Relationship between inflammation markers and prognostic factors in grade I-II small-size (<4 cm) endometrioid type endometrial carcinoma

Year 2019, , 30 - 34, 14.03.2019

Varol Gülseren , Mustafa Kocaer İlker Çakır İsa Aykut Özdemir , Mehmet Gökçü Muzaffer Sancı , Kemal Güngördük

https://doi.org/10.16948/zktipb.443246

Abstract

Objectives:
To investigate the association between neutrophil / lymphocyte ratio (NLO) and
platelet / lymphocyte ratio (PLO) values and prognostic factors (myometrial
invasion, cervical invasion, lymph node involvement, and stage) in the complet
blood count of patients with <40 mm grade I-II endometrioid type endometrial
carcinoma (EEC).

Materials and Methods: In
this study, we retrospectively reviewed the records of patients who received
EEC diagnosis and underwent hysterectomy and retroperitoneal lymphadenectomy in
the gynecological clinic of Tepecik Training and Research Hospital between
January 2013 and January 2016. Grade I-II patients with tumors size less than
40 mm were studied and included in the study. Receiver operating characteristic
(ROC) curve analysis was used to determine the optimal cut-off value of
predictive prognostic factors in the EEC.

Results:
Patients with deep myometrial invasion, presence of cervical invasion, presence
of lymph node metastasis and advanced stage tumors were found to be higher of
NLO, PLO and CA125 values, and all results were found to be statistically
significant. According to ROC curve analysis, NLO was found to be the factor
with the highest area under curve for advanced stage, lymph node metastasis and
deep myometrial invasion. However, the highest area under curve for cervical
invasion was shown to have PLO value.

Conclusion: In
the grade I-II <4 cm tumors EEC patients who include advanced stage, lymph
node metastasis, deep myometrial invasion and cervical stromal invasion were
higher mean NLO, PLO and CA125 values. Systemic inflammation markers were found
to be associated with poor prognosis in EEC patients with grade I-II tumor size
<4 cm.

Keywords

Neutrophil / lymphocyte ratio, Platelet / lymphocyte ratio, Endometrium cancer

Grade I-II Küçük Tümörlü (<4 cm) Endometrioid Tip Endometriyum Kanserinde İnflamasyon Belirteçlerinin Prognostik Faktörler ile İlişkisi

Abstract

Amaç:
40 mm’den küçük grade I-II endometrioid tip endometriyum kanseri (EEC)
hastalarında ameliyat öncesi periferal kan örneğinden bakılan tam kan sayımında
elde edilen nötrofil/ lenfosit oranı (NLO) ve platelet/ lenfosit oranı (PLO) değerleri
ile prognostik faktörler (myometriyal invazyon derinliği, servikal invazyon,
lenf nodu tutulumu, ve evre) arasındaki ilişkiyi araştırmakdır.

Materyal
metod: Bu çalışmada, Ocak 2013-Ocak 2016 tarihleri ​​arasında
Tepecik Eğitim ve Araştırma Hastanesi Jinekolojik Onkoloji kliniğinde, EEC
tanısını alan ve histerektomi ve retroperitoneal lenfadenektomi işlemi yapılan
hastaların kayıtlarını retrospektif olarak gözden geçirdik. Sadece 40 mm’den
küçük tümörü olan ve grade I-II hastalar incelendi ve çalışmaya dahil edildi. EEC'de
prediktif prognostik faktörlerin optimal eşik (cut-off) değerini belirlemek için
ROC (Receiver operating characteristic) eğrisi analizi kullanıldı.

Bulgular:
Hastaların prognostik faktörlerinden derin myometriyal invazyon, servikal
invazyon varlığı, lenf nodu metastazı varlığı ve ileri evre tümörü olanlarda
NLO, PLO ve CA125 değerlerinin daha yüksek olduğu ve tüm sonuçların istatiksel
olarak anlamlı olduğu tespit edildi. Yapılan ROC analizinde ileri evre, lenf
nodu metastazı ve derin myometriyal invazyon için en yüksek eğri altında kalan
alana sahip faktörün NLO olduğu bulundu. Ancak servikal invazyon için en yüksek
eğri altında kalan alana PLO değerinin sahip olduğu gösterildi.

Sonuç:
Prognostik faktörlerden ileri evre, lenf nodu metastazı, derin myometriyal
invazyon ve servikal stromal invazyon varlığında grade I-II <4 cm tümörü
olan EEC hastalarında bakılan ortalama NLO, PLO ve CA125 değerlerinin daha
yüksek olduğu gösterildi. Sistemik inflamasyon belirteçlerinin grade I-II tümör
boyutu <4 cm olan EEC hastalarında kötü prognoz ile ilişkili olduğu
saptandı.

Keywords

Nötrofil/ lenfosit oranı, Platelet/ lenfosit oranı, endometriyum kanseri

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