Association between postpartum depression and synthetic oxytocin use for postpartum hemorrhage prevention and treatment
Abstract
Objective:The aim of this study was to examine the relationship
between postpartum synthetic oxytocin administration and the development of
depressive and anxiety disorders after delivery.
Materiyal and methods: We hypothesized that women exposed to
postpartum exogenous oxytocin would have a reduced risk of postpartum
depressive and anxiety disorders compared with those without exposure. The
cases were examined under two groups as "Oxytocin users" (n = 100)
and "Control" (n = 100) groups . Oxytocin group was given introvenous
oxytocin just after the delivery for postpartum hemorrhage prevention and treatment.
Questionnaires of depression and maternal anxiety were performed at the sixth
week after the delivery.
Results: The incidence of depression (4%) in the oxytocin group was
significantly lower than the control group (14%) (p: 0.026, p <0.05).
Patients who do not use oxytocin have a 3.9-fold greater risk of developing
depression. We identified a relationship between using oxytocin for postpartum
hemorragie and decreased postpartum depressive symptoms.
Conclusion: Our findings suggest using exogenous oxytocin may
contribute to postpartum symptoms of depression and anxiety among women. Future
research should watch the longitudinal role of exogenous oxytocin in maternal
mood and anxiety, the safety of high-dose long-term use of oxytocin.
Keywords
References
- Noble RE. Depression in women. Metabolism 2005; 54:49–52.
- Dawson G, Ashman S.B, Panagiotides H, Hessl D, Self J, Yamada E. et al. Preschool outcomes of children of depressed mothers: role of maternal behavior, con- textual risk, and children’s brain activity. Child Dev 2003;74:1158– 1175.
- World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. World Health Organization, Geneva. 1992.
- Ross L.E. Measurement issues in postpartum depression Part 1: Anxiety as a feature of postpartum depression. Arch. Womens Ment. Health 2003; 6, 51–57.
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, fifth ed. American Psychiatric Publishing, Arlington, VA. 2013
- Beck C.T. Predictors of postpartum depression: an update. Nurs. Res. 2001; 50, 275–285.
- Perani CV, Slattery DA. Using Animal Models to study Postpartum Psychiatric Disorders. Br J Pharmacol. 2014; 16(10):12640.
- Kim S, Soeken T. A, Cromer S. J, Martinez S. R, Hardy L.R, Strathearn L. Oxytocin and postpartum depression: Delivering on what’s known and what’s not. Brain Research. 2014; 1580:219–232.
- Skrundz M, Bolten M, Nast I, Hellhammer D. H, Meinlschmidt G. Plasma Oxytocin Concentration during Pregnancy is associated with Development of Postpartum Depression. Neuropsychopharmacology. 2011; 36(9):1886–1893.
- Garfield L, Giurgescu C, Carter C. S, Holditch-Davis D, McFarlin B. L, Schwertz D, et al. Depressive symptoms in the second trimester relate to low oxytocin levels in African-American women: a pilot study. Archives of Women’s Mental Health. 2015; 18(1):123–129.
- Feldman, R. Oxytocin and social affiliation in humans. Hormones and Behavior, 2012; 61, 380–391. Riem M. M, Van Ijzendoorn M. H, Tops M, Boksem M. A, Rombouts S. A, Bakermans-Kranenburg M. J. No laughing matter: intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter. Neuropsychopharmacology 2012; 37, 1257–1266.
- Fields H, Greene JWJ, Franklin RR. Intravenous Pitocin in Induction and Stimulation of Labor: A study of 3754 cases. Obstetrics & Gynecology. 1959; 13(3):353–359.
- ACOG. ACOG Practice Bulletin No. 107: Induction of labor. Obstet Gynecol. 2009; 114(2 Pt 1):386– 397.
- Westhoff G, Cotter AM, Tolosa JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev. 2013;10.
- Cox E. Q, Stuebe A, Pearson B, Grewen K, Rubinow D, Meltzer-Brody S. Oxytocin and HPA stress axis reactivity in postpartum women. Psychoneuroendocrinology. 2015; 55:164–172.
- Massey SH, Backes KA, Schuette SA. Plasma oxytocin concentration and depressive symptoms: a review of current evidence and directions for future research. Depression and Anxiety. 2016
- Gu V, Feeley N, Gold I, Hayton B, Robins S, Mackinnon A, et al. Intrapartum Synthetic Oxytocin and Its Effects on Maternal Well-Being at 2 Months Postpartum. Birth. 2016; 43(1):28– 35.
- Guastella A. J, Howard A. L, Dadds M. R, Mitchell P, Carson D. S. A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 2009; 34:917–923.
- Feldman, R, Gordon, I, Zagoory-Sharon, O. Maternal and paternal plasma, salivary, and urinary oxytocin and parent- infant synchrony: considering stress and affiliation components of human bonding. Dev. Sci 2011; 14, 752–761
Postpartum kanamanın önlenmesi ve tedavisinde kullanılan sentetik oksitosinin postpartum depresyon ile ilişkisi
Abstract
Amaç:
Doğum sonrası depresyon (PPD), en sık görülen doğum sonrası psikiyatrik
bozukluktur. Oksitosin (OT), nöropsikiyatrik durumlar hakkında olası bir teşhis
ve tedavi aracı olarak dikkat çekmiştir. Son zamanlarda, çalışmalar eksojen
oksitosin uygulamalarının maternal beyin yanıtındaki rolünü incelemeye
başlamıştır. Bu çalışmanın amacı postpartum sentetik oksitosin uygulaması ile
doğum sonrası depresif ve anksiyete bozuklukları arasındaki ilişkiyi
incelemektir.
Materyal
ve Metot: Postpartum ekzojen oksitosine maruz kalan
kadınların, postpartum depresif ve anksiyete bozukluğu riskinin maruz
kalmayanlara kıyasla daha düşük olacağı varsayılmıştır. Olgular "Oksitosin
kullanılan" (n = 100) ve "Kontrol" (n = 100) grupları olmak üzere
iki grup altında incelenmiştir. Oksitosin grubuna postpartum kanamanın
önlenmesi ve tedavisi için doğumdan hemen sonra intravenöz oksitosin verildi.
Doğum sonrası altıncı haftada depresyon ve maternal anksiyete anketleri
yapıldı.
Bulgular: Oksitosin grubunda depresyon insidansı (% 4)
kontrol grubundan (% 14) anlamlı derecede düşüktü (p: 0.026, p <0.05).
Oksitosin kullanmayan hastalarda depresyon gelişme riski 3.9 kat daha fazla
bulundu. Postpartum kanama için oksitosin kullanımı ile postpartum depresyon
semptomlarının azalması arasında bir ilişki saptadık.
Sonuç:
Bulgularımız ekzojen OT kullanılmasının kadınlarda doğum sonrası depresyon ve
anksiyete semptomlarına katkıda bulunabileceğini göstermektedir. Daha fazla
sayıda çalışma ile ekzojen oksitosinin maternal ruh hali ve kaygı üzerindeki
uzun dönem sonuçları ve yüksek dozda uzun süreli OT kullanımının güvenilirliği
araştırılmalıdır.
References
- Noble RE. Depression in women. Metabolism 2005; 54:49–52.
- Dawson G, Ashman S.B, Panagiotides H, Hessl D, Self J, Yamada E. et al. Preschool outcomes of children of depressed mothers: role of maternal behavior, con- textual risk, and children’s brain activity. Child Dev 2003;74:1158– 1175.
- World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. World Health Organization, Geneva. 1992.
- Ross L.E. Measurement issues in postpartum depression Part 1: Anxiety as a feature of postpartum depression. Arch. Womens Ment. Health 2003; 6, 51–57.
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, fifth ed. American Psychiatric Publishing, Arlington, VA. 2013
- Beck C.T. Predictors of postpartum depression: an update. Nurs. Res. 2001; 50, 275–285.
- Perani CV, Slattery DA. Using Animal Models to study Postpartum Psychiatric Disorders. Br J Pharmacol. 2014; 16(10):12640.
- Kim S, Soeken T. A, Cromer S. J, Martinez S. R, Hardy L.R, Strathearn L. Oxytocin and postpartum depression: Delivering on what’s known and what’s not. Brain Research. 2014; 1580:219–232.
- Skrundz M, Bolten M, Nast I, Hellhammer D. H, Meinlschmidt G. Plasma Oxytocin Concentration during Pregnancy is associated with Development of Postpartum Depression. Neuropsychopharmacology. 2011; 36(9):1886–1893.
- Garfield L, Giurgescu C, Carter C. S, Holditch-Davis D, McFarlin B. L, Schwertz D, et al. Depressive symptoms in the second trimester relate to low oxytocin levels in African-American women: a pilot study. Archives of Women’s Mental Health. 2015; 18(1):123–129.
- Feldman, R. Oxytocin and social affiliation in humans. Hormones and Behavior, 2012; 61, 380–391. Riem M. M, Van Ijzendoorn M. H, Tops M, Boksem M. A, Rombouts S. A, Bakermans-Kranenburg M. J. No laughing matter: intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter. Neuropsychopharmacology 2012; 37, 1257–1266.
- Fields H, Greene JWJ, Franklin RR. Intravenous Pitocin in Induction and Stimulation of Labor: A study of 3754 cases. Obstetrics & Gynecology. 1959; 13(3):353–359.
- ACOG. ACOG Practice Bulletin No. 107: Induction of labor. Obstet Gynecol. 2009; 114(2 Pt 1):386– 397.
- Westhoff G, Cotter AM, Tolosa JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev. 2013;10.
- Cox E. Q, Stuebe A, Pearson B, Grewen K, Rubinow D, Meltzer-Brody S. Oxytocin and HPA stress axis reactivity in postpartum women. Psychoneuroendocrinology. 2015; 55:164–172.
- Massey SH, Backes KA, Schuette SA. Plasma oxytocin concentration and depressive symptoms: a review of current evidence and directions for future research. Depression and Anxiety. 2016
- Gu V, Feeley N, Gold I, Hayton B, Robins S, Mackinnon A, et al. Intrapartum Synthetic Oxytocin and Its Effects on Maternal Well-Being at 2 Months Postpartum. Birth. 2016; 43(1):28– 35.
- Guastella A. J, Howard A. L, Dadds M. R, Mitchell P, Carson D. S. A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 2009; 34:917–923.
- Feldman, R, Gordon, I, Zagoory-Sharon, O. Maternal and paternal plasma, salivary, and urinary oxytocin and parent- infant synchrony: considering stress and affiliation components of human bonding. Dev. Sci 2011; 14, 752–761
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research |
| Authors | |
| Publication Date | June 15, 2019 |
| Published in Issue | Year 2019 |