The efficacy of oral maintenance treatment with ritodrine in threatened preterm labor

Year 2002, Volume: 33 Issue: 2, 12 - 15, 01.03.2002

Nuran Can Güleş Banu Çağlarbaşı Özay Oral Semih Tuğrul

Abstract

Objective: This study was undertaken to determine, in a prospective study, the effect of oral Ritodrine after successful intravenous tocolysis on averaged gestational age at delivery, latency period, averaged so: birth weight, neonatal length of stay in intensive care unit, neonatal mortality and morbidity. Materials and Methods: A total of 124 pregnant women threatened with preterm labor between 27 and 36 weeks of gestation were randomized as group treated with Ritodrine (5 mg orally, every 2 hours in the 24 hours and followed by 5 mg orally, every 4 hours until 36th week) or plasebo group. The patients, who had recurrent preterm delivery threat, had been retreated with IV Tocolysis. Results: Of the 124 patient who had been randomized, 24 were excluded from study because of various complications and lost to follow up, leaving for 50 patients for each group. Averaged gestational age at delivery (34,94+2,78 vs 34,32±2,25, p=0,28), latency period ( 19,15± vs 18,7±17,03, p=0,89), averaged birth weight (2480,2±662,3 gr vs 2338,4+537,5 gr p=0,24) neonatal length of stay in intensive care unit (9,92±5,69 vs 12,66±11,25, p=0,42). No statistical difference were documented between the groups. Conclusion: Use of oral Ritodrine after successful parenteral tocolysis during 27th to 34th weeks of gestation had no extra beneficial effect.

Keywords

Morbidity, Mortality, Prospective Studies, Ritodrine, Tocolytic Agents, Administration, Oral, Injections, Intravenous

Erken doğum tehdidi olgularında ritodrin ile idame oral tokolitik tedavinin etkinliği

Abstract

Arnaç: İntravenöz Ritodrin ile başarılı bir şekilde tedavi edilen hastalarda oral Ritodrin ile idame tokolitik tedavinin, ortalama doğum haftası, latent period, ortalama yenidoğan ağırlığı, yoğunbakımda kalma süresi ve neonatal mortalite ve morbidite üzerindeki etkilerini araştırmak. Materyal ve metod: Başarılı İntravenöz tokolitik tedavi sonrası, 27- 36. gebelik haftalarındaki 124 olgu Ritodrin alan (ilk 24 saat boyunca 12x1 oral 5mg Ritodrin ve 36. gebelik haftasına kadar günde 6x1 oral 5mg Ritodrin) ve almayan kontrol grubu olarak randomize edildi. Rekürren preterm eylemler IV Ritodrin ile tedavi edildi.. Bulgular: Gebelik sonuçları 100 olguda değerlendirildi. İki grup arasında doğumdaki ortalama gebelik haftası (34,942±2,78 ve 34,325±2,25 p=0,28), latent period (19,15+16,85 ve 18,7 ±17,03 p=0,89), rekürren preterm eylem (3 ve 16 p= 0,46 ), doğum ağırlığı ( 2480,2±662,36gr ve 2338,4±537,55 gr p=0,24 ), yeni doğan yoğun bakımında kalış süresi (9,92+5,69 ve 12,66±11,25, p=0,42) olarak bulundu. Karşılaştırılan tüm veriler açısından iki grup arasında istatistiksel olarak anlamlı bir fark tesbit edilmedi. Sonuç: Erken doğum tehdidinin İntravenöz Ritodrin ile tedavi edilmesinden sonra oral Ritodrin tedavisi ilave bir fayda sağlamamaktadır.

Keywords

Hastalık oranı, Ölüm oranı, İleriye dönük çalışma, Ritodrin, Tokolitik ajanlar, İlaç uygulama, oral, Enjeksiyon, ven içi

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