Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi

Ufuk Yılmaz; Hakan Peker; Adalet Zati; Şeyma Baştürk; Leyla Altuntaş; Ateş Karateke

doi:10.16948/zktb.41764

The significance of serum uric acid levels in hypertensive diseases of pregnancy

Year 2003, Volume: 34 Issue: 1, 19 - 25, 01.02.2003

Ufuk Yılmaz Hakan Peker Adalet Zati Şeyma Baştürk Leyla Altuntaş Ateş Karateke

Abstract

Objective: Our purpose was to evaluate if uric acid levels at hypertensive diseases of pregnancy has clinical utility on severity of preeclampsia and perinatal prognosis. Material - Method: 267 patients whose serum uric acid levels have been measured during 3rd trimester of pregnancy were involved in our study. These patients have been examined under four groups. These groups were; control (n=110), mild preeclampsia (n=68), severe preeclampsia (n=72) and chronic hypertension (n=17). Average serum uric acid levels, age, gravida, parity, abortion, live birth, gestational week, birth weight, hemoglobin, hematocrit and platelet levels have been compared between all groups by using GraphPadPrisma V.3 packet program. Results: Comparing mild preeclampsia and severe preeclampsia groups seperately with the control group according to avarage serum uric acid levels, serious diversity has been found (p0,05 ). When severe and mild preeclampsia groups have been compared with each other according to serum uric acid levels, distinction was statistically meaningful (p

Keywords

Pregnancy Trimester, Third, Uric Acid, Pre-Eclampsia, Hypertension

References

1. Slemmons J, Bogert L. The uric acid content of maternal and fetal blood. J Biol Chem 1917; 32: 63-69
2. Acien P, Lioret G, Lloret M. Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings, lnt j Gynecol Obstet 1990; 32: 229-35
3. Sagen N, Kjell H, Nilsen S. Serum urate as a predictor of fetal outcome in severe preeclampsia. Acta Obstet Gynecol Scand 1984; 63: 71-75
4. Hayashi T. Uric acid and endogenous clearance studies in normal pregnancy and toxemias of pregnancy. Am J Obstet Gynecol 1956; 71:859-70
5. Redman CVG, Beilin LJ, Bonnar J, Wilkinson RH. Plasma urate measurements in predicting fetal death in hypertensive pregnancy. Lancet 1976; 2: 1370-73
6. Roberts J. Pregnancy related hypertension. In: Creasy R, Resnik R, eds. Maternal Fetal Medicine: principles and practice 3rd ed. Philadelphia: WB Saunders; 1994. p. 804-43
7. Schuster E, Weppelmann B. Plasma urate measurements and fetal outcome in preeclampsia. Gynecol Obstet Invest 1981; 12: 162-67
8. Boyle JA, Campbell S, Duncan AM, Greig WR, Buchanan WW. Serum uric acid levels in normal pregnancy with observations on the renal excretion of urate in pregnancy. J Clin Pathol 1966; 19: 501-03
9. Chesley L, Williams L. Renal glomerular and tubular function is relation to the hyperuricemia of preeclampsia and eclampsia. Am J Obstet Gynecol 1945; 50: 367-75
10. Chesley LC. The movement of radioactive sodium in normal pregnant, nonpreg-nant, and preeclamptic women. Am J Obstet Gynecol 1970; 106: 530-33
11. Gallery ED, Ross M, Grigg R, Bean C. Are the renal functional changes of human pregnancy caused by prostacyclin? Prostaglandins 1985; 30: 1019-29
12. D'Anna R, Bavıera G, Scilipoti A, Leonardi I, Leo R. The clinical utility of serum uric acid measurements in preeclampsia and transient hypertension in pregnancy. Panminerva Med 2000; 42:101-103
13. Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol 1996; 174: 288-91
14. Faggioni R, Gatti S, Demitri MT, et al. Role of xanthine oxidase and reactive oxygen intermediates in LPS and TNF induced pulmonary edema. J Lab Clin Med 1994; 123:394-99
15. Falciani F, Ghezzi P, Terao M, Cazzaniga G, Garaniti E. Interferons induce xanthine dehydrogenase gene expression in L1929 cells. Biochem J 1992; 285: 1001-08
16. Dupont GP, Huecksteadt TP, Marshall BC, Ryan US, Michael JR, Hoidal JR. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothe-lial cells. J Clin Invest 1992; 89:197-202
17. Cunningham FG. Hypertensive disorders in pregnancy. In: Cunningham FG, Mac Donald PC, Gant NF, Leveno KJ, Gilstrap LC, Hankins GDV, Clark SL, eds. Williams Obstetrics 21 th ed. Connecticut: 18. Voto LS, Illia R, Darbon-G rosso HA, Imaz FU, Margulies M. Uric acid levels : a useful index of the severity of preeclamp-sia and perinatal prognosis. J Perinat Med 1988; 16: 123-26
19. Kharb S. Hyperuriceniia, oxidadve stres in preeclampsia, letter to the editor. Clin Chimica Acta 2001; 305: 201-203
20. Lim KH, Friedman SA, Ecker JL, Kao L, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol 1998; 178: 1067-71.

Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi

Year 2003, Volume: 34 Issue: 1, 19 - 25, 01.02.2003

Ufuk Yılmaz Hakan Peker Adalet Zati Şeyma Baştürk Leyla Altuntaş Ateş Karateke

Abstract

Amaç: Gebelerin hipertansif hastalıklarında ürik asit düzeylerinin, hastalığın ağırlığı ve perinatal sonuçları hakkında klinik öneminin olup olmadığının araştırılması. Materyal ve Metod: Çalışmamıza serum ürik asit düzeyleri 3. trimester içinde ölçülen 267 olgu alındı. Bu olgular toplam dört grupta incelendi. Bu gruplar kontrol (n=110), hafif preeklampsi (n=68), ağır preeklampsi (n=72) ve kronik hipertansiyon (n=17) olarak oluşturuldu. Bütün gruplar arasında ortalama serum ürik asit düzeyleri, yaş, gravida, parite, abortus, yaşayan çocuk, gestasyonel hafta, doğum kilosu, hemoglobin, hematokrit ve trombosit düzeyleri Graph PadPrisma V3 paket programı kullanılarak karşılaş tırıldı. Bulgular: Kontrol grubu ile hafif ve ağır preeklampsi grupları, ortalama serum ürik asit düzeylerine göre ayn ayrı kıyaslan dığında, önemli derecede farklılık saptandı (p0,05). Ağır ve hafif preeklampsi grupları serum ürik asit düzeyleri açısından kendi aralarında kıyas landığında ise, istatistiki yönden fark anlamlıydı (p

Keywords

Gebelik trimester, üçüncü, Ürik asit, Preeklampsi, Hipertansiyon

References

1. Slemmons J, Bogert L. The uric acid content of maternal and fetal blood. J Biol Chem 1917; 32: 63-69
2. Acien P, Lioret G, Lloret M. Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings, lnt j Gynecol Obstet 1990; 32: 229-35
3. Sagen N, Kjell H, Nilsen S. Serum urate as a predictor of fetal outcome in severe preeclampsia. Acta Obstet Gynecol Scand 1984; 63: 71-75
4. Hayashi T. Uric acid and endogenous clearance studies in normal pregnancy and toxemias of pregnancy. Am J Obstet Gynecol 1956; 71:859-70
5. Redman CVG, Beilin LJ, Bonnar J, Wilkinson RH. Plasma urate measurements in predicting fetal death in hypertensive pregnancy. Lancet 1976; 2: 1370-73
6. Roberts J. Pregnancy related hypertension. In: Creasy R, Resnik R, eds. Maternal Fetal Medicine: principles and practice 3rd ed. Philadelphia: WB Saunders; 1994. p. 804-43
7. Schuster E, Weppelmann B. Plasma urate measurements and fetal outcome in preeclampsia. Gynecol Obstet Invest 1981; 12: 162-67
8. Boyle JA, Campbell S, Duncan AM, Greig WR, Buchanan WW. Serum uric acid levels in normal pregnancy with observations on the renal excretion of urate in pregnancy. J Clin Pathol 1966; 19: 501-03
9. Chesley L, Williams L. Renal glomerular and tubular function is relation to the hyperuricemia of preeclampsia and eclampsia. Am J Obstet Gynecol 1945; 50: 367-75
10. Chesley LC. The movement of radioactive sodium in normal pregnant, nonpreg-nant, and preeclamptic women. Am J Obstet Gynecol 1970; 106: 530-33
11. Gallery ED, Ross M, Grigg R, Bean C. Are the renal functional changes of human pregnancy caused by prostacyclin? Prostaglandins 1985; 30: 1019-29
12. D'Anna R, Bavıera G, Scilipoti A, Leonardi I, Leo R. The clinical utility of serum uric acid measurements in preeclampsia and transient hypertension in pregnancy. Panminerva Med 2000; 42:101-103
13. Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol 1996; 174: 288-91
14. Faggioni R, Gatti S, Demitri MT, et al. Role of xanthine oxidase and reactive oxygen intermediates in LPS and TNF induced pulmonary edema. J Lab Clin Med 1994; 123:394-99
15. Falciani F, Ghezzi P, Terao M, Cazzaniga G, Garaniti E. Interferons induce xanthine dehydrogenase gene expression in L1929 cells. Biochem J 1992; 285: 1001-08
16. Dupont GP, Huecksteadt TP, Marshall BC, Ryan US, Michael JR, Hoidal JR. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothe-lial cells. J Clin Invest 1992; 89:197-202
17. Cunningham FG. Hypertensive disorders in pregnancy. In: Cunningham FG, Mac Donald PC, Gant NF, Leveno KJ, Gilstrap LC, Hankins GDV, Clark SL, eds. Williams Obstetrics 21 th ed. Connecticut: 18. Voto LS, Illia R, Darbon-G rosso HA, Imaz FU, Margulies M. Uric acid levels : a useful index of the severity of preeclamp-sia and perinatal prognosis. J Perinat Med 1988; 16: 123-26
19. Kharb S. Hyperuriceniia, oxidadve stres in preeclampsia, letter to the editor. Clin Chimica Acta 2001; 305: 201-203
20. Lim KH, Friedman SA, Ecker JL, Kao L, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol 1998; 178: 1067-71.

There are 19 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Ufuk Yılmaz This is me Hakan Peker This is me Adalet Zati This is me Şeyma Baştürk This is me Leyla Altuntaş This is me Ateş Karateke This is me
Publication Date	February 1, 2003
Published in Issue	Year 2003 Volume: 34 Issue: 1

Cite

APA	Yılmaz, U., Peker, H., Zati, A., Baştürk, Ş., et al. (2003). Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi. Zeynep Kamil Tıp Bülteni, 34(1), 19-25. https://doi.org/10.16948/zktb.41764
AMA	Yılmaz U, Peker H, Zati A, Baştürk Ş, Altuntaş L, Karateke A. Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi. Zeynep Kamil Tıp Bülteni. February 2003;34(1):19-25. doi:10.16948/zktb.41764
Chicago	Yılmaz, Ufuk, Hakan Peker, Adalet Zati, Şeyma Baştürk, Leyla Altuntaş, and Ateş Karateke. “Gebeliğin Hipertansif hastalıklarında Serum ürik Asit Seviyelerinin önemi”. Zeynep Kamil Tıp Bülteni 34, no. 1 (February 2003): 19-25. https://doi.org/10.16948/zktb.41764.
EndNote	Yılmaz U, Peker H, Zati A, Baştürk Ş, Altuntaş L, Karateke A (February 1, 2003) Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi. Zeynep Kamil Tıp Bülteni 34 1 19–25.
IEEE	U. Yılmaz, H. Peker, A. Zati, Ş. Baştürk, L. Altuntaş, and A. Karateke, “Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi”, Zeynep Kamil Tıp Bülteni, vol. 34, no. 1, pp. 19–25, 2003, doi: 10.16948/zktb.41764.
ISNAD	Yılmaz, Ufuk et al. “Gebeliğin Hipertansif hastalıklarında Serum ürik Asit Seviyelerinin önemi”. Zeynep Kamil Tıp Bülteni 34/1 (February 2003), 19-25. https://doi.org/10.16948/zktb.41764.
JAMA	Yılmaz U, Peker H, Zati A, Baştürk Ş, Altuntaş L, Karateke A. Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi. Zeynep Kamil Tıp Bülteni. 2003;34:19–25.
MLA	Yılmaz, Ufuk et al. “Gebeliğin Hipertansif hastalıklarında Serum ürik Asit Seviyelerinin önemi”. Zeynep Kamil Tıp Bülteni, vol. 34, no. 1, 2003, pp. 19-25, doi:10.16948/zktb.41764.
Vancouver	Yılmaz U, Peker H, Zati A, Baştürk Ş, Altuntaş L, Karateke A. Gebeliğin hipertansif hastalıklarında serum ürik asit seviyelerinin önemi. Zeynep Kamil Tıp Bülteni. 2003;34(1):19-25.