrogen level was 5.2 pg/mL. Fibroepithelial hyperplasia was diagnosed based on anamnesis, clinical examination, and laboratory analysis. Ovariohysterectomy operation was performed as the treatment. One day after the operation, cabergoline was administered orally at a dose of 5 µg/kg/day for 5 days. At the two weeks-follow-up examination, a significant regression in the mammary glands size and a end of milk production were observed. In conclusion, fibroepithelial hyperplasia in the mammary glands of a young queen that was brought to our clinic were successfully cured endogenously by surgical method and exogenously by medical drug administration.

Keywords

Cabergoline, fibroepithelial hyperplasia, ovariohysterectomy, Queen

References

• Allen, H. L. (1973). Feline mammary hypertrophy. Veterinary Pathology, 10, 501-508. https://doi.org/10.1177/030098587301000603
• Baştan, A., Özenç, E., Pir, Y. İ., & Beceriklisoy, H. B. (2004). A case of mammary hypertrophy İn a female cat. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 51(2), 159-160.
• Bonatto, G. L., Gariba, V., Favero, L. J., Kano, N. N., de Sousa, R. S., & Albernaz, V. G. P. (2021). Mammary fibroepithelial hyperplasia in a male cat. Acta Scientiae Veterinariae, 49. https://doi.org/10.22456/1679-9216.111672
• Görlinger, S., Kooistra, H. S., Van den Broek, A., & Okkens, A. C. (2002). Treatment of fibroadenomatous hyperplasia in cats with aglepristone. Journal of Veterinary Internal Medicine, 16(6), 710-713. https://doi.org/10.1111/j.1939-1676.2002.tb02412.x
• Johnston, S. D., Kustritz, M.V. R., & Olson, P. N. S. (2001). Canine and Feline Theriogenology. Saunders, Philadelphia, PA.
• Keskin, A., Yilmazbas, G., Simsek, G., & Seyrek-Intas, K. (2008). Mammary hyperplasia in a pregnant queen. Australian Veterinary Practitoner, 2008, 38(2), 75-77.
• Kutzler, M., & Wood, A. (2006). Non-surgical methods of contraception and sterilization. Theriogenology, 66(3), 514-525. https://doi.org/10.1016/j.theriogenology.2006.04.014
• Küçükbekir, Ç., Uçmak, Z. G., Kirşan, İ., & Tek, Ç. (2020). A case of feline fibroepithelial hyperplasia in a male cat. Journal of Istanbul Veterinary Sciences, 4(1), 8-12. https://doi.org/10.30704/http-www-jivs-net.691787
• Loretti, A. P., Ilha, M. R. S., Breitsameter, I., & Faraco, C. S. (2004). Clinical and pathological study of feline mammary fibroadenomatous change associated with depot medroxyprogesterone acetate therapy. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 56, 270-274. https://doi.org/10.1590/S0102-09352004000200020
• Melo, E. H., Câmara, D. R., Notomi, M. K., Jabour, F. F., Garrido, R. A., Nogueira, A. C., & de Souza, F. W. (2021). Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment. Journal of Feline Medicine and Surgery, 23(4), 351-356. https://doi.org/10.1177/1098612X20950551
• Munson, L. (2006). Contraception in felids. Theriogenology, 66, 126-134. https://doi.org/10.1016/j.theriogenology.2006.03.016
• Nak, D., Nak, Y., Seyrek-Intas, K., & Kumru, I. H. (2004). Treatment of feline mammary fibroadenomatous hyperplasia with aglepristone. Australian Veterinary Practitoner, 34(4), 161-162.
• Silva, T., & Silva, F. (2012). Hiperplasia mamária felina: Um relato de caso. Enciclopédia Biosfera, Centro Científico Conhecer, 8(14), 634-640.
• Uçmak, M., Enginler, S., Gündüz, M., Kirşan, İ., & Sönmez, K. (2011). Treatment of feline mammary fibroepithelial hyperplasia with the combination of aglepristone and cabergoline. Journal of The Faculty of Veterinary Medicine, 37(1), 69-73.
• Vitasek, R., & Dendisova, H. (2006). Treatment of feline mammary fibroepithelial hyperplasia following a single injection of proligestone. Acta Veterinaria Brno, 75(2), 295-297. https://doi.org/10.2754/avb200675020295
• Voorwald, F. A., Lopes, C., Silveira, G. C., Lima, D. T., Silva, M. D. F. C. D., Andreão, N. B., & Toniollo, G. H. (2021). Severe mammary fibroepithelial hyperplasia due to single injection of medroxyprogesterone acetate in two male cats. Ciência Rural, 51, 1-9. https://doi.org/10.1590/0103-8478cr20200171.