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Traditional, Phytochemical, Nutritional and Biological Importance of Pithecellobium dulce (Roxib.) Benth

Year 2024, Volume: 34 Issue: 2, 354 - 380, 30.06.2024
https://doi.org/10.29133/yyutbd.1329407

Abstract

Pithecellobium dulce (P. dulce) is described in this review in terms of its botanical features, traditional uses, phytoconstituents, biological activities, and nutritional value. The aril of the fruit is consumed raw as food in many countries like India for its sweet taste. The plant phytoconstituents possess anti-ulcerogenic, anti-microbial, anti-inflammatory, and anti-diabetic properties. The plant’s different extracts contain a variety of bioactive phytochemicals, including flavonoids, saponins, and tannins. People have been paying attention to medicinal plants over the past few years due to their incredible significance in the medication discovery process, their effectiveness, safety, and lack of negative side effects. P. dulce is a highly regarded plant in traditional medicine because of its diverse biological and nutraceutical properties. This review covers information regarding traditional uses, nutritional values, phytochemicals, and pharmacological activities of the different extracts as well as the pure compounds isolated from P. dulce's different parts and extracts.

References

  • Akter, M., Hasan, M. M., Barmon, J., Akhter, S., Parvin, M. S., & Islam, M. E. (2020). In vitro assessment of antioxidant activity and anti-bacterial screening of Pithecellobium dulce leaves against resistant bacteria. Journal of Pharmacognosy and Phytochemistry, 9(1), 2016–2022.
  • Akter, M., Parvin, M. S., Hasan, M. M., Rahman, M. A. A., & Islam, M. E. (2022). Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves. BMC Complementary Medicine and Therapies, 22(1). https://doi.org/10.1186/s12906-022-03633-x
  • Aldarhami, A., Bazaid, A. S., Alhamed, A. S., Alghaith, A. F., Ahamad, S. R., Alassmrry, Y. A., Alharazi, T., Snoussi, M., Qanash, H., Alamri, A., Badraoui, R., Kadri, A., Binsaleh, N. K., & Alreshidi, M. (2023). Antimicrobial Potential of Pithecellobium dulce Seed Extract against Pathogenic Bacteria: In Silico and In Vitro Evaluation. BioMed Research International, 2023. https://doi.org/10.1155/2023/2848198
  • Alhamed, A. S., Alqinyah, M., Alghaith, A. F., Algahtani, M. M., Alqahtani, F., Nasr, F. A., Alqahtani, A. S., Noman, O. M., Bazaid, A. S., Almalki, R. H., Abdel Rahman, A. M., Alhazzani, K., & Alanazi, A. Z. (2023). Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells. Open Chemistry, 21(1). https://doi.org/10.1515/chem-2023-0362
  • Bagchi, S., & Jayaram, K. K. (2016). Studies on water soluble polysaccharides from Pithecellobium dulce (Roxb.) Benth. seeds. Carbohydrate Polymers, 138, 215–221. https://doi.org/https://doi.org/10.1016/j.carbpol.2015.11.018
  • Bautista, B. S., García, D. E., Barrera, N. L. L., Reyes, C. R., & Wilson, C. L. (2003). Seasonal evaluation of the postharvest fungicidal activity of powders and extracts of huamuchil Pithecellobium dulce: Action against Botrytris cinerea, Penicillium digitatum and Rhizopus stolonifer of strawberry fruit. Postharvest Biology and Technology, 29(1), 81–92. https://doi.org/10.1016/S0925-5214(02)00244-2
  • Bhat, M. A., Malik, R. A., Prakash, P., & Lone, A. M. (2018). Preparation and evaluation of antibacterial potential of Pithecellobium dulce root extract against gram positive and gram negative bacteria. Microbial Pathogenesis, 116, 49–53. https://doi.org/10.1016/j.micpath.2018.01.013
  • Bobade, A. (2017). Methanolic extraction and isolation of bioactive chemicals from Pithecellobium dulce leaves by column chromatography and GC-MS studies. Research Journal of Chemical Science, 7(1), 49–52.
  • Bobade, A. (2019). GC-MS Analysis of Bioactive Compound in Ethanolic Extract of Pithecellobium dulce Leaves. Acta Scientific Pharmaceutical Sciences, 3(11), 08–13. https://doi.org/10.31080/ASPS.2019.03.0412
  • Chandran, P. G. R., & Balaji, S. (2008). Phytochemical Investigation and Pharmocological Studies of the Flowers of Pithecellobium dulce. Ethnobotanical Leaflets, 12, 245–253.
  • Dhanisha, S. S., Drishya, S., & Guruvayoorappan, C. (2022b). Traditional knowledge to clinical trials: A review on nutritional and therapeutic potential of Pithecellobium dulce. Journal of Basic and Clinical Physiology and Pharmacology, 33(2), 133–142. https://doi.org/10.1515/jbcpp-2020-0166
  • Dhanisha, S., Drishya, S., & Guruvayoorappan, C. (2022a). Pithecellobium dulce inhibits pulmonary metastasis induced by B16F10 melanoma cells in C57BL/6 via regulating EGFR/STAT/ NFκB /AKT signaling axis. Journal of Food Biochemistry, 46(12), 1–20. https://doi.org/10.1111/jfbc.14466
  • Dhanisha, S., Drishya, S., Mony, R., & Guruvayoorappan, C. (2021). Polyphenolic rich fraction of Pithecellobium dulce attenuates methotrexate induced oxidative stress and associated tissue injury by regulating the TNF α, IL 1β and IL 6 pro inflammatory cytokines . International Journal of Functional Nutrition, 2(3). https://doi.org/10.3892/ijfn.2021.17
  • Dhivya, D., & Niranjan, B. M. (2013). Anticonvulsant Activity of The Crude Flavonoid Fraction of Pithecellobium dulce Leaf. Asian Journal of Phytomedicine and Clinical Research, 1(3), 160–166.
  • Govindarajan, M., & Rajeswary, M. (2015). Repellent properties of Pithecellobium dulce (Roxb.) Benth. (Family: Fabaceae) against filariasis vector, Culex quinquefasciatus Say (Diptera: Culicidae). Journal of Medicinal Herbs and Ethnomedicine, 1(1) 103–107. https://doi.org/10.5455/jmhe.2015-08-018
  • Govindarajan M., & Rajeswary M. (2014). Mosquito larvicidal and ovicidal properties of Pithecellobium dulce (Roxb.) Benth. (Fabaceae) against Culex quinquefasciatus Say (Diptera: Culicidae). Journal of Coastal Life Medicine, 2(4), 308-312. https://doi.org/10.12980/jclm.2.2014b583
  • Govindarajan, M., Rajeswary, M., & Sivakumar, R. (2013). Larvicidal and ovicidal efficacy of Pithecellobium dulce (Roxb.) Benth. (Fabaceae) against Anopheles stephensi Liston and Aedes aegypti Linn. (Diptera: Culicidae) M. The Indian Journal of Medical Research (IJMR), 138(1), 129–134.
  • Hepzibah, W., Vajida, J., & Balaji, M. (2017). Studies on Antibacterial activity of Pithecellobium dulce (Roxb.) Benth against food pathogens-Gram negative bacteria. International Journal of Novel Trends in Pharmaceutical Sciences, 7(3), 76–80. https://scienztech.org/index.php/ijntps/article/view/221
  • Idris, M., Soni, H., Hetal, S., & Amit, A. (2020). Determination of Antimicrobial Activity Using Methanolic Extract of Pithecellobium dulce Plant Leaves. Indian Journal of Applied Research, 10(3). https://doi.org/10.36106/ijar
  • Jagadeeshwar, K., Kulandaivelu, U., Alavala, R. R., Koteswara, R. G. S. N., Prasanth, D. S. N. B. K., & Sreeharsha, N. (2021). Evaluation of anti-obesity of Pithecellobium dulce against high fat diet induced obesity in experimental animals. Research Journal of Pharmacy and Technology, 14(3), 1447–1452. https://doi.org/10.5958/0974-360X.2021.00258.4
  • Jalique, S. M. (2017). ID2010 Cytotoxicity of aqueous and ethanolic bark extracts of Pithecellobium dulce against human carcinoma cells. Biomedical Research and Therapy, 4(5), S44. https://doi.org/10.15419/bmrat.v4iS.253
  • Jamshidi, K. F., Lorigooini, Z., & Amini, K. H. (2018). Medicinal plants: Past history and future perspective. Journal of Herbmed Pharmacology, 7(1), 1-7. https://doi.org/10.15171/jhp.2018.01
  • Kalavani, R., Sabitha, B. R., Jeyanthi, K. A., Sankari, T. U., & Kanna, A. V. (2016). Evaluation of anti-inflammatory and antibacterial activity of Pithecellobium dulce (Benth) extract. Biotechnol Res, 2(4), 148–154.
  • Katekhaye, S. D., & Kale, M. S. (2012). Antioxidant and free radical scavenging activity of Pithecellobium dulce (Roxb.) Benth wood bark and leaves. Free Radicals and Antioxidants, 2(3), 47–57. https://doi.org/10.5530/ax.2012.3.7
  • Katekhaye, S. D., & Laddha, K. S. (2015). Coumarins and a Triterpenoid from Pithecellobium dulce. Chemistry of Natural Compounds, 51(5), 956–958. https://doi.org/10.1007/s10600-015-1460-z
  • Katekhaye, S. D., & Nagmoti, D. M. (2013). α-Glucosidase and α-amylase inhibitory activities of Pithecellobium dulce bark and leaves. Phytopharmacology, 4(1), 123–130.
  • Kirthy, R., Komara, V P. K., & Mogal, S. B. (2022). Nutritional, Health and Therapeutic Benefits of Pithecellobium dulce. Agriculture and Food, 4(10), 231–233.
  • Knauth, P., Acevedo, H. G. J., Cano, M. E., Gutiérrez, L. M., & López, Z. (2018). In Vitro Bioactivity of Methanolic Extracts from Amphipterygium adstringens (Schltdl.) Schiede ex Standl., Chenopodium ambrosioides L., Cirsium mexicanum DC., Eryngium carlinae F. Delaroche, and Pithecellobium dulce (Roxb.) Benth. Used in Traditional Medicine in Mexico. Evidence-Based Complementary and Alternative Medicine, 2018. https://doi.org/10.1155/2018/3610364
  • Kotb, S. S., Ayoub, I. M., El-Moghazy, S. A., & Singab, A. N. B. (2020). Profiling the Lipophilic Fractions of Pithecellobium dulce Bark and Leaves Using GC/MS and Evaluation of Their Antioxidant, Antimicrobial and Cytotoxic Activities. Chemistry and Biodiversity, 17(7). https://doi.org/10.1002/cbdv.202000048
  • Kotb, S. S., Ayoub, I. M., El-Moghazy, S. A., Nasser Singab, A. B., and Iriny Ayoub, A. M. (2022). Phytochemical analysis of Pithecellobium dulce (Roxb) Benth Bark via UPLC-ESI-MS/MS and Evaluation of its Biological Activity. Natural Product Research, 38(8), 1424–1429. https://doi.org/10.1080/14786419.2022.2140153
  • Kulkarni, K. V., & Jamakhandi, V. R. (2018). Medicinal uses of Pithecellobium dulce and its health benefits. Journal of Pharmacognosy and Phytochemistry, 7(2), 700–704.
  • Kumar, M., Govindrajan, J., & Nyola, N. (2017). Antihyperglycemic potential of saponin-enriched fraction from Pithecellobium dulce Benth. seed extract. Pharmacognosy Research, 9(5), S23–S26. https://doi.org/10.4103/pr.pr_18_17
  • Kumar, M., Nehra, K., & Duhan, J. (2013). Phytochemical analysis and antimicrobial efficacy of leaf extracts of Pithecellobium dulce. Asian Journal of Pharmaceutical and Clinical Research, 6(1), 70–76. https://www.researchgate.net/publication/260613163
  • Kumari, S. (2017). Evaluation of phytochemical analysis and antioxidant and antifungal activity of Pithecellobium dulce leaves extract. Asian Journal of Pharmaceutical and Clinical Research, 10(1), 370–375. https://doi.org/10.22159/ajpcr.2017.v10i1.15576
  • Lakshmi, Y.S., Mala, D., Gopalakrishnan, S., Banu, F., & Brindha, V. (2014). Antimicrobial Activity of Silver Nanoparticles from Pithecellobium dulce. Indian Journal of Nano Science, 2(7), 1–3, July 2014.
  • López, A. G., Verdugo, G. S. E., Montes, A. J., Díaz, C. S. P., Miranda, S. V., Salazar, S. N. Y., & Delgado, V. F. (2019). Bioguided isolation of N-malonyl-(+)-tryptophan from the fruit of Pithecellobium dulce (Roxb.) Benth. that showed high activity against Hymenolepis nana. Natural Product Research, 35(4), 593–599. https://doi.org/10.1080/14786419.2019.1590709
  • López, Z., Joel, S. F., Knauth, P., Villarruel, J. B., López, Z., Solís, D. B., Rico, J., Salazar, J., & Knauth, P. (2013). Cytotoxicological effects and antimicrobial activity of Pithecellobium dulce (Guamúchil) extracts. Ethnopharmacology, September, Morelia (Mich.), Mexico. https://www.researchgate.net/publication/279804207_Cytotoxicological_effects_and_antimicrobial_activity_of_Pithecellobium_dulce_Guamuchil_extracts.
  • Manna, P., Bhattacharyya, S., Das, J., Ghosh, J., & Sil, P. C. (2011). Phytomedicinal role of Pithecellobium dulce against CCl4 mediated hepatic oxidative impairments and necrotic cell death. Evidence-Based Complementary and Alternative Medicine, 2011. https://doi.org/10.1093/ecam/neq065
  • Megala, J., & Geetha, A. (2010). Free radical-scavenging and H+, K+-ATPase inhibition activities of Pithecellobium dulce. Food Chemistry, 121(4), 1120–1128. https://doi.org/10.1016/j.foodchem.2010.01.059
  • Megala, J., & Geetha, A. (2012a). Acute and sub-acute toxicity study of hydroalcoholic fruit extract of Pithecellobium dulce. Natural Product Research, 26(12), 1167–1171. https://doi.org/10.1080/14786419.2011.562206
  • Megala, J., & Geetha, A. (2012b). Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. Journal of Ethnopharmacology, 142(2), 415–421. https://doi.org/10.1016/j.jep.2012.05.011
  • Megala, J., & Geetha, A. (2015). Effect of Pithecellobium dulce (Roxb.) Benth. fruit extract on cysteamine induced duodenal ulcer in rats. Indian Journal of Experimental Biology, 53, 657–664.
  • Mishra, N., Srivastava, V., Hashmi, A., Awasthi, H., Deep, P., and Verma, S. (2021). Pharmacological screening of ethanolic extract of Pithecellobium dulce for antiarthritic activity in Rats. Indian Journal of Natural Products and Resources, 12(3), 418ــ 424. https://doi.org/10.56042/ijnpr.v12i3.31100
  • Mule, V. S., Naikwade, N. S., Magdum, C. S., & Jagtap, V. A. (2016). Effect of Pithecellobium dulce benth leaves in dexamethasone induced diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences, 8(9), 317–320. https://doi.org/10.22159/ijpps.2016v8i9.12988
  • Mule, V. S., Potdar V. H., Jadhav S. D., & Disouza J. I. (2011). Neuropharmacological Profile of Aqueous and Ethanolic Extract of Pithecellobium dulce Benth Leaves in Mice. Research J. of Pharmacology and Pharmacodynamics, 3(1), 27–30. https://www.researchgate.net/publication/227859952
  • Murugesan, S., Lakshmanan, D. K., Arumugam, V., & Alexander, R. A. (2019). Nutritional and therapeutic benefits of medicinal plant Pithecellobium dulce (Fabaceae): A review. Journal of Applied Pharmaceutical Science, 9(7), 130–139. https://doi.org/10.7324/JAPS.2019.90718
  • Nagendr, M., Mani, D., S., Ravi, S., D., Swarnalatha, D., Nagendra, M., & Jyotshna, T. (2019). In vitro anti-inflammatory activity of aqueous extract of Pithecellobium dulce. Journal of Pharmacognosy and Phytochemistry, 8(5), 200–201.
  • Nagmoti, D. M., & Juvekar, A. R. (2013). In vitro inhibitory effects of Pithecellobium dulce (Roxb.) Benth. seeds on intestinal-glucosidase and pancreatic-amylase. Journal of Biochemical Technology, 4(3), 616–621.
  • Nagmoti, D. M., Kothavade, P. S., Bulani, V. D., Gawali, N. B., & Juvekar, A. R. (2015). Antidiabetic and antihyperlipidemic activity of Pithecellobium dulce (Roxb.) Benth seeds extract in streptozotocin-induced diabetic rats. European Journal of Integrative Medicine, 7(3), 263–273. https://doi.org/10.1016/j.eujim.2015.01.001
  • Nigam, S. K., Gopal, M., Uddin, R., Yoshikawa, K., Miwako, K., & Arihara, S. (1997). Pithedulosides A-G, Oleanane Glycosides from Pithecellobium dulce. Phytochemistry, 44(7), 1329–1334. https://doi.org/10.1016/s0031-9422(96)00725-x
  • Olmedo, J. A., Jimenez, C. A. L., Bugarin, A., Zamilpa, A., Gives, P. M., Villa, M. A., López, A. M. E., Olivares, P. J., Delgado, N. E. J., & González, C. M. (2022). Phenolic Acids and Flavonoids from Pithecellobium dulce (Robx.) Benth Leaves Exhibit Ovicidal Activity against Haemonchus contortus. Plants, 11(19). https://doi.org/10.3390/plants11192555
  • Orwa, C., Mutua, A., Kindt, R., Jamnadass, R., & Anthony, S. (2009). Agroforestree Database: a tree reference and selection guide version 4.0. World Agroforestry Centre, Kenya. http://worldagroforestry.org/output/agroforestree-database/. Access date: July 1.
  • Pal, P. B., Pal, S., Manna, P., & Sil, P. C. (2012). Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death. Pathophysiology, 19(2), 101–114. https://doi.org/10.1016/j.pathophys.2012.02.001
  • Palanivel, Agrawal, S. K., Manjulvani, Senthil, K. K., Karthikeyan, V., Periyasamy., & Sivakumar GM. (2014). Evaluation of Anti-Ulcer Activity of Pithecellobium dulce (Seeds) In Rats Using Pylorus Ligation. World Journal Of Pharmacy And Pharmaceutical Sciences, 3(3), 2175–2184.
  • Pithayanukul, P., Ruenraroengsak, P., Bavovada, R., Pakmanee, N., Suttisri, R., & Saen-Oon, S. (2005). Inhibition of Naja kaouthia venom activities by plant polyphenols. Journal of Ethnopharmacology, 97(3), 527–533. https://doi.org/10.1016/j.jep.2004.12.013
  • Ponmozhi, P., Geetha, M., Saravana, K. M., & Devi, P. S. (2011). Extraction of Anthocyanin and Analysing Its Antioxidant Properties from Pithecellobium dulce Fruit Pericarp. Asian Journal of Pharmaceutical and Clinical Research, 4(1), 41– 45.
  • Poongodi, T., & Hemalatha, R. (2015). In Vitro Cytotoxicity, Phytochemistry and Gc-Ms Analysis of Pithecellobium dulce Leaves. World Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 1266–1276.
  • Pradeepa, S., Subramanian, S., & Kaviyarasan, V. (2013). Biochemical evaluation of antidiabetic properties of Pithecellobium dulce fruits studied in streptozotocin induced experimental diabetic rats.International Journal of Herbal Medicine, 1(4), 21–28.
  • Praveen, A., Prasath, K., Kalyan, B., & Babu, I. (2010). Antidiabetic activity of bark extract of Pithecellobium dulce benth in alloxan-induced diabetic rats. Natural Product An Indian Journal (NPAIJ), 6(4), 201–204.
  • Praylin, S., Research, S., Singh, S. P., & Kumar, S. P. (2015). In vitro antidiabetic activity of compounds from Pithecellobium dulce fruit peel. International Journal of Pharmaceutical Chemistry, 5(4). https://doi.org/10.7439/ijpc
  • Rajan, S., & kumar, R. T. (2010). Hypolipidemic activity of Pithecellobium dulce Benth. in Triton Wr-1339 Induced Hyperlipidemic Rats. International Journal of Chemical and Pharmaceutical Sciences, 1(2), 50–53.
  • Raju, K., & Jagadeeshwar, K. (2014). Phytochemical Investigation and Hepatoprotective Activity of Ripe Fruits of Pithecellobium dulce in Albino Rats. Scholars Academic Journal of Pharmacy (SAJP), 3(6), 449–454.
  • Raman, N., Sudharsan, S., Veerakumar, V., Pravin, N., & Vithiya, K. (2012). Pithecellobium dulce mediated extra-cellular green synthesis of larvicidal silver nanoparticles. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 96, 1031–1037. https://doi.org/10.1016/j.saa.2012.08.011
  • Rao, B. G., Samyuktha, P., Ramadevi, D., & Heera, B. (2018). Review of Literature: Phytopharmacological Studies on Pithecellobium dulce. Journal of Global Trends in Pharmaceutical Sciences, 9(1), 4797–4807.
  • Roselin, C., & Parameshwari, S. (2022). A systematic review on the materialistic use of Pithecellobium dulce in food formulations. Materials Today: Proceedings, 66, 996–1001. https://doi.org/10.1016/j.matpr.2022.04.779
  • Sahu, N. P., & Mahato, S. B. (1994). Anti-Inflammatory Triterpene Saponins of Pithecellobium dulce: Characterization of An Echinocystic Acid Bisdesmoside. Phytochemistry, 37(5), 1425–1427. https://doi.org/https://doi.org/10.1016/s0031-9422(00)90425-4
  • Saxena, V. K., & Singal, M. (1998). Genistein 4’-O-α-L-rhamnopyranoside from Pithecellobium dulce. Fitoterapia, 69(1), 305–306.
  • Saxena, V. K., & Singhal, M. (1999). Novel prenylated flavonoid from stem of Pithecellobium dulce. Fitoterapia, 70, 98–100. https://doi.org/10.1016/S0367-326X(98)00012-4
  • Selvan, S. A., & Muthukumaran, P. (2011). Analgesic and anti-inflammatory activities of leaf extract of Pithecellobium dulce Benth. International Journal of PharmTech Research CODEN, 3(1), 337–341.
  • Shanmugakumar., S.D, Amerjothy.S, & Balakrishna.K. (2006). Pharmacognostical, Antibacterial and Antifungal potentials of the leaf extracts of Pithecellobium dulce Benth. Pharmacognosy Magazine, 2(7), 163–167.
  • Sharma, M. (2016). Selective cytotoxicity and modulation of apoptotic signature of breast cancer cells by Pithecellobium dulce leaf extracts. Biotechnology Progress, 32(3), 756–766. https://doi.org/10.1002/btpr.2261
  • Shweta, S. (2013). A review on pharmacological activities of Pithecellobium dulce extract, and there effective doses. Journal of Medical Pharmaceutical and Allied Sciences, 5, 35–45. www.jmpas.com
  • Singh, R..L., & Mamta, S. (2013). Oxidative DNA damage protective activity and antioxidant and hepatoprotective potentials of Pithecellobium dulce plant. J Nutr Food Sci, 3(4), 2nd International Conference and Exhibition on Nutritional Science and Therapy, July 15-17, Marriott Philadelphia Downtown, USA. https://doi.org/http://dx.doi.org/10.4172/2155-9600.S1.010
  • Sneha, D., Prashanth, S., Kaveti, V. S., & Boggula, N. (2020). Systematic Review of Pithecellobium dulce (Roxb.) Benth.: A Traditional Medicinal Herb. Journal For Innovative Development in Pharmaceutical and Technical Science (JIDPTS), 3(5), 1–9.
  • Srinivas, G., Geeta, H., Shashikumar, J., & Champawat. (2018). A review on Pithecellobium dulce: A potential medicinal tree. International Journal of Chemical Studies, 6(2), 540–544.
  • Sugumaran, M., Vetrichelvan, T., & Darlin Quine, S. (2009). Anti inflammatory activity of Folklore: Pithecellobium dulce Benth. Research J. Pharm. and Tech, 2(4).
  • Sugumaran, M., Vertichelvan, T., & Darlin Quine, S. (2008). Anticonvulsant Activity of Folklore Pithecellobium Dulce Benth. Biomedical & Pharmacology Journal, 1(1), 223–225.
  • Sugumaran, M., Vetrichelvan, T., & Quine, S. D. (2008a). Antidiarrhoeal activity on leaf extracts of Pithecellobium dulce extract. Biosciences, Biotechnology Research Asia, 5(1), 421–424.
  • Sugumaran, M., Vetrichelvan, T., & Quine, S. D. (2008b). Locomotor Activity of Leaf extracts of Pithecellobium dulce Benth. Ethnobotanical Leaflets, 12, 490–493.
  • Sukantha, T. A., Sripathi, S. K., & Ravindran, N. T. (2014). Antibacterial activity of selected medicinal plant in traditional treatment of wound infection in southeast India. International Journal of Pharmacy and Pharmaceutical Sciences, 6(11), 511ــ513. https://www.researchgate.net/publication/274062544
  • Sukantha, T. A., Sripathi, S. K., & Ravindran, N. T. (2016). Anti-Diabetic Activity of Aqueous Extract oof Pithecellobium dulce Benth Fruit Peel on Streptozotocin Induced Diabetic Rats. Journal of Advances in Chemistry , 12(15), 4807–4815.
  • Sukantha, T. A., Sripathi, S. K., Ravindran, N. T., & Balashanmugam, P. (2011). Evaluation of In Vitro Antioxidant and Antibacterial Activity of Pithecellobium dulce Benth Fruit Peel. International Journal of Current Research, 3(11), 378–382. https://www.researchgate.net/publication/230688534
  • Sul, K., Chaware, V., & Redasani, V. (2021). Evaluation of Hepatoprotective Activity of Leaves Extract of Pithecellobium dulce In Experimental Animals. Asian Journal of Pharmaceutical Research and Development, 9(4), 39–46. https://doi.org/10.22270/ajprd.v9i4985
  • Thangarajan, P., Anumanthan, A., Venkatachalam, U., Sivakumar, S., & Somaskanda, C. (2015). Cardioprotective Activity of Pithecellobium dulce Fruit Peel on Isoproterenol-Induced Myocardial Infarction in Rats. Int. J. Pharm. Sci. Rev. Res, 30(1), 133–136.
  • Toudji, G. A., Damintoti, K. S., & Yao, A. (2017). Acute and sub-acute toxicity of Pithecellobium dulce (Roxb.) Benth. stem bark hydroalcoholic extract on Wistar rats. Journal of Pharmacy and Pharmacognosy Research, 5(5), 310–319. https://www.researchgate.net/publication/318795837
  • Vanitha, V., & Manikandan, K. (2016). Bio-activity Guided Determination of Active Compounds in the Leaves of Pithecellobium dulce. RASĀYAN Journal of Chemistry (RJC), 9(3), 471–477.
  • Vargas, M. Á. F., Kuri, G. A., Vargas, M. H., Chávez, S. J. L., Ferriz, M. R. A., Hernández, S. L. G., & Guzmán, M. S. H. (2020). Phenolic profile and antioxidant capacity of Pithecellobium dulce (Roxb) Benth: a review. Journal of Food Science and Technology, 57(12), 4316–4336. https://doi.org/10.1007/s13197-020-04453-y
  • Venu, C., Ramanjaneyulu, K., Satish, R. N., Vijaya, L. B., & Bhavana, A. (2016). Evaluation of antidiarrhoeal activity of ethanolic extracts of Pithecellobium dulce on castor oil-induced diarrhoea in albino Wistar rats. Discovery, 52(246), 1494–1496.
  • Wichaidit, W., & Thongyoo, P. (2023). A novel γ-lactone isolated from the leaves of Pithecellobium dulce (Roxb.) Benth. and its xanthine oxidase activity. Natural Product Research, 37(7), 1168–1176. https://doi.org/10.1080/14786419.2021.1999943
  • Yoshikawa, K., Suzaki, Y., Tanaka, M., Arihara, S., & Nigam, S. K. (1997). Three Acylated Saponins and a Related Compound from Pithecellobium dulce. Journal of Natural Products, 60(12), 1269–1274. https://doi.org/10.1021/np9703555
Year 2024, Volume: 34 Issue: 2, 354 - 380, 30.06.2024
https://doi.org/10.29133/yyutbd.1329407

Abstract

References

  • Akter, M., Hasan, M. M., Barmon, J., Akhter, S., Parvin, M. S., & Islam, M. E. (2020). In vitro assessment of antioxidant activity and anti-bacterial screening of Pithecellobium dulce leaves against resistant bacteria. Journal of Pharmacognosy and Phytochemistry, 9(1), 2016–2022.
  • Akter, M., Parvin, M. S., Hasan, M. M., Rahman, M. A. A., & Islam, M. E. (2022). Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves. BMC Complementary Medicine and Therapies, 22(1). https://doi.org/10.1186/s12906-022-03633-x
  • Aldarhami, A., Bazaid, A. S., Alhamed, A. S., Alghaith, A. F., Ahamad, S. R., Alassmrry, Y. A., Alharazi, T., Snoussi, M., Qanash, H., Alamri, A., Badraoui, R., Kadri, A., Binsaleh, N. K., & Alreshidi, M. (2023). Antimicrobial Potential of Pithecellobium dulce Seed Extract against Pathogenic Bacteria: In Silico and In Vitro Evaluation. BioMed Research International, 2023. https://doi.org/10.1155/2023/2848198
  • Alhamed, A. S., Alqinyah, M., Alghaith, A. F., Algahtani, M. M., Alqahtani, F., Nasr, F. A., Alqahtani, A. S., Noman, O. M., Bazaid, A. S., Almalki, R. H., Abdel Rahman, A. M., Alhazzani, K., & Alanazi, A. Z. (2023). Phytochemical analysis and anticancer activity of the Pithecellobium dulce seed extract in colorectal cancer cells. Open Chemistry, 21(1). https://doi.org/10.1515/chem-2023-0362
  • Bagchi, S., & Jayaram, K. K. (2016). Studies on water soluble polysaccharides from Pithecellobium dulce (Roxb.) Benth. seeds. Carbohydrate Polymers, 138, 215–221. https://doi.org/https://doi.org/10.1016/j.carbpol.2015.11.018
  • Bautista, B. S., García, D. E., Barrera, N. L. L., Reyes, C. R., & Wilson, C. L. (2003). Seasonal evaluation of the postharvest fungicidal activity of powders and extracts of huamuchil Pithecellobium dulce: Action against Botrytris cinerea, Penicillium digitatum and Rhizopus stolonifer of strawberry fruit. Postharvest Biology and Technology, 29(1), 81–92. https://doi.org/10.1016/S0925-5214(02)00244-2
  • Bhat, M. A., Malik, R. A., Prakash, P., & Lone, A. M. (2018). Preparation and evaluation of antibacterial potential of Pithecellobium dulce root extract against gram positive and gram negative bacteria. Microbial Pathogenesis, 116, 49–53. https://doi.org/10.1016/j.micpath.2018.01.013
  • Bobade, A. (2017). Methanolic extraction and isolation of bioactive chemicals from Pithecellobium dulce leaves by column chromatography and GC-MS studies. Research Journal of Chemical Science, 7(1), 49–52.
  • Bobade, A. (2019). GC-MS Analysis of Bioactive Compound in Ethanolic Extract of Pithecellobium dulce Leaves. Acta Scientific Pharmaceutical Sciences, 3(11), 08–13. https://doi.org/10.31080/ASPS.2019.03.0412
  • Chandran, P. G. R., & Balaji, S. (2008). Phytochemical Investigation and Pharmocological Studies of the Flowers of Pithecellobium dulce. Ethnobotanical Leaflets, 12, 245–253.
  • Dhanisha, S. S., Drishya, S., & Guruvayoorappan, C. (2022b). Traditional knowledge to clinical trials: A review on nutritional and therapeutic potential of Pithecellobium dulce. Journal of Basic and Clinical Physiology and Pharmacology, 33(2), 133–142. https://doi.org/10.1515/jbcpp-2020-0166
  • Dhanisha, S., Drishya, S., & Guruvayoorappan, C. (2022a). Pithecellobium dulce inhibits pulmonary metastasis induced by B16F10 melanoma cells in C57BL/6 via regulating EGFR/STAT/ NFκB /AKT signaling axis. Journal of Food Biochemistry, 46(12), 1–20. https://doi.org/10.1111/jfbc.14466
  • Dhanisha, S., Drishya, S., Mony, R., & Guruvayoorappan, C. (2021). Polyphenolic rich fraction of Pithecellobium dulce attenuates methotrexate induced oxidative stress and associated tissue injury by regulating the TNF α, IL 1β and IL 6 pro inflammatory cytokines . International Journal of Functional Nutrition, 2(3). https://doi.org/10.3892/ijfn.2021.17
  • Dhivya, D., & Niranjan, B. M. (2013). Anticonvulsant Activity of The Crude Flavonoid Fraction of Pithecellobium dulce Leaf. Asian Journal of Phytomedicine and Clinical Research, 1(3), 160–166.
  • Govindarajan, M., & Rajeswary, M. (2015). Repellent properties of Pithecellobium dulce (Roxb.) Benth. (Family: Fabaceae) against filariasis vector, Culex quinquefasciatus Say (Diptera: Culicidae). Journal of Medicinal Herbs and Ethnomedicine, 1(1) 103–107. https://doi.org/10.5455/jmhe.2015-08-018
  • Govindarajan M., & Rajeswary M. (2014). Mosquito larvicidal and ovicidal properties of Pithecellobium dulce (Roxb.) Benth. (Fabaceae) against Culex quinquefasciatus Say (Diptera: Culicidae). Journal of Coastal Life Medicine, 2(4), 308-312. https://doi.org/10.12980/jclm.2.2014b583
  • Govindarajan, M., Rajeswary, M., & Sivakumar, R. (2013). Larvicidal and ovicidal efficacy of Pithecellobium dulce (Roxb.) Benth. (Fabaceae) against Anopheles stephensi Liston and Aedes aegypti Linn. (Diptera: Culicidae) M. The Indian Journal of Medical Research (IJMR), 138(1), 129–134.
  • Hepzibah, W., Vajida, J., & Balaji, M. (2017). Studies on Antibacterial activity of Pithecellobium dulce (Roxb.) Benth against food pathogens-Gram negative bacteria. International Journal of Novel Trends in Pharmaceutical Sciences, 7(3), 76–80. https://scienztech.org/index.php/ijntps/article/view/221
  • Idris, M., Soni, H., Hetal, S., & Amit, A. (2020). Determination of Antimicrobial Activity Using Methanolic Extract of Pithecellobium dulce Plant Leaves. Indian Journal of Applied Research, 10(3). https://doi.org/10.36106/ijar
  • Jagadeeshwar, K., Kulandaivelu, U., Alavala, R. R., Koteswara, R. G. S. N., Prasanth, D. S. N. B. K., & Sreeharsha, N. (2021). Evaluation of anti-obesity of Pithecellobium dulce against high fat diet induced obesity in experimental animals. Research Journal of Pharmacy and Technology, 14(3), 1447–1452. https://doi.org/10.5958/0974-360X.2021.00258.4
  • Jalique, S. M. (2017). ID2010 Cytotoxicity of aqueous and ethanolic bark extracts of Pithecellobium dulce against human carcinoma cells. Biomedical Research and Therapy, 4(5), S44. https://doi.org/10.15419/bmrat.v4iS.253
  • Jamshidi, K. F., Lorigooini, Z., & Amini, K. H. (2018). Medicinal plants: Past history and future perspective. Journal of Herbmed Pharmacology, 7(1), 1-7. https://doi.org/10.15171/jhp.2018.01
  • Kalavani, R., Sabitha, B. R., Jeyanthi, K. A., Sankari, T. U., & Kanna, A. V. (2016). Evaluation of anti-inflammatory and antibacterial activity of Pithecellobium dulce (Benth) extract. Biotechnol Res, 2(4), 148–154.
  • Katekhaye, S. D., & Kale, M. S. (2012). Antioxidant and free radical scavenging activity of Pithecellobium dulce (Roxb.) Benth wood bark and leaves. Free Radicals and Antioxidants, 2(3), 47–57. https://doi.org/10.5530/ax.2012.3.7
  • Katekhaye, S. D., & Laddha, K. S. (2015). Coumarins and a Triterpenoid from Pithecellobium dulce. Chemistry of Natural Compounds, 51(5), 956–958. https://doi.org/10.1007/s10600-015-1460-z
  • Katekhaye, S. D., & Nagmoti, D. M. (2013). α-Glucosidase and α-amylase inhibitory activities of Pithecellobium dulce bark and leaves. Phytopharmacology, 4(1), 123–130.
  • Kirthy, R., Komara, V P. K., & Mogal, S. B. (2022). Nutritional, Health and Therapeutic Benefits of Pithecellobium dulce. Agriculture and Food, 4(10), 231–233.
  • Knauth, P., Acevedo, H. G. J., Cano, M. E., Gutiérrez, L. M., & López, Z. (2018). In Vitro Bioactivity of Methanolic Extracts from Amphipterygium adstringens (Schltdl.) Schiede ex Standl., Chenopodium ambrosioides L., Cirsium mexicanum DC., Eryngium carlinae F. Delaroche, and Pithecellobium dulce (Roxb.) Benth. Used in Traditional Medicine in Mexico. Evidence-Based Complementary and Alternative Medicine, 2018. https://doi.org/10.1155/2018/3610364
  • Kotb, S. S., Ayoub, I. M., El-Moghazy, S. A., & Singab, A. N. B. (2020). Profiling the Lipophilic Fractions of Pithecellobium dulce Bark and Leaves Using GC/MS and Evaluation of Their Antioxidant, Antimicrobial and Cytotoxic Activities. Chemistry and Biodiversity, 17(7). https://doi.org/10.1002/cbdv.202000048
  • Kotb, S. S., Ayoub, I. M., El-Moghazy, S. A., Nasser Singab, A. B., and Iriny Ayoub, A. M. (2022). Phytochemical analysis of Pithecellobium dulce (Roxb) Benth Bark via UPLC-ESI-MS/MS and Evaluation of its Biological Activity. Natural Product Research, 38(8), 1424–1429. https://doi.org/10.1080/14786419.2022.2140153
  • Kulkarni, K. V., & Jamakhandi, V. R. (2018). Medicinal uses of Pithecellobium dulce and its health benefits. Journal of Pharmacognosy and Phytochemistry, 7(2), 700–704.
  • Kumar, M., Govindrajan, J., & Nyola, N. (2017). Antihyperglycemic potential of saponin-enriched fraction from Pithecellobium dulce Benth. seed extract. Pharmacognosy Research, 9(5), S23–S26. https://doi.org/10.4103/pr.pr_18_17
  • Kumar, M., Nehra, K., & Duhan, J. (2013). Phytochemical analysis and antimicrobial efficacy of leaf extracts of Pithecellobium dulce. Asian Journal of Pharmaceutical and Clinical Research, 6(1), 70–76. https://www.researchgate.net/publication/260613163
  • Kumari, S. (2017). Evaluation of phytochemical analysis and antioxidant and antifungal activity of Pithecellobium dulce leaves extract. Asian Journal of Pharmaceutical and Clinical Research, 10(1), 370–375. https://doi.org/10.22159/ajpcr.2017.v10i1.15576
  • Lakshmi, Y.S., Mala, D., Gopalakrishnan, S., Banu, F., & Brindha, V. (2014). Antimicrobial Activity of Silver Nanoparticles from Pithecellobium dulce. Indian Journal of Nano Science, 2(7), 1–3, July 2014.
  • López, A. G., Verdugo, G. S. E., Montes, A. J., Díaz, C. S. P., Miranda, S. V., Salazar, S. N. Y., & Delgado, V. F. (2019). Bioguided isolation of N-malonyl-(+)-tryptophan from the fruit of Pithecellobium dulce (Roxb.) Benth. that showed high activity against Hymenolepis nana. Natural Product Research, 35(4), 593–599. https://doi.org/10.1080/14786419.2019.1590709
  • López, Z., Joel, S. F., Knauth, P., Villarruel, J. B., López, Z., Solís, D. B., Rico, J., Salazar, J., & Knauth, P. (2013). Cytotoxicological effects and antimicrobial activity of Pithecellobium dulce (Guamúchil) extracts. Ethnopharmacology, September, Morelia (Mich.), Mexico. https://www.researchgate.net/publication/279804207_Cytotoxicological_effects_and_antimicrobial_activity_of_Pithecellobium_dulce_Guamuchil_extracts.
  • Manna, P., Bhattacharyya, S., Das, J., Ghosh, J., & Sil, P. C. (2011). Phytomedicinal role of Pithecellobium dulce against CCl4 mediated hepatic oxidative impairments and necrotic cell death. Evidence-Based Complementary and Alternative Medicine, 2011. https://doi.org/10.1093/ecam/neq065
  • Megala, J., & Geetha, A. (2010). Free radical-scavenging and H+, K+-ATPase inhibition activities of Pithecellobium dulce. Food Chemistry, 121(4), 1120–1128. https://doi.org/10.1016/j.foodchem.2010.01.059
  • Megala, J., & Geetha, A. (2012a). Acute and sub-acute toxicity study of hydroalcoholic fruit extract of Pithecellobium dulce. Natural Product Research, 26(12), 1167–1171. https://doi.org/10.1080/14786419.2011.562206
  • Megala, J., & Geetha, A. (2012b). Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. Journal of Ethnopharmacology, 142(2), 415–421. https://doi.org/10.1016/j.jep.2012.05.011
  • Megala, J., & Geetha, A. (2015). Effect of Pithecellobium dulce (Roxb.) Benth. fruit extract on cysteamine induced duodenal ulcer in rats. Indian Journal of Experimental Biology, 53, 657–664.
  • Mishra, N., Srivastava, V., Hashmi, A., Awasthi, H., Deep, P., and Verma, S. (2021). Pharmacological screening of ethanolic extract of Pithecellobium dulce for antiarthritic activity in Rats. Indian Journal of Natural Products and Resources, 12(3), 418ــ 424. https://doi.org/10.56042/ijnpr.v12i3.31100
  • Mule, V. S., Naikwade, N. S., Magdum, C. S., & Jagtap, V. A. (2016). Effect of Pithecellobium dulce benth leaves in dexamethasone induced diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences, 8(9), 317–320. https://doi.org/10.22159/ijpps.2016v8i9.12988
  • Mule, V. S., Potdar V. H., Jadhav S. D., & Disouza J. I. (2011). Neuropharmacological Profile of Aqueous and Ethanolic Extract of Pithecellobium dulce Benth Leaves in Mice. Research J. of Pharmacology and Pharmacodynamics, 3(1), 27–30. https://www.researchgate.net/publication/227859952
  • Murugesan, S., Lakshmanan, D. K., Arumugam, V., & Alexander, R. A. (2019). Nutritional and therapeutic benefits of medicinal plant Pithecellobium dulce (Fabaceae): A review. Journal of Applied Pharmaceutical Science, 9(7), 130–139. https://doi.org/10.7324/JAPS.2019.90718
  • Nagendr, M., Mani, D., S., Ravi, S., D., Swarnalatha, D., Nagendra, M., & Jyotshna, T. (2019). In vitro anti-inflammatory activity of aqueous extract of Pithecellobium dulce. Journal of Pharmacognosy and Phytochemistry, 8(5), 200–201.
  • Nagmoti, D. M., & Juvekar, A. R. (2013). In vitro inhibitory effects of Pithecellobium dulce (Roxb.) Benth. seeds on intestinal-glucosidase and pancreatic-amylase. Journal of Biochemical Technology, 4(3), 616–621.
  • Nagmoti, D. M., Kothavade, P. S., Bulani, V. D., Gawali, N. B., & Juvekar, A. R. (2015). Antidiabetic and antihyperlipidemic activity of Pithecellobium dulce (Roxb.) Benth seeds extract in streptozotocin-induced diabetic rats. European Journal of Integrative Medicine, 7(3), 263–273. https://doi.org/10.1016/j.eujim.2015.01.001
  • Nigam, S. K., Gopal, M., Uddin, R., Yoshikawa, K., Miwako, K., & Arihara, S. (1997). Pithedulosides A-G, Oleanane Glycosides from Pithecellobium dulce. Phytochemistry, 44(7), 1329–1334. https://doi.org/10.1016/s0031-9422(96)00725-x
  • Olmedo, J. A., Jimenez, C. A. L., Bugarin, A., Zamilpa, A., Gives, P. M., Villa, M. A., López, A. M. E., Olivares, P. J., Delgado, N. E. J., & González, C. M. (2022). Phenolic Acids and Flavonoids from Pithecellobium dulce (Robx.) Benth Leaves Exhibit Ovicidal Activity against Haemonchus contortus. Plants, 11(19). https://doi.org/10.3390/plants11192555
  • Orwa, C., Mutua, A., Kindt, R., Jamnadass, R., & Anthony, S. (2009). Agroforestree Database: a tree reference and selection guide version 4.0. World Agroforestry Centre, Kenya. http://worldagroforestry.org/output/agroforestree-database/. Access date: July 1.
  • Pal, P. B., Pal, S., Manna, P., & Sil, P. C. (2012). Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death. Pathophysiology, 19(2), 101–114. https://doi.org/10.1016/j.pathophys.2012.02.001
  • Palanivel, Agrawal, S. K., Manjulvani, Senthil, K. K., Karthikeyan, V., Periyasamy., & Sivakumar GM. (2014). Evaluation of Anti-Ulcer Activity of Pithecellobium dulce (Seeds) In Rats Using Pylorus Ligation. World Journal Of Pharmacy And Pharmaceutical Sciences, 3(3), 2175–2184.
  • Pithayanukul, P., Ruenraroengsak, P., Bavovada, R., Pakmanee, N., Suttisri, R., & Saen-Oon, S. (2005). Inhibition of Naja kaouthia venom activities by plant polyphenols. Journal of Ethnopharmacology, 97(3), 527–533. https://doi.org/10.1016/j.jep.2004.12.013
  • Ponmozhi, P., Geetha, M., Saravana, K. M., & Devi, P. S. (2011). Extraction of Anthocyanin and Analysing Its Antioxidant Properties from Pithecellobium dulce Fruit Pericarp. Asian Journal of Pharmaceutical and Clinical Research, 4(1), 41– 45.
  • Poongodi, T., & Hemalatha, R. (2015). In Vitro Cytotoxicity, Phytochemistry and Gc-Ms Analysis of Pithecellobium dulce Leaves. World Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 1266–1276.
  • Pradeepa, S., Subramanian, S., & Kaviyarasan, V. (2013). Biochemical evaluation of antidiabetic properties of Pithecellobium dulce fruits studied in streptozotocin induced experimental diabetic rats.International Journal of Herbal Medicine, 1(4), 21–28.
  • Praveen, A., Prasath, K., Kalyan, B., & Babu, I. (2010). Antidiabetic activity of bark extract of Pithecellobium dulce benth in alloxan-induced diabetic rats. Natural Product An Indian Journal (NPAIJ), 6(4), 201–204.
  • Praylin, S., Research, S., Singh, S. P., & Kumar, S. P. (2015). In vitro antidiabetic activity of compounds from Pithecellobium dulce fruit peel. International Journal of Pharmaceutical Chemistry, 5(4). https://doi.org/10.7439/ijpc
  • Rajan, S., & kumar, R. T. (2010). Hypolipidemic activity of Pithecellobium dulce Benth. in Triton Wr-1339 Induced Hyperlipidemic Rats. International Journal of Chemical and Pharmaceutical Sciences, 1(2), 50–53.
  • Raju, K., & Jagadeeshwar, K. (2014). Phytochemical Investigation and Hepatoprotective Activity of Ripe Fruits of Pithecellobium dulce in Albino Rats. Scholars Academic Journal of Pharmacy (SAJP), 3(6), 449–454.
  • Raman, N., Sudharsan, S., Veerakumar, V., Pravin, N., & Vithiya, K. (2012). Pithecellobium dulce mediated extra-cellular green synthesis of larvicidal silver nanoparticles. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 96, 1031–1037. https://doi.org/10.1016/j.saa.2012.08.011
  • Rao, B. G., Samyuktha, P., Ramadevi, D., & Heera, B. (2018). Review of Literature: Phytopharmacological Studies on Pithecellobium dulce. Journal of Global Trends in Pharmaceutical Sciences, 9(1), 4797–4807.
  • Roselin, C., & Parameshwari, S. (2022). A systematic review on the materialistic use of Pithecellobium dulce in food formulations. Materials Today: Proceedings, 66, 996–1001. https://doi.org/10.1016/j.matpr.2022.04.779
  • Sahu, N. P., & Mahato, S. B. (1994). Anti-Inflammatory Triterpene Saponins of Pithecellobium dulce: Characterization of An Echinocystic Acid Bisdesmoside. Phytochemistry, 37(5), 1425–1427. https://doi.org/https://doi.org/10.1016/s0031-9422(00)90425-4
  • Saxena, V. K., & Singal, M. (1998). Genistein 4’-O-α-L-rhamnopyranoside from Pithecellobium dulce. Fitoterapia, 69(1), 305–306.
  • Saxena, V. K., & Singhal, M. (1999). Novel prenylated flavonoid from stem of Pithecellobium dulce. Fitoterapia, 70, 98–100. https://doi.org/10.1016/S0367-326X(98)00012-4
  • Selvan, S. A., & Muthukumaran, P. (2011). Analgesic and anti-inflammatory activities of leaf extract of Pithecellobium dulce Benth. International Journal of PharmTech Research CODEN, 3(1), 337–341.
  • Shanmugakumar., S.D, Amerjothy.S, & Balakrishna.K. (2006). Pharmacognostical, Antibacterial and Antifungal potentials of the leaf extracts of Pithecellobium dulce Benth. Pharmacognosy Magazine, 2(7), 163–167.
  • Sharma, M. (2016). Selective cytotoxicity and modulation of apoptotic signature of breast cancer cells by Pithecellobium dulce leaf extracts. Biotechnology Progress, 32(3), 756–766. https://doi.org/10.1002/btpr.2261
  • Shweta, S. (2013). A review on pharmacological activities of Pithecellobium dulce extract, and there effective doses. Journal of Medical Pharmaceutical and Allied Sciences, 5, 35–45. www.jmpas.com
  • Singh, R..L., & Mamta, S. (2013). Oxidative DNA damage protective activity and antioxidant and hepatoprotective potentials of Pithecellobium dulce plant. J Nutr Food Sci, 3(4), 2nd International Conference and Exhibition on Nutritional Science and Therapy, July 15-17, Marriott Philadelphia Downtown, USA. https://doi.org/http://dx.doi.org/10.4172/2155-9600.S1.010
  • Sneha, D., Prashanth, S., Kaveti, V. S., & Boggula, N. (2020). Systematic Review of Pithecellobium dulce (Roxb.) Benth.: A Traditional Medicinal Herb. Journal For Innovative Development in Pharmaceutical and Technical Science (JIDPTS), 3(5), 1–9.
  • Srinivas, G., Geeta, H., Shashikumar, J., & Champawat. (2018). A review on Pithecellobium dulce: A potential medicinal tree. International Journal of Chemical Studies, 6(2), 540–544.
  • Sugumaran, M., Vetrichelvan, T., & Darlin Quine, S. (2009). Anti inflammatory activity of Folklore: Pithecellobium dulce Benth. Research J. Pharm. and Tech, 2(4).
  • Sugumaran, M., Vertichelvan, T., & Darlin Quine, S. (2008). Anticonvulsant Activity of Folklore Pithecellobium Dulce Benth. Biomedical & Pharmacology Journal, 1(1), 223–225.
  • Sugumaran, M., Vetrichelvan, T., & Quine, S. D. (2008a). Antidiarrhoeal activity on leaf extracts of Pithecellobium dulce extract. Biosciences, Biotechnology Research Asia, 5(1), 421–424.
  • Sugumaran, M., Vetrichelvan, T., & Quine, S. D. (2008b). Locomotor Activity of Leaf extracts of Pithecellobium dulce Benth. Ethnobotanical Leaflets, 12, 490–493.
  • Sukantha, T. A., Sripathi, S. K., & Ravindran, N. T. (2014). Antibacterial activity of selected medicinal plant in traditional treatment of wound infection in southeast India. International Journal of Pharmacy and Pharmaceutical Sciences, 6(11), 511ــ513. https://www.researchgate.net/publication/274062544
  • Sukantha, T. A., Sripathi, S. K., & Ravindran, N. T. (2016). Anti-Diabetic Activity of Aqueous Extract oof Pithecellobium dulce Benth Fruit Peel on Streptozotocin Induced Diabetic Rats. Journal of Advances in Chemistry , 12(15), 4807–4815.
  • Sukantha, T. A., Sripathi, S. K., Ravindran, N. T., & Balashanmugam, P. (2011). Evaluation of In Vitro Antioxidant and Antibacterial Activity of Pithecellobium dulce Benth Fruit Peel. International Journal of Current Research, 3(11), 378–382. https://www.researchgate.net/publication/230688534
  • Sul, K., Chaware, V., & Redasani, V. (2021). Evaluation of Hepatoprotective Activity of Leaves Extract of Pithecellobium dulce In Experimental Animals. Asian Journal of Pharmaceutical Research and Development, 9(4), 39–46. https://doi.org/10.22270/ajprd.v9i4985
  • Thangarajan, P., Anumanthan, A., Venkatachalam, U., Sivakumar, S., & Somaskanda, C. (2015). Cardioprotective Activity of Pithecellobium dulce Fruit Peel on Isoproterenol-Induced Myocardial Infarction in Rats. Int. J. Pharm. Sci. Rev. Res, 30(1), 133–136.
  • Toudji, G. A., Damintoti, K. S., & Yao, A. (2017). Acute and sub-acute toxicity of Pithecellobium dulce (Roxb.) Benth. stem bark hydroalcoholic extract on Wistar rats. Journal of Pharmacy and Pharmacognosy Research, 5(5), 310–319. https://www.researchgate.net/publication/318795837
  • Vanitha, V., & Manikandan, K. (2016). Bio-activity Guided Determination of Active Compounds in the Leaves of Pithecellobium dulce. RASĀYAN Journal of Chemistry (RJC), 9(3), 471–477.
  • Vargas, M. Á. F., Kuri, G. A., Vargas, M. H., Chávez, S. J. L., Ferriz, M. R. A., Hernández, S. L. G., & Guzmán, M. S. H. (2020). Phenolic profile and antioxidant capacity of Pithecellobium dulce (Roxb) Benth: a review. Journal of Food Science and Technology, 57(12), 4316–4336. https://doi.org/10.1007/s13197-020-04453-y
  • Venu, C., Ramanjaneyulu, K., Satish, R. N., Vijaya, L. B., & Bhavana, A. (2016). Evaluation of antidiarrhoeal activity of ethanolic extracts of Pithecellobium dulce on castor oil-induced diarrhoea in albino Wistar rats. Discovery, 52(246), 1494–1496.
  • Wichaidit, W., & Thongyoo, P. (2023). A novel γ-lactone isolated from the leaves of Pithecellobium dulce (Roxb.) Benth. and its xanthine oxidase activity. Natural Product Research, 37(7), 1168–1176. https://doi.org/10.1080/14786419.2021.1999943
  • Yoshikawa, K., Suzaki, Y., Tanaka, M., Arihara, S., & Nigam, S. K. (1997). Three Acylated Saponins and a Related Compound from Pithecellobium dulce. Journal of Natural Products, 60(12), 1269–1274. https://doi.org/10.1021/np9703555
There are 90 citations in total.

Details

Primary Language English
Subjects Medicinal and Aromatic Plants
Journal Section Articles
Authors

Alaa El-hewehy 0000-0001-9622-2932

Engy Mohsen 0009-0007-5723-9476

Ahlam M. El-fishawy 0000-0003-4925-7395

Marwa A. A. Fayed 0000-0001-5609-7436

Early Pub Date June 16, 2024
Publication Date June 30, 2024
Acceptance Date December 29, 2023
Published in Issue Year 2024 Volume: 34 Issue: 2

Cite

APA El-hewehy, A., Mohsen, E., M. El-fishawy, A., Fayed, M. A. A. (2024). Traditional, Phytochemical, Nutritional and Biological Importance of Pithecellobium dulce (Roxib.) Benth. Yuzuncu Yıl University Journal of Agricultural Sciences, 34(2), 354-380. https://doi.org/10.29133/yyutbd.1329407
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Yuzuncu Yil University Journal of Agricultural Sciences by Van Yuzuncu Yil University Faculty of Agriculture is licensed under a Creative Commons Attribution 4.0 International License.