Bladder tumor in individuals under the age of 20: 3 Case reports

Abstract

Bladder cancer is the second most common urological cancer according to statistics and it is an important cause of mortality and morbidity. The median age of incidence of bladder cancer have been reported as 69 in men and 71 in women. Herein we presented 3 patients younger than 20 years old with transitional cell carcinoma of bladder (superficial, low grade according to the 2004 WHO/ISUP classification system) and discussed these patients in the light of the literature.  Despite the fact that transitional cell carcinoma of bladder is rare under the age of 20, patients with hematuria and risk factors for bladder cancer should be examined for bladder cancer regardless of age. 

Keywords

• Bladder tumor
• young
• occupational exposure
• smoking

20 yaş ve altında mesane tümörü: 3 Olgu sunumu

Abstract

Mesane kanserleri istatistiklere göre ikinci en sık görülen ürolojik kanser olup, mortalite ve morbiditenin önemli bir nedenini oluşturmaktadır. Mesane kanserinin erkeklerdeki görülme ortanca yaşı 69, kadınlarda 71 olarak bildirilmiştir. Bu çalışmada hematuri yakınmasıyla başvuran mesane karsinomu tanısı konan, transüretral rezeksiyon uygulanan ve histopatolojik inceleme sonucunda WHO/ ISUP 2004 sınıflamasına göre yüzeyel, düşük grade’li değişici epitel hücreli karsinom tanısı olan 20 yaş ve altında 3 olguyu nadir görülmesi nedeniyle sunmayı ve literatür bilgileri ile karşılaştırmayı amaçladık.  Değişici epitel hücreli mesane karsinomunun 20 yaşın altında nadir olduğu bilinmektedir. Ancak, semptomatik, sigara içme alışkanlığı olan ve riskli meslek gruplarında çalışan hastalarda yaşa bakılmaksızın mesane karsinomu araştırılmalıdır. 

Keywords

• Mesane tümörü
• genç
• mesleki maruziyet
• sigara

References

1. 1. Bandis SH, Muray T, Borden S. Cancer statistics. Ca Can- cer J Clin 1999;49:8-31.
2. 2. Loehrer P, Einhom LH, Elson PJ, Crawford ED, Kuebler P, Tannock I, et al. A randomized comparison of cispla- tin alone or in combination with methotrexate, vinblas- tine and doxorubicin in patients with metastatic ürothe- lial carcinoma: a Cooperative Group Study. J Clin Oncol 1992;10:1066-73.
3. 3. Madrid Garcia FJ, Parra Muntaner L, Rivas Escudero JA, Sanchez E, Monsalve Rodriguez M, Gomez Cisneros S et al. Transitional cell bladder carcinoma in patients younger than 40 years of age. Arch Esp Urol 1998;:991-4.
4. 4. Aydın S, Yılmaz Y, Özen S, Şengül E. 20 yaşında görülen değişici epitel hücreli mesane tümörü olgusu. Van Tıp Der- gisi 2001;8:102-4.
5. 5. Ward E, Halperin W, Thun M, Grossman HB, Fink B, Koss L et al. Bladder tumors in two young males occupationally exposed to MBOCA. Am J Ind Med 1988;14:267-72.
6. 6. Aboutaieb R, Dakir M, Sarrf I, el Moussaoui A, Bennani S, el Mrini M et al. Bladder tumors in young patients. Prog Urol 1998;8:43-6.
7. 7. Özbey I, Aksoy Y, Bicgi O, Polat O, Okyar G. Transitional cell carcinoma of the bladder in patients under 40 years of age. Int Urol Nephrol 1999;31:655-9.
8. 8. Ikeda I, Terao T, Nakagomi K, Masuda M, Hirokawa M. Recurrent transitional cell carcinoma of the bladder in a young woman: report of a case. Hinyokika Kiyo 1992; 38:1261-3.

9. 9. Laurenti C, De Dominicis C, Mattioli D, Rocchegiani A, Franco G, dal Forno S, et al. Transitional cell neoplasm of the bladder in childhood: presentation of a clinical case. Arch Esp Urol 1993;46:51-4.
10. 10. Yarmohammadi A, Ahmadnia H, Zare M. Transitional cell carcinoma in children: Report of a case and review of the literature. Urology Journal 2005;2:120-1.
11. 11. Linn JF, Sesterhann I, Mostofi FK, Schoenberg M. The mo- lecular characteristics of bladder cancer in young patients. J Urol 1998;159:1493.
12. 12. Wan J, Grosman HB. Bladder carcinoma in patients age 40 years or younger. Cancer 1989;64:178.
13. 13. Cole P, Hoover R, Friedell GH. Occupation and cancer of the lower urinary tract. Cancer 1972;29:1250.
14. 14. Case RAM, Hosker ME, McDonald DB, et al. Tumors of the urinary bladder in workmen engaged in the manufac- ture and use of certain dyestuff intermediates in the British chemical industry. Br J Ind Med 1954;11:75.
15. 15. Silverman DT, Levin LI, Hoover RN, et al. Occupational risk of bladder cancer in the United States: I. White men. J Natl Cancer Inst 1989;81:1472.
16. 16. Silverman DT, Levin LI, Hoover RN, et al. Occupational risk of bladder cancer in the United States: n. Nonwhite men. J Natl Cancer Inst 1989b;81:1480.
17. 17. Morrison AS, Cole P. Epidemiology of bladder cancer. Urol Clin North Am 1976;3:13.
18. 18. Burch JD, Rohan TE, Howe GR, et al. Risk of bladder can- cer by source and type of tobacco exposure: A case-control study. Int J Cancer 1989;44:622.
19. 19. Augustine A, Hebert JR, Kabat GC, et al. Bladder cancer in relation to cigarette smoking. Cancer Res 1988;48:4405.