The Effectiveness of Postcoital Antimicrobial Prophylaxis Low Dose Nitrofurantoin in Uncomplicated Recurrent Urinary Tract İnfections Among Non-Pregnant Premenopausal Women

Year 2019, , 39 - 41, 14.03.2019

Kemal Sandal , Murat Yassa Arzu Bilge Tekin Mehmet Akif Sargın , Niyazi Tuğ

https://doi.org/10.16948/zktipb.445759

Cited By: 1

Abstract

Introduction

Recurrent urinary tract infection (RUTI)
is an important public health problem in terms of disease management. Most
frequently the agent is Escherichia coli. Protection methods include
continous and post-coital prophylaxis, latter has similar efficiency with
lesser drug dosage. In this study we aimed to investigate the efficiency of
post-coital prophylaxis in prevention of RUTI.

 

Material and Method

We retrospectively evaluated
premenopausal, non-pregnant, and sexually active adult women whom were
suggested to use single dose of 50 mg of nitrofurantion per oral in terms of
post-coital prophylaxis for six months along with lifestyle modifications. Data
of follow up examination after six months of therapy were also included.

 

Results

Thirty nine patients were included. One
patient couldn’t complete the prophylaxis due to gastrointestinal side effects.
Data of thirty eight patients were statistically evaluated. There wasn’t any
recurrence of RUTI and success rate was 100%. In terms of follow up
examinations, one patient had a recurrent four months after the end of prophylaxis.
Overall success rate for twelve months was 97.4%.

 

Conclusion

Post-coital prophylaxis with low dose
nitrofurantion was found both effective and safe for treatment of
premenopausal, non-pregnant women with RUTI for both six months of treatment and
six months of follow up period. This effect should be further evaluated with
longitudinal prospective studies.

 

Keywords

Recurrent urogenital tract infection, Nitrofurontain, Post coital prophylaxis

Düşük Doz Nitrofurantoin ile Postkoital Antimikrobiyal Profilaksinin Premenapozal Gebe Olmayan Kadınlarda Komplike Olmayan Rekurren Uriner Trakt Enfeksiyonlarının Önlenmesinde Etkinliği

Abstract

ÖZET

Giriş
ve Amaç

Rekürren üriner trakt enfeksiyonları
(RUTE) yönetilmesi güç önemli bir halk sağlığı sorunudur. En sık etkeni Escherichia coli’dir. RUTE’nin önlenmesinde
kontinü ve post-koital profilaksi seçenekleri arasından post-koital profilaksi
daha az doz gerektirmesi ve benzer etkinlik ile öne çıkmaktadır. Bu çalışmada
post-koital profilaksinin RUTE’nin önlenmesindeki etkinliğinin araştırılması
amaçlanmıştır.

Materyal ve Metod

Bu retrospektif çalışmaya RUTE
sebebiyle düşük doz nitrofurantoin ile post-koital profilaksi ve yaşam tarzı
değişiklikleri uygulanan premenapozal, gebe olmayan, cinsel aktif kadınlar
dahil edilmiştir. Profilaksi altı ayda sonlandırılmış ve sonraki altı aylık
takipleri değerlendirilmiştir.

Bulgular

Çalışmaya toplam 39 hasta dahil
edilmiştir. 1 hasta hafif gastrointestinal yan etki üzerine ilacı bırakmıştır. Tanımlayıcı
istatistik analizine 38 hasta dahil edilmiştir. Profilaksi süresince hiçbir
hastada rekürrens görülmemiş olup başarı oranı %100’dür. Profilaksi sonrası
altı aylık dönemde ise 1 hastada (%2.63) 4.ayda rekürrens görülmüştür.
Profilaksi başlangıcından itibaren 12 aylık başarı %97.37 (n=37/38) olarak
bulunmuştur.

Sonuç

Düşük doz (50 mg) nitrofurantoin ile
post-koital profilaksisi; premenapoz, gebe olmayan rekürren üriner trakt
enfeksiyonlu kadınlarda profilaksi süresince ve profilaksi sonrası ilk altı
ayda etkili ve güvenli bulunmuştur. Bu etkinin doğrulanması için longitudinal
prospektif çalışmalara ihtiyaç vardır.

Keywords

Nitrofurontain, Rekürren Üriner Trakt Enfeksiyonları, Postkoital profilaksi

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