Abstract
Introduction: Testicular tumors constitute 1-2% of male malignancies. It comes with painless testicular mass. In some cases, diagnosis is supported with serum parameters. In our study we examined the relationship between whole blood parameters and lymphadenopathy and metastatic in patients with testicular cancer.
Material and Method: In our clinic data of patients who underwent radical orchiectomy surgery with preoperatively diagnosed with testicular cancer between the years 2007-2014 were retrospectively evaluated. 108 patients who have testicular cancer in pathology report were included in our study. Whole blood parameters of patients with or without lymphadenopathy and metastasis were compared.
Results: The mean age of the patients were 34.6 ± 9.3. 39 of the patients included in the study had (36.11%) LAP, 14 (12.9%) had metastases. A statistically significant relationship was found between metastases and hematocrit, the number of white cells and platelets. Significant correlations were observed only in between lymphadenopathy and platelet count.
Conclusion: According to results of our study a relationship were detected between hematological parameters and metastasis and LAP. If these findings are supported by larger series we believe that it can be used in the management of testicular cancer.
Keywords
References
- 1. Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn- Cedermark G, Fizazi K, et al; European Association of Urology. EAU guidelines on testicular cancer: 2015 limited update. Eur Urol. Eur Urol 2015;68:1054-68.
- 2. Ilic D, Misso ML. Screening for testicular cancer. Cochrane Database Syst Rev 2011; 16:CD007853.
- 3. Shanmugalingam T, Soultati A, Chowdhury S, Rudman S, Van Hemelrijck M. Global incidence and outcome of testicular cancer. Clin Epidemiol 2013;17:417-27.
- 4. Horwich A, Shipley J, Huddart R. Testicular germ-cell cancer. Lancet 2006;367:754-65.
- 5. Tesfamariam B. Involvement of platelets in tumor cell metastasis. Pharmacol Ther 2016;157:112-9.
- 6. Lou XL, Sun J, Gong SQ, Yu XF, Gong R, Deng H. Interaction between circulating cancer cells and platelets: clinical implication. Chin J Cancer Res 2015;27:450-60.
- 7. Słabuszewska-Jóźwiak A, Dmoch-Gajzlerska E, Kozakiewicz B, Jakiel G. The prognostic significance of thrombocytosis in ovarian cancer. Ann Agric Environ Med. 2015;22:731-5.
- 8. Barber EL, Boggess JF, Van Le L, Kim KH, Bae-Jump VL, Brewster WR, Soper JT, Gehrig PA. Association of Preoperative Thrombocytosis and Leukocytosis With Postoperative Morbidity and Mortality Among Patients With Ovarian Cancer. Obstet Gynecol 2015;126:1191-7.
- 9. Baburao A, Narayanswamy H. Clinico-Pathological Profile and Haematological Abnormalities Associated with Lung Cancer in Bangalore, India. Asian Pac J Cancer Prev 2015;16:8235-8.
Abstract
Giriş: Testis tümörleri erkek malignitelerinin %1-2’sini oluşturmaktadır. Ağrısız testiküler kitle ile kendini gösterir. Bazı durumlarda serum parametreleri ile tanı desteklenir. Çalışmamızda testis tümörlü hastaların tam kan parametreleri ile metastaz ve lenfadenopati durumları arasındaki ilişki incelendi.
Yöntem ve Gereçler: Kliniğimizde 2007- 2014 yılları arasında testis tümörü öntanısı ile radikal orşiektomi ameliyatı yapılmış olan hastaların bilgileri geriye dönük olarak tarandı. Patoloji raporu testis tümörü olarak yorumlanan 108 hasta çalışmaya alındı. Lenfadenopatisi veya metastazı bulunan ve bulunmayan hastaların hemogram parametreleri ile karşılaştırıldı.
Bulgular: Çalışmaya alınan hastaların yaş ortalaması 34.6±9.3 olarak hesaplandı. Çalışmaya alınan hastaların 39’unda (%36.11) LAP, 14’ünde (%12.9) metastaz tespit edildi. Metastaz varlığı ile hemotokrit, beyaz küre ve trombosit sayıları arasında istatistiksel anlamlı ilişki tespit edildi. Bu parametrelerden sadece trombosit sayısı ile lenfadenopati varlığı arasında istatistiksel anlamlı korelasyon tespit edildi.
Sonuç: Çalışmamızın sonucunda elde edilen veriler ışığında hematolojik parametreler ile metastaz ve lenfadenopati varlığı arasında ilişki tespit edilmiştir. Bu bulguların daha geniş serilerle desteklenmesi durumunda testis kanserli hastaların takibinde kullanılabileceği kanaatindeyiz.
Keywords
References
- 1. Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn- Cedermark G, Fizazi K, et al; European Association of Urology. EAU guidelines on testicular cancer: 2015 limited update. Eur Urol. Eur Urol 2015;68:1054-68.
- 2. Ilic D, Misso ML. Screening for testicular cancer. Cochrane Database Syst Rev 2011; 16:CD007853.
- 3. Shanmugalingam T, Soultati A, Chowdhury S, Rudman S, Van Hemelrijck M. Global incidence and outcome of testicular cancer. Clin Epidemiol 2013;17:417-27.
- 4. Horwich A, Shipley J, Huddart R. Testicular germ-cell cancer. Lancet 2006;367:754-65.
- 5. Tesfamariam B. Involvement of platelets in tumor cell metastasis. Pharmacol Ther 2016;157:112-9.
- 6. Lou XL, Sun J, Gong SQ, Yu XF, Gong R, Deng H. Interaction between circulating cancer cells and platelets: clinical implication. Chin J Cancer Res 2015;27:450-60.
- 7. Słabuszewska-Jóźwiak A, Dmoch-Gajzlerska E, Kozakiewicz B, Jakiel G. The prognostic significance of thrombocytosis in ovarian cancer. Ann Agric Environ Med. 2015;22:731-5.
- 8. Barber EL, Boggess JF, Van Le L, Kim KH, Bae-Jump VL, Brewster WR, Soper JT, Gehrig PA. Association of Preoperative Thrombocytosis and Leukocytosis With Postoperative Morbidity and Mortality Among Patients With Ovarian Cancer. Obstet Gynecol 2015;126:1191-7.
- 9. Baburao A, Narayanswamy H. Clinico-Pathological Profile and Haematological Abnormalities Associated with Lung Cancer in Bangalore, India. Asian Pac J Cancer Prev 2015;16:8235-8.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | February 1, 2017 |
| Published in Issue | Year 2017 Volume: 12 Issue: 1 |