Erkek infertilitesinde seminal leptin seviyelerinin semen parametreleri ve DNA fragmantasyonu ile ilişkisi

Year 2017, , 39 - 43, 15.02.2017

Şule Ayla , İlknur Keskin Tuba Varlı Yelke Tuğçe Önel Serçin Karahüseyinoğlu

https://doi.org/10.16948/zktipb.288940

Abstract

Giriş:
Bu çalışmamızda insan semen leptin düzeylerini ve semen parametreleri ile
ilişkisinin incelenmesi amaçlanmıştır.

Materyal-Metod:
Normal ve oligoastenoteratospermik 30 hastalık gruplar oluşturuldu. Hastaların
semen örneklerinde leptin ve DNA fragmantasyon düzeyleri incelendi, ayrıca
sperm sayısını ve motilite oranlarını içeren semen parametreleri değerlendirildi.

Bulgular:
İnfertil hastalarda sperm sayısı ve motilite oranları normal gruba göre anlamlı
olarak azalmıştır: 6,40±4,29 (x10⁶/mL), % 38,63±14,92 (p<0,0001). DNA
fragmantasyon oranları normal grupta % 21,00±8,23 olarak gözlenirken infertil
erkeklerde % 38,43±14,23  oranıyla
anlamlı olarak yüksek bulunmuş, semen leptin oraları ise normal grupta
347,58±111,13 ng/mL olarak  gözlenirken, infertil grupta 267,63±56,36 ng/mL düzeyi ile anlamlı
olarak azaldığı gözlenmiştir. İnfertil gruplar kendi içinde incelendiği zaman
ise semen leptin düzeyi ile yaş, volüm, sperm sayısı ve motilitesi arasında
istatistiksel olarak anlamlı olacak bir ilişki saptanmamıştır.

Sonuç:
Çalışmamızda, oligoastenoteratozoospermik erkek infertilitesinde serum leptin
seviyelerinin azalmış olduğunu, ama sperm motilitesi ile anlamlı bir ilişkinin
bulunmadı gözlemlenmiştir. Leptinin semende tanısal bir kriter olarak
kullanılabilmesi için daha geniş kapsamlı çalışmaların yapılması gerektiği
düşünülmektedir

Keywords

Leptin, oligoastenoteratozoospermi, erkek infertilitesi

The relationship of seminal leptin levels with semen parameters and DNA fragmentation

Abstract

Objective:
The objective of
this study is to investigate the relationship between human seminal leptin
levels and semen parameters.

Material
& Methods: Study
groups include 30 males with oligoasthenoteratozoospermia and 30 males who have
normal semen parameters. Leptin and DNA fragmentation levels were investigated
in both groups, along with a variety of semen parameters including sperm count
and motility.

Results:
In comparison with the normal males,
sperm count and motility have decreased significantly in infertile patients: 6,40±4,29(x10⁶/mL), %, 38,63±14,92 (p<0,0001).  DNA fragmentation levels were found as
21,00±8,23 %   and
38,43±14,23 %,  in normal and patient
groups respectively. Seminal leptin levels were 347,58±111,13 ng/mL in the normal group, while there was a significant
decrease to 267,63±56,36 ng/mL in the infertile group. Among infertile patient
groups, no significant difference was observed regarding the relationship
between seminal leptin levels and age, volume, sperm count and motility.

Conclusion: In our study it was demonstrated that, serum leptin
levels decrease in oligoasthenoteratozoospermic infertile males, while there is
not a significant relation with the motility of sperm. In order to use seminal
leptin levels as a diagnostic tool more extensive studies are needed.

Keywords

Leptin, oligoasthenoteratozoospermia, male infertility

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