Case Report
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Year 2022, Volume: 1 Issue: 2, 25 - 31, 31.12.2022

Abstract

References

  • Azumi, N., & Battifora, H. (1987). The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms: a comprehensive immunohistochemical formalin and alcohol-fixed tumors. American Journal of Clinical Pathology, 88(3), 286-296. https://doi.org/10.1093/ajcp/88.3.286
  • Baum, B., & Hewicker-Trautwein, M. (2015). Classification and epidemiology of mammary tumors in pet rabbits (Oryctolagus cuniculus). Journal of Comparative Pathology. 152(4), 291-298. https://doi.org/10.1016/j.jcpa.2015.01.009
  • Baum, B. (2021). Not just uterine adenocarcinoma-neoplastic and non-neoplastic masses in domestic pet rabbits (Oryctolagus cuniculus): a review. Veterinary Pathology, 58(5), 890-900. https://doi.org/10.1177/03009858211002190
  • Bertram, C. A., Bertram, B., Bartel, A., Ewringmann, A., Fragoso-Garcia, M. A., Erickson, N. A., Müller, K., & Klopfleisch, R. (2021). Neoplasia and tumor-like lesions in pet rabbits (Oryctolagus cuniculus): A retrospective analysis of cases between 1995 and 2019. Veterinary Pathology, 58(5), 901-911. https://doi.org/10.1177/0300985820973460
  • Cervantes-Arias, A., Pang, L. Y., & Argyle, D. J. (2013). Epithelial‐mesenchymal transition as a fundamental mechanism underlying the cancer phenotype. Veterinary and Comparative Oncology, 11(3), 169-184. https://doi.org/10.1111/j.14765829.2011.00313.x
  • Degner, S., Schoon, H. A., Laik-Schandelmaier, C., Aupperle-Lellbach, H., & Schöniger, S. (2018). Estrogen receptor-α and progesterone receptor expression in mammary proliferative lesions of female pet rabbits. Veterinary Pathology, 55, 838-848. https://doi.org/10.1177/0300985818788611
  • Hüdaverdi, E., & Kıran M. M. (2005). Veteriner onkoloji. Damla Ofset.
  • Jubb, K.V.F., Kennedy, P.C., & Palmer, N. (2012). Pathology of domestic animals. In: R.A. Foster, & M.G. Maxie (Ed.), Pathology of the Mammae (pp.451- 464). Academic Press.
  • Listrom, M. B., & Dalton, L.W. (1987). Comparison of keratin monoclonal antibodies MAK-6, AE1: AE3, and CAM-5.2., American Journal of Clinical Pathology, 88(3), 297-301. https://doi.org/10.1093/ajcp/88.3.297
  • Maertens, L., Lebas, F., & Szendrö, Z.S. (2006). Rabbit milk: A review of quantity, quality and non-dietary affecting factors. World Rabbit Science, 14, 205-230. https://doi.org/10.4995/wrs.2006.565
  • Raposo-Ferreira, T. M., Brisson, B. K., Durham, A. C., Laufer-Amorim, R., Kristiansen, V., Puré, E., Volk, S. V., & Sorenmo, K. (2018). Characteristics of the epithelial-mesenchymal transition in primary and paired metastatic canine mammary carcinomas. Veterinary Pathology, 55(5), 622-633. https://doi.org/10.1177/0300985818776054
  • Schöniger, S., Horn, L. C., & Schoon, H. A. (2014). Tumors and tumor-like lesions in the mammary gland of 24 pet rabbits: A histomorphological and immunohistochemical characterization. Veterinary Pathology, 51, 569-580. https://doi.org/10.1177/0300985813497486
  • Sikoski, P., Trybus, J., Cline, J. M., Muhammad, F. S., Eckhoff, A., Tan, J., Lockard, M., Jolley, T., Britt, S., & Kock, N. D. (2008). Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus). Comparative Medicine, 58, 297-300.
  • Walter, B., Poth T., Bohmer E., Braun, J., & Matis, U. (2010). Uterine disorders in 59 rabbits. Veterinary Record, 166(8), 230-233. https://doi.org/10.1136/vr.b4749

A case of cystic mammary adenocarcinoma in rabbit

Year 2022, Volume: 1 Issue: 2, 25 - 31, 31.12.2022

Abstract

Mammary adenocarcinomas are a type of malignant tumor frequently encountered in domestic animals. It is rarely seen in rabbits, most often in cats and dogs. In recent years, cases of mammary tumors in domestic rabbits have been increasing. Cases such as adenosquamous carcinomas, anaplastic carcinomas, carcinomas in situ, spindle cell carcinomas and carcinosarcomas have also been reported, most commonly in rabbits, along with variants of invasive adenocarcinomas. In this case, a biopsy sample taken from the mammary region of a 6-year-old female hybrid rabbit was examined histopathologically and immunohistochemically. As a result of the examinations, histopathologically, a large number of neoplastic cells with features of malignancy were found in the breast tissue. Cystic formations filled with proteinous material of varying sizes were found in the neoplastic tissue. Anti-cytokeratin and anti-vimentin expressions of neoplastic cells were observed in immunohistochemical findings. A diagnosis of mammary cystadenocarcinoma was made in the presence of histopathological and immunohistochemical findings. According to the authors' knowledge, the cyst adenocarcinoma variant is rarely encountered among mammary tumors observed in rabbits.

References

  • Azumi, N., & Battifora, H. (1987). The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms: a comprehensive immunohistochemical formalin and alcohol-fixed tumors. American Journal of Clinical Pathology, 88(3), 286-296. https://doi.org/10.1093/ajcp/88.3.286
  • Baum, B., & Hewicker-Trautwein, M. (2015). Classification and epidemiology of mammary tumors in pet rabbits (Oryctolagus cuniculus). Journal of Comparative Pathology. 152(4), 291-298. https://doi.org/10.1016/j.jcpa.2015.01.009
  • Baum, B. (2021). Not just uterine adenocarcinoma-neoplastic and non-neoplastic masses in domestic pet rabbits (Oryctolagus cuniculus): a review. Veterinary Pathology, 58(5), 890-900. https://doi.org/10.1177/03009858211002190
  • Bertram, C. A., Bertram, B., Bartel, A., Ewringmann, A., Fragoso-Garcia, M. A., Erickson, N. A., Müller, K., & Klopfleisch, R. (2021). Neoplasia and tumor-like lesions in pet rabbits (Oryctolagus cuniculus): A retrospective analysis of cases between 1995 and 2019. Veterinary Pathology, 58(5), 901-911. https://doi.org/10.1177/0300985820973460
  • Cervantes-Arias, A., Pang, L. Y., & Argyle, D. J. (2013). Epithelial‐mesenchymal transition as a fundamental mechanism underlying the cancer phenotype. Veterinary and Comparative Oncology, 11(3), 169-184. https://doi.org/10.1111/j.14765829.2011.00313.x
  • Degner, S., Schoon, H. A., Laik-Schandelmaier, C., Aupperle-Lellbach, H., & Schöniger, S. (2018). Estrogen receptor-α and progesterone receptor expression in mammary proliferative lesions of female pet rabbits. Veterinary Pathology, 55, 838-848. https://doi.org/10.1177/0300985818788611
  • Hüdaverdi, E., & Kıran M. M. (2005). Veteriner onkoloji. Damla Ofset.
  • Jubb, K.V.F., Kennedy, P.C., & Palmer, N. (2012). Pathology of domestic animals. In: R.A. Foster, & M.G. Maxie (Ed.), Pathology of the Mammae (pp.451- 464). Academic Press.
  • Listrom, M. B., & Dalton, L.W. (1987). Comparison of keratin monoclonal antibodies MAK-6, AE1: AE3, and CAM-5.2., American Journal of Clinical Pathology, 88(3), 297-301. https://doi.org/10.1093/ajcp/88.3.297
  • Maertens, L., Lebas, F., & Szendrö, Z.S. (2006). Rabbit milk: A review of quantity, quality and non-dietary affecting factors. World Rabbit Science, 14, 205-230. https://doi.org/10.4995/wrs.2006.565
  • Raposo-Ferreira, T. M., Brisson, B. K., Durham, A. C., Laufer-Amorim, R., Kristiansen, V., Puré, E., Volk, S. V., & Sorenmo, K. (2018). Characteristics of the epithelial-mesenchymal transition in primary and paired metastatic canine mammary carcinomas. Veterinary Pathology, 55(5), 622-633. https://doi.org/10.1177/0300985818776054
  • Schöniger, S., Horn, L. C., & Schoon, H. A. (2014). Tumors and tumor-like lesions in the mammary gland of 24 pet rabbits: A histomorphological and immunohistochemical characterization. Veterinary Pathology, 51, 569-580. https://doi.org/10.1177/0300985813497486
  • Sikoski, P., Trybus, J., Cline, J. M., Muhammad, F. S., Eckhoff, A., Tan, J., Lockard, M., Jolley, T., Britt, S., & Kock, N. D. (2008). Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus). Comparative Medicine, 58, 297-300.
  • Walter, B., Poth T., Bohmer E., Braun, J., & Matis, U. (2010). Uterine disorders in 59 rabbits. Veterinary Record, 166(8), 230-233. https://doi.org/10.1136/vr.b4749
There are 14 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Case Reports
Authors

Gözde Okuyucu 0000-0001-5433-3271

Volkan İpek 0000-0001-5874-7797

Zafer Özyıldız 0000-0002-6009-9191

Publication Date December 31, 2022
Submission Date November 2, 2022
Published in Issue Year 2022 Volume: 1 Issue: 2

Cite

APA Okuyucu, G., İpek, V., & Özyıldız, Z. (2022). A case of cystic mammary adenocarcinoma in rabbit. Veterinary Journal of Kastamonu University, 1(2), 25-31.