Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Emine Doğan; Burak Kaptaner; Abdulahad Doğan

doi:10.53433/yyufbed.1107438

EN TR

Toxic Effects of Bisphenol F on Rat Pancreas

Abstract

In this study, it was aimed to investigate the toxic effects of bisphenol F (BPF) on rat pancreas. Toward this aim, twenty eight male Wistar albino rats were exposed to BPF at concentrations of 0, 20, 100, and 500 mg/kg of body weight (b.w.) via oral gavage for 28 days. According to the histological examinations, the presence of cells displaying vacuolar degeneration in the pancreatic Langerhans islets was determined after BPF exposure. Histomorphometric measurements demonstrated that averages of the islet diameter and area decreased in the groups exposed to BPF concentrations of 100 and 500 mg/kg of b.w. In addition, the percentage of immunohistochemically-stained insulin-positive  cells in the islets was determined to have diminished significantly at all of the groups exposed to BPF. The levels of serum fasting glucose, total blood HbA1c, serum C-peptide or insulin did not display significant changes after BPF exposure. BPF was determined to lead significant changes in the antioxidant defense system indicators of the pancreas, except for the malondialdehyde level. The results obtained herein showed that more attention should be given regarding the usage of BPF instead of bisphenol A as a safe alternative in industrial areas.

Keywords

β cell, Antioxidant indicators, Bisphenol F, Histopathology, Pancreas

Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Abstract

Bu çalışmada, bisfenol F (BPF)’nin sıçan pankreası üzerindeki toksik etkilerinin belirlenmesi amaçlandı. Bu amaç doğrultusunda yirmi sekiz adet Wistar albino erkek sıçan, BPF’ye 0, 20, 100 ve 500 mg/kg vücut ağırlığı (v.a.) konsantrasyonlarda, 28 gün boyunca oral gavaj ile maruz bırakıldı. Histolojik incelemelere göre BPF maruziyeti sonrasında, pankreatik Langerhans adacıklarında vakuolar dejenerasyon gösteren hücrelerin varlığı tespit edildi. Histomorfolojik ölçümler, BPF’nin 100 ve 500 mg/kg v.a. konsantrasyonlarına maruz bırakılan gruplarda, adacık çap ve alan ortalamalarının düştüğünü gösterdi. Ek olarak, adacıklarda immunohistokimyasal olarak boyayan insülin pozitif  hücre yüzdesinin, BPF uygulanan bütün gruplarda, anlamlı bir şekilde azaldığı tespit edildi. Serum açlık glukoz, total kan HbA1c ve serum C-peptid ile insülin seviyelerinin, BPF maruziyeti sonrasında anlamlı değişimler göstermedikleri gözlendi. BPF’nin malondialdehit düzeyi dışında, pankreas antioksidan savunma sistemi belirteçlerinde anlamlı değişimlere yol açtığı belirlendi. Elde edilen sonuçlar BPF’nin endüstriyel alanlarda, bisfenol A yerine güvenilir bir alternatif olarak, kullanımına daha fazla dikkat edilmesi gerektiğini göstermektedir.

Keywords

β hücresi, Antioksidan belirteçler, Bisfenol F, Histopatoloji, Pankreas

Supporting Institution

Van Yüzüncü Yıl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

FYL-2021-9360

Thanks

Bu çalışma Van Yüzüncü Yıl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi (Van YYÜ BAPB) tarafından, “FYL-2021-9360” numaralı proje olarak desteklenmiştir. Van YYÜ BAPB’na, sağladığı maddi destekten dolayı, teşekkür ederiz.

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Research Article

Authors

Emine Doğan
0000-0002-4484-5625
Türkiye

Burak Kaptaner ^*
0000-0003-2366-6756
Türkiye

Abdulahad Doğan
0000-0002-5438-8560
Türkiye

Publication Date

August 30, 2022

Submission Date

April 22, 2022

Acceptance Date

June 9, 2022

Published in Issue

Year 2022 Volume: 27 Number: 2

DOI

https://doi.org/10.53433/yyufbed.1107438

IZ

https://izlik.org/JA79ZR86LG

APA

Doğan, E., Kaptaner, B., & Doğan, A. (2022). Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 27(2), 436-451. https://doi.org/10.53433/yyufbed.1107438

AMA

1.Doğan E, Kaptaner B, Doğan A. Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. YYU JINAS. 2022;27(2):436-451. doi:10.53433/yyufbed.1107438

Chicago

Doğan, Emine, Burak Kaptaner, and Abdulahad Doğan. 2022. “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 27 (2): 436-51. https://doi.org/10.53433/yyufbed.1107438.

EndNote

Doğan E, Kaptaner B, Doğan A (August 1, 2022) Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 27 2 436–451.

IEEE

[1]E. Doğan, B. Kaptaner, and A. Doğan, “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”, YYU JINAS, vol. 27, no. 2, pp. 436–451, Aug. 2022, doi: 10.53433/yyufbed.1107438.

ISNAD

Doğan, Emine - Kaptaner, Burak - Doğan, Abdulahad. “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 27/2 (August 1, 2022): 436-451. https://doi.org/10.53433/yyufbed.1107438.

JAMA

1.Doğan E, Kaptaner B, Doğan A. Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. YYU JINAS. 2022;27:436–451.

MLA

Doğan, Emine, et al. “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 27, no. 2, Aug. 2022, pp. 436-51, doi:10.53433/yyufbed.1107438.

Vancouver

1.Emine Doğan, Burak Kaptaner, Abdulahad Doğan. Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. YYU JINAS. 2022 Aug. 1;27(2):436-51. doi:10.53433/yyufbed.1107438

Toxic Effects of Bisphenol F on Rat Pancreas

Abstract

Keywords

Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Abstract

Keywords

Supporting Institution

Project Number

Thanks

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Details

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Published in Issue

DOI

IZ

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