The Hemoglobin-Red Cell Distribution Width and Neutrophil -Lymphocyte Ratio in Predicting Lamina Propria Invasion in Bladder Tumors?

Year 2020, Volume: 15 Issue: 1, 11 - 18, 26.02.2020

Ali Rıza Türkoğlu , Yasemin Üstündağ , Soner Çoban , Muhammet Güzelsoy , Murat Öztürk , Atilla Satır Hakan Demirci , Kağan Huysal

https://doi.org/10.33719/yud.594637

Abstract

Purpose:
To investigate the importance of the Hemoglobin/Red cell distribution width
ratio (Hb/RDW) and Neutrophil/Lymphocyte ratio (NLR) in predicting bladder
lamina propria invasion before transurethral resection in non-muscular invasive
bladder cancer (NMIBC) patients

Methods:
The data of the patients whose pathology after transurethral resection of the
bladder was NMIBC between January 2010 and June 2016 were evaluated
retrospectively. Group 1 had Ta (mucosa involvement) and Group 2 had T1
(submucosa involvement) lesions. The age, gender, tumor size and number of
tumors of the patients were identified. The preoperative blood leucocyte (WBC),
hemoglobin (Hb), neutrophil (N), lymphocyte (L), monocyte (M), platelet (PLT),
mean platelet volume (MPV), and red cell distribution width (RDW) values were
identified and the NLR, PLR, LMR values calculated. The Hb/RDW ratio was
determined.

Results: A
total of 369 patients were evaluated. The mean age was similar between groups.
Group 1 (Ta) consisted of 219 patients (66.3±10.7 years) and Group 2 (T1) 150
patients (66.9±10.4 years) (p=0.638). NLR was higher in Group 2 than Group 1
(2.4 (1.5) and 2.2 (1.5), respectively, p=0.042) and this difference was
statistically significant. The Hb/RDW ratio in Group 2 was lower than in Group
1 (0.89±21 and 0.94±19, respectively, p=0.019) and this difference was
statistically significant.

Conclusion:
We believe that a decrease in the Hb/RDW ratio and increase in NLR, which can
be easily determined from the peripheral blood in the preoperative period, can
be associated with lamina propria invasion (T1). These studies should be
supported with prospective large series.

 

Keywords

Non-muscular invasive bladder cancer , Hemoglobin-red cell distribution width ratio , Neutrophil-lymphocyte ratio , Lamina propria invasion.

Mesane Tümörlerinde Hemoglobin-Redcell Distrubition Width Oranı (Hb/RDW) ve Neutrophil- Lymphocyte Oranı (NLR) Lamina Propria İnvazyonunu Tahmin Etmede Kullanılabilir mi?

Abstract

Amaç: Non-musculer
invazive bladder cancer (NMIBC) hastalarında Hemoglobin-Red cell Distrubition
Width oranı (Hb/RDW) ve Nötrofil/Lenfosit oranının (NLR) mesanenin transüretral
rezeksiyonu öncesi lamina propria invazyonunu önğörmede önemini araştırmak.

Materyal–methods: Ocak
2010- Haziran 2016 yılları arası mesanenin transüretral rezeksiyonu sonrası
patolojisi NMIBC olan hastaların verileri retrospektif değerlendirildi.
Hastalar Grup 1: Ta (mukoza tutulumu), Grup 2: T1 (submukoza tutulumu) olarak 2
gruba ayrıldılar. Hastaların yaşları, cinsiyetleri, tümör boyutu ve tümör
sayıları belirlendi. Preoperatif tam kan değerlerinden lökosit (WBC),
hemoglobin (Hb), nötrofil (N), lenfosit (L), monosit (M), platelet (PLT), mean
platelet volümü (MPV), Red cell Distrubition Width (RDW) değerleri belirlendikten
sonra NLR, PLR, LMR değerleri hesaplandı. Hb/RDW oranı belirlendi.

Bulgular: Patolojik
evresi NMIBC olan 369 hasta değerlendirildi. Gruplar arasında yaş farkı yoktu.
Grup 1 (Ta); 219 hasta, 66.3±10.7
yıl olup grup 2 (T1); 150 hasta,
66.9±10.4 yıl oldu (p=0.638). NLR grup 2’de grup 1’den yüksek
olup (sırasıyla 2.4 (1.5), 2.2 (1.5) ve p=0.042 ) istatistiksel olarak bu
yükseklik anlamlıdır. Gruplar arasında Hb ve RDW oranları bakımından farklılık
izlenmemesine rağmen Hb/RDW oranı grup 2’de grup 1’den düşüktür (sırasıyla
0.89±21, 0.94±19 ve p=0.019) ve istatistiksel olarak bu azalma anlamlıdır.  

Sonuç: Preoperatif
dönemde periferik kandan kolay yolla elde edilebilen Hb/RDW oranında azalma ve
NLR yükselmenin lamina propria invazyonu (T1) ile ilişkili olabileceğini
düşünmekteyiz. Bu çalışmaların prospektif geniş serili çalışmalarla
desteklenmesi gerekir.

Keywords

kasa invaze olmayan mesane kanseri , hemoglobin-red cell distrubition oranı , nötrofil-lenfosit oranı , lamina propria invazyonu

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