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Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği

Year 2018, , 9 - 11, 05.03.2018
https://doi.org/10.16948/zktipb.306583

Abstract

Objective: Rheumatoid heart disease (RHD) is an important
and preventable cause of cardiovascular disease in developing
countries. The aim of this study was to investigate the mean
platelet volume (MPV) and platelet distribution width (PDW)
in RHD.
Material and Methods: This study was carried out in Kayseri
Health Sciences University, Department of Pediatric Cardiology, with 135 children with RHD who were retrospectively
observed between February 2000 and February 2017 for seven
years and 40 healthy children with similar age and sex.
Results: The mean age of the 135 patients enrolled in the study
was 12,43 ± 3,11 years, 70 were males (51,8%) and 65 were
females (48,2%). The mean age of the control group was 12,96
± 2,55 years, 21,21 male (52,5%) and 19 female (47,5%). MPV
values of the patients were significantly lower in the RHD
group (9,43 ± 1,31 and 10,21 ± 1,25, p: 0,003).

Conversely, the PDW levels were significantly higher in the
RHD group (15,70 (15,40-16,00) and 12,25 (10,40-14,30), p:
0,001). When MPV / PDW ratio was examined, it was found to
be significantly lower in the RHD group (0,61 (0,55-0,71) and
0,87 (0,79-0,93), p: 0,001).
Conclusion: MPV values were lower and PDW values were higher when compared to controls in RHD process.

References

  • 1.Reményi B., Wilson N., Steer A., Ferreira B., Kado J., Kumar K., et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease--an evidence-based guideline. Nature Reviews Cardiology. 2012;9(5):297–309.
  • 2.Rémond M., Atkinson D., White A., Brown A., Carapetis J., Remenyi B., et al. Are minor echocardiographic changes associated with an increased risk of acute rheumatic fever or progression to rheumatic heart disease? International Journal of Cardiology. 2015;198:117–122.
  • 3.Bath PM, Butterworth RJ (1996) Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 7(2):157–161
  • 4.Pitchford SC, Page CP (2006) Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 36(4):399–401
  • 5.Herve P, Humbert M, Sitbon O, Parent F, Nunes H, Legal C et al. (2001) Pathobiology of pulmonary hypertension: the role of platelets and thrombosis. Clin Chest Med 22(3):451–458
  • 6.Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17(1):47–58
  • 7.Sert A, Aypar E, Odabas D (2012) Mean platelet volume in acute rheumatic fever. Platelets.
  • 8.Rahmi Ozdemir, Cem Karadeniz, Onder Doksoz et al. Are Mean Platelet Volume and Platelet Distribution Width Useful Parameters in Children With Acute Rheumatic Carditis. Pediatr Cardiol DOI 10.1007/s00246-013-0738-9
  • 9.Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011;17:47–58.
  • 10.Kim DA, Kim TY. Controversies over the interpretation of changes of mean platelet volume in rheumatoid arthritis. Platelets 2011;22:77–78.
  • 11.Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE, Kouroumalis EA. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776–781.
  • 12.Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volume with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 2010;9:45–50.
  • 13.Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, Kiraz S, Ertenli I, Calguneri M. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291–294
  • 14.Clarke D, Johnson PW, Banks RE, Storr M, Kinsey SE, Johnson R, Morgan G, Gordon MY, Illingworth JM, Perren TJ, et al. Effects of interleukin 6 administration on platelets and haemopoietic progenitor cells in peripheral blood. Cytokine 1996;8:717–723.
  • 15.Settin A, Abdel-Hady H, El-baz R, Saber I. Gene polymorphisms of TNF-α ( 308), IL-10 ( 1082), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol 2007;28:363–371.
  • 16.Gasparyan AY, Sandoo A, Stavropoulos-Kalinoglou A,Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: The effect of anti-TNF-α therapy. Rheumatol Int 2010;30:1125–1129.
  • 17.Yegin O, Coskun M, Ertug H (1997) Cytokines in acute rheumatic fever. Eur J Pediatr 156(1):25–29
  • 18.Hafez M, El-Morsy Z, El-Shennawy F, Hawas S, Sheishaa A, AlMarsafawy H et al (2001) Cytokine gene expression in rheumatic fever. Egypt J Immunol 8:61–76

Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği

Year 2018, , 9 - 11, 05.03.2018
https://doi.org/10.16948/zktipb.306583

Abstract



Amaç: Romatizmal kalp hastalığı (RKH), kardiyovasküler hastalıkların gelişmekte olan ülkelerde endemik seyreden önemli ve önlenebilir bir nedenidir. Bu çalışmanın amacı RKH’da ortalama trombosit hacmini (MPV) ve trombosit dağılım genişliğini (PDW) araştırmaktır. Materyal ve Metod: Bu çalışma Kayseri Sağlık Bilimleri Üniversitesi Çocuk Kardiyoloji Bölümü’nde, Şubat 2000-Şubat 2017 tarihleri arasında retrospektif olarak yedi yıllık süreçte izlenen 135 RKH’li çocuk hasta ile yaş ve cinsiyetleri benzer 40 sağlıklı çocuğu içermektedir. Bulgular: Çalışmaya alınan 135 olgunun yaş ortalaması 12,43±3,11 yıl, 70’i erkek (%51,8), 65’i kız (%48,2) idi. Kontrol grubunun yaşları ortalaması 12,96±2,55 yıl, 21’i erkek (%52,5)),19‘u kız (%47,5) olmak üzere 40 idi. Hastaların MPV değerleri RKH’lı grupta anlamlı derecede düşüktü (9,43±1,31 ve 10,21±1,25; p:0,003). Tersine PDW seviyeleri RKH’lı grupta anlamlı derecede yüksekti (15,70 (15,40-16,00) ve 12,25(10,40- 14,30); p: 0,001). MPV/PDW oranı RKH’lı grupta anlamlı derecede düşük saptandı (0,61(0,55-0,71) ve 0,87(0,79 0,93); p: 0,001). Sonuç: RKH sürecinde kontrol grubuyla kıyaslandığında MPV düşüklüğü ve PDW yüksekliği mevcutttur.

References

  • 1.Reményi B., Wilson N., Steer A., Ferreira B., Kado J., Kumar K., et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease--an evidence-based guideline. Nature Reviews Cardiology. 2012;9(5):297–309.
  • 2.Rémond M., Atkinson D., White A., Brown A., Carapetis J., Remenyi B., et al. Are minor echocardiographic changes associated with an increased risk of acute rheumatic fever or progression to rheumatic heart disease? International Journal of Cardiology. 2015;198:117–122.
  • 3.Bath PM, Butterworth RJ (1996) Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 7(2):157–161
  • 4.Pitchford SC, Page CP (2006) Platelet activation in asthma: integral to the inflammatory response. Clin Exp Allergy 36(4):399–401
  • 5.Herve P, Humbert M, Sitbon O, Parent F, Nunes H, Legal C et al. (2001) Pathobiology of pulmonary hypertension: the role of platelets and thrombosis. Clin Chest Med 22(3):451–458
  • 6.Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17(1):47–58
  • 7.Sert A, Aypar E, Odabas D (2012) Mean platelet volume in acute rheumatic fever. Platelets.
  • 8.Rahmi Ozdemir, Cem Karadeniz, Onder Doksoz et al. Are Mean Platelet Volume and Platelet Distribution Width Useful Parameters in Children With Acute Rheumatic Carditis. Pediatr Cardiol DOI 10.1007/s00246-013-0738-9
  • 9.Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011;17:47–58.
  • 10.Kim DA, Kim TY. Controversies over the interpretation of changes of mean platelet volume in rheumatoid arthritis. Platelets 2011;22:77–78.
  • 11.Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE, Kouroumalis EA. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776–781.
  • 12.Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KM, Kitas GD. Association of mean platelet volume with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 2010;9:45–50.
  • 13.Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, Kiraz S, Ertenli I, Calguneri M. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75:291–294
  • 14.Clarke D, Johnson PW, Banks RE, Storr M, Kinsey SE, Johnson R, Morgan G, Gordon MY, Illingworth JM, Perren TJ, et al. Effects of interleukin 6 administration on platelets and haemopoietic progenitor cells in peripheral blood. Cytokine 1996;8:717–723.
  • 15.Settin A, Abdel-Hady H, El-baz R, Saber I. Gene polymorphisms of TNF-α ( 308), IL-10 ( 1082), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol 2007;28:363–371.
  • 16.Gasparyan AY, Sandoo A, Stavropoulos-Kalinoglou A,Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: The effect of anti-TNF-α therapy. Rheumatol Int 2010;30:1125–1129.
  • 17.Yegin O, Coskun M, Ertug H (1997) Cytokines in acute rheumatic fever. Eur J Pediatr 156(1):25–29
  • 18.Hafez M, El-Morsy Z, El-Shennawy F, Hawas S, Sheishaa A, AlMarsafawy H et al (2001) Cytokine gene expression in rheumatic fever. Egypt J Immunol 8:61–76
There are 18 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Research
Authors

Elif Çelik

Serkan Fazlı Çelik 0000-0003-1595-802X

Publication Date March 5, 2018
Published in Issue Year 2018

Cite

APA Çelik, E., & Çelik, S. F. (2018). Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği. Zeynep Kamil Tıp Bülteni, 49(1), 9-11. https://doi.org/10.16948/zktipb.306583
AMA Çelik E, Çelik SF. Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği. Zeynep Kamil Tıp Bülteni. March 2018;49(1):9-11. doi:10.16948/zktipb.306583
Chicago Çelik, Elif, and Serkan Fazlı Çelik. “Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliği”. Zeynep Kamil Tıp Bülteni 49, no. 1 (March 2018): 9-11. https://doi.org/10.16948/zktipb.306583.
EndNote Çelik E, Çelik SF (March 1, 2018) Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği. Zeynep Kamil Tıp Bülteni 49 1 9–11.
IEEE E. Çelik and S. F. Çelik, “Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği”, Zeynep Kamil Tıp Bülteni, vol. 49, no. 1, pp. 9–11, 2018, doi: 10.16948/zktipb.306583.
ISNAD Çelik, Elif - Çelik, Serkan Fazlı. “Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliği”. Zeynep Kamil Tıp Bülteni 49/1 (March 2018), 9-11. https://doi.org/10.16948/zktipb.306583.
JAMA Çelik E, Çelik SF. Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği. Zeynep Kamil Tıp Bülteni. 2018;49:9–11.
MLA Çelik, Elif and Serkan Fazlı Çelik. “Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliği”. Zeynep Kamil Tıp Bülteni, vol. 49, no. 1, 2018, pp. 9-11, doi:10.16948/zktipb.306583.
Vancouver Çelik E, Çelik SF. Romatizmal Kalp Hastalıklarında Ortalama Trombosit Hacmi ve Trombosit Dağılım Genişliği. Zeynep Kamil Tıp Bülteni. 2018;49(1):9-11.