Short term effects of raloxifene on coagulation profile

Year 2005, Volume: 36 Issue: 2, 61 - 64, 01.03.2005

Deniz Köse Hüsamettin Uslu Özay Oral Semih Tuğrul Akif Alkan Arzu Aydın

Abstract

Objective: To evaluate the short term effects of Raloxifene use on coagulation profile. Materials and Methods: 51 patients who were followed prospectively in our menopause clinic during October 2002 - January 2004 had been evaluated. All the patients had been given 60 mg Raloxifene single dose daily for 6 months. Pretreatment and 6th month serum fibrinogen, Activated Partial Thromboplastin Time (APTT), Prothrombin Time(PT) and platelet values were recorded and statistical analysis were made by paired samples t-test in SPSS version 11,5. Results: Mean patient age was 54.1 7.67 years and mean menopause age was 7.1 5.7years. No statistically significant differences were found in terms of serum APTT, PT and fibrinogen levels in pre and post treatment groups. A significant decrease in the number of platelets was recorded in the serum samples on the 6th month, (p =0,001) Conclusion: We found that Raloxifene use dose not have a short term significant effect on coagulation parameters.

Keywords

Raloxifene, Prospective Studies, Postmenopause, Blood Coagulation

Raloksifen Hcl tedavisinin koaglasyon profiline etkisi

Abstract

Amaç: Raloksifen HC1 tedavisinin koagulasyon profili üzerine olan erken dönem etkilerinin araştırılması. Gereç ve Yöntem: Kliniğimiz menopoz polikliniğinde Ekim 2002-Ocak 2004 tarihleri arasında prospektif olarak takip edilen 51 postmenopozal hasta çalışmaya dahil edilmiştir. Tüm hastalar 6 ay boyunca günde tek doz 60 mg Raloksifen HC1 kullanmışlardır. Bazal ve 6. ay serum fibrinojen, Aktive Parsiyel Trombophstin Zamanı(APTT), Protrombin Zamam(PT) ve trombosit değerleri kayıt edilip, SPSS 11.5 ile eşlendirilmiş örneklemde t-testi kullanılarak istatistiksel olarak karşılaştmlmıştır. Bulgular: Çalışmada ortalama hasta yaşı 54,1 7,6 ve ortalama menopoz yaşı 7,1 5,7 idi. Serum fibrinojen, APTT ve PT bazal ve 6. ay değerleri arasında anlamlı bir fark saptanmazken, trombosit sayısının 6. ayda anlamlı olarak azaldığı tespit edilmiştir (p = 0,001). Sonuç: Biz çalışmamızda Raloksifen HC1 kullanımının erken dönemde koagulasyon profili üzerinde anlamlı bir değişiklik yapmadığını saptadık.

Keywords

Raloksifen, İleriye dönük çalışma, Postmenopoz, Kan pıhtılaşması

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