Neutrophil, Monocyte, Basophil and Eosinophil Evaluation of Acute Myeloid Leukemia Patients Within 4 Growth Levels

Year 2020, Volume: 1 Issue: 1, 16 - 27, 31.01.2020

İshtar Imad Mehmet Özaslan Abdulameer N. Al-rikabi

Abstract

Evaluation of sixty patients pre and post 3 and 7 protocol regimen compared with 60 apparently healthy volunteer dispersed on 4 age groups (0-15, 16-40, 41-65, 65 and above years). The results show low neutrophil count before treatment in all age groups and shows statistical differences when compared with the post treatment samples that shows elevation in count to near from control values. Evaluations of monocyte and basophil shows higher than control and post treatment count which give arise to the statistical differences to appear between treatment groups. Comparison between age groups in neutrophil and monocyte shows statistical differences when compared between age groups. Eosinophil evaluation shows no statistical differences when compared between treatment group and age group. All statistical comparisons done be ANOVA on P≤0.5.

Keywords

Neutrophil, Monocyte, Basophil and Eosinophil Evaluation of Acute Myeloid Leukemia Patients Within 4 Growth Levels

References

• References: 1- NCCN guideline. (2019). 2- Kouchkovsky, D, Abdul-Hay M. (2016). Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J. Jul 1;6(7). 3- National Cancer Institute. (2018). Physician Data Query. Adult Acute Myeloid Leukemia Treatment. 4- Döhner, H , Elihu E, Grimwade D, Amadori S, Appelbaum FR, Büchner T, Dombret H, Ebert BL, etal. (2017). Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. Jan 26; 129(4): 424–447. 5- Stone RM, Mandrekar SJ, Sanford BL, Laumann K, Geyer S, Bloomfield CD, Thiede C, et al. (2017). Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation. N Engl J Med. Aug 3;377(5):454-464. 6- Morton, L M. , Graça M. D, Margaret A. T, Clara J. K, Kenan O,Ethel S. G, Joseph F. F and Rochelle E. C. (2013). Evolving risk of therapy-related acute myeloid leukemia following cancer chemotherapy among adults in the United States, 1975-2008. Blood. Apr 11; 121(15): 2996–3004. 7- Burnett AK, Goldstone A and Hills RK. (2013). Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 31(10):1293-1301. 8- ACS. American Cancer Society. (2018). Cancer facts and figures. Cancer Journal for Clinicians.2. 33-35. 9- Stock, W, Thirman MJ. Pathogenesis of acute myeloid leukemia. (2018). Accessed at www.uptodate.com/contents/pathogenesis-of-acute-myeloid-leukemia on June 14.13:33. 10- Sysmex Beckman. (2019). Manual. 11- Chao, Shi and Eric, G. Pamer. (2011). Monocyte recruitment during infection and inflammation. Nat Rev Immunol. Oct 10; 11(11): 762–774. 12- Gnanasekaran, K K , Chacko MP, Manipadam MT, Bindra MS, Biju G and Vivi M S. (2016). Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity. Indian journal of pathology and microbiology. 59:1 ; 104-106. 13- Deng, Rui, Fang Yi Fan, Hai Yi, Li Fu, Yan Zeng, Yi Wang, Xiao Juan Miao, et al. (2017). Cytotoxic T lymphocytes promote cytarabine-induced acute myeloid leukemia cell apoptosis via inhibiting Bcl-2 expression. Experimental and therapeutic medicine. 14: 1081:1085. 14- Hatzl, S. , Uhl B, Hinterramskogler M, Leber S, Eisner F, Haring M, and Jud P. (2018). Acute myeloid leukemia with severe coagulation disorder and concomitant central nervous system bleeding – a clinical diagnostic case report. The journal of the international federation of clinical chemistry and lab medicine. 29(2). 146:151. 15- Gnanasekaran, K K , Chacko MP, Manipadam MT, Bindra MS, Biju G and Vivi M S. (2016). Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity. Indian journal of pathology and microbiology. 59:1 ; 104-106. 16- Boyer, D. F. (2016). Bone and bone marrow evaluation for eosinophilia. Arch Pathol Lab Med.140:1060–1067. 17- Cancer.net.2017. 18- Carruale,A,GiuseppinaM,RodrigoR,SilvanaB,PatriziaV,FrancescoL,GiovanniV, et al. (2019). Acute basophilic leukemia with U2AF1 mutation. Blood cells molecules and disease. 76, May: 63-65. 19- Alghazal, M. and Khan, M. AH. (2017). Acute Myeloid Leukemia with Both Meakaryoblastic & Basophilic Differentiation. Hematol Transfus Int J. 5(2):00114. 20- Holyoake, T.L.; Vetrie, D. The chronic myeloid leukemia stem cell: Stemming the tide of persistence. Blood 2017, 129, 1595-1606. 21- Toda, Y, Nagai Y, Shimomura D, Kishimori C, Tsuda K, Fukutsuka K, Hayashida M and Ohno H. (2017). Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene. Clin Case Rep. Oct 11;5(12):1938-1944. 22- Koya, J, Toshio I, Ieharu Y, Fumihiko N and Mineo K. (2017). Acute basophilic leukemia with add(3)(q12) accompanied by histamine excess symptoms. Annals of hematology. July 96 (7). 1197:1199.