Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Emine Doğan; Burak Kaptaner; Abdulahad Doğan

doi:10.53433/yyufbed.1107438

EN TR

Toxic Effects of Bisphenol F on Rat Pancreas

Öz

In this study, it was aimed to investigate the toxic effects of bisphenol F (BPF) on rat pancreas. Toward this aim, twenty eight male Wistar albino rats were exposed to BPF at concentrations of 0, 20, 100, and 500 mg/kg of body weight (b.w.) via oral gavage for 28 days. According to the histological examinations, the presence of cells displaying vacuolar degeneration in the pancreatic Langerhans islets was determined after BPF exposure. Histomorphometric measurements demonstrated that averages of the islet diameter and area decreased in the groups exposed to BPF concentrations of 100 and 500 mg/kg of b.w. In addition, the percentage of immunohistochemically-stained insulin-positive  cells in the islets was determined to have diminished significantly at all of the groups exposed to BPF. The levels of serum fasting glucose, total blood HbA1c, serum C-peptide or insulin did not display significant changes after BPF exposure. BPF was determined to lead significant changes in the antioxidant defense system indicators of the pancreas, except for the malondialdehyde level. The results obtained herein showed that more attention should be given regarding the usage of BPF instead of bisphenol A as a safe alternative in industrial areas.

Anahtar Kelimeler

β cell, Antioxidant indicators, Bisphenol F, Histopathology, Pancreas

Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Öz

Bu çalışmada, bisfenol F (BPF)’nin sıçan pankreası üzerindeki toksik etkilerinin belirlenmesi amaçlandı. Bu amaç doğrultusunda yirmi sekiz adet Wistar albino erkek sıçan, BPF’ye 0, 20, 100 ve 500 mg/kg vücut ağırlığı (v.a.) konsantrasyonlarda, 28 gün boyunca oral gavaj ile maruz bırakıldı. Histolojik incelemelere göre BPF maruziyeti sonrasında, pankreatik Langerhans adacıklarında vakuolar dejenerasyon gösteren hücrelerin varlığı tespit edildi. Histomorfolojik ölçümler, BPF’nin 100 ve 500 mg/kg v.a. konsantrasyonlarına maruz bırakılan gruplarda, adacık çap ve alan ortalamalarının düştüğünü gösterdi. Ek olarak, adacıklarda immunohistokimyasal olarak boyayan insülin pozitif  hücre yüzdesinin, BPF uygulanan bütün gruplarda, anlamlı bir şekilde azaldığı tespit edildi. Serum açlık glukoz, total kan HbA1c ve serum C-peptid ile insülin seviyelerinin, BPF maruziyeti sonrasında anlamlı değişimler göstermedikleri gözlendi. BPF’nin malondialdehit düzeyi dışında, pankreas antioksidan savunma sistemi belirteçlerinde anlamlı değişimlere yol açtığı belirlendi. Elde edilen sonuçlar BPF’nin endüstriyel alanlarda, bisfenol A yerine güvenilir bir alternatif olarak, kullanımına daha fazla dikkat edilmesi gerektiğini göstermektedir.

Anahtar Kelimeler

β hücresi, Antioksidan belirteçler, Bisfenol F, Histopatoloji, Pankreas

Destekleyen Kurum

Van Yüzüncü Yıl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

FYL-2021-9360

Teşekkür

Bu çalışma Van Yüzüncü Yıl Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi (Van YYÜ BAPB) tarafından, “FYL-2021-9360” numaralı proje olarak desteklenmiştir. Van YYÜ BAPB’na, sağladığı maddi destekten dolayı, teşekkür ederiz.

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Araştırma Makalesi

Yazarlar

Emine Doğan
0000-0002-4484-5625
Türkiye

Burak Kaptaner ^*
0000-0003-2366-6756
Türkiye

Abdulahad Doğan
0000-0002-5438-8560
Türkiye

Yayımlanma Tarihi

30 Ağustos 2022

Gönderilme Tarihi

22 Nisan 2022

Kabul Tarihi

9 Haziran 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 27 Sayı: 2

DOI

https://doi.org/10.53433/yyufbed.1107438

IZ

https://izlik.org/JA79ZR86LG

APA

Doğan, E., Kaptaner, B., & Doğan, A. (2022). Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 27(2), 436-451. https://doi.org/10.53433/yyufbed.1107438

AMA

1.Doğan E, Kaptaner B, Doğan A. Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. YYUFBED. 2022;27(2):436-451. doi:10.53433/yyufbed.1107438

Chicago

Doğan, Emine, Burak Kaptaner, ve Abdulahad Doğan. 2022. “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 27 (2): 436-51. https://doi.org/10.53433/yyufbed.1107438.

EndNote

Doğan E, Kaptaner B, Doğan A (01 Ağustos 2022) Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 27 2 436–451.

IEEE

[1]E. Doğan, B. Kaptaner, ve A. Doğan, “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”, YYUFBED, c. 27, sy 2, ss. 436–451, Ağu. 2022, doi: 10.53433/yyufbed.1107438.

ISNAD

Doğan, Emine - Kaptaner, Burak - Doğan, Abdulahad. “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 27/2 (01 Ağustos 2022): 436-451. https://doi.org/10.53433/yyufbed.1107438.

JAMA

1.Doğan E, Kaptaner B, Doğan A. Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. YYUFBED. 2022;27:436–451.

MLA

Doğan, Emine, vd. “Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri”. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 27, sy 2, Ağustos 2022, ss. 436-51, doi:10.53433/yyufbed.1107438.

Vancouver

1.Emine Doğan, Burak Kaptaner, Abdulahad Doğan. Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri. YYUFBED. 01 Ağustos 2022;27(2):436-51. doi:10.53433/yyufbed.1107438

Toxic Effects of Bisphenol F on Rat Pancreas

Öz

Anahtar Kelimeler

Bisfenol F’nin Sıçan Pankreası Üzerindeki Toksik Etkileri

Öz

Anahtar Kelimeler

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster