Interstitial pneumonia: A rare complication after intravesical Mitomycin-C treatment for bladder tumor

Abstract

Sixty six years-old male patient, who underwent transurethral resection of bladder tumor and consequent intravesical Mitomycin-C chemotherapy, developed interstitial pneumonia. Forty mg intravesical Mitomycin-C was instillated weekly. Four days after the third instillation, the patient presented to emergency service with the complaint of progressive dyspnea. High resolution thorax tomography demonstrated ground glass opacity in the right upper and bilateral lower lobes, bilateral pleural effusion and interlobular septal thickening. Infection and collagen vascular disease were excluded. Symptomatic and radiological improvement achieved with discontinuation of intravesical Mitomycin-C and initiation of prednisolone treatment. Intravesical Mitomycin-C may cause rare systemic side effects like interstitial pneumonia. 

Keywords

• Mitomycin
• Lung Diseases
• Interstitial
• Pneumonia
• Urinary Bladder Neoplasms

İnterstisyel pnömoni: Mesane tümörü için uygulanan mesane içi Mitomycin-C tedavisinden sonra gelişen nadir bir komplikasyon

Abstract

Transüretral mesane tümörü rezeksiyonu sonrası mesane içi Mitomycin-C instilasyonu başlanan 66 yaşında bir erkek hastada interstisyel pnömoni gelişti. Hastaya haftalık 40 mg mesane içi Mitomycin-C uygulanmıştı ve üçüncü uygulamadan 4 gün sonra hasta acil servise ilerleyici dispne şikayeti ile başvurdu. Çekilen yüksek çözünürlüklü toraks tomografisinde akciğerin sağ üst ve her iki alt loblarında buzlu cam görüntüsü, iki taraflı plevral efüzyon ve interlobuler septal kalınlaşma görüntülendi. Akciğer infeksiyonu ve kollajen vasküler hastalıklar dışlandı. İnterstisyel pnömoni öntanısıyla Mitomycin-C tedavisinin bırakılıp prednizolon tedavisi başlanmasıyla semptomatik ve radyolojik iyileşme sağlandı. Mesane içi Mitomycin-C interstisyel pnömoni gibi nadir sistemik yan etkilere neden olabilir. 

Keywords

• İnterstisyel
• Pnömoni
• Mesane neoplazileri
• Mitomisin
• Akciğer Hastalıkları

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