Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi

Deniz Köse; Oral Özay; Tuğrul Semih; Yeşilçiçek Şükrettin; Alkan Akif

doi:10.16948/zktb.00368

Effect of L-thyroxine therapy on bone mineral density in postmenopausal patients

Year 2004, Volume: 35 Issue: 2, 49 - 53, 01.03.2004

Deniz Köse Oral Özay Tuğrul Semih Yeşilçiçek Şükrettin Alkan Akif

Abstract

Objective: to determine the effect of L-thyroxin therapy on bone mineral density in postmenopausal patients Materials and Methods: Fourhundredsixtyeight postmenopausal women were analysed in this study. Thyroid function tests and bone mineral density results were evaluated in all patients. Patients were divided into 3 groups according to BMD as normal, osteopenic and osteoporotic. Control group was consisted of 270 women who had normal BMD. The BMD results of 58 patients taking L-thyroxin therapy were compared with the control group. Results: We compared BMD results of patients who were taking L-tiroksin and the control group. Osteopeni and osteoporozis rates were similar in two groups and there were no significant difference. Conclusion: L-thyroxin therapy at physilogical doses has no effect on BMD in postmenopausal women.

Keywords

Thyroxine, Bone Density, Postmenopause

References

1. Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy Clin Endoerinol 1990 Aug; 33(2):143-53
2. Greenspan SL, Greenspan FS, Resnick N, Block. JE, Friedlan der AL, Genant HK. Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy. Am J Med 1991; 91:5-14
3. Kung AW, Pun KK. Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. JAMA 1991; 265:2688-91
4. Krolner B, Jorgensen JV, Nielsen SP. Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormones and antithyroid treatment. Clin Endocrinol (Oxf). 1983;18:439-46
5. Taelman P, Kaufman JM, Janssens X, Vandecauter H, Vermeulen A. Reduced forearm bone mineral content and biochemical evidence of increased bone turnover in women with euthyroid goitre treated with thyroid hormone. Clin Endocrinol (Oxf). 1990;33:107-17
6. Diamond T, Nery L, Hales I. A therapeutic dilemma: suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. J Clin Endocrinol Metat 1991; 72:1184-88
7. Stall GM, Harris S, Sokoll LJ, Dawson-Hughes B. Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Ann Intern Med. 1990;113:265-9
8. Mosekilde L, Eriksen EF, Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am. 1990;19:35-63
9. Fraser SA, Anderson JB, Smith DA. Osteoporosis and fractures following thyrotoxicosis. Lancet. 1971;1:981-3 10. Ross DS, Neer RM, Chester Ridgway E, Daniels GH. Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. Am J Med. 1987;82:1167-71
11. Krolner B. Nielsen SP. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies
Clin Sci 1982:62:329-36 12. Nilas L, Christiansen C. The pathophysiology of peri and postmenopausal bone loss. Br J Obstet Gynecol 1989:96:580-7 13. Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 1986:7:379-408

Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi

Year 2004, Volume: 35 Issue: 2, 49 - 53, 01.03.2004

Deniz Köse Oral Özay Tuğrul Semih Yeşilçiçek Şükrettin Alkan Akif

Abstract

Amaç: Postmenopozal dönemde L-tiroksin tedavisinin kemik 'mineral yoğunluğu (BMD) üzerindeki etkisini değerlendirmek Materyal ve Metod: Hastanemiz menopoz polikliniğine başvuran 468 olgu çalışmaya alındı.Tüm hastalarda tiroid fonksiyon testleri ve BMD sonuçları değerlendirildi. Hastalar BMD'ne göre normal, osteopeni ve osteoporoz olmak üzere üç gruba ayrıldı. BMD'si normal olan 270 olgu kontrol grubunu oluşturdu. L-tiroksin kullanan 58 hastanın sonuçları tedavi almayan olgularla karşılaştırıldı. Bulgular: L-tiroksin kullanan hastalar ile tedavi almayan olguların BMD'leri değerlendirildiğinde her iki grup arasında osteopeni ve osteoporoz açısından anlamlı bir fark saptanmadı. Sonuç: Fizyolojik dozlarda L-tiroksin alan postmenopozal hastalarda kemik mineral yoğunluğu etkilenmemektedir.

Keywords

Tiroksin, Kemik yoğunluğu, Postmenopoz

References

1. Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy Clin Endoerinol 1990 Aug; 33(2):143-53
2. Greenspan SL, Greenspan FS, Resnick N, Block. JE, Friedlan der AL, Genant HK. Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy. Am J Med 1991; 91:5-14
3. Kung AW, Pun KK. Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. JAMA 1991; 265:2688-91
4. Krolner B, Jorgensen JV, Nielsen SP. Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormones and antithyroid treatment. Clin Endocrinol (Oxf). 1983;18:439-46
5. Taelman P, Kaufman JM, Janssens X, Vandecauter H, Vermeulen A. Reduced forearm bone mineral content and biochemical evidence of increased bone turnover in women with euthyroid goitre treated with thyroid hormone. Clin Endocrinol (Oxf). 1990;33:107-17
6. Diamond T, Nery L, Hales I. A therapeutic dilemma: suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. J Clin Endocrinol Metat 1991; 72:1184-88
7. Stall GM, Harris S, Sokoll LJ, Dawson-Hughes B. Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Ann Intern Med. 1990;113:265-9
8. Mosekilde L, Eriksen EF, Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am. 1990;19:35-63
9. Fraser SA, Anderson JB, Smith DA. Osteoporosis and fractures following thyrotoxicosis. Lancet. 1971;1:981-3 10. Ross DS, Neer RM, Chester Ridgway E, Daniels GH. Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. Am J Med. 1987;82:1167-71
11. Krolner B. Nielsen SP. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies
Clin Sci 1982:62:329-36 12. Nilas L, Christiansen C. The pathophysiology of peri and postmenopausal bone loss. Br J Obstet Gynecol 1989:96:580-7 13. Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev 1986:7:379-408

There are 11 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Deniz Köse This is me Oral Özay This is me Tuğrul Semih This is me Yeşilçiçek Şükrettin This is me Alkan Akif This is me
Publication Date	March 1, 2004
Published in Issue	Year 2004 Volume: 35 Issue: 2

Cite

APA	Köse, D., Özay, O., Semih, T., Şükrettin, Y., et al. (2004). Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni, 35(2), 49-53. https://doi.org/10.16948/zktb.00368
AMA	Köse D, Özay O, Semih T, Şükrettin Y, Akif A. Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni. March 2004;35(2):49-53. doi:10.16948/zktb.00368
Chicago	Köse, Deniz, Oral Özay, Tuğrul Semih, Yeşilçiçek Şükrettin, and Alkan Akif. “Postmenopozal dönemde L-Tiroksin Tedavisinin Kemik Mineral yoğunluğu üzerine Etkisi”. Zeynep Kamil Tıp Bülteni 35, no. 2 (March 2004): 49-53. https://doi.org/10.16948/zktb.00368.
EndNote	Köse D, Özay O, Semih T, Şükrettin Y, Akif A (March 1, 2004) Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni 35 2 49–53.
IEEE	D. Köse, O. Özay, T. Semih, Y. Şükrettin, and A. Akif, “Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi”, Zeynep Kamil Tıp Bülteni, vol. 35, no. 2, pp. 49–53, 2004, doi: 10.16948/zktb.00368.
ISNAD	Köse, Deniz et al. “Postmenopozal dönemde L-Tiroksin Tedavisinin Kemik Mineral yoğunluğu üzerine Etkisi”. Zeynep Kamil Tıp Bülteni 35/2 (March 2004), 49-53. https://doi.org/10.16948/zktb.00368.
JAMA	Köse D, Özay O, Semih T, Şükrettin Y, Akif A. Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni. 2004;35:49–53.
MLA	Köse, Deniz et al. “Postmenopozal dönemde L-Tiroksin Tedavisinin Kemik Mineral yoğunluğu üzerine Etkisi”. Zeynep Kamil Tıp Bülteni, vol. 35, no. 2, 2004, pp. 49-53, doi:10.16948/zktb.00368.
Vancouver	Köse D, Özay O, Semih T, Şükrettin Y, Akif A. Postmenopozal dönemde L-tiroksin tedavisinin kemik mineral yoğunluğu üzerine etkisi. Zeynep Kamil Tıp Bülteni. 2004;35(2):49-53.