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Glioblastoma Gelişimi, Tanı ve Tedavisinde Eksozomların Rolü

Yıl 2024, Cilt: 5 Sayı: 3, 93 - 100, 31.07.2024

Öz

Glioblastoma multiforme (GBM) yetişkinlerde görülen en
agresif ve tedaviye dirençli primer beyin tümörlerinden biridir. Son yıllarda, hücreler arası iletişimde rol oynayan küçük
hücre dışı veziküller olan eksozomlar, kanser ilerlemesi ve
tedavi direncindeki rolleri nedeniyle büyük ilgi görmektedir.
Glioblastoma kaynaklı eksozomlar, tümör hücreleri, stromal
hücreler ve bağışıklık hücreleri arasında çift yönlü sinyalleşmeyi kolaylaştırarak, tümör mikroçevresinde hücreler arası
iletişimin kilit aracıları olarak ortaya çıkmaktadır. Bu eksozomlar, tümör biyolojisinin çeşitli yönlerini kolektif bir şekilde modüle eden proteinler, nükleik asitler ve lipidler dahil
olmak üzere çeşitli biyoaktif molekül kargoları taşır. Bu moleküllerin eksozom yolu ile transferi hedef hücrede proliferasyonunu, invazyonunu, anjiyogenezi, immün baskılanmayı
ve tedavi direncini teşvik eder. Bununla birlikte, glioblastomadan elde edilen eksozomlar, tanısal ve prognostik öneme
sahip zengin bir biyomolekül repertuvarı barındırır. Ayrıca,
eksozomlar glioblastoma tedavisi için umut verici terapötik
yollar da sunmaktadır. Küçük moleküllü ilaçlar, nükleik asitler ve immünomodülatör moleküller de dahil olmak üzere
terapötik kargoları tümör hücrelerine hedefli olarak iletmek
üzere tasarlanabilirler. Sonuç olarak, eksozomların glioblastom ilerlemesi, teşhisi ve tedavisindeki rollerinin anlaşılması,
kişiselleştirilmiş tıp için yeni terapötik stratejiler ve biyobelirteçler hakkında bir bilgi birikimi sağlar ve nihayetinde bu
zorlu hastalıkta hasta sonuçlarını iyileştirmeyi amaçlar. Bu
derleme, glioblastoma ve eksozomlar arasındaki çok yönlü
etkileşimin tümör ilerlemesi, tanı ve terapötik stratejilere katkılarına ışık tutmaktadır.

Kaynakça

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Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Yardımcı Sağlık ve Rehabilitasyon Bilimi (Diğer)
Bölüm Derlemeler
Yazarlar

Varol Güler

Sacide Pehlivan

Yayımlanma Tarihi 31 Temmuz 2024
Gönderilme Tarihi 7 Haziran 2024
Kabul Tarihi 16 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 5 Sayı: 3

Kaynak Göster

AMA Güler V, Pehlivan S. Glioblastoma Gelişimi, Tanı ve Tedavisinde Eksozomların Rolü. JMS. Temmuz 2024;5(3):93-100.